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Zheng Huabin H Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. - - 2014
T helper 17 (Th17) cells are strong inducers of numerous autoimmune diseases and inflammation. However, the role of Th17 cells and interleukin (IL)‑17 in traumatic optic neuropathy (TON) are yet to be elucidated. In the present study, a rat model of TON was established using a fluid percussion brain injury device. Th17 ...
Barbosa Marcello Oliveira MO Department of Orthopaedics and Traumatology, Hospital das Forças Armadas (HFA), Brasília, DF, - - 2014
To evaluate the neuroprotective effect of epidural hypothermia in rats subjected to experimental spinal cord lesion. Wistar rats (n = 30) weighing 320-360 g were randomized to two groups (hypothermia and control) of 15 rats per group. A spinal cord lesion was induced by the standardized drop of a 10-g weight from ...
Santa Cruz Chavez Grace C GC Indiana University Purdue University - - 2014
Sex differences in baroreflex (BRx) function are well documented. Hormones likely contribute to this dimorphism but many functional aspects remain unresolved. Our lab has been investigating a subset of vagal sensory neurons that constitute nearly 50% of the total population of myelinated aortic baroreceptors (BR) in female but less than ...
Pitarokoili Kalliopi K Department of Neurology, St. Josef Hospital, Ruhr-University of Bochum, Germany. Electronic address: - - 2014
Laquinimod is an immunomodulatory drug with neuroprotective potential. We used the animal model of experimental autoimmune neuritis (EAN) in the Lewis rat to study the effects of laquinimod treatment. After immunization with the neuritogenic peptide aa 53-78 of P2 myelin protein, preventive therapy with 12.5mg/kg laquinimod once daily inhibited neuritis ...
Tanaka Miyuu M Laboratory of Veterinary Pathology, Osaka Prefecture University, Izumisano, Osaka, 598-8531, - - 2014
The vacuole formation (VF) rat is an autosomal recessive myelin mutant characterized by generalized tremor, hypomyelination, and periaxonal vacuole formation of the central nervous system (CNS). Here, we report the most likely causative gene for neurological disease in the VF rat and pursue its roles in the development and maintenance ...
Olver T Dylan TD The University of Western - - 2014
Insulin stimulates nerve arterial vasodilation through a nitric-oxide synthase (NOS) mechanism. Experimental diabetes reduces vasa nervorum NO-reactivity. Studies investigating hyperglycemia and nerve arterial vasodilation typically omit insulin-treatment and use sedentary rats resulting in severe hyperglycemia. We tested the hypotheses that i) insulin-treated experimental diabetes and inactivity (DS) will attenuate insulin-mediated ...
Zhu Yanyan Y Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University, 44# Wenhua Xi Road, Jinan, 250012, Shandong, People's Republic of China, - - 2014
Several studies support a protective effect of vitamin D on multiple sclerosis and experimental allergic encephalomyelitis (EAE), but the mechanisms of these favorable effects are unclear. Our study demonstrates that sphingosine 1-phosphate (S1P) is upregulated in the serum and spinal cords of EAE rats, but that vitamin D reverses the ...
Seong Han Yu HY 0000-0002-3089-1057 Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, - - 2014
Intracortical microstimulation (ICMS) is a technique that was developed to derive movement representation of the motor cortex. Although rats are now commonly used in motor mapping studies, the precise characteristics of rat motor map, including symmetry and consistency across animals, and the possibility of repeated stimulation have not yet been ...
Wrotek Sylwia S Department of Immunology - - 2014
Abstract Thermoregulation in patients, who suffer from multiple sclerosis (MS) is impaired and may result in either increases or decreases in body temperature. Disturbances in body temperature correlate with acute relapses, and for this reason, it is an important issue in everyday life of those who suffer from MS. Although ...
Miyamoto Katsutoshi K Department of Urology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, - - 2014
Erectile dysfunction remains a major complication after surgery of pelvic organs, especially after radical prostatectomy. The aim of this study was to assess the effect of endothelial progenitor cells on the regeneration of cavernous nerves in a rat injury model. A 2 mm length of the right and left cavernous nerves ...
Yang Pengfei P The Pharmacokinetics Lab, Anhui University of Chinese Medicine, Hefei, Anhui, 230038, China; School of pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, 230038, China; The Institute of Pharmacokinetics, Anhui Academy of Chinese Medicine, Hefei, Anhui, 230038, - - 2014
The goal of this study was to develop a novel oil-body nanoemulsion (ONE) for Ginkgolide B (GB) and to conduct pharmacokinetics and pharmacodynamics evaluations. GB-ONE was prepared by O/O emulsion method. The differences in pharmacokinetics parameters and tissue distribution of rats after oral administrated with GB-ONE were investigated by liquid ...
Song Dayong D Department of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai Fengxian District Central Hospital, Shanghai, People's Republic of - - 2014
The study reported here examined the effect of hematoporphyrin monomethyl ether (HMME)-mediated sonodynamic therapy (SDT) on C6 gliomas implanted in rat brains. Two weeks after inoculation, glioma development was evaluated by measuring tumor volume using a 1.5 T magnetic resonance imager. Rats that had a well-developed C6 glioma (usually when ...
Nowicki Marcin M Institute of Anatomy, University of - - 2013
Introduction: Nerve conduction studies provide insights into the functional consequences of axonal and myelin pathology in peripheral neuropathies. We investigated whether isoflurane inhalation anesthesia alters F-wave latencies and F-persistence in the sciatic nerve of adult rats. Methods: Ten rats were investigated at 3 different isoflurane concentrations followed by ketamine-xylazine injection ...
Di Biase A A Department of Public Veterinary Health & Food Safety, Istituto Superiore di Sanità, Rome, Italy. Electronic address: - - 2013
Recently, we investigated the effects of eicosapentaenoic acid (EPA), a fatty acid which modulates immune response and stimulates myelin gene expression, in an established model of multiple sclerosis (MS): the experimental autoimmune encephalomyelitis (EAE) induced in Dark Agouti rats. As scientific evidences and our previous studies have suggested that EPA ...
Kosacka J - - 2013
Wistar Ottawa Karlsburg W (RT1(u)) rats (WOKW) develop obesity, dyslipidemia, moderate hypertension, hyperinsulinemia and impaired glucose tolerance prone to induce peripheral neuropathy (PN). Autophagy has been shown to prevent neurodegeneration in the central and peripheral nervous system. We analyzed the potential protective role of autophagy in an established rat model ...
Biazar Esmaeil - - 2013
The aim of this study is to develop a nanofibrous polymeric nerve conduit with Schwann cells (SCs) and to evaluate its efficiency on the promotion of functional and locomotive activities in rats. The conduits were implanted into a 30-mm gap in the sciatic nerves of the rats. Four months after ...
Adzemovic Milena Z - - 2013
The association of vitamin D deficiency with higher prevalence, relapse rate and progression of multiple sclerosis (MS) has stimulated great interest in using vitamin D supplementation as a preventative measure and even a therapy for established MS. However, there is a considerable lack of evidence when it comes to an ...
Kim Sei Eun SE The Department of Physiology and the Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, Texas; - - 2013
Auditory brain stem circuits rely on fast, precise, and reliable neurotransmission to process auditory information. To determine the fundamental role of myelination in auditory brain stem function, we examined the evoked auditory brain stem response (ABR) from the Long Evans shaker (LES) rat, which lacks myelin due to a genetic ...
Mangas Arturo - - 2013
Chronic experimental autoimmune encephalomyelitis (EAE) was induced in rats to evaluate the potential protective effect of GEMSP, a mixture made up of fatty acids (FA), vitamins, and amino acids or their derivatives, linked to Poly-L-Lysine, on the myelin sheath of the optic nerve. To evaluate the effects of GEMSP on ...
Li Yiqiao - - 2013
Abstract Background/Aims Multiple sclerosis is a neurodegenerative auto-immune disease characterized by diffuse oligodendrocyte injury, axonal loss, and multifocal demyelination of myelin sheaths in the central nervous system. TRO19622 is a small cholesterol-like compound, which displays remarkable neuroprotective and neuroregenerative properties in neural cell culture and rodent models of nerve trauma. ...
Timotijević Gordana - - 2013
CXCL12 plays a protective role in CNS autoimmunity. Expression of CXCL12-γ, which has distinct structural and functional properties than the other isoforms of CXCL12, was determined in spinal cords of rats immunized to develop experimental autoimmune encephalomyelitis (EAE). CNS expression of CXCL12-γ was markedly lower in EAE-prone Dark Agouti rats ...
Angélica-Almeida Maria - - 2013
Introduction: The rat is probably the animal species most widely used in experimental studies on nerve repair. The aim of this work was to contribute to a better understanding of the morphology and blood supply of the rat brachial plexus. Material and Methods: Thirty adult rats were studied regarding brachial ...
Smith Chelsey M CM University of Wisconsin-Madison, School of Veterinary Medicine, Madison, Wisconsin 53706, - - 2013
The Long-Evans shaker (les) rat has a mutation in myelin basic protein that results in severe CNS dysmyelination and subsequent demyelination during development. During this time, les oligodendrocytes accumulate cytoplasmic vesicles, including lysosomes and membrane-bound organelles. However, the mechanism and functional relevance behind these oligodendrocyte abnormalities in les have not ...
You Yu - - 2013
Glatiramer acetate (GA) is a clinically prescribed immunomodulator drug used to treat demyelinating disease like multiple sclerosis (MS). Persistent down-regulation in the expression of myelin sheath proteins has been observed in both rats with pentylenetetrazol (PTZ) induced chronic epilepsy and some clinical epilepsy patients. Hypothetically, protection of myelin sheath by ...
Blaževski Jana - - 2013
Dark Agouti (DA) rats are highly susceptible to induction of experimental autoimmune encephalomyelitis (EAE), still they completely recover from the disease. Here, we were interested to determine contribution of major anti-inflammatory cytokines transforming growth factor (TGF)-β and interleukin (IL)-10 to the recovery of DA rats from EAE. To that extent ...
Li Lin - - 2013
Abstract 1. In the present study, we investigated the impact of 1.0% ropivacaine on the ultrastructure and proteome of the rat spinal cord. 2. Rats received three injections (90-min intervals, 0.2 mL/kg) of 0.9% NaCl, 0.5% ropivacaine or 1.0% ropivacaine via an implanted intrathecal catheter. Transmission electron microscopy was performed to ...
Boeltz Tiffany T Dept. of Cell Biology, Emory Univ. School of Medicine, 615 Michael St., Atlanta, GA 30322, - - 2013
Exercise, in the form of moderate daily treadmill training following nerve transection and repair leads to enhanced axon regeneration, but its effect on functional recovery is less well known. Female rats were exercised by walking continuously, at a slow speed (10 m/min), for 1 h/day on a level treadmill, beginning ...
Stephenson J B JB 4th Department of Plastic Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, - - 2013
To perform contralateral C7 nerve transfer in a controlled, survival rat functional magnetic resonance imaging model, so as to understand the extent of cortical plasticity after brachial plexus injury and surgical manipulation with this procedure. A total of 24 rats divided into 3 groups underwent surgery followed by functional magnetic ...
Fukushima Nanae - - 2013
Regeneration of the lateral olfactory tract (LOT) occurs spontaneously after transection in developing rats. In neonatally LOT-transected rats, we observed a newly-formed myelinated tract near the rhinal sulcus. The aim of this study was to analyze the precise re-innervated cortical areas and to demonstrate ectopic LOT myelination in neonatally LOT-transected ...
Scalabrino Giuseppe - - 2013
It is known that cobalamin (Cbl) deficiency damages myelin by increasing tumor necrosis factor (TNF)-α and decreasing epidermal growth factor (EGF) levels in rat central nervous system (CNS), and affects the peripheral nervous system (PNS) morphologically and functionally. It is also known that some polyneuropathies not due to Cbl deficiency ...
Vigaru B - - 2013
Animal models are widely used to explore the mechanisms underlying sensorimotor control and learning. However, current experimental paradigms allow only limited control over task difficulty and cannot provide detailed information on forelimb kinematics and dynamics. Here we propose a novel robotic device for use in motor learning investigations with rats. ...
Yang Shu - - 2013
We found that an enriched environment (EE) could delay the loss of myelinated fibers in the white matter of rats during normal aging. However, the reasons for the protective effects of EE on the myelinated fibers were unclear. In this present study, via the use of stereological methods, we quantitatively ...
Shuster Katherine A - - 2013
Group B Streptococcus (Streptococcus agalactiae, GBS) is a gram-positive commensal and occasional opportunistic pathogen of the human vaginal, respiratory, and intestinal tracts that can cause sepsis, pneumonia, or meningitis in human neonates, infants, and immunosuppressed persons. We report here on a spontaneous outbreak of postnatal GBS-associated disease in rats. Ten ...
Ota Ayumi - - 2013
We evaluated ranirestat, an aldose reductase inhibitor, in diabetic cataract and neuropathy (DN) in spontaneously diabetic Torii (SDT) rats compared with epalrestat, the positive control. Animals were divided into groups and treated once daily with oral ranirestat (0.1, 1.0, 10 mg/kg) or epalrestat (100 mg/kg) for 40 weeks, normal Sprague-Dawley rats, and ...
Kwiecien J M - - 2013
Cellular mechanisms of regeneration after the white matter injury are difficult to study because of severe, inflammatory response to massively damaged myelin. Myelin-lacking CNS of the adult Long Evans Shaker (LES) rat supplies a model where neuroregeneration can be studied conveniently. The crush site in the dorsal spinal column in ...
Badawoud Mohammed H - - 2013
To investigate the morphological changes in the peripheral motor system of the rat induced by exposure to lead. This study was conducted at the Anatomy Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia from January 2011 to January 2012. Female adult albino rats (n=10) were given ...
Abada Yah-Se K - - 2013
Huntington disease (HD) is frequently first diagnosed by the appearance of motor symptoms; the diagnosis is subsequently confirmed by the presence of expanded CAG repeats (> 35) in the HUNTINGTIN (HTT) gene. A BACHD rat model for HD carrying the human full length mutated HTT with 97 CAG-CAA repeats has ...
Aoki Manahito - - 2013
Oxaliplatin is commonly used anti-cancer drugs, but it frequently causes peripheral neuropathic pain. Recently, we reported that elcatonin, a synthetic analog of eel calcitonin, attenuated the oxaliplatin- and paclitaxel-induced cold and mechanical allodynia in rats. In the present study, we determined whether salmon calcitonin also had anti-allodynic effects on oxaliplatin-induced ...
Liu Yumei - - 2013
Previously, we demonstrated that electroacupuncture (EA) decreased lymphocyte infiltration into the spinal cords of rats presenting with experimental autoimmune encephalomyelitis (EAE), a disease model used in the study of multiple sclerosis (MS). The aim of this study was to characterize the effects of EA on the EAE. Female Lewis rats ...
Burke Marilyn M Dept. of Pharmacology and Toxicology, Univ. of Mississippi Medical Center, 2500 North State St. Jackson, MS 39216, - - 2013
This study examined the effect of substitution of a 2.4-megabase pair (Mbp) region of Brown Norway (BN) rat chromosome 1 (RNO1) between 258.8 and 261.2 Mbp onto the genetic background of fawn-hooded hypertensive (FHH) rats on autoregulation of renal blood flow (RBF), myogenic response of renal afferent arterioles (AF-art), K(+) ...
Ovadia Haim - - 2012
Background: Central nervous system (CNS) irradiation has detrimental effects which become evident within hours to few days and after a long latency of months and years. However, the delayed effect of irradiation on neuroimmune diseases has not been thoroughly examined. Objectives: We evaluated the delayed effects of irradiation on the ...
Scalabrino Giuseppe - - 2012
Abstract The pathogenesis of cobalamin (Cbl)-deficient (Cbl-D) neuropathy and the role of normal prions (PrPcs) in myelin maintenance are both subjects of debate. We have demonstrated that Cbl deficiency damages myelin by increasing tumor necrosis factor (TNF)-α, and decreasing epidermal growth factor (EGF) levels in the rat central nervous system ...
Barac Sorin - - 2012
Introduction Although the effect of chronic compression and surgical decompression of the diabetic rat sciatic nerve has been evaluated by walking track analysis, the measurement of sensory function by response to thermal nociceptive stimulation has not been investigated.Methods Fifteen male Wistar rats with streptozotocin-induced diabetes underwent sciatic nerve compression through a 10-mm ...
Pabbidi Mallikarjuna R MR Human and Molecular Genetics Center, Milwaukee, WI, - - 2013
This study examined the effects of transfer of a 2.4-Mbp region of rat chromosome 1 (RNO1) from Brown Norway (BN) into fawn-hooded hypertensive (FHH) rats on autoregulation (AR) of cerebral blood flow (CBF) and the myogenic response of middle cerebral arteries (MCAs). AR of CBF was poor in FHH and ...
Hansen Niels - - 2013
Stiff person syndrome (SPS) is an autoimmune CNS disorder characterized by muscle rigidity, spasms and anxiety. The majority of patients have high-titer autoantibodies (ab) against glutamate decarboxylase (GAD65). A pathogenic role of SPS-associated IgG with ab against GAD65 has been shown for anxiety-like behavior but not for the core motor ...
Wang Feng F Department of Ophthalmology, Wayne State University School of Medicine, 4717 St. Antoine Blvd., Detroit, MI 48201, - - 2012
Patients with diabetes are at an increased risk for developing corneal complications including delayed wound healing and potential vision loss. To understand the cause of diabetic keratopathy, we investigated innervation and its correlation with delayed corneal epithelial wound healing in type 2 diabetic Goto-Kakizaki (GK) rats. GK rats are smaller ...
Tanaka Miyuu - - 2012
The vacuole formation (VF) rat is an autosomal recessive myelin mutant characterized by generalized tremor and vacuole formation within the myelin of the central nervous system (CNS). The tremor is prominent between 4 and 8 weeks of age but thereafter gradually improves. The present study, aimed at producing a detailed ...
Todd William D - - 2012
How does the brain develop differently to support nocturnality in some mammals, but diurnality in others? To answer this question, one might look to the suprachiasmatic nucleus (SCN), which is entrained by light via the retinohypothalamic tract (RHT). However, because the SCN is more active during the day in all ...
Qin Fenju - - 2012
Radiofrequency fields (RF) at 1800 MHz are known to affect melatonin (MEL) and testosterone in male rats, but it remains to be determined whether RF affected circadian rhythm of these plasma hormones. Male Sprague-Dawley rats were exposed to 1800-MHz RF at 208 μw/cm(2) power density (SAR: 0.5762 W/kg) at different ...
Song Fuyong - - 2012
Occupational exposure to n-hexane produces a central-peripheral distal axonopathy, which is characterized by giant axonal swellings filled with neurofilaments (NFs). To investigate the change of NFs degradation and their possible role in n-hexane neuropathy, adult male Wistar rats were administered intraperitoneally at a dosage of 400mg/kg/day 2,5-hexanedione (2,5-HD) for 4weeks. ...
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