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Kumagai Hideki H Department of Pediatrics, Jichi Medical University, Tochigi, Japan. Electronic address: - - 2014
The speed of sound correlates well with the fat content of the liver. Therefore, non-invasive quantification of sound speed in the liver might be of diagnostic value. Here we describe a new non-invasive method that would be clinically applicable for measurement of sound speed in the liver. Sprague-Dawley rats were ...
Savilov P N PN Department of Normal Physiology, N. N. Burdenko Voronezh State Medical Academy, the Ministry of Health of the Russian Federation, Voronezh, - - 2014
Activity of phosphate-dependent glutaminase was determined in hepatocytes of white female rats, both in healthy animals and in rats with chronic CCl4-hepatitis on day 3 after liver resection and hyperbaric oxygenation. In healthy animals, activity of phosphate-dependent glutaminase was not altered after hepatic resection, but it was elevated in animals ...
Mikuriya Yoshihiro Y Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima - - 2014
Fatty liver is associated with development of hepatocellular carcinoma (HCC). However, whether fatty liver itself promotes the progression of HCC is unclear. We recently found that hepatic stellate cells (HSCs) were prominently activated in the steatotic liver. Here, we investigated whether steatotic livers promote HCC progression and whether HSCs of ...
Licari Giovanni G Discipline of Pharmacology, School of Medical Sciences, The University of Adelaide , Adelaide , Australia - - 2014
Abstract 1. Perhexiline, a chiral anti-anginal agent, may be useful to develop new cardiovascular therapies, despite its potential hepatotoxicity. 2. This study compared Dark Agouti (DA) and Sprague-Dawley (SD) rats, as models of perhexiline's metabolism and hepatotoxicity in humans. Rats (n = 4/group) received vehicle or 200 mg/kg/d of racemic perhexiline maleate for ...
Sabetkish Shabnam S Pediatric Urology Research Center, Section of Tissue Engineering and Stem Cells Therapy, Pediatric Center of Excellence, Children's Hospital Medical Center, Tehran, Iran - - 2014
Objectives: To report the results of whole liver decellularization by two different methods. To present the results of grafting rat and sheep decellularized liver matrix (DLM) into the normal rat liver and compare natural cell seeding process in homo/xenograft of DLM. To compare the results of in-vitro whole liver recellularization ...
Wu Jing - - 2014
Non-alcoholic fatty liver disease (NAFLD), an emerging public health problem, may be a highly atherogenic condition. But the relationship between fatty liver diseases and carotid atherosclerosis in small-animal is incompletely understood. The purpose of the present study was to evaluate carotid intima-media thickness (IMT) in NAFLD rats using high-frequency ultrasonic ...
Ilyechova E Yu EY Research Institute of Experimental Medicine, Pavlova str., 12, St. Petersburg, 197376 Russia. - - 2014
The influence of short and prolonged diet containing silver ions (Ag-diet) on copper metabolism was studied. Two groups of animals were used: one group of adult rats received a Ag-diet for one month (Ag-A1) and another group received a Ag-diet for 6 months from birth (Ag-N6). In Ag-A1 rats, the ...
Soffientini Ugo U Diabetes Research Group, Institute for Applied Health Research and the Department of Life Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, United - - 2014
To examine hepatic expression of cholesterol-trafficking proteins, mitochondrial StarD1 and endosomal StarD3, and their relationship with dyslipidaemia and steatosis in Zucker (fa/fa) genetically obese rats, and to explore their functional role in lipid metabolism in rat McArdle RH-7777 hepatoma cells. Expression of StarD1 and StarD3 in rat liver and hepatoma ...
Ding Chao C Department of General Surgery, Jinling Hospital Medical School of Nanjing University. Electronic address: - - 2014
It is believed that the microcirculation of multiple organs is impaired during acute peritonitis, however whether distinct susceptibilities of visceral microvasculature exists is still unknown. The present study aims to verify whether the microcirculatory alterations occur sequentially among multiple abdominal viscera during acute peritonitis. Acute peritonitis was achieved on 29 ...
Ahn Meejung M School of Medicine, Jeju National University, Jeju 690-756, Republic of Korea. Electronic address: - - 2014
The hepatoprotective activities of Lycium chinense Miller (LC) fruit extract and its component betaine were investigated under carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. The treatment of LC fruit extract significantly suppressed the increase of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the sera of CCl4 injured rats, and restored ...
Huang Yue-Hong YH Department of Gastroenterology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. - - 2014
Liver fibrosis is the common pathological outcome for the majority of chronic liver diseases. Interleukin-10 (IL-10) is a cytokine that downregulates proinflammatory responses and has a modulatory effect on liver fibrogenesis. However, little is known regarding the effect of rat interleukin‑10 (rIL‑10) gene by hydrodynamics-based transfection (HBT) on liver fibrosis ...
Koshy S M - - 2014
ABSTRACT Objectives: Increased fructose consumption causes dyslipidemia and fatty liver in postmenopausal women, both independent risk factors for cardiovascular disease. This study explored the potential mechanisms by which amla (Emblica officinalis) reduced hypercholesterolemia and hypertriglyceridemia and prevented fatty liver in fructose fed ovariectomized rat model of menopause. Methods: Sham operated ...
Ruan Zheng Z State Key Laboratory of Food Science and Technology, College of Life Science and Food Engineering, Nanchang University, Rm325, 235 Nanjing Street, Nanchang, 330047, - - 2014
This study was conducted to investigate effects of chlorogenic acid (CGA) supplementation on serum and hepatic metabolomes in rats. Rats received daily intragastric administration of either CGA (60 mg/kg body weight) or distilled water (control) for 4 weeks. Growth performance, serum biochemical profiles, and hepatic morphology were measured. Additionally, serum and liver ...
Kawase Atsushi A Department of Pharmacy, School of Pharmacy, Kinki University, Osaka, 577-8502, - - 2014
Pathophysiological changes of infection or inflammation are associated with alterations in the production of numerous absorption, distribution, metabolism and excretion-related proteins. However, little information is available on the effects of inflammation on the expression levels and activities of ATP-binding cassette (ABC) transporters. We examined the effect of acute (on day ...
Kawase Atsushi A Department of Pharmacy, School of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, 577-8502, Japan, - - 2014
Hepatic transporters and metabolic enzymes affect drug pharmacokinetics. Limited information exists on the alteration in mRNA levels of hepatic transporters and metabolic enzymes with aging. We examined the effects of aging on the mRNA levels of representative hepatic drug transporters and metabolic enzymes by analyzing their levels in 10-, 30- ...
Araújo Tiago G TG Department of Internal Medicine, State University of Campinas, Campinas, São Paulo, 13081-970, Brazil, - - 2014
The liver regeneration is an important clinical issue after major hepatectomies. Unfortunately, many organs (including the liver) exhibit age-related impairments regarding their regenerative capacity. Recent studies found that low-power laser irradiation (LPLI) has a stimulatory effect on the liver regeneration process. However, its effects in elderly remain unknown. Thus, this ...
Omugba Abam Esther - - 2014
Abstract Background: This work was designed to investigate the modulatory effects of cod liver oil on the acute exposure to carbon tetrachloride (CCL4) in experimental animal models. Methods: Markers of oxidative stress, enzymic and non-enzymic antioxidants were assessed in the liver and kidney. Results: The results showed significant (p<0.05) increase ...
Ma Chunmei C Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, - - 2014
To evaluate the hepatocyte phase of Gd-EOB-DTPA-enhanced MRI in the early diagnosis of hepatic fibrosis and cirrhosis and assessment of liver function in a rat model. In 2 groups of SD rats, liver fibrosis was induced in experimental animals by repetitive carbon tetrachloride injections, while the control group received saline ...
Al-Harbi Naif O NO Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi - - 2014
Liver is a vital organ for the detoxification of toxic substances present in the body and hepatic injury is associated with excessive exposure to toxicants. The present study was designed to evaluate the possible hepatoprotective effects of riboflavin against carbon tetrachloride (CCl4) induced hepatic injury in rats. Rats were divided ...
Kavishankar G B GB Department of Studies in Microbiology, University of Mysore, Mysore 570006, India; Department of Studies in Biochemistry, University of Mysore, Mysore 570006, - - 2014
To investigate the hepatoprotective, antioxidant and antihyperlipidemic effect of N-Trisaccharide isolated from Cucumis prophetarum (L.) on different experimental rats. N-Trisaccharide (25 and 50mg/kg.b.w), silymarin (25mg/kg) and glibenclamide (25mg/kg) was orally administered once daily for 28 days and toxicity evaluation studies were carried out. Liver damage was assessed by determining DNA ...
Lee Unji U College of Pharmacy, Ewha Womans University, Seoul, South - - 2014
The LC (liver cirrhosis induced by N-dimethylnitrosamine) and LCD (LC with diabetes mellitus induced by streptozotocin) rats have been developed as animal models for human liver cirrhosis and liver cirrhosis with diabetes mellitus, respectively. The changes in the pharmacokinetics of drugs (mainly non-renal clearance, CLNR ) in LC and LCD ...
Fudaba Yasuhiro Y Department of Surgery, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, - - 2014
This study investigated the features of fatty livers using near-infrared (NIR) spectroscopy and validated the usefulness of NIR spectroscopy for the measurement of intrahepatic triglyceride (TG) contents and evaluation of viability in fatty livers. In vitro we examined specific spectra for each purified TG fraction by NIR. In vivo the ...
Giménez-Garzó Carla C Laboratory of Neurobiology, Centro Investigación Príncipe Felipe, Eduardo Primo Yufera, 3., 46012, Valencia, - - 2014
Studies in animal models allow identifying mechanisms and treatments for cognitive and motor alterations in hepatic encephalopathy (HE). Liver diseases leading to HE in humans have different aetiologies (alcoholic, viral, etc.). The International Society for Hepatic Encephalopathy points out that satisfactory model for HE resulting from alcoholic cirrhosis are lacking. ...
Yamazaki Miho M Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, - - 2014
Liver microsomal flavin-containing monooxygenases (FMO, EC 1.14.13.8) 1 and 3 were functionally characterized in terms of expression levels and molecular catalytic capacities in human, cynomolgus monkey, rat, and minipig livers. Liver microsomal FMO3 in humans and monkeys and FMO1 and FMO3 in rats and minipigs could be determined immunochemically with ...
Karabulut Aysun Bay AB Department of Biochemistry, Faculty of Medicine, Inonu University, 44280 Malatya, Turkey. Electronic address: - - 2014
We evaluated the ability of apricot to attenuate apoptosis and oxidative stress developed during the process of 7,12-dimethylbenz[a]anthracene (DMBA) and radiotherapy in the liver of rats bearing liver damage. Fifty female Wistar rats were divided into 7 groups; (i) normal control rats; (ii) rats fed with standard diet with apricot ...
Lasram Mohamed Montassar MM Laboratory of Aggression Physiology and Endocrine Metabolic Studies, Department of Biology, Faculty of Sciences, Tunis, Tunisia. Electronic address: - - 2014
Occupational exposure to organophosphate pesticides is becoming a common and increasingly alarming world-wide phenomenon. The present study is designed to investigate the preventive effect of N-acetylcysteine on malathion-induced hepatic injury and inflammation in rats. Adult male Wistar rats of body weight 200-230g were used for the study. Malathion (200mg/kg b.w./day) ...
Chen K-D KD Center for Translational Research in Biomedical Sciences, Liver Transplantation Program, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, - - 2014
Adipose-derived mesenchymal stem cells (ASCs) have been considered to be attractive and readily available adult mesenchymal stem cells (MSCs) and are becoming increasingly popular for use in regenerating cell therapy. However, recent evidence attributed a fibrotic potential to MSCs which differentiated into myofibroblasts with highly increased α-smooth muscle actin (α-SMA) ...
Taj Darakhshan D Biotechnology and Drug Development Laboratory, Department of Biochemistry, University of Karachi, Karachi, - - 2014
Liver is the main site in the body for intense metabolism and excretion. A number of chemicals and drugs which are used routinely cause liver damage. The present study investigates the antihepatotoxic effect of Physalis peruviana whole ripe fruit, water and ethanol extracts of fruit in normal as well as ...
Li Wenting W Department of Infectious Disease, Anhui Provincial Hospital, Hefei, - - 2014
The Wnt/β-catenin signaling pathway has been reported to play an important role in liver fibrosis. This study was designed to investigate whether mesoderm-specific transcript homologue (Mest), a strong negative regulator of Wnt/β-catenin signaling, could inhibit liver fibrosis. pcDNA-Mest was transfected into hepatic stellate cells (HSCs) and rats. Rats were randomly ...
Chen Lingshan L Department of Radiology, Zhongda Hospital of Southeast University, Nanjing, - - 2014
To explore the correlation between liver iron overload and bone mineral density (BMD) in an ovariectomy (OVX) rat model, using liver magnetic resonance (MR)-T2* and dual-energy X-ray absorptiometry (DEXA). Sprague-Dawley rats received deferoxamine (DFO) or phosphate-buffered saline 3 months after bilateral OVX. MRI and DEXA were performed pre- and postoperatively. Five ...
Metushi Imir G IG Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, - - 2014
The mechanism of idiosyncratic drug reactions (IDRs) remains poorly understood. D-penicillamine treatment is associated with a wide range of autoimmune reactions including liver injury. An animal model which utilizes brown Norway (BN) rats has been used to investigate the mechanism of D-penicillamine-induced IDRs because it mimics the autoimmune reactions that ...
Seif Ansam Aly AA Faculty of Medicine, Ain Shams University, Cairo, Egypt, - - 2014
Vitamin D, most commonly associated with the growth and remodeling of bone, has been shown to ameliorate ischemia/reperfusion injury (IRI) in some tissues, yet its underlying mechanism remains elusive. This study was designed to examine the protective effect of vitamin D, if any, against hepatic IRI in rats and the ...
Hide Diana - - 2014
Hepatic microcirculatory dysfunction due to cold storage and warm reperfusion (CS+WR) injury during liver transplantation is partly mediated by oxidative stress and may lead to graft dysfunction. This is especially relevant when steatotic donors are considered. Using primary cultured liver sinusoidal endothelial cells, liver grafts from healthy and steatotic rats, ...
Jiao Kun K Department of Laboratory Animal Science, School of Basic Medical Science, Capital Medical University , Beijing, 100069 , - - 2014
Abstract Vitamin K1 is used as a liver protection drug for cholestasis-induced liver fibrosis in China, but the mechanism of vitamin K1's action in liver fibrosis is unclear. In this study, a model of liver fibrosis was achieved via bile duct ligation in rats. The rats were then injected with ...
Fernández-Martínez Eduardo E Centro de Investigación en Biología de la Reproducción, Medicina-I.C.Sa. Universidad Autónoma del Estado de Hidalgo, Hidalgo, Mexico. Electronic address: - - 2014
Oral contraceptives (OC) may cause intrahepatic cholestasis or increase a pre-established liver damage. OC effects on hepatic injury biochemical markers remain contradictory and the role of cytokines in those processes is fairly unknown. Two doses, simple or double, of the OC combination ethinylestradiol/norgestrel were administered during 14 or 28days to ...
Andersen Kasper Jarlhelt KJ Department of Surgical Gastroenterology, Aarhus University Hospital, Aarhus, Denmark. Electronic address: - - 2014
Sorafenib, a multikinase inhibitor, has been shown to halt the growth of hepatocellular carcinoma. The aim of the present study was to investigate the effect of Sorafenib on liver regeneration in healthy rats. In two substudies we examined the effect of pre- or post-operative treatment with Sorafenib (15 mg/kg/d). Wistar rats ...
Fogel Wieslawa Agnieszka WA Department of Hormone Biochemistry, Medical University of Lodz, Lodz, - - 2014
Rats with portacaval shunt (PCS) are useful experimental models of human hepatic encephalopathy in chronic liver dysfunction. We have previously shown that PCS modifies amine neurotransmitter systems in the CNS and increases voluntary alcohol intake by rats. Hepatocyte transplantation, used in acute liver failure, has recently also been applied to ...
Miyazaki Hiroshi H Department of Pediatrics, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, - - 2014
Non-alcoholic fatty liver disease is the most common liver disorder in developed countries, and its incidence is increasing in all population groups. As an antioxidant, vitamin E is effective in the treatment of non-alcoholic fatty liver disease, although the mechanism is still unclear. Methionine-choline deficient Wistar rats (n = 5) used as ...
Dai Ning N 1 Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University , Dalian, Liaoning Province, China - - 2014
Abstract Liver steatosis is characterized by lipid dysregulation and fat accumulation in the liver and can lead to oxidative stress in liver. Since proanthocyanidins are present in plant-based foods and have powerful antioxidant properties, we investigated whether proanthocyanidins can prevent oxidative stress and subsequent liver injury. Carbon tetrachloride (CCl4) treatment ...
Kajikawa Noriko N Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama - - 2014
  The effect of the carrageenan-induced acute peripheral inflammation (API) on the pharmacokinetics of the hepatically metabolizing compound midazolam (MDZ) was investigated in rats. Rats were subcutaneously treated with λ-carrageenan in the hind paw to induce API. When MDZ was intravenously administered in male rats, it was demonstrated that the plasma ...
Kim Sang-Bum SB College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of - - 2014
Puerarin (8-β-D-glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a major pharmacological component of Puerariae Radix, the root of Pueraria lobata. We investigated the effect of puerarin on hepatic cytochrome P450-mediated drug metabolism in rats and humans. The in vitro cytochrome P450 inhibitory effect of puerarin in human and rat liver microsomes was evaluated using the ...
Pereira Mayara P MP a Department of Chemistry, Federal University of Mato Grosso, Cuiabá, Mato Grosso, - - 2014
The our objective was to investigate the adaptations induced by a low-protein, high-carbohydrate (LPHC) diet in growing rats, which by comparison with the rats fed a control (C) diet at displayed lower fasting glycemia and similar fasting insulinemia, despite impairment in insulin signaling in adipose tissues. In the insulin tolerance ...
Stringer Rowan A RA Novartis Institutes for Biomedical Research , Horsham, West Sussex , - - 2014
Abstract 1.  The pharmacokinetic properties and metabolism of NVS-CRF38 [7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole], a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist, were determined in vitro and in animals. 2.  NVS-CRF38 undergoes near complete absorption in rats and dogs. In both species the compound has low hepatic extraction and is extensively distributed to tissues. ...
Vlassaks E E 1 Department of Neuropsychology, Division Neuroscience, Maastricht University, School of Mental Health and Neuroscience (MHeNS), Maastricht, the - - 2014
Hypoxic-ischemic encephalopathy (HIE) caused by fetal and perinatal asphyxia is an important cause of mortality in the neonatal period. Not only will asphyxia affect the brain but also other organs such as the liver and kidneys. Interestingly, it has been shown that liver damage is proportional to the severity of ...
Bao Cuifen C Central Laboratory - - 2014
Abstract While ischemic acute kidney injury (IAKI) is known often to cause hepatic injury, little is known about necroptosis involved in the hepatic injury. The purposes of this study were to identify necroptosis involvement and observe morphological changes of hepatocytes in hepatic injury induced by IAKI in rats. Based on ...
Lee Sang Hwa SH Sang Hwa Lee, Hyun-Soo Kim, Department of Pathology, Aerospace Medicine Research Center, Aerospace Medical Center, Republic of Korea Air Force, Chungcheongbuk-do 363-849, South - - 2014
To investigate the effect of hypoxia or hyperoxia on the progression of hepatic fibrosis and to examine the role of transforming growth factor-β (TGF-β) in the livers of rats exposed to hypoxic or hyperoxic conditions. Male Sprague-Dawley rats were injected intraperitoneally with thioacetamide to induce hepatic fibrosis and were randomly ...
Oliveira Cláudia S CS Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, 97105-900, - - 2014
This study investigated if lactating and nonlactating rats presented differences in relation to hepatic sensitivity to HgCl2 and the potential preventive role of ZnCl2. Lactating (days 3-12 of lactation) and nonlactating rats received 27 mg/kg ZnCl2 for five consecutive days and 5 mg/kg HgCl2 for five subsequent days. Lactating and nonlactating rats ...
Qi Qingan Q Southwest Hospital and Institute of Hepatobilitary Surgery, Third Military Medical University, Chongqing, - - 2014
Hepatic ischemia-reperfusion (IR) injury, an unfavorable complication of hepatectomy, could be prevented by hypothermic ischemia and ischemic preconditioning (IPC). However, the effects of these two approaches on hepatocarcinogenesis have not been examined. The aim of the study was to investigate roles of hypothermic ischemia and IPC in a chemically induced ...
Jirintai Suljid S Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke-Shi, Tochigi 329-0498, - - 2014
Although rat hepatitis E virus (HEV) has been identified in wild rats, no cell culture systems for this virus have been established. A recent report suggesting the presence of antibodies against rat HEV in human sera encouraged us to cultivate rat HEV in human cells. When liver homogenates obtained from ...
Sock E T Ngo ET Department of Kinesiology, University of Montreal, Montreal, Quebec, - - 2014
The aim of this study was to determine the effects of ovariectomy in rats on hepatic gene expression of key molecules involved in cholesterol metabolism and to verify if exercise training may play a role in preventing hypercholesterolemia in Ovx rats. Sprague-Dawley rats were ovariectomized (Ovx) or sham-operated (Sham) and ...
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