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Shen Zhou Z Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, - - 2014
To investigate the feasibility of erectile function restoration by genital branch of genitofemoral nerve (GN) to cavernous nerve (CN) transfer in rats. Thirty adult (3 months) male Sprague-Dawley rats were divided into 3 groups (n = 10 per group). Rats in sham group underwent sham operation, rats in nerve resection (NR) group ...
Kalman Eszter E School of Medical Sciences (Anatomy & Histology), University of Sydney, Sydney, NSW, - - 2014
Physical and psychological trauma which results in mood disorders and the disruption of complex behaviours is associated with reductions in hippocampal volume. Clinical evaluation of neuropathic pain reveals mood and behavioural change in a significant number of patients. A rat model of neuropathic injury results in complex behavioural changes in ...
Sachsenröder Jana J Federal Institute for Risk Assessment, - - 2014
Rats are known as reservoirs and vectors for several zoonotic pathogens. However, information on the viruses shed by urban wild rats that could pose zoonotic risk to human health is scare. Here, intestinal contents from 20 wild Norway rats (Rattus norvegicus) collected in the city of Berlin, Germany, were subjected ...
da Silva M C MC 1 Academic Center of Victoria, University of Pernambuco, Vitoria de Santo Antao, Pernambuco, - - 2014
This study investigated the effects of maternal separation on the feeding behavior of rats. A maternal separation model was used on postnatal day 1 (PND1), forming the following groups: in the maternal separation (MS) group, pups were separated from their mothers each day from PND1 to PND14, whereas in the ...
Davidson Eric P EP Department of Internal Medicine, The University of Iowa, Iowa City, IA 52242, - - 2014
Recently a new rat model for type 2 diabetes the Zucker diabetic Sprague-Dawley (ZDSD/Pco) was created. In this study we sought to characterize the development of diabetic neuropathy in ZDSD rats using age-matched Sprague-Dawley rats as a control. Rats were examined at 34 weeks of age 12 weeks after the ...
Althnaian Thnaian - - 2013
The unique characters of camel's milk make it used extensively in the field of medicine as anti-microbial, anti-diabetic and hepatoprotective agent. The lack of studies demonstrating the protective effect of camel's milk against hepatotoxic compound was the main reason beyond the conduction of the current experiment which aimed to investigate ...
Forssten Sofia D - - 2013
A negative energy balance can be accomplished by reducing the caloric intake which results in an increased feeling of hunger. This physiological state is regulated by secretion of satiety hormones. The secretion of these hormones can be influenced by ingestion of e.g. fat. Fat, dairy beverage and synbiotic mixture have ...
de Sousa Altamir Benedito - - 2013
Abstract Cyanide (CN) is an ion that has been well studied in toxicology and has been associated with several intoxication episodes: the ingestion of contaminated foods and water, chemical war, suicides, homicides, occupational exposures and the use of certain medicines. The aim of the present study was to determine the ...
Richter S Helene - - 2013
The incidence of major depression is known to be influenced by both genetic and environmental factors. In the current study, we therefore set out to investigate depressive-like behavior and its modification by environmental enrichment using rats bred for 'learned helplessness'. 45 males of congenitally helpless (cLH, n=22) and non-helpless (cNLH, ...
Ippoushi Katsunari - - 2013
Allyl isothiocyanate, a chief component of mustard oil, exhibits anticancer effects in both cultured cancer cells and animal models. The accumulation of the N-acetylcysteine conjugate of allyl isothiocyanate, the final metabolite of allyl isothiocyanate, in urine was evaluated in rats that were orally coadministered allyl isothiocyanate with fluids (e.g., water, ...
Jantscher-Krenn Evelyn - - 2013
Human milk oligosaccharides (HMO) are complex glycans that are highly abundant in human milk, but not in infant formula. Accumulating data, mostly from in vitro and animal studies, indicate that HMO benefit the breast-fed infant in multiple ways and in different target organs. In vitro incubation studies suggest that HMO ...
Moffett R Charlotte - - 2013
Gastric inhibitory polypeptide (GIP) is a gut derived peptide with multiple emerging physiological actions. Effects of pregnancy and lactation on GIP secretion and related gene expression were studied in Wistar rats. Pregnancy moderately increased feeding (p<0.05), whilst lactation substantially increased food intake (p<0.01 to p<0.001). Circulating GIP was unchanged during ...
Gregersen Soren S Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Tage-Hansens Gade 2, 8000 Aarhus C, - - 2013
Beneficial effects of milk protein on glucose metabolism have been reported. We hypothesized that dietary supplementation with specific milk protein fractions could prevent diabetes and differentially alter tissue gene expression. Therefore, we studied the effects of supplementing the diet with whey isolate, whey hydrolysate, Α-lactalbumin, and casein proteins in Zucker ...
Allen Kenneth P - - 2013
Compared with earlier editions, the eighth edition of the Guide for the Care and Use of Laboratory Animals recommends more cage floor space for female rats with litters. As such, conventional rat cages often do not supply the recommended floor space to maintain 2 adult rats and a litter in ...
Kamiya Seitaro S Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis ten bosch, Sasebo 859-3298, - - 2013
Thrombosis is characterized by congenital and acquired procatarxis. Lactic acid bacteria-fermented soybean milk products (FS-LAB) inhibit hepatic lipid accumulation and prevent atherosclerotic plaque formation. However, the therapeutic efficacy of FS-LAB against thrombosis has yet to be investigated. In this study, FS-LAB were administered subcutaneously into the tails of rats, with ...
Tonietti Paloma de Oliveira Pde - - 2013
This study investigated the occurrence of rotavirus in porcine and Rattus norvegicus, at the same time, on a pig farm in the city of Jaguariúna, São Paulo, Brazil. Swine (n = 21) and rat (n = 6) fecal samples were analyzed by nested RT-PCR assay. Rotavirus occurred in seven porcine ...
Mahmood Azizah - - 2012
To investigate the potential of Musa x paradisiaca (M. x paradisiaca) flower extracts in promoting milk production of lactating rats and its effects on growth of the suckling pups. Galactagogue activity was evaluated in terms of quantity of milk produced from the rats treated with petroleum ether, ethanol or water ...
Andrade Filipe Moreira de - - 2012
OBJECTIVE: To investigate the effects of maternal protein malnutrition during lactation on the elastic fibers in the tracheas of Wistar rat pups. METHODS: At delivery, 12 male pups of two Wistar rat dams were equally divided into two groups: control, in which the dam received water and standard rat chow ...
Wongdee Kannikar - - 2012
In lactation, the intestinal absorption of nutrients and minerals, especially calcium, is markedly enhanced to supply precursors for milk production. Little is known regarding the mechanism of this lactation-induced intestinal hyperabsorption. However, it has been postulated to result from villous hypertrophy with enlarged absorptive area and the upregulation of the ...
Franco Juliana G - - 2012
We hypothesized that resveratrol, a natural phytoalexin found in grapes, can prevent oxidative stress, obesity and its related disturbances in obese rats programmed by early weaning. Lactating Wistar rats were separated into two groups: early weaning (EW) - dams who were wrapped with a bandage to interrupt the lactation in ...
Macdonald Leah - - 2012
Due to previous work where we have demonstrated attenuated febrile responses post-lipopolysaccharide (LPS) in calorie restricted (CR) rodents we aimed to explore metabolic rate and behavioral thermoregulation in these CR animals post-LPS. Male Sprague-Dawley rats fed ad libitum (AL) or restricted to 50% (CR50%) of the AL animals' food intake ...
Oda Teiji - - 2012
Hypothermia is used in the clinic for protection of organs such as the brain against ischemic injury during aortic/complex congenital cardiac surgery or post-resuscitation encephalopathy. The principal mechanism of hypothermic protection is suppression of metabolism, however, the pleiotropic effects of cooling are incompletely understood. Here, we used a rat model ...
Corcoran Andrea E - - 2012
In adult mammals, severe hypothermia leads to respiratory and cardiac arrest, followed by death. Neonatal rats and hamsters can survive much lower body temperatures and, upon artificial rewarming, spontaneously recover from respiratory arrest (autoresuscitate), typically suffering no long-term effects. To determine developmental and species differences in cold tolerance (defined here ...
Ismaiel Nada M - - 2012
Remifentanil is a potent synthetic opioid with sedative effects. Intravenous remifentanil provides deep sedation and analgesia in laboratory animals during experimental procedures. We hypothesized that remifentanil would provide effective analgosedation during assisted mechanical ventilation without affecting respiratory mechanics in rats. Five male Sprague- Dawley rats (weight, 400 to 450 g) ...
Ando Satoko - - 2012
A decrease in core temperature during general anesthesia is attenuated by infusion of an intravenous amino acid mixture. The purpose of the present study was to investigate the influence of physical and endocrine changes caused by ovariectomy on the inhibitory effect of amino acid infusion on anesthesia-induced hypothermia. Sprague-Dawley female ...
Wrotek S - - 2011
N-acetylcysteine (NAC) has been used primarily as a mucolytic agent for the treatment of respiratory diseases. It has been recently suggested that NAC also possesses some anti-inflammatory properties. The aim of the present study is to investigate the effects of NAC on fever provoked either by bacterial lipopolysaccharide (LPS) or ...
Arokina N K - - 2011
Rats were cooled in water until attaining profound hypothermia and respiratory arrest. After removal from water, 0.5% solution of Na(2)EDTA was administered intravenously. This led to a drop of blood [Ca(2+)] by 20-30% from the baseline and promoted recovery of respiration following its arrest lasting 10.3±1.4 min. By the 30th ...
Bedani Raquel - - 2011
The aim of this study was to investigate whether the ingestion of soy yogurt fermented with Enterococcus faecium CRL 183 would modify the intestinal count of enterococci, fecal pH and ammonia content in rats fed on a diet containing red meat. The rats were placed in 4 groups: for 60 ...
Anand P P Department of Physiology, Rajah Muthiah Medical and Dental College, Annamalai University, Annamalai Nagar, Chidambaram, - - 2011
Walking track analysis which has been widely used to examine the recovery of gait functions in rats with sciatic nerve injury. The present study was aimed to objectively analyze and quantify the degree of functional recovery in locomotor behavior of rats after inflicting sciatic nerve crush injury. Wistar rats trained ...
Silva E - - 2011
Aims This study examines the effect of chronic ouabain-treatment on renal Na(+) handling in 12-week and 52-week old rats. Main methods Wistar Kyoto rats aged 5-weeks or 45-weeks were treated with ouabain or vehicle during 7weeks. Blood pressure was measured in conscious animals throughout the study. After 7weeks of treatment ...
McLaughlin Malcolm - - 2011
When Congress rejected President Lyndon Johnson’s Rat Extermination and Control Bill in the summer of 1967, in a mood of growing conservatism, it inadvertently sparked a heated political controversy that brought the desperate conditions of life in inner-city America into sharp focus. This article focuses on the issue of rat ...
Jaehne Emily J - - 2011
3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is associated with increases in core body temperature (T(C)) and depressive mood states in users. Flinders Sensitive Line (FSL) rats represent a rat model of depression originally bred from Sprague-Dawley (SD) rats. They are more sensitive to both muscarinic and serotonergic agonists and have altered thermoregulatory responses ...
Atsak Piray - - 2011
The study of the neural basis of emotional empathy has received a surge of interest in recent years but mostly employing human neuroimaging. A simpler animal model would pave the way for systematic single cell recordings and invasive manipulations of the brain regions implicated in empathy. Recent evidence has been ...
Sonoyama Kazuhiko - - 2010
BACKGROUND: Damage to renal artery myogenic tone is universally associated with progressive kidney damage. Recently, we have observed that mutations in the beta adducin subunit are associated with proteinuria in the Milan rat. Because of the role of adducin as a component of the cytoskeleton we hypothesized that this mutation ...
Young Andrew J - - 2010
The specialization of body shape to an individual's role within society represents a pinnacle of social evolution. Although commonplace among social insects, divergence in the body shapes of breeders and helpers has to date been documented in just one social vertebrate, the naked mole-rat, Heterocephalus glaber; an extraordinary species in ...
Kapur Priya - - 2010
Hot flashes are a disorder of thermoregulation due to the lack of estrogens and are the most common and characteristic climacteric complaint. Hormone replacement therapy is the gold standard treatment but now its use is limited due to several side effects. Need therefore arises to search for non-estrogenic alternatives. It ...
Gurfinkel Reuven - - 2010
OBJECTIVES: The objective was to develop a novel animal model of burns in rats and pigs. METHODS: The model uses heat that is delivered via a radiant heater with an opening of 5 cm by 5 cm, set at 400 degrees C, for 20 seconds. An advantage of this model ...
Coleman Joy C - - 2010
Since Black-tailed Tree Rats, Thallomys nigricauda, face variable thermal environments in their extensive range in southern Africa, variation in their physiological and behavioural responses to the wide range of ambient temperatures (T(a)s) was expected to play a role in the success and range of the species. Body temperature (T(b)) and ...
Fukayama Osamu O Graduate School of Information Science and Technology, The University of Tokyo, 7-3-1 Hongo, Bunkyo, JAPAN. - - 2010
An online neuro-robotic platform in the form of a small vehicle, the "RatCar" has been developed. First, a rat had neural electrodes implanted in the motor cortices to record extracellular potentials. Then, our system combined the rat and its vehicle body by hanging the rat under its floor. In this ...
Sun Lian-Wen - - 2010
To understand the tail-suspension model to simulate weightlessness better, this study was to investigate the relationship of the amount of body weight supported by forelimbs between the tilt angles of rat in the model. Normal rat had at least two basic postures. One was standing or walking, in which the ...
Izamis Maria-Louisa ML Center for Engineering in Medicine/Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, - - 2009
The basic metrics of hypermetabolism have not been thoroughly characterized in rat burn injury models. We examined three models expected to differ in sensitivity to burn injury to identify that which group(s) exhibited the most clinically relevant metabolic response. Six and 12 weeks old male CD (6 week mCD and ...
de Almeida Edvaldo Rodrigues - - 2009
Naphthoquinones have been studied extensively due to their activity as topoisomerase inhibitors. These enzymes are critical to DNA replication in cells. beta-Lapachone (beta-lap) is an o-naphthoquinone chemically obtained from lapachol. This work results in a toxicological evaluation of beta-lap in Wistar rats observing the following parameters: teratology, histology, hematology and ...
Fong Angelina Y - - 2009
We examined the effect of riluzole on expression of the central respiratory rhythm and the ability of neonates to autoresuscitate from hypothermic respiratory arrest using in vitro brainstem-spinal cord preparations of rats and hamsters. At a constant temperature of 27 degrees C, riluzole (5-200 microM) decreased the burst amplitude of ...
Puranen Lauri - - 2009
The aim of this study was to design, implement and analyze a space-efficient setup for the whole-body exposure of unrestrained Wistar rats to radiofrequency (RF) electromagnetic fields at 900 MHz. The setup was used for 2 years in a cocarcinogenesis study and part of it for 5 weeks in a ...
Gutiérrez E - - 2009
The potential involvement of the melanocortin system in the beneficial effects of heat application in rats submitted to activity-based anorexia (ABA), an analogous model of anorexia nervosa (AN), was studied. Once ABA rats had lost 20% of body weight, half of the animals were exposed to a high ambient temperature ...
Rogalska Justyna - - 2009
Brief periods of neonatal asphyxia are frequently observed. Within the CNS, the hippocampus is known to be particularly vulnerable to the damaging effects of hypoxia/ischaemia. The hippocampus contains the highest concentration of both mineralocorticoid (MR) and glucocorticoid (GR) receptors and the balance between MR/GR activation influences cell birth and death. ...
Malakouti Seyed Mansour SM Dept. of Physiology, Hamadan University of Medical Sciences, Hamadan, Iran. - - 2008
The nucleus raphe magnus (NRM) is involved in thermoregulatory processing. There is a correlation between changes in the firing rates of the cells in the NRM and the application of the peripheral thermal stimulus. we examined the effect of reversible inactivation and excitation of NRM on mechanisms involved in tail ...
Cheng Bor-Chih - - 2008
Cardiac dysfunction contributes to heatstroke genesis, which can be ameliorated by whole body cooling. A comparative analysis using two-dimensional in-gel electrophoresis of cardiac protein patterns is performed in rat controls, untreated heatstroke rats, and whole body cooling-treated heatstroke rats. After the onset of heatstroke, animals display hypotension and altered cardiac ...
Jia Xiaofeng X Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. - - 2008
Hypothermia improves outcomes after cardiac arrest (CA), while hyperthermia worsens injury. EEG recovers through periodic bursting from isoelectricity after CA, the duration of which is associated with outcome in normothermia. We quantified burst frequency to study the effect of temperature on early EEG recovery after CA. Twenty-four rats were divided ...
Jia Xiaofeng X Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA. - - 2008
Therapeutic hypothermia after cardiac arrest improves survival and functional outcomes, whereas hyperthermia is harmful. The optimal method of tracking the effect of temperature on neurologic recovery after cardiac arrest has not been elucidated. We studied the recovery of cortical electrical function by quantitative electroencephalography after 7-min asphyxial cardiac arrest, using ...
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