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El-Habashi N N Department of Veterinary Pathology, Faculty of Veterinary Medicine, Kafr El-Sheikh University, Kafr El-Sheikh, - - 2014
Pregnant rats were infected experimentally with equine herpesvirus (EHV)-9, a new neurotropic equine herpesvirus serologically similar to EHV-1, during the first and third trimesters. The inoculated dams had mild to severe neurological signs and gave birth to dead fetuses or undersized pups. Rats inoculated during the first and last trimesters ...
Tang Xuwen X Department of Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou, 510623, China, - - 2014
To investigate the protective effect of secretory receptor for advanced glycation endproducts (sRAGE) on the fetal development using rat model of gestational diabetes mellitus (GDM). The model of pregnant rats with intrauterine hyperglycemia was established by intraperitoneal injection of 25 mg/kg streptozotocin (STZ). Rats with established GDM were randomly grouped, and ...
Bozzini Carlos E CE Department of Physiology, Faculty of Odontology, University of Buenos Aires , Argentina - - 2014
Abstract Bozzini, Carlos E, Graciela M. Champin, Clarisa Bozzini, and Rosa M. Alippi. Gestational and Early Postnatal Exposure to Simulated High Altitude Does Not Modify Postnatal Body Mass Growth Trajectory in the Rat. High Alt Med Biol 15:000-000, 2014.-Postnatal hypoxia blunts body mass growth. It is also known that the ...
Hunter Amy Silvestri AS Department of Psychology, Seton Hall University, South Orange, NJ, 07079, USA, - - 2014
Both human and animal research indicate that rapid eye movement sleep (REM) plays an important role in the processing of emotional information. REM is altered after fear conditioning in rats, but this alteration can be mitigated by exposure to a naïve conspecific. In addition, both the housing condition (isolated vs ...
Baek Jong-Suep JS College of Pharmacy and Institute of Drug Research and Development, Chungnam National University , Daejeon , South Korea - - 2014
Abstract KOB extracts are a polyherbal medicine had been prescribed for the treatment of hyperhydrosis and allergic diseases such as allergic asthma and rhinitis in oriental clinics. Therefore, the pharmacokinetic studies of the KOB extract administered orally to normal rats and rhinitis-induced rats to understand the correlation of the efficacy ...
Stekolnikov Alexandr A AA Zoological Institute, Universitetskaya Embankment 1, St. Petersburg, 199034, Russia, - - 2014
A new chigger mite genus Laotrombicula n. g. and two new species, Laotrombicula khunboromi n. sp. (type-species) and L. fangumi n. sp., are described from the Laotian rock-rat Laonastes aenigmamus Jenkins, Kilpatrick, Robinson & Timmins (Rodentia: Diatomyidae). The new genus is most similar to Trombiculindus Radford, 1948 and Leptotrombidium Nagayo, ...
Shan Ling L Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen, Medical Centre, Nijmegen, The - - 2014
Anxiety disorders are influenced by both environmental and genetic factors. A well-known example for gene x environment interactions in psychiatry is the low activity (s) allelic variant of the serotonin transporter (5-HTT) promoter polymorphism (5-HTTLPR) that in the context of stress increases risk for depression and post-traumatic stress disorder (PTSD). ...
Anholt Heather - - 2013
abstract : The ear mange mite, Notoedres muris (Astigmata: Sarcoptidae), is a parasitic burrowing mite of black and Norway rats (Rattus rattus and Rattus norvegicus), which causes a proliferative dermatitis primarily affecting the ears. We characterize the ecology of N. muris in a group of black and Norway rats trapped ...
Liu Jing J Department of Neonatology and NICU of Bayi Children's Hospital, General Hospital of Beijing Military Command, Beijing 100700, - - 2013
From pregnancy to parturition, Sprague-Dawley rats were daily administered a low protein diet to establish a model of intrauterine growth restriction. From the 12(th) day of pregnancy, 300 mg/kg rine was daily added to food until spontaneous delivery occurred. Brain tissues from normal neonatal rats at 6 hours after delivery, ...
Bahgat Iman M - - 2013
Rodents and their ectoparasites were studied inside and outside houses in the newly settled areas, east of lakes, Ismailia Governorate, Egypt. Forty traps per month in each of the two sides were used for collecting rodent during 2009. From 221 rodent were collected from inside houses; Mus musculus N=115 (52.04%), ...
Yokooji Tomoharu - - 2013
The absorption pathway(s) of a representative food allergen, lysozyme, and the mechanisms of lysozyme absorption facilitated by non-steroidal anti-inflammatory drugs were examined by intestinal closed-loop and re-circulating perfusion methods in rats. The absorption rate of fluorescein isothiocyanate (FITC)-labeled lysozyme in the proximal intestine was higher than that for a marker ...
Murata N - - 2013
In orthodontic tooth movement (OTM), we should be concerned about external root resorption (ERR) as an undesirable iatrogenic problem, but its mechanisms are not fully understood. Since our previous epidemiologic studies found that patients with allergic diseases showed higher rates of ERR during orthodontic treatment, we explored the possible effect ...
Radenković Mirjana - - 2013
The acute negative inotropic and chronotropic effects of the commercial extract of ginkgo leaf (Gingium(®)) and ethanolic extracts of onion bulbs and celery root on spontaneous and noradrenalin-stimulated contractions of the Wistar rat atria were investigated. All analyzed extracts exerted negative inotropic effects on the isolated rat atria. Among the ...
Huang Li-Qin LQ Vector Laboratory, Institute of Pathogens and Vectors, Dali University (Branch of Key Laboratory for Preventing and Controlling Plague of Yunnan Province), Dali, Yunnan, 671000, China. - - 2013
During a survey lasting from 1990 to 2008, we captured 4,113 Asian house rats, Rattus tanezumi Temminck 1844 (Rodentia: Muridae) from 28 counties of Yunnan Province in southwestern China. From these rats, a total of 19,304 gamasid mites (Acari: Mesostigmata) were collected and identified as comprising 50 different species. The ...
Izdebska Joanna N - - 2013
One of the least researched groups of parasitic arthropods in the brown rat Rattus norvegicus (Berkenhout, 1769) are skin mites from the family of Sarcoptidae. Specimens representing two species of sarcoptic mites were found in 30 examined rats from northern Poland: Notoedres muris Megnin, 1877 and Trixacarus diversus Sellnick, 1944. ...
Inagaki Hideaki - - 2012
It is known that long-term post-weaning individual housing significantly reduces emissions of 22-kHz calls in male rats. In this study, we assessed post-weaning successive changes in 22-kHz calls emitted by male rats under two different types of post-weaning housing conditions (individually and socially). In addition, we evaluated the critical point ...
Sun Na - - 2012
There is currently no validated animal model for evaluating the potential allergenicity of food proteins. This study aimed to compare the allergic reactions between BN and Wistar rats after oral exposure to ovalbumin (OVA) by studying immune responses and clinical manifestations. Female BN and Wistar rats were orally exposed to ...
Chappell Ann M AM Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, - - 2013
Rodent studies have demonstrated that adolescent social isolation results in many behavioral perturbations, including increases in anxiety-like behaviors. Socially isolated (SI) rats have also been shown to self-administer greater amounts ethanol (EtOH) in some, but not all, studies. Here, we tested whether juvenile social isolation increases EtOH drinking using an ...
Nautiyal Manisha - - 2012
ANG II-stimulated production of reactive oxygen species (ROS) through NADPH oxidase is suggested to activate MAPK pathways, which are implicated in neurally mediated pressor effects of ANG II. Emerging evidence suggests that ANG-(1-7) up regulates MAPK phosphatases to reduce MAPK signaling and attenuate actions of ANG II. Whether angiotensin peptides ...
Kawarazaki Hiroo - - 2012
OBJECTIVES:: To elucidate the roles that renal mineralocorticoid receptor-Rac1 interactions and oxidative stress play in salt-induced hypertension and renal injury in prepubertal rats. METHODS:: Three-week-old male Sprague Dawley rats were uninephrectomized (UNx) and fed a high-salt (8% NaCl) diet for 4 weeks. Five were left untreated, whereas the remaining rats ...
Bilman Victor - - 2012
The renin-angiotensin (Ang) system (RAS) plays an important role in the control of glucose metabolism and glycemia. Several studies demonstrated that the effects of angiotensin-(1-7) are mainly opposite to the actions of biological angiotensin II. Recent studies have demonstrated that rats with increased circulating angiotensin-(1-7), acting through the G protein ...
Zheleznova Nadezhda N - - 2012
The renal medullary thick ascending limb (mTAL) of the Dahl salt-sensitive (SS) rat is the site of enhanced NaCl reabsorption and excess superoxide production. In the present studies we isolated mitochondria from mTAL of SS and salt-resistant control strain SS.13(BN) rats on 0.4 and 8% salt diet for 7 days ...
Takenaka Tsuneo - - 2012
Previous studies have reported that high salt intake paradoxically activates tubuloglomerular feedback (TGF) in type-1 diabetes. Using Zucker lean (ZL) and diabetic fatty (ZDF) rats on normal and high salt diets, renal hemodynamics and the renin-angiotensin system (RAS) were characterized. On normal salt diet, glomerular filtration rate (GFR) was higher ...
Hirose Junzo - - 2012
Dipeptidyl peptidase III (DPP III), the zinc peptidase, has a unique helix portion in the metal-binding motif (HELLGH). The enzyme activity of the cupric derivative of rat DPP III (Cu(II)-rat DPP III) for Lys-Ala-β-NA is about 30% of that of the wild-type enzyme. On the other hand, the enzyme activity ...
van der Lubbe Nils - - 2012
We and others have recently shown that angiotensin II can activate the sodium chloride cotransporter (NCC) through a WNK4-SPAK-dependent pathway. Because WNK4 was previously shown to be a negative regulator of NCC, it has been postulated that angiotensin II converts WNK4 to a positive regulator. Here, we ask whether aldosterone ...
Cho Hyun-Min - - 2012
The Na(+)-K(+)-2Cl(-) cotransporter 1 (NKCC1) is upregulated in diverse models of hypertension. We hypothesized that NKCC1 is upregulated via histone modification in the aortas of angiotensin II (Ang II)-induced hypertensive rats. An osmotic mini-pump containing Ang II was implanted in the subcutaneous tissues of the backs of Sprague-Dawley (SD) rats ...
Huang Yanjie - - 2012
Despite suppression of the circulating renin-angiotensin system (RAS), high salt intake (HSI) aggravates kidney injury in chronic kidney disease. To elucidate the effect of HSI on intrarenal RAS, we investigated the levels of intrarenal prorenin, renin, (pro)renin receptor (PRR), receptor-mediated prorenin activation, and ANG II in chronic anti-thymocyte serum (ATS) ...
Williams Jan M JM Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi 39216, - - 2012
This study examined whether substitution of chromosome 5 containing the CYP4A genes from Brown Norway rat onto the Dahl S salt-sensitive (SS) genetic background upregulates the renal production of 20-HETE and attenuates the development of hypertension. The expression of CYP4A protein and the production of 20-HETE were significantly higher in ...
Morizane Shintaro - - 2012
OBJECTIVE: The comorbidity of excess salt and elevated plasma aldosterone has deleterious effects in cardiovascular disease. We evaluated the mechanisms behind the paradoxical increase in aldosterone biosynthesis in relation to dietary intake of salt. METHODS AND RESULTS: Dahl salt-sensitive (Dahl-S) and salt-resistant (Dahl-R) rats were fed a high-salt diet, and ...
Luft Friedrich C - - 2012
The Dahl salt-sensitive rat is a 50-year-old enigma in hypertension research. How does salt increase blood pressure? One hypothesis put forward is the involvement of reactive oxygen species produced in the renal outer medulla. A novel rat gene-deletion model in this issue of Cell Metabolism supports this argument.
Feng Di D Physiology Department, Medical College of Wisconsin, Milwaukee, WI 53226, - - 2012
NAD(P)H oxidase has been shown to be important in the development of salt-sensitive hypertension. Here, we show that the expression of a subunit of NAD(P)H oxidase, p67(phox), was increased in response to a high-salt diet in the outer renal medulla of the Dahl salt-sensitive (SS) rat, an animal model for human ...
Gabor Alexander - - 2012
Several models of chronic sympathetic hyperactivity are associated with an increase in excitatory angiotensinergic and glutamatergic activity, and a decrease in GABAergic activity in the PVN. The present study evaluated whether activation of glutamate and AT1 receptors in the PVN contributes to the maintenance of resting BP in Dahl salt ...
Ren Yan-Shun - - 2012
Small-for-size syndrome is a widely recognized clinical complication after living donor liver transplantation or extended hepatectomy due to inadequate liver mass. The purpose of this study was to investigate the role of splenectomy in rats after massive hepatectomy, a surrogate model of small-for-size graft. Rats were divided into eight groups, ...
Arumugam Somasundaram - - 2012
Edaravone, a novel antioxidant acts by trapping hydroxyl radicals, quenching active oxygen and so on. Its cardioprotective activity against experimental autoimmune myocarditis (EAM) was reported. Nevertheless, it remains to be determined whether edaravone protects against cardiac remodeling in dilated cardiomyopathy (DCM). The present study was undertaken to assess whether edaravone ...
Aller Maria-Angeles - - 2012
The portal system derives from the vitelline system, which is an extra-embryonic venous system. It could be suggested that this extraembryonic origin determines some of the characteristics attributed to portal hypertension, both compensated, i.e. prehepatic, and decompensated, i.e. fibrotic or cirrhotic. The experimental models most frequently used for studying both ...
Bülbül Mehmet - - 2012
BACKGROUND: Exposure to early life stress causes increased stress responsiveness and permanent changes in central nervous system. We have recently shown that delayed gastric emptying (GE) and accelerated colonic transit (CT) in response to acute restraint stress (ARS) was completely restored following chronic homotypic stress (CHS) in rats, via up-regulating ...
Urity Vinoo B VB University of Arizona Health Sciences Center, Department of Physiology, Tucson, Arizona 85724-5051, - - 2012
We hypothesize that the inner medulla of the kangaroo rat Dipodomys merriami, a desert rodent that concentrates its urine to more than 6,000 mosmol/kgH(2)O water, provides unique examples of architectural features necessary for production of highly concentrated urine. To investigate this architecture, inner medullary nephron segments in the initial 3,000 ...
Dittgen Tanjew - - 2012
Granulocyte-colony stimulating factor (G-CSF) improves outcome after experimental SCI by counteracting apoptosis, and enhancing connectivity in the injured spinal cord. Previously we have employed the mouse hemisection SCI model and studied motor function after subcutaneous or transgenic delivery of the protein. To further broaden confidence in animal efficacy data we ...
Gashev Anatoliy A - - 2012
The authors describe technical details of experimental protocol of gene transfection in isolated rat mesenteric lymphatic vessels (MLVs). Authors also refer to the recent publication in Microcirculation, which provides wide set of experimental evidences obtained from confocal microscopic imaging and isolated vessels functional tests, which confirmed a successful achievement of ...
Glueck Joshua T - - 2012
Urine of rats and mice is the main source of allergenic proteins that can enter the respiratory tract of laboratory animal care workers. Little is known about the levels and determinants of these exposures in the United States. We investigated the relationship between activities in animal facilities and levels of ...
Greenwood-Van Meerveld B - - 2011
Background  Copper deficiency affects the peripheral (PNS) and central (CNS) nervous systems and can lead to neurological deficits in humans. No studies have addressed whether copper deficiency affects the enteric nervous system (ENS). We hypothesized that ENS abnormalities impair intestinal function in copper deficiency. Methods  We induced copper deficiency in ...
Sukumaran Vijayakumar V Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan. - - 2012
Recent findings have suggested that a therapeutic approach to amplify or stimulate the angiotensin-converting enzyme-2 [ACE-2]-angiotensin 1-7 [ANG 1-7] mas axis could provide protection against the development of cardiovascular diseases. We investigated the cardioprotective effects of telmisartan in rats with dilated cardiomyopathy [DCM] after experimental autoimmune myocarditis [EAM]. DCM was ...
Sun Chenyou - - 2011
The H-reflex (HR) as an electrical analog of operant conditioning of the spinal stretch reflex, can affect motoneuron responses to primary afferent input. Recent data suggest that up-conditioning of the soleus (SOL) HR could enhance functional recovery after sciatic nerve transection. To explore the morphological correlates of this plasticity, the ...
Zhu Yanzhu - - 2011
Aluminum (Al) has increasingly been used in the daily life, and could cause the change of human health because it can accumulate in the organs. A rat model was thus used to examine potential effect of Al on the immune function. Forty male Wistar rats (5weeks old) weighed 110-120g were ...
Prinssen Eric P - - 2011
Functional magnetic resonance imaging (fMRI) has become an important method in clinical psychiatry research whereas there are still only few comparable preclinical investigations. Herein, we report that fMRI in rats can provide key information regarding brain areas underlying anxiety behavior. Perfusion as surrogate for neuronal activity was measured by means ...
Karakus S C - - 2011
This study aimed to investigate renal arterial resistive index measurements and urine electrolytes before and after enalapril therapy in a rat model of unilateral ureteropelvic obstruction. The transforming growth factor (TGF)-β1 response of the renal tissue was also investigated.30 Wistar albino rats were randomly allocated into 5 groups (n=6). Group ...
Brookes Steven J - - 2011
Enamelin is an extracellular enamel matrix protein essential for normal amelogenesis. After secretion, porcine enamelin is processed to generate several enamelin-degradation products. The cumulative 32-kDa enamelin is the most abundant enamelin present, and various roles for this molecule have been suggested. However, the proteolytic cleavage sites in porcine enamelin that ...
Jo Chor Ho - - 2011
Proteinuria is a major promoter that induces tubulointerstitial injury in glomerulopathy. Dietary salt restriction may reduce proteinuria, although the mechanism is not clear. We investigated the effects of dietary salt restriction on rat kidneys in an animal model of glomerular proteinuria. Male Sprague-Dawley rats were used and divided into 3 ...
Louis Xavier L - - 2012
We hypothesized that a low-dose resveratrol will reverse cardiovascular abnormalities in rats fed a high-fat (HF) diet. Obese prone (OP) and obese resistant (OR) rats were fed an HF diet for 17 weeks; Sprague-Dawley rats fed laboratory chow served as control animals. During the last 5 weeks of study, treatment ...
Scalabrino Giuseppe - - 2011
Introduction: Cobalamin (Cbl) deficiency affects the peripheral nervous system (PNS) morphologically and functionally. We investigated whether the octapeptide repeat (OR) region of prion protein (PrP(C) ) (which is claimed to have myelinotrophic properties) is involved in the pathogenesis of rat Cbl-deficient (Cbl-D) polyneuropathy. Methods: We intracerebroventricularly administered antibodies (Abs) against ...
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