Search Results
Results 1 - 50 of 1197
1 2 3 4 5 6 7 8 9 10 >
Peng Xiao-Hui XH Urology Department, Hainan Medical University Affiliated Hospital, Haikou, Hainan-571102, China; Urology Department, Xiangya Hospital, Changsha, Hunan-410008, - - 2014
To investigate the protective effect of pioglitazone on kidney injury in diabetic rat model and its mechanisms. Forty healthy Sprague Dawley rats were selected and randomly divided into five groups, with 8 rats in each group. Group A served as control group and were administered with sterile citrate buffer (i.p.) ...
Zhang Xiao-Hua XH Xiao-Hua Zhang, Min-Li Li, Bin Wang, Mei-Xia Guo, Ren-Min Zhu, Department of Gastroenterology, Jinling Hospital, Nanjing 210002, Jiangsu Province, - - 2014
To assess the effect of inhibition of caspase-1 on acute renal injury in rats with severe acute pancreatitis (SAP). Forty-two Sprague-Dawley rats were randomly divided into three groups: healthy controls (HC, n = 6), SAP rats treated with saline (SAP-S, n = 18), or SAP rats treated with a caspase-1/interleukin ...
Voisin V V Molecular Physiology Research Unit-NARILIS, UNamur, Namur, - - 2014
Wistar-Furth (WF) rat strain is usually used in models of full major histocompatibility complex-mismatched kidney transplantation. Since these rats were previously demonstrated to be resistant to several models of chronic kidney disease, the present study was aimed to investigate their potential resistance to a renal ischemia-reperfusion injury (I/R) in comparison ...
Miller Frederick J FJ Fred J. Miller & Associates LLC , Cary, NC , USA - - 2014
Abstract While inhalation toxicological studies of various compounds have been conducted using a number of different strains of rats, mechanistic dosimetry models have only had tracheobronchial (TB) structural data for Long-Evans rats, detailed morphometric data on the alveolar region of Sprague-Dawley rats and limited alveolar data on other strains. Based ...
Saito Shotaro S Department of Cardiology and Clinical Examination, Oita University, Faculty of Medicine, Oita, - - 2014
We investigated whether glucose fluctuations aggravate cardiac fibrosis and increase the occurrence of atrial fibrillation (AF) in rats with diabetes mellitus (DM). Streptozotocin-induced diabetic rats were randomly divided into 3 groups: uncontrolled DM (U-STZ) group, controlled DM (C-STZ) group, and DM with glucose fluctuations (STZ-GF) group. Glucose fluctuations were induced ...
Svitok Pavel P Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University , Bratislava , Slovak Republic - - 2014
Abstract A direct relationship exists between salt consumption and hypertension. Increased sodium intake does not automatically lead to a rise in blood pressure (BP) because of marked intra-individual variability in salt sensitivity. Wistar rats are a salt-resistant strain and increased salt intake in adults does not induce hypertension. Mechanisms regulating ...
Wangensteen Rosemary R Departamento de Ciencias de la Salud, Universidad de Jaén, Jaén 23071 - - 2014
This study assessed the impact of salt restriction on cardiac morphology and biochemistry and its effects on hemodynamic and renal variables in experimental hyperthyroidism. Four groups of male Wistar rats were used: control, hyperthyroid, and the same groups under low salt intake. Body weight, blood pressure (BP), and heart rate ...
Kedzierska Karolina K Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland. - - 2014
Aim: To analyse the impact of the most commonly used immunosuppressive drugs on the occurrence of apoptosis in the native kidneys of Wistar rats. Method: The study involved 36 rats. the animals being grouped according to the immunosuppressive regimen used. (tacrolimus. mycophenolate mofetil. cyclosporine A. rapamycin and prednisone). The rats ...
Ale-Ebrahim Mahsa M Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, - - 2014
Cholestasis liver fibrosis has been increasingly recognized as a cause of high morbidity and mortality in humans. The accumulation of toxic bile salts in a bile duct ligation (BDL) animal model plays a pivotal role in the induction of liver fibrosis. Cholestatic liver fibrosis is characterized by excessive collagen production ...
Cheng Hui H Division of Nephrology, Wuhan University, Renmin Hospital , Wuhan , People's Republic of - - 2014
Abstract Objective: To investigate the effect of urokinase-type plasminogen activator (uPA) on mesangial matrix in the kidney of diabetic rats and its related mechanisms. Methods: Diabetic Sprague-Dawley (SD) rats induced by intraperitoneal injection of streptozotocin (STZ) were randomly and evenly divided into two groups: DM + vehicle, and DM + uPA (2500 U kg(-1) uPA via ...
Ge Ying Y Univ Mississippi Med - - 2014
Previous studies have indicated that a deficiency in the renal formation of 20-hydroxyeicosatetraenoic acid (20-HETE) in Dahl S (SS) rats contributes to the development of hypertension. The present study examined whether 20-HETE production is also reduced in the renal vasculature and if the defect impairs the myogenic or tubuloglomerular feedback ...
Lu Wen W Department of Geriatrics, Renmin Hospital of Wuhan University , Wuhan, Hubei Province , P.R. China - - 2014
Abstract Objective: The aim of this study was to evaluate the roles of podocalyxin (PCX) and connective tissue growth factor (CTGF) in spontaneously hypertensive rats. Methods: Spontaneously hypertensive rats (SHR) and normotensive control Wistar-Kyoto (WKY) rats were divided into groups referred to as SHR 12W, SHR 24W, WKY 12W and ...
Nistala Ravi R University of Missouri School of Medicine, Columbia, Missouri, USA; Diabetes and Cardiovascular Center, Columbia, Missouri, USA; Department of Internal Medicine, Columbia, Missouri, USA; Division of Nephrology and Hypertension, Columbia, Missouri, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri, - - 2014
Obesity-related glomerulopathy is characterized initially by glomerular hyperfiltration with hypertrophy and then development of proteinuria. Putative mechanisms include endothelial dysfunction and filtration barrier injury due to oxidant stress and immune activation. There has been recent interest in targeting dipeptidyl peptidase 4 (DPP4) enzyme due to increasing role in non-enzymatic cellular ...
Furuse Satoshi U SU Division of Nephrology and Endocrinology, The University of Tokyo, Tokyo, Japan Division of Nephrology, Mitsui Memorial Hospital, Tokyo, - - 2014
Tubulointerstitial injury is central to the progression of end-stage renal disease. Recent studies have revealed that one of the most investigated uremic toxins, indoxyl sulfate (IS), caused tubulointerstitial injury through oxidative stress and endoplasmic reticulum (ER) stress. Because indole, the precursor of IS, is synthesized from dietary tryptophan by the ...
Uwai Yuichi Y Department of Pharmaceutics, School of Pharmacy, Aichi Gakuin University, Nagoya, Japan. Electronic address: - - 2014
Lithium, used for the treatment of bipolar disorders, is reabsorbed via sodium-transport system in the proximal tubule. This step causes intra-/inter-individual difference of lithium disposition, and it has not been unclear which transporter contributes. In this study, we examined effect of foscarnet and parathyroid hormone (PTH), inactivators for sodium-phosphate cotransporter, ...
Pang Hui H Department of Cardiovascular Medicine, Central Hospital of Xuzhou, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, Xuzhou, Jiangsu, P.R. - - 2014
It is known that apelin has definite protective effects on various cardiovascular diseases; however, the mechanism through which hypertension with heart failure (H-HF) is affected by pyroglutamylated apelin-13 (Pyr-AP13) remain unclear. Thus, in the present study, we investigated the effects of apelin on the cardiac hemodynamics in rats with hypertension ...
Wang Zhen-Chang ZC Liver Disease Center, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530023, - - 2014
To observe the effect of Rougan Huaqian granules combined with human mesenchymal stem cell (hMSC) transplantation on the liver fibrosis in carbon tetrachloride-induced cirrhosis rats. Sixty SD rats were randomly divided into five groups. The rats in control group received intraperitoneal injection of saline, while those in model control group, ...
Yoshida S S Division of Advanced Surgical Science and Technology, Graduate School of Medical Engineering, Tohoku University, Sendai, - - 2014
We previously demonstrated that collagenase H (ColH) plays a crucial role in rat islet isolation, whereas collagenase G (ColG) plays only a supporting role. We also showed that collagen III appears to be one of the key targets of ColH based on a mass spectrometry analysis. In the present study, ...
Camargo Milena Colonhese MC Oeste Paulista University, Presidente Prudente, SP, - - 2014
To evaluate the healing of skin wounds induced experimentally in rats using a crystalline cellulose membrane (Veloderm(r)). Thirty-two rats were divided into two groups: control group (CG) wounds treated with a solution of 0.9% sodium chloride and Veloderm(r) group (VG) wounds treated with a crystalline cellulose membrane. The rats were ...
Burukoglu Dilek D Department of Histology and Embryology, School of Medicine, Eskisehir Osmangazi University, Eskisehir, - - 2014
Nonsteroidal anti-inflammatory (NSAI) drugs are the most commonly used group of drugs today. Increase in the use of standard NSAI for treating pain and inflammation was restricted by the fact that these drugs were proven to possibly cause gastrointestinal and renal toxicity. Meloxicam is a NSAI that has anti-inflammatory, analgesic, ...
Tashiro Yoshihito Y Product Research Department, Chugai Pharmaceutical Co., Ltd., 1-135 Komakado, Gotemba, Shizuoka, 412-8513, - - 2014
Hypertension is a risk factor common to both chronic kidney disease and cardiovascular disease. Nicorandil is widely used for the treatment of angina. We investigated the benefits of nicorandil with respect to renal dysfunction in Dahl salt-sensitive hypertensive (DS) rats. DS rats were fed a high-salt (HS) diet and nicorandil ...
Jin Chunhua C From the Department of Physiology (C.J, J.S., C.A.S., H.O., B.B., S.D., A.G., R.P., P.M.O.) and Department of Pharmacology and Toxicology (N.A.L.), Georgia Regents University, Augusta; Department of Physiology, Medical College of Wisconsin, Milwaukee (A.M.G., H.J.J.); and Department of Biology & Physics, Kennesaw State University, Atlanta, GA - - 2014
We previously characterized a H(+) transport pathway in medullary thick ascending limb nephron segments that when activated stimulated the production of superoxide by nicotinamide adenine dinucleotide phosphate oxidase. Importantly, the activity of this pathway was greater in Dahl salt-sensitive rats than salt-resistant (SS.13(BN)) rats, and superoxide production was enhanced in ...
Elmas Onur O Department of Physiology, Mugla Sıtkı Kocman University, Mugla, Turkey - - 2014
Corrosive oesophagitis is a common health problem in children. Scar tissue can develop during the recovery period, and as a result, serious narrowing of the oesophagus can develop, in turn causing morbidity and mortality. In previous studies, it was argued that tamoxifen (TAM) may have antifibrotic effects beyond its oestrogen ...
Onur T T University of California, 4150 Clement Street Surgery 112, San Francisco, California 94121, - - 2014
Our objective in this article is to test the hypothesis that type 2 diabetes mellitus (T2DM) is a factor in the onset and progression of osteoarthritis, and to characterise the quality of the articular cartilage in an appropriate rat model. T2DM rats were obtained from the UC Davis group and ...
Fellner Robert C RC Georgia Regent - - 2014
High dietary salt is common in western countries and is an important contributor to increased cardiovascular disease. Autoregulation of renal blood flow (RBF) and glomerular filtration rate (GFR) is an essential function of the renal microcirculation, which could be affected by excessive dietary salt. High salt (HS) increases renal reactive ...
Henriques Helene Nara HN Department of Pathology, Universidade Federal Fluminense, Niteroi, - - 2014
Background: This study aimed to evaluate the effect of long-term high-dose tibolone on the bladders and urethras of ovariectomized rats. Methods: Bilateral ovariectomy was performed in 14 young adult rats randomly divided into 2 groups. Experimental rats (n = 9) received 1 mg/day of tibolone orally; control rats (n = ...
Shin Jeong Hun JH Department of Internal Medicine, Hanyang University College of Medicine , Seoul , Republic of Korea - - 2014
Abstract Background: Otsuka Long-Evans Tokushima fatty (OLETF) rats are an established model of diabetic nephropathy. However, diabetes and diabetic nephropathy (DN) in OLETF rats develop later than in other animal type 2 diabetes models. Objectives: This study was conducted to investigate the serial changes in the histopathological characteristics of DN ...
Brinson Krystal N KN Georgia Regents - - 2014
Initial studies found that female Dahl salt-sensitive (DS) rats exhibit greater blood pressure (BP) salt sensitivity than female spontaneously hypertensive rats (SHR). Based on the central role played by NO in sodium excretion and BP control, we further tested the hypothesis that blunted increases in BP in female SHR will ...
Zhou Nan N School of Medicine, Xi'an Jiaotong University, No. 76, Yanta West street, #54, 710061, Xi'an, Shaanxi Province, P.R. - - 2014
OW1 is a novel imperatorin derivative that exhibits vasodilative activity. In the present study the antihypertensive effect and inhibition effect on vascular remodeling of OW1 were investigated in 2K1C renovascular hypertensive rats. OW1-induced vasodilatation in rat mesenteric arteries and renal arteries was evaluated in vitro. 2K1C renovascular hypertensive rats were ...
Chen Qiang - - 2014
Left ventricular (LV) fibrosis is one of the most prominent pathophysiological results of hypertension. We initiated this study to investigate the effects and mechanisms of emodin and its combination with irbesartan on LV fibrosis in Goldblatt (2K1C) hypertensive rats. Goldblatt hypertension rats were prepared by two kidney one clip (2K1C) ...
Ramos Pablo - - 2014
OSA increases atrial fibrillation (AF) risk and is associated with poor AF treatment outcomes. However, a causal association is not firmly established and the mechanisms involved are poorly understood. The aims of this work were to determine whether chronic obstructive sleep apnea (OSA) induces an atrial pro-arrhythmogenic substrate and to ...
Zuo Lin L Deparment of Physiology, Shanxi Medical University, Taiyuan 030001, China; Clinical Inspection Center, Children Hospital of Shanxi, Taiyuan 030001, China; Department of Pathophysiology, Shanxi Medical University, Taiyuan 030001, China; Department of Physiology and Pathophysiology, Capital Medical University, Beijing 100069, China. - - 2014
Since the autoantibodies against the second extracellular loop of β1-adrenoceptor (β1-AABs) have been found in the sera of patients with idiopathic dilated cardiomyopathy (IDCM), the involvement of autoimmune mechanisms in the pathogenesis of many cardiovascular diseases has extensively been investigated. Our previous study found that urinary occult blood and protein ...
Gruber Helen E HE Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, NC 28232. Electronic address: - - 2014
Matrix metalloproteinase-12 (MMP-12; macrophage metalloelastase) degrades a number of extracellular matrix components which are present in the intervertebral disc, including type IV collagen, fibronectin, laminin, chondroitin sulfates, elastin and fibrinogen. MMP-12 has recently discovered relationships with cytokines and chemokines which also relate to disc cell biology. To date, no study ...
Vestergaard Bill B Biopharmaceuticals Research Unit, Novo Nordisk A/S, Måløv, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address: - - 2014
Previous distribution and histological studies have indicated that the kidneys and renal proximal tubular cells play a role in clearance of rFVIIa. However, the relative importance of the kidneys in clearance of rFVIIa has not previously been addressed. The objective of the present study was to evaluate the importance of ...
Hard Gordon C GC 1Private Consultant, Tairua, New - - 2014
The spontaneous incidence of foci of oncocytic proliferation (oncocytic hyperplasia and oncocytoma) was assessed in a histopathological reevaluation of the kidneys of 2,391 male and female Fischer 344 (F344) groups of control rats from long-term carcinogenicity studies (involving 24 chemicals) that had been conducted by the National Toxicology Program. The ...
Tian Jihua J Department of Nephrology, The Affiliated People's Hospital of Shanxi Medical University, Shanxi Provincial People's Hospital, Shanxi Kidney Disease Institute, Taiyuan, PR - - 2014
Background: IgA nephropathy (IgAN) is the most frequent glomerulonephritis worldwide. Different therapeutic approaches have been tested against IgAN. The present study was designed to explore the renoprotective potential of low-dose mammalian target of rapamycin (mTOR) inhibitor rapamycin in an IgAN rat model and the possible mechanism of action. Methods: After ...
Khan Md Abdul Hye MA Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, - - 2014
Azilsartan medoxomil (AZL-M), an angiotensin II receptor blocker, demonstrates antihypertensive and organ protective effects in hypertension. We investigated the efficacy of AZL-M to ameliorate metabolic syndrome and kidney damage associated with type 2 diabetes using Zucker diabetic fatty (ZDF) rats. ZDF rats were treated with vehicle or AZL-M for 8 ...
Ebaid Hossam - - 2014
While it is known that advanced age alters the recruitment of neutrophils during wound healing, thereby delaying the wound healing process, little is known about prolonged wound healing in advanced ages. Thus, we investigated the correlation of neutrophil recruitment with healing events, and the impact of whey protein (WP) on ...
Sharma Dharmender D Department of Zoology, Punjab Agricultural University, Ludhiana 141004, India. Electronic address: - - 2014
Organophosphate (OP) pesticides toxic manifestations have been associated with enhanced generation of reactive oxygen species (ROS) which culminates into oxidative stress (OS). Triazophos (TZ), a broad spectrum OP, was used in the present study to investigate toxic effects on liver and kidney of female albino rats at three sub-chronic dose ...
Mohammadzadeh Elham E Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, - - 2014
Skin extracellular matrix, which contains type I and type III collagens, is involved in skin development. The aim of this study was to investigate type III collagen distribution pattern as well as its changes during pre and post-natal skin morphogenesis in rats. Ventral skins of Wistar rat embryos at different ...
Rodrigues André F AF Departamento de Ciências Naturais, Centro de Ciências Exatas e Naturais, Universidade Regional de Blumenau, Blumenau, Santa Catarina, - - 2014
In the present study, we investigated the in vitro effect of hypoxanthine on the activities of antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase, as well as on thiobarbituric-acid-reactive substances (TBA-RS), in the renal cortex and medulla of rats. Results showed that hypoxanthine, at a concentration ...
Bridges Christy C CC Mercer University School of Medicine, Division of Basic Medical Sciences, Macon, Georgia 31207. Electronic address: - - 2014
Progressive loss of functioning nephrons, secondary to age-related glomerular disease, can impair the ability of the kidneys to effectively clear metabolic wastes and toxicants from blood. Additionally, as renal mass is diminished, cellular hypertrophy occurs in functional nephrons that remain. We hypothesize that these nephrons are exposed to greater levels ...
Shortliffe Linda M Dairiki LM Departments of Urology, Stanford University School of Medicine, Stanford, CA. Electronic address: - - 2014
Testosterone (T) affects male development, maturation, and aging, but limited data exist on testosterone effects on the juvenile genitourinary system. We hypothesized that T has bladder and kidney developmental effects, and investigated this in juvenile male rats. To examine T effect, prepubertal male Wistar rats (age 21 days) were divided ...
Yasui Takahiro - - 2014
Melamine was recently identified as a risk factor for renal calculi following the milk powder contamination in China. However, the long-term natural history of melamine exposure and its renal effects remain unknown. We evaluated renal function and other adverse health effects using a rat model administered melamine and cyanuric aid, ...
Yamazaki Hidenori H The Second Department of Internal Medicine, University of Toyama, - - 2014
Renal vascular structural properties and their alterations by removal of uraemic toxins with AST-120, an oral adsorbent, were examined in subtotal nephrectomised rats. Eight- or 9-week old Sprague-Dawley rats received 3/4 nephrectomy (n=18) and thereafter were fed 24.5% protein diet with (AST; n=9) or without (No AST; n=9) AST-120 (0.4 ...
Zhang Chao C Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin 300052, - - 2014
Laminectomy is a widely accepted treatment for lumbar disorders. Epidural Fibrosis (EF) is a common post-laminectomy or post-discectomy complication, which is thought to cause recurrent pain. RNA interference (RNAi) is a process by which double-stranded RNA triggers the destruction of mRNAs sharing the same sequence. Previously, extra-cellular signal-regulated kinase (ERK) ...
Jia Zhiqiang Z Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, PR - - 2014
An experiment was conducted to determine the toxic effects of zearalenone (ZEN) on oxidative stress, inflammatory cytokines, biochemical and pathological changes in the kidney of pregnant rats, and to explore the possible mechanism in ZEN induced kidney damage. The rats were fed a normal diet treated with 0.3, 48.5, 97.6 ...
He Jiake J Department of Pharmaceutics, University of Washington, Seattle, Washington, 98195; Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, 210009, P.R. - - 2014
We have reported an unusual, but clinically significant, digoxin (DIG)-bupropion (BUP) drug interaction (DDI), where BUP increased DIG renal clearance by 80%. To investigate the mechanism(s) of this unusual DDI, we first determined the effect of BUP, its circulating metabolites or their combination on [(3) H]-DIG transport by cells expressing ...
Seif Ansam Aly - - 2014
Osteoporosis poses a significant public health issue. It is a skeletal disorder characterized by compromised bone strength that predisposes to increased risk of fracture. There is a direct relationship between the lack of estrogen after menopause and the development of osteoporosis. About 33% of women over 50 will experience bone ...
Zambrano Sonia S Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, Sevilla, - - 2014
The development of renal fibrosis is a consequence of arterial hypertension. L-carnitine plays an essential role in the β-oxidation of fatty acids, and we have previously demonstrated hypotensive, antioxidant, and anti-inflammatory effects of L-carnitine in arterial hypertension. This work aims to analyze the effect of L-carnitine on renal fibrosis and ...
1 2 3 4 5 6 7 8 9 10 >