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Martina Jonsson J Chemistry and Toxicology Research Unit, Finnish Food Safety Authority (Evira), Mustialankatu 3, FI-00790 Helsinki, - - 2014
Moniliformin is a Fusarium mycotoxin mainly produced by several species infecting grains in different climatic conditions. According to our previous studies, it is acutely toxic to rats, with an LD50 cut-off value of 25mg/kg b.w. To further assess the possible health risks of low dose exposure to moniliformin, a subacute ...
Poon Shirley - - 2014
The efficacy of using hair as a biomarker for exposure to polybrominated diphenyl ether (PBDE) flame retardants was assessed in humans and an animal model. Paired human hair and serum samples were obtained from adult men and women (n=50). In parallel, hair, serum, liver and fat were collected from adult ...
Pucaj Kresimir K Nucro-Technics, Toronto, Ontario, Canada, M1H - - 2014
This study examined the safety, pharmacodynamic (PD), and pharmacokinetic (PK) biosimilarity of the human recombinant erythropoietin (EPO) products ior(®) EPOCIM and Eprex(®) following a 28-day repeated intravenous dose administration in male and female Sprague-Dawley rats with a 14-day recovery period. Safety profiling was based on clinical observations, clinical pathology, and ...
Dasdag S - - 2014
Oral tissues are important parts of body that absorbs radiation emitted from mobile phones which is the most popular technological equipment in the world. Because of the limited studies in this field, we aimed to investigate the effect of Radio Frequency (RF) radiation emitted from 900 MHz mobile phones on ...
Wang Jianfeng J Department of Pain Management, Shandong Provincial Hospital Affiliated to Shandong University, Jinan City, Shandong Province, China; Department of Pain Management, Qilu Hospital, Shandong University, Jinan City, Shandong Province, - - 2014
Obesity is associated with augmented peripheral inflammation and pain sensitivity in response to inflammatory stimulation, but the underlying mechanisms remain unclear. Emerging evidence has shown that activation of peroxisome proliferator-activated receptor-α (PPARα) in central nervous system controls peripheral inflammation and pain. We hypothesized that obesity might down-regulate PPARα in the ...
Di Fan F School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, - - 2014
Dehydroeffusol is a naturally occurring phenanthrene isolated from Juncus effusus. In the context of screening new drugs against gastrointestinal spasms, we investigated its effects on isolated rat jejunum in vitro. Dehydroeffusol (30-90 µM) slightly and transiently enhanced contractions in a concentration-dependent manner but significantly inhibited the contractions induced by KCl (100 mM), ...
Wang Yu Y Department of Pharmacology, Beijing Institute of Heart Lung and Blood Vessel Diseases-Beijing An Zhen Hospital, Capital Medical - - 2014
Our previous studies found that Hydroxysafflor yellow A (HSYA), an active ingredient in Carthamus tinctorius L., has anti-inflammatory and anti-fibrosis properties. In this study, we investigated the effect of HSYA on small airway remodeling (SAR) in a chronic obstructive pulmonary disease (COPD) rat model induced by cigarette smoke and lipopolysaccharide ...
Lu Silu S Department of Physiology, University of Mississippi Medical - - 2014
In vitro superoxide activates pulmonary endothelial TRPM2 channels and increases the capillary filtration coefficient (Kf). We hypothesized that pulmonary capillary Kf is increased in a model of type I diabetes due to elevated vascular superoxide and resultant TRPM2 channel activation. Type I diabetes was induced in Zucker rats using streptozotocin. ...
Watanabe Sadahiro S Department of Radiology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, - - 2014
The effect of inhalation of hydrogen-containing gas (1.3% hydrogen + 20.8% oxygen + 77.9% nitrogen) (HCG) on radiation-induced dermatitis and on the healing of healing-impaired skin wounds in rats was examined using a rat model of radiation-induced skin injury. An X-ray dose of 20 Gy was irradiated onto the lower ...
Van der Meeren A - - 2014
Abstract Purpose: To investigate the consequences of alveolar macrophage (AM) depletion on Mixed OXide fuel (MOX: U, Pu oxide) distribution and clearance, as well as lung damage following MOX inhalation. Materials and Methods: Rats were exposed to MOX by nose only inhalation. AM were depleted with intratracheal administration of liposomal ...
Nakano Yuko Y Onco-Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University, Kagawa 761-0793, - - 2014
Chronic inflammatory effects of single intratracheal instillation (i.t.) of quartz on rat lung tumorigenesis were examined using 4 different animal models. At first, in order to determine an appropriate dose of quartz i.t. to promote lung tumorigenesis, F344 male rats were administrated single 0, 0.5, 1, 2 or 4mg quartz/rat ...
Dhakal Kiran - - 2014
Lower chlorinated PCBs, such as PCB3, are air contaminants in buildings and outdoors. Metabolites of PCB3 are potential endocrine disrupting chemicals and genotoxic agents. We studied the disposition of phenolic and sulfated metabolites after acute nose-only inhalation exposure to airborne PCB3 for 2 h in female rats. Inhalation exposure was ...
Gao Fu-Sheng FS Department of Respiratory Medicine, The Affiliated Hospital of Weifang Medical College, Weifang, - - 2014
ABSTRACT Epidemiologic studies suggest that increased concentrations of airborne spores of Aspergillus fumigatus closely relate to asthma aggravation. Chronic exposure to A. fumigatus aggravates airway inflammation, remodeling, and airway hyperresponsiveness in asthmatic rats. The effects of chronic exposure to A. fumigatus on epidermal growth factor receptor (EGFR) expression in the ...
Herring Matt J MJ University of California - - - 2014
Rationale: Alveolarization in humans and nonhuman primates begins during prenatal development. Advances in stereological counting techniques allow accurate assessment of alveolar number; however, these techniques have not been applied to the developing human lung. Methods: Based on the recent ATS guidelines for stereology, lungs from human autopsies, ages 2 months ...
Wei Jin-Song JS Chinese Medicine Hospital of Jingshan County Department of Medicine Hubei, Jinshan - - 2014
In order to determine whether local anesthetics directly affect the propagation and strength of myometrial contractions, we compared the effects of bupivacaine, ropivacaine, lidocaine and tetracaine on the contractions of myometrium isolated from pregnant and non-pregnant rats. Full-thickness myometrial strips were obtained from 18- to 21-day pregnant and non-pregnant Sprague-Dawley ...
Zhang Dan D Department of Obstetrics and Gynaecology, Shengjing Hospital of China Medical University, Shenyang, - - 2014
Introduction: Recently, emerging evidence has indicated that preeclamptic women who have angiotensin receptor agonistic autoantibodies (AT1-AA), these antibodies contribute to features of the disease. Aim: The purpose of this study was to determine the role of spiral artery remodeling in mediating AT1-AA-induced hypertension and intrauterine growth restriction in pregnant rats. We hypothesized ...
Choi Bo-Hwa BH Department of Pharmacology, Inha University College of Medicine by BK 21 Project, Incheon 400-711, South - - 2014
The aim of the present study was to use an animal model of interstitial cystitis (IC) in order to investigate the histology and function of the bladder, with a particular focus on mast cell degranulation and response to detrusor overactivity (DO) to tolterodine. A total of 18 female Sprague‑Dawley rats were ...
Wang Yang Y Department of Pathophysiology, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China; Department of Respiratory Medicine, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, - - 2014
To explore the effects of heme oxygenase-1 (HO-1) on vascular dysfunction in high fat diet streptozotocin-induced type 2 diabetic (T2D) rats. Rats received a high-fat diet followed by a low dose of streptozotocin (30mg/kg) to induce T2D. T2D rats were treated with hemin (1, 5, or 25mg/kg) or carbon monoxide-releasing ...
Yao Hsien-Tsung HT Department of Nutrition, China Medical University, 91, Hsueh-shih Road, Taichung 404, Taiwan. Electronic address: - - 2014
The effect of commercially available green tea (GT) and black tea (BT) drinks on drugmetabolizing enzymes (DME) and oxidative stress in rats was investigated. Male Wistar rats were fed a laboratory chow diet and GT or BT drink for 5 weeks. Control rats received de-ionized water instead of the tea ...
Kemp Brandon A BA Division of Endocrinology and Metabolism, Department of Medicine - - 2014
Excess weight gain contributes up to 65 of the risk of primary hypertension, and the increase in blood pressure in response to high-fat diet (HFD) is preceded by significant increases in renal tubular sodium (Na(+)) reabsorption. In normal rats, intrarenal ghrelin infusion increases distal nephron-dependent Na(+) reabsorption via activation of ...
Oakes Jessica M JM - - 2014
Aerosolized drugs are increasingly being used to treat chronic lung diseases or to deliver therapeutics systemically through the lung. The influence of disease, such as emphysema, on particle deposition is not fully understood. Using magnetic resonance imaging (MRI), the deposition pattern of iron oxide particles with mass median aerodynamic diameter ...
Iacobellis Francesca F Department of Radiology, Azienda Ospedaliero Universitaria di Cagliari-Polo di Monserrato, SS 554 Monserrato, 09045 Cagliari, Italy. - - 2014
Objectives- The aim of this study was to detect the onset, evolution, and meaning of extraluminal free fluid in a rat model of small-bowel obstruction using high-frequency microsonography. Methods- Small-bowel obstruction was surgically created in 8 rats divided into 2 groups of 4 rats each. All rats were examined by ...
Sumi Genichiro G Department of Obstetrics and Gynecology, Affiliated Takii Hospital, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka, 570-8507, - - 2014
We previously reported that shakuyaku-kanzo-to, a kampo medicine consisting of shakuyaku and kanzo, has an inhibitory effect on myometrial contractions in pregnant women. In this study, we evaluated the effects of kanzo, glycyrrhizin (a major component of kanzo), glycyrrhetinic acid (GA; a major metabolite of glycyrrhizin), shakuyaku, and paeoniflorin (a ...
Egger Christine C 1Novartis Institutes for BioMedical - - 2014
Idiopathic pulmonary fibrosis is a progressive and lethal disease, characterized by loss of lung elasticity and alveolar surface area, secondary to alveolar epithelial cell injury, reactive inflammation, proliferation of fibroblasts and deposition of extracellular matrix. The effects of oropharyngeal aspiration of bleomycin in Sprague Dawley rats and C57BL/6 mice, as ...
Kikuchi Chigusa C Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City - - 2014
Endothelium-derived superoxide induces vascular dysfunctions. The aim of this study was to examine the activity of protein kinase C (PKC) isoforms and endothelial nitric oxide synthase (eNOS), which leads to vascular superoxide production in type 2 diabetes, in addition to the effects of pravastatin. We studied these mechanisms in Otsuka ...
Jeong Keun-Yeong KY Neuroscience Research Institute, Korea University Medical College, Seoul, Republic of Korea; Department of Radiation Oncology, Yonsei University Medical College, Seoul, Republic of Korea. Electronic address: - - 2014
The transient receptor potential vanilloid 1 (TRPV1) is a cation channel that serves as a polymodal detector of noxious stimuli such as capsaicin. Therefore, capsaicin treatment has been used to investigate the physiological function of TRPV1. Here, we report physiological changes induced by treating neonatal rats with capsaicin. Capsaicin (50mg/kg) ...
Staal Yvonne C M YC 1TNO Triskelion BV, Zeist, The - - 2014
The interaction between exposure to nanomaterials and existing inflammatory conditions has not been fully established. Multiwalled carbon nanotubes (MWCNT; Nanocyl NC 7000 CAS no. 7782-42-5; count median diameter in atmosphere 61 ± 5 nm) were tested by inhalation in high Immunoglobulin E (IgE)-responding Brown Norway (BN) rats with trimellitic anhydride ...
Houin Paul R PR Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, - - 2014
Background: Inhalation of sulfur mustard (SM) and SM analog, 2-chloroethyl ethyl sulfide (CEES), cause fibrinous cast formation that occludes the conducting airways, similar to children with Fontan physiology-induced plastic bronchitis. These airway casts cause significant mortality and morbidity, including hypoxemia and respiratory distress. Our hypothesis was that intratracheal heparin, a ...
Adebayo Abiodun Humphrey AH Biochemistry & Molecular Biology Unit, Department of Biological Sciences, Covenant University, PMB 1023, Canaan Land, Ota, - - 2014
Anchomanes difformis is a tropical plant that has been used in folklore to treat diverse complications. The leaf extract of A. difformis was investigated for possible anti-nociceptive and anti-inflammatory effects in albino wistar rats. In these independent studies, two sets of twenty five rats were divided into five groups of ...
Li Zhipeng Z State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Media, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, - - 2014
Osthole has been reported to possess a variety of pharmacological activities, such as antiinflammatory effect. In the present study, we have investigated the effect of osthole on lung inflammation associated with carrageenan-induced pleurisy in rats. The result showed that osthole could inhibit significantly pleural exudates formation and PMNs infiltration. Histological ...
Pauluhn Jürgen J Bayer Pharma AG, Wuppertal, Germany. Electronic address: - - 2014
Toluene diisocyanate (TDI), a known human asthmagen, was investigated in skin-sensitized Brown Norway rats for its concentration x time (Cxt)-response relationship on elicitation-based endpoints. The major goal of study was to determine the elicitation inhalation threshold dose in sensitized, re-challenged Brown Norway rats, including the associated variables affecting the dosimetry ...
Simpson J A JA Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada K7L 3N6. Electronic address: - - 2014
Mechanical respiratory loads induce cardiorespiratory failure, presumably by increasing O2 demand concurrently with decreases in O2 availability (decreased PaO2). We tested the hypothesis that asphyxia alone can cause cardiorespiratory failure ("failure") in pentobarbital-anesthetized rats. We also tested the hypothesis that hypoxia, not hypercapnia, is responsible by supplying supplemental O2 during ...
Wang Yang Y Department of Pathophysiology, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China; Department of Respiratory Medicine, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, - - 2014
To explore effects of heme oxygenase-1 (HO-1) on vascular dysfunction in high fat diet streptozotocin-induced type 2 diabetic (T2D) rats. Rats received a high-fat diet followed by a low dose of streptozotocin (30mg/kg) to induce T2D. T2D rats were treated with hemin (1, 5, or 25mg/kg) or Carbon monoxide-releasing molecule-2 ...
Ardizzone Michele M Via Bligny 4, 15033 Casale Monferrato, AL, Italy. Electronic address: - - 2014
Asbestos has been banned in many countries, including Italy. However, sources of exposure may still exist, due to asbestos in-situ or past disposal of asbestos-containing waste. In an urban area with past high environmental exposure, like Casale Monferrato, the lung fiber burden in sentinel animals may be useful to identify ...
Risse Paul-Andre PA 1McGill - - 2014
Innate airway hyperresponsiveness (AHR) is well modeled by two strains of rat, the hyperresponsive Fischer 344 rat and the normoresponsive Lewis rat. Arginase has been implicated in AHR associated with allergic asthma models. We addressed the role of arginase in innate AHR using the Fischer-Lewis model. In vivo arginase inhibition ...
Beyazyıldız Emrullah E 1 Department of Ophthalmology, Gazi Mustafa Kemal State Hospital , Ankara, Turkey - - 2014
Abstract Purpose: The aim of the current study is to compare the effects of two corticosteroids, prednisolone acetate 1% (PA) and loteprednol etabonate 0.5% (LE), for the treatment of benzalkonium chloride (BAC)-induced dry eye syndrome (DES) in rats. Methods: DES was established by topical administration of 0.2% BAC, a commonly ...
Hudkins Robert L RL Discovery and Product Development, Teva Pharmaceutical Global R&D, 145 Brandywine Parkway, West Chester, PA 19380, USA. Electronic address: - - 2014
A series of fused cyclopropyl-4,5-dihydropyridazin-3-one (3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one) phenoxypiperidine analogs was designed and synthesized, leading to the identification of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a) as a second-generation pyridazin-3-one H3R antagonist. Compound R,S-4a was a potent H3R functional antagonist in vivo in the rat dipsogenia model, demonstrated potent wake activity in the rat EEG/EMG model, and ...
de Oliveira Gisele Pena GP 1Laboratory of Pulmonary Investigation, 2Laboratory of Cellular and Molecular Physiology Carlos Chagas Filho Biophysics Institute, 3Laboratory of Frontiers in Neuroscience, Institute of Biomedical Sciences, 4Laboratory of Cellular Pathology, 5Laboratory of Inflammation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, 6Department of Pathology, School of Medicine, University of São Paulo, Brazil, 7IRCCS AOU San Martino-IST, Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Largo Rosanna Benzi 8, 16132, Genoa, - - 2014
Malnutrition is a risk factor for infection, compromising immune response. Glutamine (Gln) protects the lungs and distal organs in well-nourished septic and non-septic conditions; however, no study to date has analyzed the effects of glutamine in the presence of sepsis and malnutrition. In the present work, we tested the hypothesis ...
Xiang Lusha L Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, - - 2014
Lung capillary filtration coefficient (Kf) and impacts of oxidative stress have not been determined in the setting of severe trauma, especially in obese patients who exhibit increased lung injury. We hypothesized that severe trauma leads to a greater increase in lung Kf in obesity due to exacerbated production of and/or ...
Kdkp Kumari K Department of Biochemistry, University of Sri Jayewardenepura, Gangodawilla, Nugegoda, Sri - - 2014
Almost all part of the plant Aegle marmelos (Bael tree) has been used in the traditional medicine systems of Asian countries to treat various diseases over many centuries. The water extract of the dried flowers of A. marmelos is a commonly used beverage among Sri Lankan population in rural areas. ...
Sin'kov M A MA Research Institute of Complex Cardiovascular Problems, Siberian Division of the Russian Academy of Medical Sciences, Kemerovo, Russia, - - 2014
We present an original and safe experimental model of the rat aorta angioplasty with a paclitaxel-releasing balloon catheter. No toxic effects of the drug on experimental animals were detected.
Zou Yimin Y The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Diseases, the First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, - - 2014
Peribronchiolar fibrosis is an important feature of small airway remodeling (SAR) in cigarette smoke-induced COPD. The aim of this study was to investigate the role of gelatinases (MMP9, MMP2) and epithelial-mesenchymal transition (EMT) in SAR related to wood smoke (WS) exposure in a rat model. Forty-eight female Sprague-Dawley rats were ...
Wang Ya-Juan YJ Zhejiang Respiratory Drugs Research Laboratory of SFDA of China, School of Medicine, Zhejiang University, Hangzhou 310058, China ; Clinical College of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230038, - - 2014
This paper indicated that inactivated Bordetella pertussis (iBp) can enhance the lung airway hyperreactivity of the rats sensitized and challenged with OVA. The mechanisms were involved in the upregulation of cAMP-PDE activity and PDE4A, PDE4D, and PDE3 gene expression in the lungs. But only PDE4 activity was different between the ...
Hsu Wing-Sze WS 0000-0003-1119-0535 School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 Bei San Huan Dong Lu, Chao Yang District, Beijing 100029, - - 2014
In this study, we try to evaluate the effects of acupuncture stimulation with different amounts at Sanyinjiao (SP6) on uterine contraction and uterus microcirculation in rats with dysmenorrhea of cold coagulation syndrome and to explore whether there is direct relativity between "De qi" and needle stimulus intensity. Diestrus female rats ...
Sadamura-Takenaka Yukari Y Department of Pulmonary Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan; Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, - - 2014
Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary vascular resistance leading to right ventricular failure and death. Recent studies have suggested that chronic inflammatory processes are involved in the pathogenesis of PAH. However, the molecular and cellular mechanisms driving inflammation have not been fully elucidated. To elucidate the roles ...
Takehara Hiroshi H Public Interest Incorporated Foundation BioSafety Research Center - - 2014
Usefulness of bronchoalveolar lavage fluid (BALF) and pleural cavity lavage fluid (PLF) as an experimental material was evaluated for the assessment of pulmonary toxicity of chemicals in rats. From the viewpoint of safety, isoflurane can be used for euthanasia/anesthesia because there was no difference in biological properties of BALF between ...
Sharp Jody J Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, - - 2014
Housing enrichment for rodents continues to be a discussion topic within the animal care community. The objective of this study was to determine the extent to which a complex housing environment affects heart rate, blood pressure, and activity of rats when undisturbed and after exposure to stressful challenges and whether ...
Kouadio Kouame K Department of Environmental and Preventive Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan. ; Eco-epidemiology Unit, Department of Environmental Health, Institut Pasteur of Côte d'Ivoire, Côte d'Ivoire, West - - 2014
We established a Wistar rat model of asthma caused by toluene diisocyanate (TDI) exposure, and investigated the relationship between TDI exposure concentrations and respiratory hypersensitivity, airway inflammation, and cytokine secretions in animals, to better understand the mechanism of TDI induced occupational asthma. Wistar rats were exposed to two different concentrations ...
Scarritt Michelle Eagle ME Tulane University School of Medicine, Center for Stem Cell Research and Regenerative Medicine, 1430 Tulane Avenue, SL-99, New Orleans, Louisiana, United States, 70112, 504-988-7711 ; - - 2013
There are an insufficient number of donor organs available to meet the demand for lung transplantation. This issue could be addressed by regenerating functional tissue from diseased or damaged lungs that would otherwise be deemed unsuitable for transplant. Detergent-mediated whole-lung decellularization produces a three-dimensional natural scaffold that can be repopulated ...
Hao Chang Fu CF Department of Occupational Health and Occupational Disease, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, - - 2013
To study the role of insulin-like growth factor II receptor in free silica-induced transdifferentiation of primary rat lung fibroblasts. Rat lung fibroblasts and rat alveolar macrophages were cultured. A transdifferentiation model of primary rat lung fibroblasts was induced by free silica. Levels of α-SMA protein, IGF-IIR protein and mRNA were ...
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