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Kisko Theresa M TM Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada. Electronic address: - - 2014
During playful interactions, juvenile rats emit many 50-kHz ultrasonic vocalizations, which are associated with a positive affective state. In addition, these calls may also serve a communicative role - as play signals that promote playful contact. Consistent with this hypothesis, a previous study found that vocalizations are more frequent prior ...
Wei Fei F Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China. Electronic address: - - 2014
Pax6 functions as a pleiotropic regulator in eye development and neurogenesis. Its splice variant Pax6 5a has been cloned in many vertebrate species including human and mouse, but never in rat. This study focused on the cloning and characterization of the Pax6 5a orthologous splicing variant in rat. It was ...
Cho Jun Woo - - 2014
[This corrects the article on p. 402 in vol. 46, PMID: 24368966.].
Li Ling L Department of Pharmacy, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, - - 2014
Resveratrol is a polyphenol produced by several plants. It has been demonstrated that it has anti-inflammatory, antitumor, and anti-diabetic effects in animal models. However, its side effects are generally unclear. In the present study, we reported that resveratrol inhibited luteinizing hormone-stimulated androgen production in rat immature Leydig cells. Further analysis ...
Hirabayashi Masumi - - 2013
This study was designed to investigate whether supplementation of 2i medium with LIF and/or forskolin would support establishment of germline-competent rat ES cell lines. Due to the higher likelihood of outgrowth rates, supplementation of forskolin with or without LIF contributed to the higher establishment efficiency of ES cell lines in ...
Hirabayashi M - - 2013
Rat embryonic stem (ES) cell lines can be established in culture medium containing inhibitors for glycogen synthase kinase 3 (GSK3) and mitogen-activated protein kinase (MEK). We confirmed reproducibility of the 2i culture system in establishing rat ES cell lines (Hirabayashi et al. 2010 Mol. Reprod. Dev. 77, 94) and the ...
Zhou Li - - 2013
Germline stem cell lines possess the abilities of self-renewal and differentiation, and have been established from both mouse and human ovaries. Here, we established a new female germline stem cell (FGSC) line from postnatal rats by immunomagnetic sorting for Fragilis, which showed a normal karyotype, high telomerase activity, and a ...
Yamaguchi Tomonori - - 2013
Rat posterolateral lumbar fusion (PLF) models have been used to assess safety and effectiveness of new bone substitutes and osteoinductive growth factors using palpation, radiography, micro-computed tomography (µCT) and histology as standard methods to evaluate spinal fusion. Despite increased numbers of PLF studies involving alternative bone substitutes and growth factors, ...
Rhieu Steve Y - - 2013
3-epi-1α,25-dihydroxyvitamin D3 (3-epi-1α,25(OH)2 D3 ), a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2 D3 ), exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion. These VDR-mediated actions of 3-epi-1α,25(OH)2 D3 needed an explanation as 3-epi-1α,25(OH)2 D3 , unlike 1α,25(OH)2 D3 , ...
Lin Hsin-Tang - - 2013
The transgenic papaya is a valuable strategy for creating plants resistant to papaya ring spot virus (PRSV) infection and increasing production. This study was further performed to evaluate the comparative toxicity effects of the newly developed transgenic line of the fruits of two backcross transgenic papaya lines (2210 and 823) ...
Yamauchi Masahiro - - 2013
We have shown that two multidomain adaptor proteins, p140Cap and vinexin, interact with each other and are likely to be involved in neurotransmitter release. Because the basic molecular mechanism governing neurotransmitter and insulin secretion is conserved, these two proteins may also to play pivotal roles in insulin secretion. We therefore ...
Goepfrich Anja A AA Research Group Developmental Neuropsychopharmacology, Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, - - 2013
Many laboratories obtain their experimental animals from commercial suppliers and are therefore dependent on their conditions and breeding schedules. A breeding stop or the substitution of a particular rat line by the supplier forces the customers to abandon their conventional test animals and to re-establish all behavioral paradigms with a ...
Tagliati Federico - - 2013
[This corrects the article on p. e75194 in vol. 8.].
Lee Nam-Jin - - 2012
This study was designed to undertake a risk assessment to identify the health status of rats fed with somatic cell nuclear transfer (SCNT)-cloned Korean native beef cattle (Hanwoo) meat for 26 weeks. The rats were randomly divided into 5 groups, each consisting of 12 male (142.6 ± 5.23 g) and ...
Moreno-Sanz G G Departments of Pharmacology and Biological Chemistry, University of California, Irvine, Irvine, CA 92697, - - 2012
URB937 is a peripherally restricted inhibitor of the anandamide-deactivating enzyme fatty-acid amide hydrolase (FAAH). Despite its limited access to the CNS, URB937 produces marked antinociceptive effects in rodents. URB937 is actively extruded from the CNS by the ATP-binding cassette (ABC) membrane transporter, Abcg2. Tissue Abcg2 levels are markedly different between ...
Greco Rosaria - - 2012
Objective.- In this study, we evaluated the influence of sex and estrogen treatment on nitroglycerin (NTG)-induced neuronal activation in the rat brain. Background.- Systemic NTG activates cerebral nuclei of rat involved in nociceptive transmission, as well as in neuroendocrine and autonomic functions. These changes are considered relevant for migraine, since ...
Fraga Angela - - 2012
The objective was to study male and female rats exposed to Activity-Based Anorexia (ABA; simultaneous exposition to food restriction and free access to an activity wheel) under two conditions of sound attenuation, by means of different arrangements of wheels (standard versus isolation) in the laboratory room. Regardless of the sound ...
Ramirez Maria Cecilia - - 2012
The hypothalamic-growth hormone (GH)-liver axis represents a new concept in endocrine regulation of drug toxicity. Preponderant sex differences are found in liver gene expression, mostly dependent on the sexually dimorphic pattern of GH secretion which is set during the neonatal period by gonadal steroids. We tested if GH-dependent sexually dimorphic ...
Bayless Daniel W - - 2012
The goal of the current study was to explore sex differences in attentional processes in adult rats using a test of attention shown to be dependent upon the prefrontal cortex. Male and female adult Long-Evans rats were trained on the 5-choice serial reaction time task. This task requires rats to ...
van den Bos Ruud R Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, The Netherlands. - - 2012
The Iowa Gambling Task (IGT) measures decision-making processes by simulating real-life decisions involving reward, punishment, and uncertainty of outcomes. In humans, men show more choices for the advantageous option than women. Here, we investigated sex differences in a rat model of the IGT (r-IGT). In our r-IGT mildly food-deprived rats ...
Parent Carine I - - 2012
Variations in maternal care influence important life history traits that determine reproductive fitness. The adult female offspring of mothers that show reduced levels of pup licking/grooming (LG; i.e., low-LG mothers) show increased defensive responses to stress, accelerated pubertal development, and greater sexual receptivity than the female offspring of high-LG mothers. ...
Ishizuka Noriko N Faculty of Health Care, Kiryu University, 606-7 Azami, Kasakake-cho, Midori-shi, Gunma 379-2392, - - 2012
In neural regulation of the endocrine pancreas, there is much evidence to suggest that vagal efferents alter insulin and glucagon secretion, but less information on the effects of vagal afferents. In this study, we investigated the role and function of afferent fibers of the vagus nerve in normal and ventromedial ...
Huff James - - 2012
Carcinogenesis bioassays were conducted by giving 2,4,6-trichlorophenol [2,4,6-TCP] in feed to groups of 50 male and female Fischer rats and male B6C3F1 mice for two years. Dietary concentrations were 0 [20/group], 5000 [0.5%], or 10,000 [1%] ppm. Female mice began with 10,000 and 20,000ppm but after 38weeks were lowered due ...
Ramos Hugo Valter Lisboa HV Federal University of São Paulo, SP, - - 2012
The vibration of the vocal fold lamina propria is an important factor involved in vocal production and aging may change the amount of hyaluronic acid in the vocal fold leading to dysphonia. This study compares the concentration of hyaluronic acid in vocal folds of aged and young female rats. experimental. ...
Bolton Jessica L - - 2012
The present study investigated the preference of prepubescent and adult rats for an unrelated conspecific over a closely related conspecific (e.g., father, mother). Preference was measured by the amount of time spent in the vicinity of the stimulus animals as well as who was visited first. To prevent mating behavior, ...
Kampfmann Iris - - 2012
BACKGROUND: Wistar rats are frequently used in toxicologic studies; however, the impact of animal source on hematologic reference intervals (RI) is not known. OBJECTIVE: The purpose of this study was to compare hematologic data of Wistar rats obtained from 2 breeders and to calculate preliminary RI for the Sysmex XT-2000iV ...
Jaramillo Lorenza María - - 2012
The use of Lewis rats in embryonic tissue transplantation experiments can present a challenge because of the fertility problems associated with this strain. The authors used estrous cycle phase determination to time pairings of reproductively active females and males in order to increase the likelihood that mating would occur. During ...
Wang Dan - - 2012
The present study aimed to investigate the pharmacokinetic variation of ofloxacin based on gender-related difference in the expression of multidrug resistance-associated protein (Abcc2/Mrp2) in rat kidney. The concentrations of ofloxacin in rat plasma and urine were determined after tail vein administration (30 mg x kg(-1)) by high-performance liquid chromatography (HPLC) ...
Smith Jeremy T - - 2012
The perinatal nutritional environment can permanently influence body weight, potentially leading to changes in puberty onset and reproductive function. We hypothesized that perinatal under- or overfeeding would alter puberty onset and influence concentrations of a neuropeptide crucial for successful puberty, kisspeptin. We manipulated Wistar rat litter sizes to derive small ...
Vasquez Carol - - 2012
Studies have shown that N-methyl-D-aspartate (NMDA) receptors play a critical role in pain processing at different levels of the central nervous system. In this study, we used female adult Wistar rats to examine the effects of antagonizing the NR2B subunit of the NMDA receptor in phasic and tonic pain processes. ...
Kushwaha H N - - 2012
Reports regarding drug toxicity and adverse events resulting from coadministration of multiple drugs are increasing at an alarming rate. CDRI-97/78 is an 1,2,4-trioxane antimalarial agent under development which gets metabolized to the in vivo active metabolite 97/63. In order to assess its drug interaction potential, CDRI-97/78 was administered alone and ...
Wahajuddin - - 2012
Lumefantrine has been reported to be mainly bio-transformed by cytochrome P450 isozyme 3A4 in to desbutyl-lumefantrine (DLF) in human liver microsomes. Since, CYP3A is expressed in a sex specific manner in rats, it could be expected that the pharmacokinetics of lumefantrine would be changed in male rats compared with those ...
Kanazu Takushi - - 2012
In vitro and in vivo inhibitions of cytochrome P450 (CYP) 3A with mechanism-based inhibition (MBI) by macrolides were investigated using dexamethasone-treated female rats (DEX-female rats). In in vitro CYP inhibition studies using erythromycin (ERM) and clarithromycin (CAM), similar inhibition responses were observed between human and DEX-female rat liver microsomes, however ...
Shabani Mohammad - - 2012
Vincristine, an anticancer drug, is known to induce neuronal cell damage. We have elucidated the alteration in performance of the hippocampus and cerebellum following chronic vincristine treatment (0.2 mg·(kg body mass)(-1)·week(-1)) in male and female rats. Intraperitoneal injection of vincristine in adolescent rats caused impairment of motor and cognitive behavior. In ...
Baladi Michelle G - - 2012
RATIONALE: Dopamine systems vary through development in a manner that can impact drugs acting on those systems. Dietary factors can also impact the effects of drugs acting on dopamine systems. OBJECTIVES: This study examined whether eating high fat chow alters locomotor effects of cocaine (1-56 mg/kg) in adolescent and adult female ...
Minematsu Tsuyoshi - - 2012
YM155 monobromide is a novel small-molecule survivin suppressant. The pharmacokinetics, distribution, and excretion of YM155/[(14) C]YM155 were investigated using males and pregnant or lactating female rats after a single intravenous bolus administration. For the 0.1, 0.3 and 1 mg/kg YM155 doses given to male rats, increases in area under the plasma ...
Xu Tingting - - 2012
Dioscin is the major active compound in many traditional Chinese medicines (TCMs), while safety evaluation of this natural product has not yet been investigated. Therefore, the aim of this study was to evaluate the 90-day subchronic toxicity of dioscin in rats. The rats were divided into four groups and dioscin ...
Hobbs Cheryl A - - 2012
Styrene-acrylonitrile Trimer (SAN Trimer), a by-product in production of acrylonitrile styrene plastics, was identified at a Superfund site in Dover Township, NJ, where childhood cancer incidence rates were elevated for a period of several years. SAN Trimer was therefore tested by the National Toxicology Program in a 2-year perinatal carcinogenicity ...
Zakharova Elena E Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, Rm 4113A (D-80), Miami, FL 33136, - - 2012
Many factors influence the rewarding effects of drugs such as cocaine. The present study was done to determine whether social and environmental factors alter behavior in adolescent male and female rats. On postnatal day (PND) 23, rats were housed in one of several same-sex conditions. Both social (number of rats ...
Masaka Tomohiro - - 2012
ObjectiveThere is a strong male predominance of oesophageal adenocarcinoma, which might be related to the higher prevalence of precursor lesions such as erosive reflux oesophagitis in men compared with women. This experiment investigated the gender difference in a reflux oesophagitis model of rats and explored the potential role of oestrogen ...
Mutlu Esra E Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United - - 2012
Vinyl chloride (VC) is an industrial chemical that is known to be carcinogenic to animals and humans. VC primarily induces hepatic angiosarcomas following high exposures (≥50 ppm). VC is also found in Superfund sites at ppb concentrations as a result of microbial metabolism of trichloroethylene and perchloroethylene. Here, we report ...
Lukkes Jodi L JL Department of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, CO 80309-0354, USA. - - 2012
Our previous studies have shown that post-weaning social isolation of male rats leads to sensitization of serotonergic systems and increases in anxiety-like behavior in adulthood. Although studies in humans suggest that females have an increased sensitivity to stress and risk for the development of neuropsychiatric illnesses, most studies involving laboratory ...
Wei Bo - - 2012
Gender differences in gastrointestinal physiology and hepatic metabolizing enzyme systems may potentially modify drug absorption and disposition during spaceflight. This study evaluated the effect of simulated weightlessness on gender-related pharmacokinetic differences of intravenously administered antipyrine, a marker compound for hepatic oxidative metabolism, using the tail-suspended (TS) rat model for microgravity. ...
Fedotova Julia - - 2012
The aim of the present study was to explore the hedonic effects of D(2) receptor agonist, quinpirole and D(2) receptor antagonist, and sulpiride alone or in combination with a low dose of 17β-E(2)-estradiol (17β-E(2)) in the adult ovariectomized female rats (OVX). OVX rats of Wistar strain were used in all ...
Padzys Guy S - - 2012
Padzys GS, Tankosic C, Trabalon M, Martrette J-M. Craniofacial development and physiological state after early oral breathing in rats. Eur J Oral Sci 2012; 120: 21-28. © 2011 Eur J Oral Sci In this study we determined whether craniofacial development in rats could be influenced by an early temporary (3 d) ...
Kim Moonsuk - - 2011
Using a complete spinal cord transection model, the present study employed a combinatorial strategy comprising rat bone marrow stem cells (rBMSCs) and polymer scaffolds to regenerate neurological function after spinal cord injury (SCI) of different lengths. SCI models with completely transected lesions were prepared by surgical removal of 1 mm ...
Ciftci Gulay - - 2011
The aim of this study was to investigate the effects of aging on central nervous system steroid and myelin basic protein (MBP) profiles in. In total of 47 male Sprague-Dawley rats (newborn, 1, 6, 12 and 24-months-old) were used in the study. Tissues were obtained from the cerebellum and parietal, ...
Furuta Akira A Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. - - 2011
This study was conducted to investigate the urethral compensatory mechanisms to maintain urinary continence after pudendal nerve injury. In naive, acute pudendal nerve transection (PNT) and 4 weeks after PNT (PNT-4w) female rats, leak point pressures (LPPs) during bladder compression were measured before and after the application of hexamethonium (C6), ...
Semler Joerg - - 2011
Precise assessment of motor deficits after traumatic spinal cord injury (SCI) in rodents is crucial for understanding the mechanisms of functional recovery and testing therapeutic approaches. Here we analyzed the applicability to a rat SCI model of an objective approach, the single-frame motion analysis, created and used for functional analysis ...
Liu Yu - - 2011
Cell tracking using iron oxide nanoparticles has been well established in MRI. However, in experimental rat models, the intrinsic iron signal derived from erythrocytes masks the labeled cells. The research evaluated a clinically applied Gd-DTPA for T1-weighted positive enhancement for cell tracking in spinal cord injury (SCI) rat models. MSCs ...
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