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Yuan Fang F Department of Physiology, Hebei Medical University, Shijiazhuang, China; Hebei Collaborative Innovation Center for Cardio-cerebrovascular Disease, Shijiazhuang, - - 2014
High-fructose intake induces nonalcoholic fatty liver disease (NAFLD) and chronic intermittent hypobaric hypoxia (CIHH) has beneficial effects on the body. We hypothesized that CIHH has protective effects on the impaired hepar in fructose-fed rats. Sprague Dawley rats (male, 160~180 g) were randomly divided into 4 groups: control group (CON), fructose ...
El'chaninov A V AV Laboratory of Growth and Development, Research Institute of Human Morphology, the Russian Academy of Medical Sciences, Moscow, Russia, - - 2014
The proliferation and death of hemopoietic cells in the regenerating liver of 17-day outbred albino rat fetuses were studied during 2 days after resection of 20% of the organ. The mitotic index of hemopoietic cells in the resected liver increased signifi cantly 24 h after the operation in comparison with ...
Okay Erdem E Department of General Surgery, Kocaeli University School of Medicine, Umuttepe, Kocaeli, Turkey, - - 2014
In this study, we examined the effect of preoperatively administered resveratrol (RV) and mesenchymal stem cells (MSCs) on regeneration of partially hepatectomized rat liver. We also evaluated the effect of RV on homing of MSCs. MSCs were isolated from bone marrow and cultured in vitro. Wistar albino rats were randomly ...
Cao Wen W Department of Pharmacology, Guangxi Medical University, Nanning, - - 2014
Combination therapy with taurine, epigallocatechin gallate, and genistein was effective in alleviating the progression of liver fibrosis in our previous study. To better understand the anti-fibrotic mechanisms of combination therapy, an iTRAQ-based proteomics approach was used to study the expression profiles of proteins in carbon tetrachloride-induced liver fibrosis rats following ...
Ajiboye T O TO Antioxidants, Free Radicals, Functional Foods and Toxicology Research Laboratory, Department of Biological Sciences, Al-Hikmah University, Ilorin, Nigeria. - - 2014
The effect of 2-(2-nitrovinyl)furan on the redox status of male rat liver and kidney was evaluated. Twenty male rats were randomized into four groups; group A received olive oil and groups B, C, and D rats received 12.5, 25, and 50 mg/kg bodyweight of 2-(2-nitrovinyl)furan intraperitoneally, daily at 24 h ...
Baena Miguel M Department of Pharmacology and Therapeutic Chemistry, School of Pharmacy, University of Barcelona, - - 2014
Supplementation with 10% liquid fructose to female rats for 2weeks caused hepatic steatosis through increased lipogenesis and reduced peroxisome proliferator activated receptor (PPAR) α activity and fatty acid catabolism, together with increased expression of the spliced form of X-binding protein-1 (Rebollo et al., 2014). In the present study, we show ...
Shin Dae Hwan DH College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, 361-763, - - 2014
Anthracycline anticancer agents are widely used in the cancer chemotherapy for hepatocelluar carcinoma. However, accurate kinetic analyses of the hepatocellular uptake and efflux of the drugs have not been reported. We, therefore, investigated the hepatobiliary transport of epirubicin, an anthracycline derived antibiotic, after intravenous (i.v.) infusion in rats. The hepatic ...
Moreau F F Diabète et Thérapie Cellulaire EA 7294, Centre Européen d'Etude du Diabète, Université de Strasbourg, Strasbourg, - - 2014
Liver and pancreas share key roles in glucose homeostasis. Liver regeneration is associated with systemic modifications and depends especially on pancreatic hormones. The aim of the study was to investigate the role of systemic factors released after two-thirds hepatectomy (2/3H) on early possible consequences of liver regeneration on endocrine pancreas ...
Jiménez-Lamana Javier J Group of Analytical Spectroscopy and Sensors (GEAS), Institute of Environmental Sciences (IUCA), University of Zaragoza, Pedro Cerbuna 12, 50009 Zaragoza, Spain. - - 2014
A comprehensive study of the bioavailability of orally administered silver nanoparticles (AgNPs) was carried out using a rat model. The silver uptake was monitored in liver and kidney tissues, as well as in urine and in feces. Significant accumulation of silver was found in both organs, the liver being the ...
Hickman DaShawn A DA Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, - - 2014
Portal fibroblasts (PF) are one of the two primary cell types contributing to the myofibroblast population of the liver and are thus essential to the pathogenesis of liver fibrosis. Monocyte chemoattractant protein-1 (MCP-1) is a known profibrogenic chemokine that may be of particular importance in biliary fibrosis. We examined the ...
Ahmed Soheir Kamal SK Department of Histology, Faculty of Medicine, Ain Shams University, Cairo, - - 2014
Variety of pathological factors including viral hepatitis, alcohol and drug abuse, metabolic diseases, autoimmune diseases and congenital abnormalities can cause hepatic injury. Liver transplantation is the treatment of choice for end-stage liver diseases, however, it faces several difficulties. So the aim of the work is to evaluate the effect of ...
Pöstényi Zita Z Department of Pharmacology and Pharmacotherapy, Semmelweis University, Nagyvárad tér 4, Budapest, Hungary. Electronic address: - - 2014
Validated HPLC analysis was developed in order to monitor the level of 4-fluorodeprenyl in rats. Male Wistar rats were intraperitoneally treated with 30mg/kg of (-)-4-fluorodeprenyl. The rats were sacrificed after 5, 15, 30 and 60min of treatment, and various tissues were isolated, such as serum, brain, CSF, liver, testis and ...
Tega Yuma Y University of - - 2014
Nicotine is an addictive alkaloid in cigarette smoke and is responsible for tobacco dependence. It is important to consider the blood-to-liver transport of nicotine in order to understand the nicotine elimination from the body since most of the nicotine is converted to inactive metabolites by cytochrome P450 localized in the ...
Hu Jian Jun JJ Department & Institute of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing, - - 2014
Chronic liver diseases always increase the risk of liver failure after hepatectomy. We aimed to explore the protective effect of portal vein clamping without hepatic artery blood control (PVC) on a cirrhotic rat liver that underwent ischemia and reperfusion. Carbon tetrachloride-induced cirrhotic rats were randomly assigned to four groups as ...
Ryan Jennifer C - - 2014
Clinical studies indicate that hepatic drug transport may be altered in chronic kidney disease (CKD). Specifically, uremic solutes associated with CKD have been found to alter the expression and/or activity of hepatocyte transporters in experimental animals and in cultured cells. However, given the complexity and adaptability of hepatic transport, it ...
Dudea Marina M Physiology Department, University of Medicine and Pharmacy "Iuliu HaĊ£ieganu," Cluj-Napoca, - - 2014
The purpose of the study described here was to evaluate the usefulness of the elastographic strain ratio in the assessment of liver changes in an experimental animal setting and the hepatoprotective effects of chitosan. Ultrasonography and Strain Ratio calculation were performed before and after bile duct ligation (BDL) in three ...
Zhao Yanling Y China Military Institute of Chinese Medicine, 302 Military Hospital of China, Beijing 100039, China. Electronic address: - - 2014
HIF-1α/mTOR signaling pathway is considered to play a crucial role in genesis and progress of tissue fibrosis. The elevation of HIF-1α and mTOR is relevant to CCl4 induced liver fibrotic rats. Paeoniflorin has been consistently shown to exhibit multiple pharmacological effects in liver disease. However, so far, no research demonstrates ...
Wang Wen-Fei WF College of Life Science, Northeast Agricultural University, 59 Mucai Street, Xiangfang District, Harbin, 150030, - - 2014
The aim of this study is to investigate the role of FGF21 in obesity-related inflammation in livers of monosodium glutamate (MSG)-induced obesity rats. The MSG rats were injected with recombinant murine fibroblast growth factor 21(FGF21) or equal volumes of vehicle. Metabolic parameters including body weight, Lee's index, food intake, visceral ...
Werner Wiebke - - 2014
Studies on liver regeneration following partial hepatectomy (PH) have identified several microRNAs (miRNAs) that show a regulated expression pattern. These studies involve major surgery to access the liver, which is known to have intrinsic effects on hepatic gene expression and may also affect miRNA screening results. We performed two-third PH ...
Lagadec Matthieu M From the Laboratory of Physiological and Molecular Imaging of the Abdomen and Department of Radiology, DHU Unity, University Paris Diderot, Sorbonne Paris Cité, INSERM UMR 1149 Center of Research on Inflammation, Beaujon University Hospital, 100 Boulevard du Général Leclerc, 92110 Clichy, France (M.L., S.D., C.G., M.R., S.A.L., C.M.P., V.V., J.L.D., B.E.V.B.); Department of Hepatology, DHU Unity, University Paris Diderot, INSERM UMR 1149, Beaujon University Hospital, Clichy, France (M.F., R.M.); Department of Pathology, DHU Unity, University Paris Diderot, INSERM UMR 1149, Beaujon University Hospital, Clichy, France (V.P.); and Department of Medical Imaging, University Hospitals of Geneva, Geneva, Switzerland - - 2014
Purpose To compare the value of enhancement and pharmacokinetic parameters measured at dynamic gadoxetate-enhanced magnetic resonance (MR) imaging in determining hepatic organic anion transporter expression in control rats and rats with advanced liver fibrosis. Materials and Methods Institutional animal review board approval was received before the study began. Advanced liver ...
Zhang Qiuyang Q Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Mailbox 210, #24 Tongjiaxiang, Nanjing, 210009, Jiangsu, People's Republic of - - 2014
Multidrug resistance protein 2 (Mdr2), encoded by ATP-binding cassette b4 (Abcb4), serves as a phospholipid flippase that is indispensable for phosphatidylcholine translocation. However, little was known about the regulation of Mdr2 in Sprague-Dawley rats, although they are commonly used for pre-clinical investigation as well as mechanistic study. Present study aims ...
Li Bin B College of Food Science, Shenyang Agricultural University, 120 Dongling Road, Shenyang, 110866, People's Republic of - - 2014
Alcohol-induced oxidative stress plays a crucial role in the pathological development of alcoholic liver disease. The aim of this study was to investigate the effects of triterpenoid from Schisandra chinensis on oxidative stress in alcohol-induced liver injury in rats. We found that the administration of triterpenoid attenuated alcohol-induced oxidative stress ...
Solin A V AV Department of Pathophysiology, Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia, - - 2014
We compared changes in the liver structure in stress-resistant and stress-sensitive rats under conditions of chronic stress exposure. The number of degenerative cells, specific area of degenerative part of hepatocyte cytoplasm, and specific area of intralobular sinusoidal capillaries increased in animals of both groups. These parameters were significantly higher in ...
Li Ming M Department of Microecology, School of Basic Medical Science, Dalian Medical University, No. 9 Western Section, Lvshun South Street, Lvshunkou District, 116044, Dalian, - - 2014
To investigate the effects of orally administrated Saccharomyces boulardii (S. boulardii) on the progress of carbon tetrachloride (CCl4)-induced liver fibrosis, 34 male Wistar rats were randomly divided into four experimental groups including the control group (n = 8), the cirrhotic group (n = 10), the preventive group (n = 8), and the treatment group (n = 8). Results ...
Reyes-Esparza Jorge J Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca, - - 2014
The purpose of this research was to describe the pharmacokinetic parameters of β-hydroxyphosphocarnitine (β-HPC; CAS No. 1220955-20-3) after a single oral dose in rats and rabbits as well as to assess the impact of 14 weeks of β-HPC (100 mg/kg) treatment on the serum metabolites and liver enzymes, body weight, ...
Sadi Gokhan G Department of Biology, Faculty of Science, Karamanoglu Mehmetbey University, Karaman, - - 2014
The increased consumption of high-fructose corn syrup (HFCS) may contribute to the worldwide epidemic of fatty liver. In this study, we have investigated whether HFCS intake (20 % beverages) influences lipid synthesis and accumulation in conjunction with insulin receptor substrate-1/2 (IRS-1; IRS-2), endothelial nitric oxide synthase (eNOS), sirtuin 1 (SIRT1) and ...
Han Yuyan - - 2014
Background & Aims: Biliary hyperplasia and liver fibrosis are common features in cholestatic liver disease. Melatonin is synthesized by the pineal gland as well as the liver. Melatonin inhibits biliary hyperplasia of bile duct ligated (BDL) rats. Since melatonin synthesis (by the enzyme serotonin N-acetyltransferase, AANAT) from the pineal gland ...
Hung Wei-Lun WL Institute of Food Science and Technology, National Taiwan University, No.1, Section 4, Roosevelt Road, Taipei 10617, Taiwan. - - 2014
Garcinol, a polyisoprenylated benzophenone derivative, mainly isolated from Garcinia indica fruit rind, has been suggested to exhibit many biological benefits including antioxidative, anti-inflammatory, and anti-tumor activities. The aim of this study is to evaluate the protective effects of garcinol on dimethylnitrosamine (DMN)-induced liver fibrosis in rats. The administration of DMN ...
Zhang L L Department of Surgery, Organ Transplant Center, Shanghai Changzheng Hospital, Shanghai Second Military Medical University, Shanghai, China. - - 2014
Tacrolimus is a potent immunosuppressive agent mainly used for allogeneic solid organ transplantation. Although usage of tacrolimus led to a significant increase in short-term allograft survival, the long-term morbidity remains high. Endothelin-1 (ET-1) is reported to be associated with increased vascular resistance, CNI-induced nephrotoxicity and chronic rejection. In the present ...
Kim Myung-Joo MJ Department of Hotel Cuisine, Suseong College, Daegu, 706-022, Republic of - - 2014
This study investigated the effects of umbelliferone (UF) on alcoholic fatty liver and its underlying mechanism. Rats were fed a Lieber-DeCarli liquid diet with 36% of calories as alcohol with or without UF (0.05 g/L) for 8 weeks. Pair-fed rats received an isocaloric carbohydrate liquid diet. UF significantly reduced the severity ...
Li Gang G School of Life Science, Yantai University, Yantai, and the Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, China. E-mail. - - 2014
To investigate the protective effect of Herpetospermum pedunculosum (H. pedunculosum) seed oil against carbon tetrachloride (CCl4)-induced liver damage. This experimental study was conducted at the Northwest Institute of Plateau Biology, Chinese Academy of Sciences, and Yantai University, China from November 2012 to May 2013. The H. pedunculosum seed oil was ...
Zhu Dong D Dong Zhu, Hui Zhang, Hong-Yan Wang, Xin Li, You-Qing Xu, Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, - - 2014
To evaluate the role of the (13)C-methacetin breath test ((13)C-MBT) in the assessment of acute liver injury in a rat model. Acute liver injury in rats was induced by a single intraperitoneal injection of D-galactosamine (D-GalN). Forty-eight male Sprague-Dawley rats were randomly assigned to a control group (n = 8) ...
Hou Wei-Yu WY Key Lab for Pharmacology of Ministry of Education, Zunyi Medical College, Zunyi 563003, - - 2014
Organic anion-transporting polypeptides (Oatps) play important roles in transporting endogenous substances and xenobiotics into the liver and are implicated in drug-drug interactions. Many factors could influence their expression and result in alterations in drug disposition, efficacy and toxicity. This study was aimed to examine the development-, aging-, and sex-dependent Oatps ...
Subramanian Raju R Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, CA, 91320 - - 2014
The dysregulation of phosphatidylinositol 3-kinase (PI3K)-dependent pathways is implicated in several human cancers making it an attractive target for small molecule PI3K inhibitors. A series of potent pyridyltriazine-containing inhibitors of class Ia PI3Ks were synthesized and a subset of compounds was evaluated in exploratory repeat-dose rat toxicology studies. Daily oral ...
Lian Christine Guo CG Program in Dermatopathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, - - 2014
The level of 5-hydroxymethylcytosine (5-hmC) converted by ten-eleven translocation (TET) family is decreased in cancers. However, whether 5-hmC level is perturbed in early stages of carcinogenesis caused by genotoxic carcinogens is not defined. 5-hmC levels and TET2 expression were measured in liver of rats treated with genotoxic carcinogens, riddelliine, or ...
Jiang Weiwei W Department of Neonatal Surgery, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing, 210008, - - 2014
A critical role of the Toll-like receptor (TLR)-4 and its downstream mediators in the pathogenesis of small-for-size liver graft injury has been documented. Recently, the microRNA-146 (miR-146) was identified as a potent negative regulator of the TLR4 signaling pathway. In this study, the role of miR-146a and miR-146b in the ...
Kadioglu Teoman Cem - - 2014
Insufficient vas length for performing a tension-free vasovasostomy is a problem occasionally encountered by microsurgeons. Herein we evaluated utilization of a non-vascularized vas deferens autograft in a rat model. Segments of isolated vas deferens, 2.5 cm in length, were used as bilateral autografts in 15 rats. Each autograft was implanted ...
Brêtas Salomão S School of Medicine, Federal University of Minas Gerais, - - 2014
To determine whether tension in the spermatic cord of rats causes lesions in the testis, epididymis or vas deferens. Forty Wistar rats were randomly allocated into four groups. A traction force of 1.6 Newton (N) in group I and 1 N in group II was applied to the right spermatic ...
Atilgan Dogan D Department of Urology, Faculty of Medicine, Gaziosmanpasa University, Tokat 60100, - - 2014
The present study aimed to evaluate the effect of pomegranate juice (PJ) on oxidative stress (OS) and sperm concentration in a rat model of testicular torsion-detorsion. A total of 21 Wistar albino rats were randomly divided into three groups, each consisting of seven rats, as follows: i) control group, which ...
El-Beshbishy Hesham A HA Medical Laboratories Technology Department, Faculty of Applied Medical Sciences, Taibah University, Madinah, Saudi Arabia; Biochemistry Department, Al-Azhar University, Nasr City, Cairo 11751, Egypt. Electronic address: - - 2014
Bi-n-butyl phthalate (BNBP) is an environmental pollutant. The aim of this study was to evaluate the protective effect of lipoic acid (LA) against testicular dysfunction associated with the intake of to BNBP- intoxicated rats. Adult male Wistar rats were divided into 4 groups of 6 animals each, and received medication ...
Mor Firdevs F Mehmet Akif Ersoy University, Faculty of Veterinary, Department of Pharmacology and Toxicology, 15030 Burdur, Turkey. Electronic address: - - 2014
Ochratoxin A (OTA) causes pathological lesions in the organs of animals. Males are more sensitive to OTA exposure than females but the reasons for this are unknown. The objective of this study was to explore the role of testosterone in male rats with OTA-related pathogenesis. To test the effect of ...
Hu Linlin L Department of Pharmaceutical Analysis, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, - - 2014
G004 is a novel sulfonylurea hypoglycemic drug which aimed at reducing macro- and micro-vascular complications as well as controlling glucose excursion in type 2 diabetes mellitus. The pharmacokinetics of G004 in rats was sex- and dose-dependent over the dose range of 1-10 mg kg(-1). The mean AUC values in the female rats ...
Ribeiro Carina T CT (a)Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, - - 2014
We assessed reproductive and testicular function in adult rats after testicular torsion created before, during and after puberty, and with vs without resveratrol or arginine treatment. Age matched rats were divided into groups, including simulated surgery without testicular torsion, 720-degree testicular torsion for 4 hours, testicular torsion with resveratrol treatment and ...
Loi Barbara B Neuroscience Institute, National Research Council of Italy, Section of Cagliari, S.S. 554, km. 4,500, I-09042 Monserrato (CA), - - 2014
Sardinian alcohol-preferring (sP) rats have been selectively bred for high alcohol preference and consumption. When exposed to the standard, home cage 2-bottle "alcohol (10%, v/v) vs. water" choice regimen with continuous access, male sP rats consume daily approximately 6 g/kg alcohol. Conversely, when exposed to the intermittent (once every other day) ...
Meerts Sarah H SH Department of Psychology, Carleton College, Northfield, MN 55057. Electronic address: - - 2014
The present study tested whether the display of paced mating behavior in female rats over four weekly tests is affected by sexual experience and whether test parameters, i.e., ending the test based on time or number of stimulations received, influence behavioral changes. In Experiment 1A rats with nonpaced sexual experience ...
Beaufrère A M AM Dominique Meynial-Denis (PhD), Human Nutrition Unit, INRA and Human Nutrition Research Center, Theix 63122 - St Genes Champanelle, France. Phone: +33 (0)4 73 62 43 13; Fax: +33 (0)4 73 62 47 55; E-mail address: - - 2014
Glutamine is the preferred fuel for the rat small intestine and promotes the growth of intestinal mucosa, especially in the event of gut injury. Quantitatively, glutamine is one important precursor for intestinal citrulline release. The aim of this study was to determine whether the effect of glutamine on the increase ...
He Wei W Department of Gastroenterology, the Third Affiliated Hospital of Soochow - - 2014
Autophagy is involved in the activation of hepatic stellate cells (HSCs), which is the key process of liver fibrosis. We reasoned that chloroquine, based on its ability to inhibit autophagy, might exert beneficial effects in liver fibrosis. Liver fibrosis in rats was induced by carbon tetrachloride (CCl4). Rats were divided ...
Gunay Yusuf Y Department of Surgery, Atakent Hospital, Acibadem University, Halkali, 34678 Istanbul, - - 2014
Introduction. The role of chronic cholestasis (CC) in liver injury and fibrosis remains unclear. The aims of this study were to define the role of endothelial nitric oxide synthase (e-NOS) in CC and the protective effect of N-acetyl-L-cysteine (NAC) in liver and kidney injury. Materials and Methods. Group A (sham ...
Atta Hussein H Department of Surgery, Faculty of Medicine, Minia University, El-Minia, - - 2014
Hepatocyte growth factor (HGF) gene transfer inhibits liver fibrosis by regulating aberrant cellular functions, while mutant matrix metalloproteinase-9 (mMMP-9) enhances matrix degradation by neutralizing the elevated tissue inhibitor of metalloproteinase-1 (TIMP-1). It was shown that ASH1 and EZH2 methyltransferases are involved in development of liver fibrosis; however, their role in ...
Abdul-Majeed Shakila S Center for Hypertension and Personalized Medicine, Program in Physiological Genomics, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, United States of - - 2014
A Disintegrin And Metalloproteinase with ThromboSpondin motifs16 (ADAMTS-16) is a member of a family of metalloproteinases. Using a novel zinc-finger nuclease based gene-edited rat model harboring a targeted mutation of the Adamts16 locus, we previously reported this gene to be linked to blood pressure regulation. Here we document our observation ...
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