Search Results
Results 451 - 500 of 540
< 1 2 3 4 5 6 7 8 9 10 11 >
Malhotra K M - - 1982
Rats were coexposed to lead (Pb) and Copper (Cu) through drinking water and intraperitoneally, respectively, for a period of 21 days. Neurochemical studies in these rats showed significant reduction in the activity of adenosine triphosphatase, cytochrome-c-oxidase, diaphorase and in the levels of biogenic amines in the rats simultaneously exposed to ...
Fowler C J - - 1982
Km and Vmax values of monoamine oxidase (MAO) A and B towards 5-hydroxytryptamine were determined for rat brain homogenates after the in vitro inhibition of one of the two forms by the selective inhibitors clorgyline and l-deprenyl. Km values of 178 and 1170 microM, and Vmax values of 0.73 and ...
Argiolas A - - 1982
The effect of apomorphine and haloperidol on DOPA accumulation after inhibition of DOPA decarboxylase activity with NSD 1015 was compared in the substantia nigra (SN) and caudate nucleus (CN) of normal rats and rats deprived of nigral afferences from the striatum by means of intrastriatal kainic acid. In normal rats ...
Westerink B H - - 1982
A highly sensitive method for the determination of 3-methoxytyramine (3-MT) in nervous tissue is described. The method is based on a rapidly performed isolation of 3-MT on small columns of Sephadex G 10, followed by reverse-phase high-performance liquid chromatography in conjunction with a rotating disk electrochemical detector. The detection limit ...
Beck O - - 1981
The occurrence and concentration of the four 5-methoxyindoles: 5-methoxtryptamine, 5-methoxytryptophol, 5-methyoxyindole-3-acetic acid and melatonin in the pineal gland of pig, cow, sheep and rat was investigated. The analytical method involved the use of deuterated analogues as internal standards and capillary column gas chromatography - mass spectrometry. The analyses of pineal ...
Pegg A E - - 1981
Two pathways exist for the formation of putrescine in rat liver. Putrescine can be produced by the action of L-ornithine decarboxylase, an inducible enzyme which can be irreversibly inhibited by the drug, alpha-difluoromethylornithine. A method for quantitating the amount of active ornithine decarboxylase protein present in the liver under various ...
Boulton A A - - 1981
The biosynthesis and urinary excretion of the trace amines PE, mTA, pTA and TRYP have been investigated after systemic injection in the rat and ingestion in the human. In the rat the likely precursors phe, tyr, DOPA and PE, radioactively labelled, were injected in tracer and supplemented doses. pTA was ...
Eastman D F - - 1981
The effects of individual pyrrolizidine alkaloids on the mixed-function oxidase (MFO) enzyme aminopyrine N-demethylase were determined in rat liver 10 000 X g supernatant. The pyrrolizidine alkaloids, senecionine, seneciphylline and retrorsine were obtained from Senecio vulgaris. Senecionine and seneciphylline were found to be linear mixed-type inhibitors while retrorsine was found ...
Nistico' G - - 1981
The inhibiting effects of indoprofen were compared with those of indomethacin on prostaglandin-synthetase activity in rat hypothalamus. A dose-dependent inhibition of PG-synthetase activity was obtained after intramuscular administration of both antiphlogistic agents; however, indoprofen was found more powerful. In conclusion, the present experiments provide additional evidence against the idea that ...
Sourkes T L - - 1981
The catabolism of 14C-putrescine (1,4-tetramethylene-diamine) to labeled CO2 in small laboratory animals has been studied extensively in order to establish the influence of nutritional, endocrine and other factors on this process. Special attention has been paid to treatments that are known to affect the activity of diamine oxidase (DAO, histaminase, ...
Koudelová J - - 1981
The effect of short-term fasting and thirst, prolonged fasting and hypoxic hypoxia upon the activity of cytochrome oxidase was studied in mitochondrial fractions obtained from the brain and the liver. The investigation was carried out in two groups of rats, 5 and 60 days old. a) The activity of cytochrome ...
Parkinson D - - 1980
The ability of MAO-A and MAO-B to metabolize benzylamine in vitro has been investigated in mitochondrial preparations from rat liver and heart. Although under normal circumstances benzylamine appeared to be metabolized exclusively by MAO-B in the rat liver, a contribution by both MAO-A and a clorgyline-resistant enzyme component was revealed ...
Rosenfeld M R - - 1980
Pergolide stimulates adenylate cyclase activity in homogenates of rat striatum. In contrast, bromocriptine and lisuride are inactive. GTP enhances the stimulation produced by pergolide and has no effect on the other ergots tested. The stimulation produced by pergolide is inhibited by haloperidol but not by molindone. It is concluded that ...
Mueller R A - - 1980
Resting and CO2 stimulated respiration were measured by means of a whole-body plethysmograph in rats lightly anaesthetized with halothane. Rats pretreated neonatally with intracisternal 5,7-dihydroxytryptamine (5,7-DHT) to destruct permanently central serotonergic neurones had significantly lower resting and CO2 stimulated respiratory frequency (RF) and minute volume (VM) than naive rats. In ...
Fowler C J - - 1980
Pretreatment of rat liver homogenates with 1.5 x 10(-4) M SKF 525A is without effect on the activity of monoamine oxidase-A, but results in a decrease in the concentration of clorgyline required for the inhibition of this enzyme form. Such a result is consistent with the hypothesis that rat liver ...
Kiuchi K - - 1980
The effect of riboflavin deficiency on the activity of L-gulonolactone oxidase [L-gulono-gamma-lactone: oxygen 2-oxidoreductase, EC 1.1.3.8] and on vitamin C status was studied. A marked decrease in the specific activity of L-gulonolactone oxidase was observed in the liver microsomes isolated from riboflavin-deficient rats: the specific activity was approx. one-third of ...
Kawabata Y - - 1980
In adult rats the activity of proline oxidase is high in the liver and kidney and moderate in the brain and heart, but it is not detectable in the lung, skeletal muscle, spleen, or small intestine. The activity in the liver is 1.5 times higher in females than males. Administration ...
Missala K - - 1980
Rats treated acutely with aminoguanidine, a potent inhibitor of diamine oxidase, or with heparin display reduced ability to metabolize 14C-putrescine to radioactive carbon dioxide. After either drug rats recover 50% of the ability to catabolize putrescine in 15--18 h. This is in close agreement with the half-time for recovery of ...
Harbert C A - - 1980
A series of 5-aryltetrahydro-gamma-carbolines was prepared by a novel N-arylation procedure and tested for neuroleptic activity in a rat antiamphetamine model. The systematic exploration of structural parameters leading to 8-fluoro-5-(4-fluorophenyl)-2-[4-hydroxy-4-(4-fluorophenyl)butyl]-2,3,5-tetrahydro-1H-pyrido[4,3-b]indole (CP-36,584, flutroline), a potent and long-acting neuroleptic compound, is described. These semirigid compounds provide a new, structurally distinct series with ...
Gripois D - - 1980
We studied the noradrenaline content, and monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT) activities in brown adipose tissue (BAT) of normal, hypothyroid, and hyperthyroid developing rat. In the newborn, thyroid hormones are necessary for the increase in noradrenaline content which occurs between 0 and 5 days. Hypothyroidism increases both MAO and ...
Le Hir M - - 1980
Using a new biological microassay the activities of three peroxisomal oxidases in single microdissected periportal and perivenous zones of the liver acinus were measured. Whereas urate oxidase is homogeneously distributed through the acinus, the activities of D-aminoacid oxidase and alpha-hydroxyacid oxidase are respectively 1.80- and 2.71-fold higher in the periportal ...
Keane P E - - 1979
Rats were administered toloxatone 100 mg kg-1 p.o., and killed 0.5 to 8 hours later. Toloxatone reversibly inhibited type A MAO, but did not affect the activity of type B MAO in whole brain. Cerebral concentrations of noradrenaline, dopamine and 5-hydroxytryptamine were increased after toloxatone, while their metabolite concentrations were ...
Dial E J - - 1979
Experiments were made to test the proposal that rat heart mitochondrial monoamine oxidase (MAO) differs from that in certain other organs. Using kynuramine as the substrate, cardiac MAO of rats was compared with that in the vas deferens and liver. While the relative proportions of type A and B MAO ...
Briggs I - - 1979
Depletion of rat brain serotonin by p-chlorophenylalanine (PCPA) pretreatment, or of monoamines by reserpine pretreatment, was associated with reduced spontaneous firing rates of bulbar reticular neurones. Administration of 5-hydroxytryptophan to PCPA-treated rats reversed the reduction of neuronal activity. It is suggested that the results indicate a tonic excitatory serotoninergic input ...
Ryder T A - - 1979
A coupled peroxidatic oxidation technique is presented which employs benzylamine and tyramine as substrates and clorgyline, deprenyl, phenelzine and pargyline as specific inhibitors. Using this technique with frozen sections of human term placenta and rat liver, the histochemical localization of monocamine oxidase A and B and bnezylamine oxidase has been ...
Coupet J - - 1979
The effects of loxapine and its hydroxylated metabolites 7-hydroxyloxapine and 8-hydroxyloxapine on 3H-spiroperidol binding to rat striatal membranes were investigated. Whereas 7-hydroxyloxapine and loxapine displayed strong affinities for 3H-spiroperidol binding sites, 8-hydroxyloxapine was essentially inactive. The potency of 7-hydroxyloxapine to displace 3H-spiroperidol is 1.5 times and 8 times those of ...
Andersson A C - - 1979
The formation as well as the content of cadaverine were determined in different tissues of pregnant and non-pregnant rats. The placenta and ovary were most potent in the ability to form cadaverine. To our knowledge this is the first report of an in vitro formation of cadaverine linked to a ...
Gorrod J W - - 1979
1. Pyridine-N-oxides have been identified as metabolites in vitro of several 3-substituted pyridines. 2. Factors affecting the metabolism of these pyridines in vitro have been studied, and conditions which give the most metabolism have been established. 3. 'Pyridine-N-oxidase' activity resides mainly in the hepatic and pulmonary microsomal fractions. 4. A ...
Kunimoto N - - 1979
The regional distribution of type A, type A and B and type B activity of monoamine oxidase (MAO) in individual nuclei of the rat hypothalamus was studied according to quantitative micromethods with clorgyline as a specific inhibitor of type A MAO. As results, type A and type B MAO were ...
Hollister A S - - 1979
The potentiation of the stimulatory response to L-dihydroxyphenylalanine (L-dopa) in 6-hydroxydopamine-treated rats given a peripheral decarboxylase inhibitor occurred only after treatments that destroyed dopamine-containing fibers, Destruction of serotonin- or norepinephrine-containing fibers did not potentiate the action of L-dopa. Furthermore, other data indicated thatL-dopa-induced activity could not be attributed to release ...
Fowler C J - - 1979
The interaction between rat brain monoamine oxidase-B and J-508, an analogue of L-deprenil, has been investigated. J-508 inhibits rat brain monoamine oxidase-B in a manner consistent with a 'suicide' reaction, and is so potent an inhibitor that it produces inhibition at concentrations of the same order as those of the ...
Quiring K - - 1979
For induction of reticulocytosis, rats had been routinely treated with the haemolytic agent, acetyl-phenylhydrazide (APH), and monoamine oxidase (MAO) activity was determined in reticulocytes. Since hydrazines are known to be irreversible inhibitors of MAO, the MAO inhibiting potency of APH was assessed in vitro and in vivo. Only in vivo, ...
Rinne A - - 1979
The rat epidermal SH-protease inhibitor was localized by the PAP method in the squamous epithelium of rat proventricle. Brown accumulation due to the peroxidase reaction was seen in the superficial and middle layers of squamous epithelia. The localization of the inhibitor in squamous epithelium is the same as we have ...
Smith G S - - 1978
Changes in the respiratory state of rat liver mitochondria caused significant changes (up to 10-fold) in the rates of oxidative deamination of tyramine, indicating interactions between the inner coupling membrane and the monoamine oxidase sites in the outer membrane, and suggesting the possibility that monoamine oxidase is regulated by the ...
Madhok T C - - 1978
The oxygen enzymically inserted as a hydroxy function by rat liver post-mitochondrial fraction into the 25-position of cholecalciferol to giver 25-hydroxycholecaliferol is derived exclusively from molecular O2. Therefore like the other two cholecalciferol hydroxylases, i.e. 25-hydroxycholecalciferol 1alpha-hydroxylase and 25-hydroxycholecalciferol 24-hydroxylase, the cholecalciferol 25-hydroxylase is also a mono-oxygenase ('mixed-function oxidase').
Pandey B R - - 1978
Six 1-[N-acetyl(4-phenylpiperidino)]-3-aryl carbamides were synthesized, characterized and evaluated for their anticonvulsant, monoamine oxidase inhibitory and antihemolytic properties. These compounds (100 mg/kg, i.p.) provided 10--80% protection against pentylenetetrazol-induced seizures in mice. All carbamides (1 mM) inhibited (34--82%) in vitro activity of rat brain monoamine oxidase and provided 18--51% protection against in ...
Lai F M - - 1978
Monoamine oxidase (MAO) activity was assayed both in central and peripheral blood vessels of spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar Kyoto rats (WKR). The activity of MAO in the brain and peripheral vasculature was essentially the same in both SHR and WKR. It can therefore be concluded that ...
Loriette C - - 1978
The patterns of development of cysteine oxidase (CO) and cysteine sulfinic acid decarboxylase (CSD) in rat liver are not similar. It was observed that CO is not under sex control as CSD is. The results obtained agree with the idea that, in liver, as well as in brain, CSD is ...
Iyer K S - - 1978
Racemic and dextro forms of propranolol were equipotent in their anticonvulsant activity in normal rats by the MES test. In an attempt to determine any difference in the anticonvulsant activity of the two forms a variety of adrenergic agents were used, viz. phenoxybenzamine, reserpine, alphamethyl dopa and acetazolamide. There was ...
Freundt K J - - 1978
A single 8-h exposure to trans-1,2-dichloroethylene (t-DCE) or cis-1,2-dichloroethylene (c-DCE) at 200 ppm (hygienic standard in workplaces) resulted in a significant increase in the hexobarbital sleeping time, the zoxazolamine paralysis time, and the metabolic formation of 4-aminoantipyrine from aminopyrine in adult female Wistar rats. Higher DCE concentrations caused a dose-dependent ...
Kopple J D - - 1978
The enzyme, diamine oxidase, is present in many tissues and plays a role in the metabolism of certain amines, some of which may be toxic. In renal failure, plasma diamine oxidase activity was found to be increased in chronically uremic patients and before and after dialysis therapy in patients undergoing ...
Sourkes T L - - 1978
1. The ability of rats to metabolize radioactive putrescine to 14CO2 in vivo has been studied. 2. Animals made deficient in pyridoxine exhibit a significantly lower rate of catabolism of the diamine. 3. There dose not appear to be an important interaction between the effects of the deficiency and those ...
Hazama H - - 1978
The distribution and development of type A and type B monoamine oxidase (MAO) activities in the hippocampal region of the rat was investigated with biochemical microdetermination. Type A MAO is absolutely dominant and unevenly distributed in the hippocampus. The development of type A MAO in the hippocampus seems to be ...
Ismahan G - - 1978
The effect of selective monoamine oxidase (MAO) inhibitors clogyline and deprenyl upon glycogen stores in brain, heart and liver and upon blood glucose were examined for a possible link between the activity of the oxidase and metabolism of carbohydrates. The experiments were performed in normally fed rats and rats subjected ...
Bachmann E - - 1978
Repeated oral administration of commonly used suspending media, gum arabic, gum tragacanth, methylcellulose, and carboxymethylcellulose-Na to rats caused uncoupling of oxidative phosphorylation in liver and heart mitochondria and partial inhibition of mixed function oxidases of liver endoplasmic reticulum, as measured by 2-biphenylhydroxylation and 4-biphenylhydroxylation. There were considerable differences between the ...
Mason J - - 1978
The sulphide metabolism of rats fed molybdate up to levels of 1000 ppm molybdenum was examined and large decreases in hepatic sulphite oxidase activity observed; overall sulphide oxidation capacity was also reduced. Molybdate but not tungstate caused increases in the total plasma copper of guinea pigs but in particular the ...
Quiring K - - 1977
After "chemically induced reticulocytosis" in rats by treatment with acetyl-phenylhydrazide, monoamine oxidase (MAO) activities were determined in erythrocyte preparations of these animals. Studies on subcellular fractions obtained by differential centrifugation showed that the enzyme activity of rat reticulocytes is a classical mitochondrial MAO. The patterns of inhibition produced by clorgyline ...
Gripois D - - 1977
The activity of monoamine oxidase (MAO) towards tryptamine has been determined in heart, brain and liver of the 21.5 day old rat fetus. The activity was compared between normal, thyroxine and propylthiouracil (PTU) treated animals. Hypothyroidism induced by PTU leads to a decrease in the activity of the three organs, ...
Sourkes T L - - 1977
The in vivo rates of catabolism of 14C-labelled pentylamine, ethylamine, putrescine, and cadaverine were studied in thyroidectomized rats and others made hyperthyroid by the daily administration of 0.2 mg of L-thyroxine per kilogram for 20--21 days. Hyperthyroid rats metabolized the monoamines at an accelerated rate; thyroidectomized animals oxidized pentylamine at ...
Dial E J - - 1977
Monoamine oxidase (MAO) activity was characterized using whole tissue homogenates and kynuramine as the substrate. In rat vasa deferentia, kynuramine deamination was differentially inhibited by clorgyline, less so by deprenyl and not at all by pargyline. These studies, and mixed substrate experiments with tryptamine, proved that kynuramine is a substrate ...
< 1 2 3 4 5 6 7 8 9 10 11 >