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Mimura Shima S Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, - - 2014
Recent studies suggest that small non‑coding microRNAs (miRNAs or miRs) play an important role in the regulation of genes involved in various cellular and developmental processes. However, the expression of miRNAs during the aging process remains largely unknown. The aim of the present study was to analyze miRNA expression profiles in ...
Li Menghua M College of Life Science, Henan Normal University, Xinxiang, 453007, P. R. - - 2014
Under normal physiological conditions, the majority of hepatocytes are in the functional state (G0 phase). After injury or liver partial hepatectomy (PH), hepatocytes are rapidly activated to divide. To understand the mechanism underlying hepatocyte G0/G1 transition during rat liver regeneration, we used the Rat Genome 230 2.0 Array to determine ...
Zhang Kaizhi K China-Japan Union Hospital, Jilin University, Changchun, Jilin 130033, P.R. - - 2014
β-diketone-cobalt complexes, a family of newly synthesized non-platinum metal compounds, exhibit potential antitumor activity; however, the antitumor mechanism is unclear. The current study investigated the mechanism by which β-diketone-cobalt complexes inhibit rat C6 glioma cell proliferation. It was found that β-diketone-cobalt complexes suppress rat C6 glioma cell viability in a ...
Pasqua T - - 2013
Plasma Chromogranin-A(CgA) concentrations correlate with severe cardiovascular diseases, while CgA-derived vasostatin-I and catestatin elicit cardio-suppression via an anti-adrenergic/NO-cGMP mediated mechanism. Whether these phenomena are related is unknown. We here investigated whether and to what extent full-length CgA directly influences heart performance and may be subjected to stimulus-elicited intracardiac processing. Using ...
Marissal-Arvy Nathalie - - 2013
Objective: Individual differences in macronutrient selection, particularly fat and carbohydrate, and associated body weight gain are partly inherited as polygenic traits, but the potential genetic pathways are unknown. Our study aimed to give an overview of the Quantitative Trait Loci (QTLs) and candidate gene pathways influencing these differences in rat. ...
Molina Doris P - - 2012
In rats, as in humans, normal aging is characterized by a decline in hippocampal-dependent learning and memory, as well as in glutamatergic function. Both growth hormone (GH) and insulin-like growth factor-I (IGF-I) levels have been reported to decrease with age, and treatment with either GH or IGF-I can ameliorate age-related ...
Cedó Lídia - - 2012
Grape seed procyanidin extract (GSPE) has been reported to modify glucose metabolism and β-cell functionality through its lipid-lowering effects in a diet-induced obesity model. The objective of the present study was to evaluate the effects of chronically administrated GSPE on the proteomic profile of pancreatic islets from Zucker fatty (ZF) ...
Chen Yong-Hua - - 2012
Fibrosis plays a key role in the development of liver cirrhosis. In this study, we investigated the effect of growth hormone and interferon gamma on hepatic collagen synthesis and the proliferation of hepatic stellate cells in a cirrhotic rat model. Cirrhosis was induced in rats using carbon tetrachloride. Rats were ...
Aoki Tomohiro - - 2012
Despite a high mortality and morbidity of subarachnoid hemorrhage due to an intracranial aneurysm (IA), there is no effective medical treatment to prevent the rupture of IAs. Recent studies have revealed the involvement of the transactivation of proinflammatory genes by nuclear factor-κB (NF-κB) and Ets-1 in the pathogenesis of IA ...
Nishizawa Hitoshi - - 2012
The progression to nonalocoholic steatohepatitis (NASH) from simple steatosis is associated with the mitochondrial dysfunction, enhanced oxidative stress, and inflammation. Recently, it has been reported that the prevalence of NAFLD (nonalcoholic fatty liver disease) /NASH is increased in patients with adult growth hormone deficiency (AGHD), suggesting that the deficiencies in ...
Hill Justin J - - 2012
Physical and chemical constraints imposed by the periinfarct glial scar may contribute to the limited clinical improvement often observed after ischemic brain injury. To investigate the role of some of these mediators in outcome from cerebral ischemia, we treated rats with the growth-inhibitory chondroitin sulfate proteoglycan neurocan, the growth-stimulating heparan ...
Menendez-Castro Carlos - - 2012
Epidemiologic studies revealed an association between intrauterine growth restriction and an increased risk to develop cardiovascular diseases, like atherosclerosis or hypertension, in later life. Whether or not intrauterine growth restriction contributes to the development of atherosclerotic lesions, however, is unclear. We tested the hypothesis that intrauterine growth restriction aggravates experimentally ...
Yang Ying-Ying - - 2012
Leptin, the ob gene product, is a protein released from adipocytes and has been detected in fibrotic and cirrhotic livers. Leptin in brain has an inhibitory effect on food intake. Nonalcoholic steatohepatitis (NASH) is characterized by hyperleptinemia. This study explores the possible mechanisms of hyperleptinemia in relation to increased intrahepatic ...
Wang Hai-Ying - - 2012
To determine the effect of Houttuynia cordata Aetherolea on connective tissue growth factor and adiponectin in a rat model of diabetes mellitus (DM). DM was induced in rats using streptozotocin (STZ) and high glucose-lipid animal feed. Animals were then treated with Houttuynia cordata Aetherolea for 8 weeks. Changes in connective ...
Vida Vladimiro L - - 2012
OBJECTIVE: To evaluate the effect of a continuous infusion of basic fibroblast growth factor on the adaptive potential of the right ventricular myocardium after 30 days of mechanically induced overload in rats.Materials and methodsWe banded the pulmonary trunk, so as to increase the systolic workload of the right ventricle, in ...
Rosevear Henry M - - 2012
OBJECTIVE: To investigate the effect of the combination of locally delivered growth factors and oral sildenafil citrate on cross-conduit microrecanalization. METHODS: A total of 42 rats were divided into 7 groups. Of the 42 rats, 6 underwent bilateral vasectomy and bilateral end-to-end vasovasostomy and 12 underwent bilateral vasectomy. Of the ...
Dilnawaz Fahima - - 2012
There is much interest in utilizing the intrinsic properties of magnetic nanoparticles (MNPs) for the theranostic approaches in medicine. With an aim to develop a potential therapeutics for glioma treatment, efficacy of aqueous dispersible paclitaxel loaded MNPs (Pac-MNPs) were studied in glioblastoma cell line (U-87). The identified potential receptor, glycoprotein ...
Xie Yuan - - 2012
Dysregulations of cytochrome P450s (CYPs) under liver injury have been extensively studied. However, little is known about the possible reversing effects of hepatoprotective agents, the understanding of which is of great importance in guiding clinical dosage adjustment for patients with liver injury. This study aims to investigate the dysregulation patterns ...
Bu Shumin - - 2012
Postmenopausal osteoporosis is associated with high level of adipogenesis within the bone marrow at the expense of osteoblast population. The mechanical effect on β-catenin through phosphorylation of glycogen synthase kinase-3β (GSK-3β) is critical for inhibition of adipogenesis in mesenchymal stem cells in vitro. In present study, we hypothesized that treadmill ...
Honorato-Sampaio Kinulpe - - 2012
Several studies have shown the presence of components of the renin-angiotensin system (RAS) in mammalian ovaries and their involvement in ovarian physiology. We have previously shown the presence of angiotensin-(1-7) [Ang-(1-7)], an important biologically active component of the RAS, and its receptor, Mas, in rat, rabbit and human ovaries. We ...
Yu Wei-Min - - 2012
SUMMARY AT A GLANCE -: The manuscript by Yu et al. is the first to examine the efficacy of leflunomide in treating diabetic nephropathy. AIM: To further reveal the effects of leflunomide on renal protection and on inflammatory response using streptozotocin (STZ) induced diabetic rats. METHOD: male Wistar rats were ...
Owen Suzzanne J - - 2012
This study examined the effect of age, ovariectomy and dietary phytoestrogen ingestion on adenosine A(2B) receptor mediated relaxant responses and mRNA expression of adenosine receptor subtypes in the rat isolated bladder. Female Wistar rats (8 weeks) were anaesthetised and the ovaries were removed (ovx) or left intact (sham). Rats were fed ...
Cuenya Lucas - - 2012
In consummatory successive negative contrast (cSNC), when rats receive 32% of sweetened water and are unexpectedly exposed to 4% of the same solution, they consume less than those who received 4% regularly. In consummatory extinction (cE), rats receiving a 32% or 4% sugar solution stop lapping when presented with an ...
Koss Wendy A - - 2012
Changes in reproductive hormones, such as estrogen, play a role in mood regulation. The present study examined strain differences (Long-Evans vs. Wistar-Hannover) in the behavioral and biochemical effects of estrogen manipulation. Adult ovariectomized female rats were treated with estradiol, vehicle, or withdrawn from estradiol. The two strains demonstrated differential behavioral ...
López-Menduiña M - - 2012
OBJECTIVE: Adjuvant-induced arthritis is an experimental model of rheumatoid arthritis that inhibits the GH-IGF-I axis and decreases body weight gain and muscle mass. Although chronic GH or IGF-I treatment increases body weight gain in arthritic rats, muscle resistance to GH and IGF-I is a very common complication in inflammatory diseases. ...
Cavone L - - 2012
The hexahydric alcohol mannitol is widely used to shift fluids from the intracellular to the extracellular compartments, to increase diuresis and improve mucus clearance in the airways. In principle, because of its physicochemical properties, topical mannitol might also draw fluids out of epidermis or mucosa. Here, we report that topical ...
Huang Chiung-Chun - - 2012
Females and males react differently to stress. Our previous studies revealed that acute stress facilitates the induction of long-term depression (LTD) in hippocampal CA1 region. However, it remains unknown whether sex difference exists in the effect of stress on LTD. Using an acute unpredictable and inescapable restraint-tailshock stress paradigm, we ...
Yang Hui - - 2012
Previous human intervention trial demonstrated that vitamin E (Ve) and selenium (Se) supplementation decreased esophageal cancer deaths among younger participants, but may have no effect or produce an opposite effect among older ones. In this study, we intended to mimic this human nutritional trial to determine the chemopreventive effects of ...
Simpson Joy - - 2012
In clinical populations, sex differences in disease prevalence, symptoms and outcome have been established. Despite this, female rats are frequently omitted from preclinical research; growing preclinical evidence, however, illustrates meaningful sex differences in behavioural, neurochemical and neuroanatomical endpoints. This review outlines the effects of sex on tests of depression- and ...
Anderson Wesley - - 2012
This was a prospective, randomized, between-subjects experimental study to investigate the anxiolytic effects of naringenin, a component of mentha aquatica, and its potential interaction with the benzodiazepine binding site on the γ-aminobutyric acid (GABAA) receptor in the rat. Fifty-five rats were assigned to one of 5 groups with 11 rats ...
Cyphert J M - - 2012
In former mine workers and residents of Libby, Montana, exposure to amphibole-contaminated vermiculite has been associated with increased incidences of asbestosis and mesothelioma. In this study, long-term effects of Libby amphibole (LA) exposure were investigated relative to the well-characterized amosite asbestos in a rat model. Rat-respirable fractions of LA and ...
Veit A P T - - 2012
We examined the effects of ascorbic acid supplementation on myosin-V, calcitonin gene-related peptide (CGRP) and vasoactive intestinal polypeptide (VIP) immunoractivities in the myenteric neurons in aging rats. Male rats were divided into groups: young 90-day-old rats (E90), 345-day-old control rats (E345), 428-day-old control rats (E428), 90- to 345-day-old rats treated ...
Dou Zhiying - - 2012
Vinegar and wine processing of medicinal plants are two traditional pharmaceutical techniques which have been used for thousands of years in China. Tetrahydropalmatine (THP), dehydrocorydaline (DHC) and protopine are three major bioactive molecules in Rhizoma Corydalis. In this study, a simple and reliable HPLC method was developed for simultaneous analysis ...
Rendón-Huerta Juan A - - 2011
Fructans contribute significantly to dietary fiber with beneficial effects on gastrointestinal physiology in healthy individuals and offer a promising approach to treating some diseases. Two experiments (Experiment 1 = rats with normal weight; Experiment 2 = obese rats) were developed to compare the effects of three fructan sources (Cichorium intybus ...
Boyce Vanessa S VS Department of Neurobiology and Behavior, Life Sciences Building, Room 532, State University of New York at Stony Brook, Stony Brook, NY 11794-5230, - - 2012
We compared the effect of viral administration of brain-derived neurotrophic factor (BDNF) or neurotrophin 3 (NT-3) on locomotor recovery in adult rats with complete thoracic (T10) spinal cord transection injuries, in order to determine the effect of chronic neurotrophin expression on spinal plasticity. At the time of injury, BDNF, NT-3 ...
Ishida Keiko - - 2011
AIM: Although pravastatin has known pleiotropic effects against adverse cardiovascular conditions, little is known about its effects on endothelium-derived contracting factor (EDCF)-mediated signalling. We aimed to determine the effects of pravastatin on the production of and responses to EDCF in superior mesenteric arteries isolated from rats at the chronic stage ...
Recinto Patrick - - 2012
Methamphetamine affects the hippocampus, a brain region crucial for learning and memory, as well as relapse to drug seeking. Rats self-administered methamphetamine for 1 h twice weekly (intermittent-short-I-ShA), 1 h daily (limited-short-ShA), or 6 h daily (extended-long-LgA) for 22 sessions. After 22 sessions, rats from each access group were withdrawn ...
Jinno Fumihiro - - 2011
The pharmacokinetics of 4-amino-3-chlorophenyl hydrogen sulfate, M-III of resatorvid, in rats and dogs were investigated using radio-labeled M-III ([(14)C]M-III). The elimination half-life of (14)C in the plasma of rats was about 1/30 of that of dogs after iv dosing of [(14)C]M-III at 0.5 mg/kg to rats and dogs. The in ...
Żarnowski Tomasz - - 2012
Targeting mechanisms that result in increased concentrations of kynurenic acid (KYNA) in the brain has been considered as a therapeutic approach for the treatment of epilepsy and certain neurodegenerative disorders. Recently, KYNA has been implicated in the effects produced by the high-fat and low-protein/carbohydrate ketogenic diet (KD) in a report ...
Burrell Louise M - - 2011
Renin angiotensin system (RAS) blockade slows but does not prevent the cardiovascular complications of chronic kidney disease (CKD). Angiotensin converting enzyme (ACE) 2 is differentially regulated in acute kidney injury with increased cardiac ACE2, but decreased kidney ACE2 levels. This study investigated the effect of long-term ACE inhibition on cardiac ...
Mattioli Theresa-Alexandra - - 2011
We evaluated the antinociceptive effects of acute and chronic morphine administered spinally via lumbar puncture in intrathecally catheterized and sham-surgery rats. The effects of acute morphine did not differ between groups. Catheterized rats developed tolerance to chronic morphine more rapidly, compared with sham and naive rats. Therefore, catheter presence facilitated ...
El-Mas Mahmoud M - - 2012
We have previously shown that acute exposure of male rats to nicotine preferentially attenuates baroreceptor-mediated control of reflex tachycardia in contrast to no effect on reflex bradycardia. Here, we investigated whether female rats are as sensitive as their male counterparts to the baroreflex depressant effect of nicotine and whether this ...
Forte Amalia - - 2011
PURPOSE: Restenosis is a complex and heterogeneous pathophysiological phenomenon occurring in patients submitted to revascularization procedures. Previous studies proved the antirestenotic properties of injected allogenic mesenchymal stromal cells (MSCs) in an experimental model of rat carotid (re)stenosis induced through arteriotomy. In this study we describe some of the effects subsequent ...
Mathes C M - - 2012
Roux-en-Y gastric bypass (RYGB) surgery has been shown to decrease consummatory responsiveness of rats to high sucrose concentrations, and genetic deletion of glucagon-like peptide-1 receptors (GLP-1R) has been shown to decrease consummatory responsiveness of mice to low-sucrose concentrations. Here we assessed the effects of RYGB and pharmacological GLP-1R modulation on ...
Said Faika - - 2011
Background: Bisphosphonates are indicated for the treatment of osteoporosis. However, they could have an adverse effect on specific sites like the Bisphosphonate-related osteonecrosis of the jaw. The aim of this study was to investigate the effect of Etidronate on the resorption and apposition sides of the periodontium in ovariectomized rats. ...
Bruner Natalie R - - 2011
The prenatally stressed (PS) rat shows enhanced conditioned fear and increased behavioral inhibition in response to footshock compared to control (CON) rats. It is unclear whether this facilitated learning will occur only with aversive stimulation, or if it will also be observed in the context of positive reinforcement. There are ...
Cha Jae-Young - - 2011
Betaine prevents hepatic damage caused by ethanol and carbone tetrachloride (CCl4) in rats. Present study was to investigate the effect of betaine on the hepatic microsomal triglyceride transfer protein (MTP) mRNA expression in orotic acid (OA)-induced fatty liver in rats. OA feeding was attributed to the significant increase in the ...
Guo Jing - - 2011
The transplantation of hepatic progenitor cells (HPCs) is a promising alternate approach to liver transplantation for patients with end-stage liver disease. Here, we report a novel technique for HPCs isolation from normal adult rat livers (no preexposure to chemicals and no injury). HPCs were isolated from normal adult rat livers ...
Erkhembayar Suvd - - 2011
Selenium in supra-nutritional doses is tumour-preventative in animal models and in humans. In this work, we have compared the effect of sodium selenite on tumour growth in a rat hepatocarcinogenesis model with the effect of sodium selenite on the regeneration of liver mass after partial hepatectomy. In the tumour model, ...
Zicha J - - 2011
Aim:  Endothelin-1 (ET-1) plays an important role in the pathogenesis of salt-dependent forms of hypertension in adult rats but its participation in salt hypertension elicited in immature rats is still unknown. Therefore we compared ET-1 role in the development or the maintenance of salt hypertension induced in young (4-week-old) or ...
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