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Zhang D D Department of Radiology, XinQiao Hosptial, Third Military Medical University, ChongQing 400037, People's Republic of China. Electronic address: - - 2014
To detect the β-amyloid plaques (Aβ) in a rat model of Alzheimer's disease (AD) using superparamagnetic iron oxide nanoparticles coated with 1,1-dicyano-2-[6-(dimethylamino)-naphthalene-2-yl] propene carboxyl derivative (DDNP-SPIO). DDNP-SPIO was prepared in a previous trial. The binding affinity of DDNP-SPIO to Aβ was tested using fluorescence spectrophotometry in vitro. In vivo, five AD rats ...
Mikolić Anja A Institute for Medical Research and Occupational Health, Zagreb, - - 2014
Diet is the main source of cadmium (Cd) exposure. Gastrointestinal absorption increases during pregnancy. Cadmium accumulated in the placenta may interfere with nutrient transport to the foetus. Data on the potential of Cd to act as a steroid disruptor of pregnancy are limited. We evaluated the effects of oral Cd ...
Dokuyucu Recep R Department of Medical Physiology, Medical Faculty, Mustafa Kemal University, 31100, Hatay, Turkey. Electronic address: - - 2014
We aimed to determine the presence of oxidative stress in rhinitis medicamentosa (RM) and to evaluate the effect of erdosteine (ED) on mucosal changes in a rat model. Twenty-four male rats were used in this experimental study. Three groups were created. Group 1 (n=8) was the control group. Two puffs ...
Cao Chang C Division of Nutritional Sciences, Cornell University, Ithaca, - - 2014
Dietary heme contributes to iron intake, yet regulation of heme absorption and tissue utilization of absorbed heme remains undefined. In a rat model of iron overload, we used stable iron isotopes to examine heme- and nonheme-iron absorption in relation to liver hepcidin and to compare relative utilization of absorbed heme ...
Kador Peter F PF Department of Pharmaceutical Sciences, University of Nebraska Medical Center , Omaha, - - 2014
Abstract Purpose: Based on the hypothesis that oral nutraceuticals do not adequately reach all ocular tissues in the anterior segment, we evaluated the ability of a 3% concentration of the ingredients in a topical nutraceutical antioxidant formulation called Optixcare Eye Health (Optixcare EH) to ameliorate oxidative stress in rat models ...
Ackerman Zvi Z Department of Medicine, Hadassah-Hebrew University Medical Center, Mount Scopus Campus, P.O. Box 24035, 91240, Jerusalem, Israel, - - 2014
An increase in hepatic iron concentration might exacerbate liver injury. However, it is unknown whether hepatic iron overload may exacerbate acute liver injury from various toxins. Therefore, we evaluated how manipulations to increase hepatic iron concentration affected the extent of acute liver injury from thioacetamide. In this study, we used ...
Empl Michael T MT Institute for Food Toxicology and Analytical Chemistry, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173, Hannover, - - 2014
L-Carnitine, a key component of fatty acid oxidation, is nowadays being extensively used as a nutritional supplement with allegedly "fat burning" and performance-enhancing properties, although to date there are no conclusive data supporting these claims. Furthermore, there is an inverse relationship between exogenous supplementation and bioavailability, i.e., fairly high oral ...
Zhao Yanli Y Department of Pharmaceutics, School of Pharmaceutical Sciences, Shandong University , Jinan, Shandong Province , - - 2014
Abstract The aim of this study is to prepare a stable phosphatidylcholine/bile salt micelles with Pluronic F127-polyethylenimine conjugates (F127-PEI), d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), soybean phosphatidylcholine (SPC) and sodium cholate (NaC) and to elucidate the effects and possible mechanism of micelle components on the intestinal absorption of paclitaxel (PTX) ...
Saini R K RK Plant Cell Biotechnology Department, CSIR-Central Food Technological Research Institute, Mysore 570 020, - - 2014
In this study, the effects of iron depletion and repletion on biochemical and molecular indices of iron status were investigated in growing male Wistar rats. We hypothesized that iron from Moringa leaves could overcome the effects of iron deficiency and modulate the expression of iron-responsive genes better than conventional iron ...
Yang Ying-Ying YY Division of General Medicine; Division of Clinical Skill Training, Department of Medical Education; Institute of Clinical Medicine; Department of Medicine, National Yang-Ming University School of Medicine. Electronic address: - - 2014
Intestinal hyper-permeability, impaired peritoneal macrophages (PMs) phagocytosis, and, bacterial translocation (BT) resulting in increased systemic and local infection/inflammation such as spontaneous bacterial peritonitis (SBP), together with increased tumor necrosis factor-α (TNFα) levels, are all implicated in the pathogenesis of cirrhosis-related complications. Manipulation of cannabinoid receptors (CB1R and CB2R), which are ...
Surampalli Gurunath G Department of Pharmacology, Vaagdevi Institute of Pharmaceutical Sciences , Warangal, Andhra Pradesh , India - - 2014
Abstract Objective: To assess the effect of naringenin on the intestinal biochemical composition, function and histology for gastrointestinal toxicity since it has not yet been adequately exploited for safety through standard assays. Methods: Here, we describe naringenin (1 mM, 10 mM and 100 mM, respectively) or sodium deoxycholate (10 mM) effects on isolated brush ...
Welch K D KD USDA-ARS Poisonous Plant Research Laboratory, 1150 E. 1400 N., Logan, Utah 84341, USA. Electronic address: - - 2014
A number of plant toxins have been shown to be teratogenic to livestock. The teratogenic action of some of these alkaloids is mediated by nicotinic acetylcholine receptors (nAChR). However, for many of these alkaloids it is difficult to obtain sufficient quantities of individual alkaloids to perform teratology studies in livestock ...
Dreon Marcos S MS Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), Universidad Nacional de La Plata (UNLP) - CONICET CCT, La Plata, Argentina; Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, - - 2014
The spread of the invasive snail Pomacea canaliculata is expanding the rat lungworm disease beyond its native range. Their toxic eggs have virtually no predators and unusual defenses including a neurotoxic lectin and a proteinase inhibitor, presumably advertised by a warning coloration. We explored the effect of egg perivitellin fluid ...
Yan Denglu - - 2014
This research aims to investigate magnetic resonance imaging (MRI) in the tibial epiphyseal growth plate development of Wistar rat. Fifty weanling Wistar rats were divided by a computerized blocking procedure into five groups. The rats received standard commercial feed with or without T-2 toxin additive, low-protein feed with or without ...
Shinoda Shoko S Tokyo Metropolitan University - - 2014
Regular "mucosal block" is characterized by decreased uptake of a normal iron load 3-72 h after the administration of excess iron (generally 10 mg) to iron deficient animals. We found that short-acting mucosal block could be induced by much lower iron concentration and much shorter induction time than previously reported, ...
Merchant Hamid A HA Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, - - 2014
Age-mediated changes in gut physiology are considerations central to the elucidation of drug performance from oral formulations. Using rats of different age groups we measured the pH, buffer capacity, fluid volume, osmolality, and surface tension of gastrointestinal (GI) fluids, and therein explored the impact of these variables on prednisolone and ...
Wei Meng M Dialysis Department of Nephrology Hospital, First Affiliated Hospital of Medicine School, Xi'an Jiaotong University, Xi'an, Shaanxi, - - 2014
Uremia is characterized by intestinal bacterial translocation, which contributes to the development of microinflammation. Probiotics enhance the intestinal barrier and overall health of the host. The present study investigated whether the probiotic Bifidobacterium animalis subsp. lactis Bi-07 alleviates bacterial translocation and ameliorates microinflammation in experimental uremia. Sixty Sprague-Dawley rats were ...
Zhang Hai H Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai 200433, China; Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, - - 2014
Aconitum carmichaeli (AC) is a well-known herbal medicine for its excellent pharmacological effects and toxicity. The monoester-diterpenoid alkaloids (MDAs), including benzoylmesaconine (BMC), benzoylaconine (BAC) and benzoylhyaconine (BHC), are the main active components in AC. The aim of this research is to reveal the dynamic changes of 3 MDAs using pharmacokinetics ...
Wei Shi-Chao SC Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China, - - 2014
The intestinal absorption of berberine (Ber) and its structural modified compound 8-hydroxy dihydroberberine (Hdber) was compared, and their effects on the intestinal absorption of sugar by perfusion experiment were investigated in order to reveal the mechanism of low dose and high activity of Hdber in the treatment of hyperglycemia. The ...
Liu Jia J Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, - - 2014
Aim:To investigate the routes of elimination and excretion for triptolide recovered in rats.Methods:After a single oral administration of [(3)H]triptolide (0.8 mg/kg, 100 μCi/kg) in Sprague Dawley rats, urine and fecal samples were collected for 168 h. To study biliary excretion, bile samples were collected for 24 h through bile duct ...
Wang Su-Jun SJ Department of Clinical Pharmacy, Guangdong Pharmaceutical University , Guangzhou , - - 2014
Abstract Context: Caffeic acid (CA) is widely distributed in edible plants, and it is beneficial to human health by exerting various biological effects. The potential pharmacological activities of CA are dependent on its absorption in the gastrointestinal tract. Objective: To investigate the bioavailability of CA in rats and its absorption ...
Chang Jae Won JW a Department of Otolaryngology, School of Medicine , Ajou University, Suwon, Korea and Center for Cell Death Regulating Biodrugs, School of Medicine, Ajou University , Suwon , - - 2014
Numerous studies' attempts to improve radiation-induced oral mucositis have not produced a qualified treatment yet. Our aim was to investigate the effectiveness of Korean red ginseng (KRG) on radiation-induced damage in an in vivo rat model. After 20 Gy of irradiation, rats were divided randomly into the following 4 groups: ...
Caporossi Cervantes C Federal University of Mato Grosso, Department of Surgery, CuiabaMT, Brazil, PhD, Associate Professor, Division of Digestive Surgery, Department of Surgery, Federal University of Mato Grosso (UFMT), Cuiaba-MT, Brazil. Conception, design, intellectual and scientific content of the - - 2014
To validate the gastroschisis experimental model in female rats and the effects on the glutamine fetal morphology during pregnancy. Twelve pregnant rats Wistar were separated in two groups: Group I (n = 6 rats, 71 fetuses) took glutamine and Group II (n = 6 rats, 75 fetuses) took isocaloric supplementation. ...
Jena Prasant Kumar PK Institute of Science, Nirma University, Sarkhej-Gandhinagar Highway, Chandlodia, Ahmedabad, 382481, Gujarat, - - 2014
The objective of present investigation was to study the effect of gut microbiota alteration by oral administration of targeted delivery of pH sensitive cefdinir microspheres to high-fructose-fed (HFD) rats. Rats were fed with a high-fructose diet with or without cefdinir microsphere administration for 30 days. The fecal microbiota community, oral glucose ...
Wang Xiaoying X Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, 151 Malianwa North Road, Haidian District, Beijing, 100193, People's Republic of - - 2014
The goal of this study is to investigate the biotransformation of ginsenoside Rg1 in vivo. A highly sensitive and specific LC-MS/MS method was developed and used for metabolite identification in rat feces and urine after oral administration of ginsenoside Rg1 . Four metabolites of Rg1 were detected in rat feces ...
Zhou Wei W Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. Electronic address: - - 2014
Toll-like receptor (TLR)-4 and TLR-2 play an essential role in the pathogenesis of necrotizing enterocolitis (NEC). In this study, we investigated the protective effect of glutamine (Gln) in an NEC neonatal rat model, and the potential association with TLR-4 and TLR-2 expression in local intestinal tissues. Preterm neonatal rats were ...
Liu Hongming H Division of Pharmaceutics, College of Pharmacy, Jinan University , Guangzhou , People's Republic of - - 2014
Abstract 1. The promising anticancer agent SNX-2112 (a novel Hsp90 inhibitor) is poorly bioavailable after oral administration. Here, we aim to determine the role of P-glycoprotein (P-gp) in the intestinal absorption of SNX-2112. 2. We found that SNX-2112 significantly stimulated P-gp ATPase activity in in vitro ATPase assay with a small EC50 ...
Felgines Catherine C Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, Equipe ECREIN, Laboratoire de Pharmacognosie et Phytothérapie, 28 Place Henri-Dunant, BP 38, F-63001 Clermont-Ferrand Cedex 1, - - 2014
Lemon verbena (Aloysia triphylla) infusion, a widely consumed herbal tea, contains significant amounts of polyphenols such as flavone diglucuronides and phenylpropanoid glycosides (mainly verbascoside). We have recently shown that lemon verbena infusion offers beneficial effects against dextran sodium sulphate (DSS)-induced colonic inflammation in rats. The present study aimed to evaluate ...
You Hai-Sheng HS Department of Pharmacy, The First Affiliated Hospital of Medical College, Xi'an, - - 2014
Scutellarin (SG) and its aglycone, Scutellarein (S), are flavonoids of therapeutic cardiocerebrovascular disease. SG was hydrolyzed by bacterial enzyme into S which was absorbed in the intestine. The aim of this study was to determine the effects of the microflora in the intestinal lumen and the efflux transporter of intestinal ...
Wan Changrong C CAU-BUA TCVM Teaching and Researching Team, College of Veterinary Medicine, China Agricultural University (CAU), Beijing 100193, PR - - 2014
The present study investigated the effects of simulated transport stress on morphology and gene expression in the small intestine of laboratory rats. Sprague Dawley rats were subjected to 35°C and 0.1×g on a constant temperature shaker for physiological, biochemical, morphological and microarray analysis before and after treatment. The treatment induced ...
Kulkarni Ashutosh A Celgene Corporation, 10300 Campus Point Dr, Suite 100, San Diego, CA 92121, - - 2014
With the goal of refining our discovery DMPK workflow, we conducted a retrospective analysis on internal Celgene compounds by calculating the physicochemical properties and gathering data from several assays including solubility, rat and human liver S9 stability, Caco-2 permeability, and rat intravenous (iv.) and oral pharmacokinetics. Our analysis identified plasma ...
Feng Xinchi X School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China. - - 2014
Although linarin possesses diverse pharmacological activities, its poor oral bioavailability has been a concern for further development. The present study aimed to demonstrate the feasibility of improving the oral absorption of linarin in rats with a bioenhancer‒piperine. First, the intestinal permeability of linarin in the presence and absence of verapamil ...
Wang Xianqin X Analytical and Testing Center, Wenzhou Medical University, Wenzhou 325035, - - 2014
Hydrogen sulfide (H2S) is the second leading cause of toxin related death (after carbon monoxide) in the workplace. H2S is absorbed by the upper respiratory tract mucosa, and it causes histotoxic hypoxemia and respiratory depression. Cocktail method was used to evaluate the influences of acute H2S poisoning on the activities ...
Lou Juanya - - 2014
Inflammation of the small intestine may occur in type 2 diabetes. This study aimed to investigate whether ATP-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) were altered in chronic inflammation of the small intestine of type 2 diabetic rats. Thirty-two male Sprague-Dawley rats were used. Eight rats in the control ...
Sakai Yoko Y Department of Anesthesiology, Tokushima University - - 2014
Propofol causes vasodilation via endothelium-dependent and -independent mechanisms. Because endothelial function is impaired with aging, the effects of propofol on endothelium-dependent vasodilation might be altered by aging. The aim of this study was thus to determine the effects of aging on vascular responses to propofol. Young (4-6 weeks old) or ...
Huo Yan Y Tianjin University of Traditional Chinese Medicine, 312 Yuquan Road, Nankai District Tianjin, Tianjin 300193, - - 2014
Cortex Eucommia has been used as a kidney-tonifying herbal medicine with a long history of compatibility with Fructus Psoraleae. Geniposide (GP) and geniposidic acid (GPA) are the two main chemical components in Cortex Eucommia. In the present study, the effects of Fructus Psoraleae extract (FPE) on intestinal absorption kinetics of ...
Yokooji Tomoharu T Department of Pathophysiology and Therapeutics, Institute of Biomedical and Health Sciences, Hiroshima - - 2014
Ingested proteins are absorbed from the intestinal lumen via the paracellular and/or transcellular pathways, depending on their physicochemical properties. In this study, we investigated the absorption pathway(s) of ovalbumin (OVA), an egg white-allergen, as well as the mechanisms of aspirin-facilitated OVA absorption in rats. In situ intestinal re-circulating perfusion experiments ...
Himsworth Chelsea G - - 2013
Clostridium difficile is an important cause of enteric infections in people. Recently, concerns have been raised regarding whether animals could be a source of C. difficile spores. Although colonization has been identified in a number of domestic species, the ability of commensal pests to serve as a reservoir for C. ...
Sedin John - - 2013
The mechanism by which the duodenum adjusts the luminal osmolality remains unclear. The aim was to compare the duodenal osmoregulation in response to different hyperosmolar solutions in Sprague-Dawley and Dark-Agouti rats and to elucidate whether cyclooxygenase-2 inhibition affects these responses. The duodenum was perfused in situ with a 700-milliosmolar solution ...
Islam Mohammed A MA Division of Toxicology, Wageningen University, Wageningen, The - - 2014
This study compares conversion of three major soy isoflavone glucosides and their aglycones in a series of in vitro intestinal models. In an in vitro human digestion model isoflavone glucosides were not deconjugated, whereas studies in a Caco-2 transwell model confirmed that deconjugation is essential to facilitate transport across the ...
O'Malley Dervla - - 2013
Irritable bowel syndrome (IBS) is a common, debilitating gastrointestinal (GI) disorder characterized by episodic exacerbations of symptoms such as abdominal pain, bloating and altered bowel habit. Contributory factors for the development of IBS include genetics, childhood trauma and prior GI infection leading to chronic low-grade inflammation or immune activation. Additional ...
Chattopadhyay Pronobesh - - 2013
Our study aimed to determine the cardiac toxicities of T-2 toxin, a representative mycotoxin that frequently contaminates maize, cereals, and other agricultural products, harvested and stored under damp and cold conditions. Dermal exposure to T-2 toxin caused severe cardiotoxicity in experimental Wistar rats. Electrocardiography studies showed the conduction abnormalities including ...
Wahajuddin - - 2013
In quest to explore the reason for lumefantrine low and variable bioavailability, we investigated the possible role of P-gp in lumefantrine intestinal absorption. In situ single pass intestinal perfusion study in rats with P-gp inhibitor verapamil/quinidine and ATPase assay with human P-gp membranes indicated that lumefantrine is a substrate of ...
Hanna-Mitchell Ann T - - 2013
Botulinum neurotoxin serotype A (BoNT/A) has emerged as an effective treatment of urinary bladder overactivity. Intravesical lipotoxin (BoNT/A delivery using liposomes), which may target the urothelium, is effective in blocking acetic acid induced hyperactivity in animals. The objective of this study was to assess the possible site of toxin action ...
Attili-Qadri Suha - - 2013
An original oral formulation of docetaxel nanocapsules (NCs) embedded in microparticles elicited in rats a higher bioavailability compared with the i.v. administration of the commercial docetaxel solution, Taxotere. In the present study, various animal studies were designed to elucidate the absorption process of docetaxel from such a delivery system. Again, ...
Xie Weibin - - 2013
Previous studies have shown that meranzin hydrate (MH) may be beneficial in depressive disorders. However, to the best of our knowledge, the pharmacokinetic characteristics of MH in depression have not previously been investigated. Chronic mild stress (CMS) in rats is used as a model of depression. The present study was ...
Beutheu Stéphanie - - 2013
Increased intestinal permeability occurs during chemotherapy-induced intestinal mucositis. Previous data suggest that glutamine and arginine may have additive or synergic effects to limit intestinal damage. The present study aimed to evaluate the effects of glutamine and arginine, each alone or in combination, on gut barrier function during methotrexate (MTX)-induced mucositis ...
Kovalenko Pavlo L - - 2013
IMPORTANCE The normal absorptive function and structural maintenance of the intestinal mucosa depend on a constant process of proliferation of enterocytic stem cells followed by progressive differentiation toward a mature phenotype. The mechanisms that govern enterocytic differentiation in the mucosa of the small intestine are poorly understood. OBJECTIVE To determine ...
Cueno Marni E - - 2013
Orally-administered catechin has long been known to have several beneficial effects on the mammalian host, however, the effects of orally supplemented catechin on the host through gingival tissues has not yet been established. Here, we elucidated the effects of orally supplemented catechin in the rat heart blood mitochondria. We used ...
Sibaldo de Almeida Cristhiano - - 2013
Cylindrospermopsin (CYN) induces toxicity in pregnant mice when administered intraperitoneally. This study investigated whether oral exposure to CYN (0.03, 0.3 and 3 μg/Kg) during pregnancy causes toxic effects and impairs gestation in rats. The results of reproductive performance and teratology studies were similar between the control and experimental dams. Our ...
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