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Granado Miriam M Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma, 28029 Madrid, Spain; CIBER Fisiopatología de Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain. Electronic address: - - 2014
Aging is associated with alterations in the cardiovascular system such as increased vasoconstriction and decreased vasodilatation. Some of these changes are partially reversed by caloric restriction. Endothelin-1 is a potent vasoconstrictor which levels increased with age. The aim of this study is to analyze the role of endothelin-1 in the ...
Xu Hongzeng H Department of Cardiology, The fourth Affiliated Hospital, China Medical - - 2014
Background:Impairment of coronary flow reserve (CFR) has been generally demonstrated in diabetic patients and animals with microvascular complications but without obvious obstructive coronary atherosclerosis. There have been few studies investigating CFR in cases of relatively well-controlled therapy. The purpose of this study is to evaluate the effect of treatment with ...
Sakamoto Hiroaki H Department of Cardiovascular Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan - - 2014
Previously, in our laboratory, synchrotron radiation coronary microangiography (SRCA) using Langendorff-perfused rat hearts could visualize a coronary artery of 50 µm in diameter. However, in vivo rat SRCA poses the problem of compromised temporal resolution due to the rapid heart rate of rats. To establish a simple method of in vivo rat SRCA ...
Wu Haohao - - 2014
The mechanisms by which meat enhances human absorption of non-heme iron remain unknown. Recently, anchovy (Engraulis japonicus) muscle protein hydrolysate (AMPH) was found to mediate the formation of nano-sized ferric hydrolysis products in vitro. The current paper evaluates the effects of AMPH on the bioavailability and the intestinal speciation of ...
Vafina E Z EZ Department of Theory of Physical Education, Institute of Physical Culture, Sports and Restorative Medicine, Kazan (Volga Region) Federal University, Kazan, Russia, - - 2014
We analyzed parameters of the pumping function of the heart in rats subjected to enhanced motor activity after a preliminary 70-day hypokinesia under conditions of α- and β-adrenergic receptor stimulation with norepinephrine followed by blockade of β-adrenergic receptor with propranolol (obsidian) and α1-adrenergic receptors with doxazosin. After norepinephrine administration, the ...
Matsuura Tetsuya T a Department of Chemistry and Bioengineering , Graduate School of Engineering, Iwate University , Morioka , - - 2014
To verify the effects of hiba essential oil in restrained stressed rats, we analyzed physiological variables and psychophysiological behavior. Stressed-HEO rats inhaled hiba essential oil aroma after restraint period. The quantities of food and water intake and the excretion amount of stressed rats were smaller than those of non-stressed control ...
Wiley Jenny L JL RTI International, 3040 Cornwallis Rd, Research Triangle Park, NC 27709. Electronic address: - - 2014
Synthetic indole-derived cannabinoids, originally developed to probe cannabinoid CB1 and CB2 receptors, have become widely abused for their marijuana-like intoxicating properties. The present study examined the effects of indole-derived cannabinoids in rats trained to discriminate Δ(9)-tetrahydrocannabinol (Δ(9)-THC) from vehicle. In addition, the effects of Δ(9)-THC in rats trained to discriminate ...
Lozić Maja M Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine University of Belgrade, 11000 Belgrade, - - 2014
The paraventricular nucleus (PVN) of the hypothalamus is an important integrative site of neuroendocrine control of the circulation. We investigate the role of oxytocin receptors (OTRs) in PVN in cardiovascular homeostasis. Experiments were performed in conscious male Wistar rats equipped with radiotelemetric device. The PVN was unilaterally co-transfected with an ...
Imamura Tetsuya T Department of Lower Urinary Tract Medicine, Shinshu University School of Medicine, Matsumoto, - - 2014
This study determined if muscarinic receptors could mediate the cold stress-induced detrusor overactivity induced in type 2 diabetes mellitus rats. Ten-week-old female Goto-Kakizaki diabetic rats (n = 12) and Wister Kyoto non-diabetic rats (n = 12) were maintained on a high-fat diet for 4 weeks. Cystometric investigations of the unanesthetized rats were carried out at room ...
Lee Jing-Yi JY Institute of Pharmacology, National Yang-Ming University, No. 155, Sec. 2, Li-Nong St., Taipei, 11221, - - 2014
Liver cirrhosis is characterized by increased intrahepatic vascular resistance and enhanced vasocontractile responsiveness that impedes portal inflow and elevates portal pressure, in which endothelin-1 (ET-1) plays a role. Diabetes and glucose influence vasoresponsiveness but their impact on the intrahepatic vascular bed in cirrhosis is unknown. To investigate intrahepatic ET-1 vasoresponsiveness ...
Yong Weidong W Institute of Laboratory Animal Science , Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing, China; Department of Pediatrics , Indiana University School of Medicine, Indianapolis, - - 2014
Corticotropin-releasing hormone (CRH) and urocortins (UCNs) bind to corticotropin-releasing hormone type 2 receptor (CRF2 receptor ), a Gs protein-coupled receptor that plays an important role in modulation of anxiety and stress responses. The Crhr2 gene maps to a quantitative trait locus (QTL) for alcohol preference on chromosome 4 previously identified ...
Kullmann F Aura FA Department of Pharmacology, Urogenix, Inc./Astellas Pharma, Durham, NC 27703. Electronic address: - - 2014
Bombesin receptors (BB receptors) and bombesin related peptides are expressed in the lower urinary tract of rodents. Here we investigated whether in vivo activation of BB receptors can contract the urinary bladder and facilitate micturition in sham rats and in a diabetic rat model of voiding dysfunction. In vivo cystometry ...
Tu Jian J Australian School of Advanced Medicine, Macquarie University, Sydney, New South Wales, - - 2014
Object Notch signaling has been suggested to promote the development and maintenance of arteriovenous malformations (AVMs), but whether radiosurgery inhibits Notch signaling pathways in AVMs is unknown. The aim of this study was to examine molecular changes of Notch signaling pathways following radiosurgery and to explore mechanisms of radiosurgical obliteration ...
Deng Hong-Zhu HZ Department of Pediatrics, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Department of Pediatrics, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, - - 2014
Insulin resistance has been observed in individuals born small for gestational age (SGA) with catch-up growth (CUG), yet the mechanisms involved remain unclear. This study examined the role of GH and insulin signaling crosstalk in insulin resistance of SGA rats with CUG. SGA rats were developed by dietary restriction in ...
Zhang Xiaotian X Institute of Cardiovascular Disease Research, Xuzhou Medical College, Jiangsu Province, P. R. - - 2014
The value of restenosis after percutaneous coronary intervention (PCI) is recognized worldwide, especially for diabetic patients. Interleukin-1/Toll-like receptor (IL-1/TLR) signaling is involved in innate and adaptive immune responses, but whether and how the IL-1/TLR-induced nuclear factor kappa B (NFκB) pathway plays key roles in intimal formation is unclear. The underlying ...
Ponce de León Verónica V Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, - - 2014
Transcription Activator-Like Effector Nucleases (TALEN) are potential tools for precise genome engineering of laboratory animals. We report the first targeted genomic integration in the rat using TALENs (Transcription Activator-Like Effector Nucleases) by homology-derived recombination (HDR). We assembled TALENs and designed a linear donor insert targeting a pA476T mutation in the ...
Vaucher Laurent L Department of Urology and Reproductive Medicine, Weill Cornell Medical College, New York, New York, United States of America; Population Council, Center for Biomedical Research, New York, New York, United States of America; Department of Urology, Centre Hospitalier Universitaire Vaudois, Lausanne, - - 2014
Estradiol (E2) modulates testicular functions including steroidogenesis, but the mechanisms of E2 signaling in human testis are poorly understood. GPER-1 (GPR30), a G protein-coupled membrane receptor, mediates rapid genomic and non-genomic response to estrogens. The aim of this study was to evaluate GPER-1 expression in the testis, and its role ...
Knapp Jürgen J Department of Anaesthesiology, University of Heidelberg, Heidelberg, - - 2014
We demonstrate the usefulness of left ventricular pressure-volume (PV) loops generated by the use of conductance catheter measurements and investigate the influence of the type of general anesthesia on postresuscitation myocardial dysfunction in a rat model of cardiac arrest (CA) and subsequent cardiopulmonary resuscitation. A total of 42 Wistar-Han rats ...
Schijven D D Department of Women's and Children's Health, Uppsala University, - - 2013
The Flinder Sensitive Line (FSL) is a rat strain that displays distinct behavioral and neurochemical features of major depression. Chronic selective serotonin reuptake inhibitors(SSRIs) are able to reverse these symptomsin FSL rats. It is well known that several abnormalities in the serotonergic system have been found in FSL rats, including ...
Rossi Francesca - - 2013
The current study has investigated the role of the metabotropic glutamate receptor subtype 8 (mGluR8) in the dorsal striatum (DS) in modulating thermonociception and rostral ventromedial medulla (RVM) ON and OFF cell activities in conditions of neuropathic pain induced by the spare nerve injury (SNI) of the sciatic nerve in ...
Guerrero Ligia - - 2013
The regular consumption of flavonoids has been associated with reduced mortality and a decreased risk of cardiovascular diseases. The proanthocyanidins found in plasma are very different from the original flavonoids in food sources. The use of physiologically appropriate conjugates of proanthocyanidins is essential for the in vitro analysis of flavonoid ...
Snoeren Eelke M S - - 2013
This review focusses on the role of serotonin and especially 5-HT1A receptors in female rat sexual behavior. In addition, the differences and/or similarities with male rats are discussed. Overall, in both males and females 5-HT1A receptors do not appear to be involved in sexual behavior under normal circumstances, but become ...
Zhou Ye-Bo - - 2013
Intermedin (IMD) is a member of calcitonin/calcitonin gene-related peptide family, which shares the receptor system consisting of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMPs). This study investigated the effects of IMD in paraventricular nucleus (PVN) on renal sympathetic nerve activity and mean arterial pressure and its downstream mechanism ...
Hall Joseph M - - 2013
Voluntary exercise (VEx) has profound effects on neural and behavioral plasticity, including recovery of CNS trauma and disease. However, the unique regional cortical adaption to VEx has not been elucidated. In a series of experiments, we first examined whether VEx would restore and retain neurotrophin levels in several cortical regions ...
Teske Jennifer A - - 2013
Obesity resistance due to elevated orexin signaling is accompanied by high levels of spontaneous physical activity (SPA). The behavioral and neural mechanisms underlying this observation have not been fully worked out. We determined the contribution of hypothalamic orexin receptors (OXR) to SPA stimulated by orexin A (OXA), whether OXA-stimulated SPA ...
Antonilli Letizia - - 2013
We have previously found that phenanthrenic opioids, including codeine, modulate morphine glucuronidation in the rat. Here codeine and five of its derivatives were compared in their effects on the synthesis of morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) from morphine by rat liver microsomal preparations, and by primary cultures of rat hepatocytes ...
Zhou Zhifeng Z Laboratories of Neurogenetics and Clinical and Translational Studies and Section on Synaptic Pharmacology, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD - - 2013
Identification of genes influencing complex traits is hampered by genetic heterogeneity, the modest effect size of many alleles, and the likely involvement of rare and uncommon alleles. Etiologic complexity can be simplified in model organisms. By genomic sequencing, linkage analysis, and functional validation, we identified that genetic variation of Grm2, ...
Cai Huan - - 2013
Calorie restriction (CR) is a lifestyle intervention employed to reduce body weight and improve metabolic functions primarily via reduction of ingested carbohydrates and fats. Taste perception is highly related to functional metabolic status and body adiposity. We have previously shown that sweet taste perception diminishes with age; however, relatively little ...
Ikeda Atsuo - - 2013
Abstract Conclusion: We found a difference in expression sites between TAS2Rs and ENaC (epithelial sodium channels). The number of TAS2R-positive cells and ENaC-positive cells were decreased in zinc-deficient diet rats. These findings suggest that decreased expression of taste receptor genes may play an important role in the onset of zinc ...
Gandaglia Giorgio - - 2013
To study micturition and bladder overactivity in female rats after chronic treatment with the fatty acid amide hydrolase (FAAH) inhibitor oleoyl ethyl amide (OEtA). Sprague-Dawley rats received daily subcutaneous injections of OEtA (0.3 mg/kg), or vehicle for 2 weeks. Cystometries, organ bath studies, Western blot, and immunofluorescence were then used. Expressions ...
Cervantes-Durán Claudia - - 2013
The role of 5-HT receptors in fluoxetine-induced nociception and antinociception in rats was assessed. Formalin produced a typical pattern of flinching and licking/lifting behaviors. Local peripheral ipsilateral, but not contralateral, pre-treatment with fluoxetine (0.3-3 nmol/paw) increased in a dose-dependent fashion 0.5% formalin-induced nociception. In contrast, intrathecal pretreatment with fluoxetine (0.3-3 ...
Niu Hui-Fang - - 2013
Neuropeptide Y (NPY), a sympathetic neurotransmitter, is highly associated with baroreflex dysfunction and multiple cardiac diseases such as diabetic myocardiopathy. In the present study, we aimed to explore the role of peripheral NPY Y1 receptor (Y1R) and Y2 receptor (Y2R), which are dominantly present in peripheral cardiovascular control, in baroreflex ...
Pérez-Castrillón Jose L JL Institute of Endocrinology and Nutrition, University of Valladolid, Rio Hortega University Hospital, Valladolid, Spain. Electronic address: - - 2013
The aim of this experimental study was to evaluate the expression of 4 genes (osteocalcin, sclerostin (SOST), insulin receptor, and transcription factor forkhead box protein (FOXO1) in the bone cells of Goto-Kakizaki (GK) rats and the expression of these genes in response to bariatric surgery. We designed an experimental study ...
Nasrin Sweety - - 2013
The aim of this study was to characterize pharmacological effects of gosha-jinki-gan (GJG) and green tea extract (GTE), on urodynamic parameters, bladder receptors, and urinary cytokines in rats with cyclophosphamide (CYP)-induced cystitis. Urodynamic parameters in CYP-treated rats were measured using the cystometric method. Muscarinic and purinergic receptors in rat tissues ...
Yuan Fang - - 2013
The present study was designed to investigate the role of opioid receptors in the vasorelaxation effect of chronic intermittent hypobaric hypoxia (CIHH) in thoracic aorta rings and the underlying mechanism in rats. Adult male Sprague-Dawley (SD) rats were randomly divided into 2 groups: CIHH treatment group and control group. The ...
Owen Suzzanne J - - 2013
This study examined the effect of age, ovariectomy and dietary phytoestrogen ingestion on 17-β-estradiol-mediated relaxant responses and messenger RNA (mRNA) and protein expression of oestrogen receptor subtypes in the rat isolated bladder. Female Wistar rats (8 weeks) were anaesthetised, and the ovaries were removed (ovx) or left intact (sham). Rats were ...
Ko Il-Gyu - - 2013
Attention-deficit hyperactivity disorder (ADHD) is a neurobehavioral disorder characterized by inattention, hyperactivity and impulsivity. In the present study, we investigated the effects of swimming exercise on the symptoms of ADHD in correlation with the expression levels of dopamine and the dopamine D2 receptor. Adult male spontaneous hypertensive rats (SHRs) were ...
Uvin Pieter P Department of Development and Regeneration, Laboratory of Experimental Urology, Campus Gasthuisberg, Katholieke Universiteit Leuven, Leuven, - - 2013
First-line pharmacotherapy for overactive bladder consists of anticholinergics. However, patient compliance is exceptionally low, which may be due to progressive loss of effectiveness. To decipher the involved molecular mechanisms and to evaluate the effects of chronic systemic administration of anticholinergics on bladder function and on muscarinic and purinergic receptors expression ...
Numpang Ben - - 2013
Fetal growth restriction (FGR) is associated with impaired neurodevelopmental outcomes in affected newborns. The pathogenesis of FGR-associated neurodevelopmental impairment implicates abnormal hippocampal function. The steroid hormone estrogen and its receptor, estrogen receptor alpha (ERα), are involved in the normal programming of hippocampal development and structure. However, the impact of FGR ...
Jensen Kendal K Scott & White Healthcare - Digestive Disease Research Center, Temple, TX, - - 2013
Epidemiological studies have indicated smoking to be a risk factor for the progression of liver diseases. Nicotine is the chief addictive substance in cigarette smoke and has powerful biological properties throughout the body. Nicotine has been implicated in a number of disease processes, including increased cell proliferation and fibrosis in ...
Yamauchi Katsuya K Heart and Vascular Institute and Department of Anesthesiology, Penn State College of Medicine, Hershey, PA 17033, USA. - - 2013
Ligating the femoral artery for 72 h in decerebrated rats exaggerates the exercise pressor reflex. The sensory arm of this reflex is comprised of group III and IV afferents, which can be either sensitized or stimulated by PGE2. In vitro studies showed that endoperoxide (EP) 3 and 4 receptors were ...
Li Xia - - 2013
OBJECTIVE: Endothelin (ET) is involved in uterine contractions. Our previous study showed that leonurine hydrochloride (LH) inhibits abnormal bleeding caused by incomplete abortion through an increase in uterine contractions in rats. The present study was conducted to show that LH treatment regulates the ET-mediated signal pathway in abortion in rats. ...
Stäubert C C Institute of Biochemistry, Medical Faculty, University Leipzig, Leipzig, - - 2013
The trace amine-associated receptor (Taar) family displays high species- and subtype-specific pharmacology. Several trace amines such as β-phenylethylamine (β-PEA), p-tyramine and tryptamine are agonists at TA(1) but poorly activate rat and mouse Taar4. Using rat TA(1) and Taar4 chimera, we identified determinants in transmembrane helices 3 and 6, which, when ...
Moreno M - - 2013
RATIONALE: Previously we demonstrated reduced D(2/3) receptor availability in the ventral striatum of hyper-impulsive rats on the five-choice serial reaction time task (5-CSRTT). However, the anatomical locus of D(2/3) receptor dysfunction in high impulsive (HI) rats is unknown. OBJECTIVE: In the present study, we investigated whether D(2/3) receptor dysfunction in ...
Coleman Brian R - - 2013
Maladaptive conditioned responses (CRs) contribute to psychiatric disorders including anxiety disorders and addiction. Methods of reducing these CRs have been considered as possible therapeutic approaches. One such method is extinction, which involves exposure to CR-eliciting cues in the absence of the event they once predicted. In animal models, extinction reduces ...
Caprioli Daniele D Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, - - 2013
We have previously shown that impulsivity in rats predicts the emergence of compulsive cocaine seeking and taking, and is coupled to decreased D2/3 receptor availability in the ventral striatum. As withdrawal from cocaine normalises high impulsivity in rats, we investigated, using positron emission tomography (PET), the effects of response-contingent cocaine ...
Vanessa Ho W S - - 2013
Recent studies suggest that endocannabinoid signalling is modulated by 17β-estradiol (17Eβ) however it is unclear if this applies to the cardiovascular actions of anandamide, a major endocannabinoid. This study examined the in vitro effects of 17Eβ on vasorelaxation to anandamide in myograph-mounted small mesenteric arteries obtained from Wistar rats and ...
Qi Li - - 2013
As a twin therapy of acupuncture in traditional Chinese medicine, moxibustion has shown its effects in relieving abdominal pain in irritable bowel syndrome (IBS) patients and IBS rat models, but its mechanisms are largely unknown. In this paper, we determined the role of spinal dynorphin and orphanin-FQ system in analgesic ...
Wu Na N Department of Neurology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, People's Republic of - - 2013
Recent studies have shown that expression of G protein-coupled receptor kinase 6 (GRK6) and β-arrestin1 in the striatum is closely associated with hyperactive dopamine receptors in rats with levodopa-induced dyskinesia (LID). Our research group has shown that Tianqi antitremor granules have a significant effect on the motor complications of Parkinson's ...
Xu Yumin - - 2013
Acute-on-chronic liver failure (ACLF) is an acute deterioration of established liver disease. Blocking the TNF (tumor necrosis factor)/TNFR (tumor necrosis factor receptor) 1 pathway may reduce hepatocyte apoptosis/necrosis, and subsequently decrease mortality during development of ACLF. We demonstrated that a long-acting TNF antagonist (soluble TNF receptor: IgG Fc [sTNFR:IgG-Fc]) prevented/reduced ...
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