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Mascena Guilherme Veras GV Health Sciences Center, Federal University of Pernambuco, Campina Grande, PB, - - 2014
To evaluate the treatment outcome of severe peritonitis in rats with increasing age. Thirty Wistar rats stratified in three groups: group I - six month-old; group II - 12 month-old; and group III - 18 month-old, underwent autogenously fecal peritonitis (6 ml/kg rat), and were treated with intravenous meropenem. The ...
Fert Ingrid I Université Paris-Descartes, Sorbonne Paris Cité, Laboratoire d'Excellence Inflamex, Institut Cochin, and INSERM U1016, CNRS (UMR 8104), Paris, - - 2014
In HLA-B27-transgenic rats, the development of a disorder that mimics spondyloarthritis (SpA) is highly correlated with dendritic cell (DC) dysfunction. The present study was undertaken to analyze the underlying mechanisms of this via transcriptome analysis. Transcriptome analysis of ex vivo-purified splenic CD103+CD4+ DCs from B27-transgenic rats and control rats was ...
He Fen F State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China; Department of Radiation Oncology, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of - - 2014
Patients received cranial-irradiation can be affected with cognitive deficits and decreasing hippocampal neurogenesis. In this work, we characterized the cognitive ability and immune-induced neurogenesis of the pre- and post-treated cranial-irradiated rats with Glatiramer acetate (GA), known as a weak CNS auto-antigen. The GA-treated rats displayed better cognitive abilities in Morris ...
Fert Ingrid I Université Paris-Descartes Institut Cochin, INSERM U1016, CNRS UMR8104, 75014, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Laboratoire d'Excellence Inflamex, 75014, Paris, - - 2013
Objective: In rats transgenic for HLA-B27 (B27 rat), the development of a disorder mimicking spondyloarthritis (SpA) is tightly correlated with DCs dysfunction. To dissect the underlying mechanisms, we studied the transcriptome of ex vivo purified CD103(+) CD4(+) DCs. Methods: Transcriptome analysis was performed on splenic CD103(+) CD4(+) DCs from B27 ...
Kılıç Kaya K Istanbul Training and Research Hospital, Department of Neurosurgery, Samatya, - - 2013
The aim of this study is to reveal inhibitory effect of gamma knife irradiation on angiogenesis of meningiomas using rat corneal angiogenesis assay. A total of 72 rats were divided into three preliminary groups. Each group, consisting of 24 rats, was implanted to World Health Organization (WHO) grade I (typical), ...
Tang Jiayu - - 2013
Astilbin, a natural flavonoid, has been shown to have a selective immunosuppressive activity on activated T lymphocytes. In our previous study, 3'-O-methylastilbin was identified as an active metabolite in vivo. However, more comprehensive information regarding the kinetics and metabolic characteristics of astilbin is yet unknown. Here, we isolated and identified ...
Nagai Noriaki - - 2013
Recent findings have implicated the involvement of interferon-γ (IFN-γ), a part of the Th1 cytokine response, in the retinal inflammation of diabetic patients. In the present study, we investigate whether hyperglycemia relates to the expression of interleukin 18 (IL-18), and leads to the production of IFN-γ in the retinas of ...
Schmilovitz-Weiss Hemda - - 2013
Genetic factors implicated in the pathogenesis of non-alcoholic fatty liver disease are poorly understood. Our aim was to characterize three genes involved in a rat model of non-alcoholic fatty liver disease and investigate the effect of rosiglitazone and bezafibrate. Five rats were fed a chow diet (controls) and 18 a ...
Sridharan Vijayalakshmi - - 2012
Radiotherapy of intrathoracic and chest wall tumors may lead to exposure of the heart to ionizing radiation, resulting in radiation-induced heart diseases (RIHD). The main manifestations of RIHD become apparent many years after treatment and include cardiomyopathy and accelerated atherosclerosis. This study examines the role of the kallikrein-kinin system (KKS) ...
Mansour Heba H HH Health Radiation Research Department, National Centre for Radiation Research and Technology, Atomic Energy Authority, P.O. Box 29, Nasr City, Cairo, Egypt. - - 2012
The study is designed to determine the therapeutic effect of caffeic acid phenethyl ester (CAPE) in minimizing radiation-induced injuries in rats. Rats were exposed to 7Gy gamma radiation, 30min later rats were injected with CAPE (10μmol/kg body, i.p.) for 7 consecutive days. Rats were sacrificed at 8 and 15 days ...
Gu Bingjie - - 2012
Sinomenine is a bioactive alkaloid isolated from the Chinese medicinal plant Sinomenium acutum. It is widely used as an immunosuppressive drug for treating rheumatic and arthritic diseases. In our previous studies, we found that sinomenine reduced cellular infiltration within the spinal cord and alleviated experimental autoimmune encephalomyelitis (EAE) in rats. ...
Tomášová L - - 2012
Prenatal irradiation is known to have aversive effects on the brain development, manifested in changes in some behavioural parameters in adult individuals. The aim of our work was to assess the effect of prenatal irradiation on different forms of behaviour and on hippocampal neurogenesis in rats. Pregnant female rats were ...
Lo Hui-Chen - - 2012
Diabetes mellitus (DM) is characterized by systemic low-grade inflammation and altered immunity. The fruiting bodies (FB) of Tremella mesenterica have been demonstrated to have anti-hyperglycemic and immunomodulatory activities. It is unclear whether submerged culture yeast-like cells (CC) of T. mesenterica have the same immune effects as FB. Here, we compared ...
Doi Hiroshi - - 2012
The purpose of the present study was to establish an experimental rat model for late radiation proctitis, and to examine the assessment strategy for late radiation proctitis. A total of 57 Wistar rats were used. Fourty-five of the rats were exposed to selective rectal irradiation with a single fraction of ...
El-Shafei M D M - - 2011
This study aimed to illustrate the histological picture of the developing rat prostate and to localise the oestrogen receptors (ERs) distribution. Fifty male albino rats were divided into five equal subgroups: subgroup 1, rats aged 2 days (before morphogenesis of prostate from urogenital sinus); subgroup 2, rats aged 1 week ...
Oloyo A K - - 2011
The effect of sex hormones on vascular reactivity is considered one of the underlying factors contributing to gender differences in cardiovascular functions and diseases. Experiments were designed to investigate the role of androgens in salt-induced hypertension by assessing the relaxation response of isolated aortic rings to acetylcholine and sodium nitroprusside ...
Takeshita Kentaro - - 2011
Epidemiological data on the relationship between hypertension and prostate cancer development are conflicting. To cast light on this question, we performed animal experiments using hybrid rats generated by crossing the spontaneously hypertensive rat (SHR) or its normotensive control Wistar Kyoto (WKY) rat with a transgenic rat for adenocarcinoma of prostate ...
Zuloaga Damian G - - 2011
Perinatal exposure to testosterone (T), which can act upon both the androgen receptor (AR) and, via aromatization of T into estrogens, upon estrogen receptors, organizes many adult behaviors in rodents. We compared behaviors in wild-type (WT) male rats and AR-deficient rats with the testicular feminization mutation (Tfm), which on the ...
Yang Xinming - - 2011
This trial explores (i) prenatally androgenized (PNA) rats as a model of polycystic ovary syndrome (PCOS) and (ii) reproductive and metabolic effects of cryptotanshinone in PNA ovaries. On days 16-18 of pregnancy, 10 rats were injected with testosterone propionate (PNA mothers) and 10 with sesame oil (control mothers). At age ...
Zhang Min-Guang - - 2010
OBJECTIVE Androgen is essential for physiological erection. Vasoactive intestinal polypeptide (VIP) is an important erectile neurotransmitter. While previous studies demonstrated that VIP expression in the penis was androgen-independent, it remains controversial whether androgen has any effect on VIP-mediated erection. The present study aims to investigate the regulatory role of androgen ...
Mizota Atsushi - - 2010
To compare the effects of carbon beam irradiation with those of proton beam irradiation on the physiology of the retina of rats. Eight-week-old Wister rats were used. The right eyes were irradiated with carbon beam (1, 2, 4, 8, and 16 Gy) or proton beam (4, 8, 16, and 24 ...
Dynlacht Joseph R - - 2010
Abstract Astronauts participating in extended lunar missions or the projected mission to Mars would likely be exposed to significant doses of high-linear energy transfer (LET) heavy energetic charged (HZE) particles. Exposure to even relatively low doses of such space radiation may result in a reduced latent period for and an ...
Ferreira-Machado Samara Cristina - - 2010
PURPOSE: To investigate changes in cardiac functional parameters and the cardiac expression of angiotensin-converting enzyme (ACE), angiotensin II type 1 receptor (AT1), procollagen type I (proc-I) and transforming growth factor-ß1 (TGF-ß1) in rats irradiated at heart. MATERIAL AND METHODS: Male Wistar rats were irradiated with a single dose of radiation ...
Bogojević Desanka - - 2011
Previously, we showed that administration of the acute-phase protein α(2)-macroglobulin (α(2)M) to rats before total-body irradiation with 6.7 Gy (LD(50/30)) of X-rays provides the same level of radioprotection as amifostine. Here, we compare the cytoprotective effects of α(2)M and amifostine on rat liver. The potential of the liver to replenish cells ...
Mirjana Mihailović - - 2010
Previously we reported that elevated circulating concentrations of the acute-phase (AP) protein α(2)-macroglobulin (α(2)M), either as typically occurring in pregnant female rats or after administration to male rats, provides radioprotection, displayed as 100% survival of experimental animals exposed to total-body irradiation with 6.7 Gy (LD(50/30)) x-rays, that is as effective as ...
Löfgren Stefan - - 2012
Purpose:  To investigate if the previously shown difference in in vivo-induced ultraviolet B radiation (UVR-B) cataractogenesis between pigmented and albino rats can be seen also with in vitro irradiation. The shielding effect of the iris and UVR absorption in the anterior segment is nullified, and inherent differences in lenticular UVR-B ...
Assayed Mohamed E - - 2010
BACKGROUND AND AIM: Sixty male Wistar rats, divided into 4 groups, 15 each, were designed as I-control rats, II-rats orally intubated with Nigella sativa oil (1 ml/kg b.wt./day) for 5 days/week, III-whole body gamma irradiated rats with the estimated LD50/30 (4 Gray) and IV-rats daily intubated with Nigella sativa oil ...
Friedrich Reinhard E - - 2010
External irradiation of advanced head and neck cancer often includes the major salivary glands, despite them not being affected by the disease. The aim of this study was to determine neuron-specific enolase (NSE) as a marker of inflammation in irradiated and non-irradiated salivary glands of the rat. This study shows ...
Kanter Mehmet - - 2010
We evaluated the effects of L-carnitine on apoptosis of germ cells in the rat testis following irradiation. Male Wistar rats were divided into three groups. Control group received sham irradiation plus physiological saline. Radiotherapy group received scrotal gamma-irradiation of 10 Gy as a single dose plus physiological saline. Radiotherapy + ...
Aunapuu Marina - - 2010
Cell proliferation and apoptosis in the remnant rat kidney after treatment with low-dose irradiation was investigated. MATERIAL AND METHODS: In the first group (n=9), adult male Wistar rats underwent 5/6 nephrectomy (NPX); in the second group (n=9), NPX was combined with low-dose irradiation. Rats without surgery and irradiation formed the ...
Marcelin Béatrice - - 2010
BACKGROUND: Gamma knife surgery (GKS) is used at subnecrotic doses for temporal lobe epilepsy (TLE) treatment. Rat models of TLE have been used to probe the mechanisms underlying GKS. Previous GKS studies on rats have used the Leksell GammaPlan (LGP) treatment planning system to determine the irradiation time to achieve ...
Tokalov Sergey V - - 2010
Human tumour xenografts in a nude rat model have consistently been used as an essential part of preclinical studies for anticancer drugs activity in human. Commonly, these animals receive whole body irradiation to assure immunosuppression. But whole body dose delivery might be inhomogeneous and the resulting incomplete bone marrow depletion ...
Du Shi-Suo - - 2009
PURPOSE: To investigate the regenerative capacity and proliferation related to cell cycle modulators in irradiated livers after partial hepatectomy (PH) in rats. METHODS AND MATERIALS: Two experimental groups were given a single dose of either 4-Gy or 8-Gy photon radiation to the whole liver following PH. The control group underwent ...
Fatemi F - - 2010
Irradiation is an important method of processing herbal drugs, while our understanding of the effects of gamma-irradiation on pharmacological properties of seed products such as caraway essential oils is however still very limited. In this study, caraway seeds were irradiated at dose levels of 0, 10 and 25kGy. After extracting ...
Mihailović Mirjana - - 2009
BACKGROUND: Administration of the acute-phase protein alpha2-macroglobulin (MG) prior to total-body irradiation of rats with a 6.7 Gy (LD50) dose of X-rays exerts a radioprotective effect. MATERIAL/METHODS: MG was administered 30 min before irradiation with a 6.7 Gy (LD50) dose of X-rays. Its radioprotective efficacy was compared with that of ...
Mihailović Mirjana - - 2009
The importance of alpha2-macroglobulin (alpha2M) in natural radioprotection was studied by examining its radioprotective effectiveness in rat models of exogenously and endogenously, preexposure-increased alpha2M. Radioprotective efficacy was ascertained by the postirradiation survival rate, the restoration of body weight, and the leukocyte count, which were monitored during a 4-week follow-up period. ...
Zong Zhao-Wen - - 2009
Our previous study indicated that systemically transplanted dermal multipotent cells (DMCs) were recruited more frequently to bone morrow (BM) of rats with sublethal irradiation than that of normal rats, and the interactions between stromal-derived factor (SDF-1) and its receptor (CXC chemokine receptor 4, CXCR4) played an important role in this ...
van der Wielen Gerard J - - 2009
INTRODUCTION: External beam radiotherapy for prostate cancer leads to erectile dysfunction in 36%-43% of patients. The underlying mechanism is largely unknown, although some clinical studies suggest that the arterial supply to the corpora cavernosa is responsible. Two animal experimental studies reported on the effects of a single fraction of prostate ...
Zhao Jian Dong - - 2009
Liver has a strong potential for regeneration after physical, biological or chemical injury, but no data have been reported so far on liver regeneration in response to irradiation injury. The present experiment in rats was designed to clarify whether partial liver irradiation could induce and stimulate the unirradiated part of ...
Robello Elizabeth - - 2009
This study was aimed to assess the content of total Fe, Ferritin (Ft) and labile Fe pool (LIP) in developing rat brain exposed in utero to 1 Gy of gamma-irradiation. A significant increase (2.3-fold) in the total Fe content of the fetal rat brain irradiated in utero was observed from ...
Rousseau Julia - - 2009
To evaluate the efficacy of prolonged intracerebral (i.c.) administration of carboplatin by means of ALZET osmotic pumps, in combination with radiotherapy for the treatment of intracranial F98 glioma in rats. Seven days after stereotactic implantation of F98 glioma cells into the brains of Fischer rats, carboplatin was administrated i.c. by ...
Wan Ibrahim Wan Aini - - 2009
A CD-modified micellar EKC (CD-MEKC) method with 2-hydroxypropyl-gamma-CD (HP-gamma-CD) as chiral selector for the enantioseparation of three chiral triazole fungicides, namely hexaconazole, penconazole, and myclobutanil, is reported for the first time. Simultaneous enantioseparation of the three triazole fungicides was successfully achieved using a CD-MEKC system containing 40 mM HP-gamma-CD and ...
Kilciksiz Sevil - - 2008
Our study aimed to investigate the potential radioprotective effects of N-acetylcysteine (NAC) by comparing its biochemical effects with those of WR-2721, as a representative of clinically used radioprotectors, in preventing oxidative damage caused by gamma irradiation (single dose, 6Gy) in normal rat tissue. The rats (n=40) were divided randomly and ...
Asari Tetsuya - - 2009
1. Using rats, we examined the muscarinic receptor subtype mediating pilocarpine-induced parotid salivary secretion and the contributions of ion transporter systems (effluxes of K+ and Cl(-)) and aquaporin-5 (AQP5) translocation to this response in parotid glands in irradiated-induced xerostomia. 2. Salivary secretion was significantly lower in irradiated compared with sham-irradiated ...
Hernández María - - 2008
The aim of the present study is to evaluate the neuroprotective effect of two antiglaucomatous substances, regardless of their hypotensive effect in the eye. Brimonidine, which does not reduce IOP when administered intraperitoneally, and latanoprost, which has a renowned hypotensive effect topically. We examined rat retinal ganglion cell (RGC) survival ...
Moriconi Federico - - 2008
The aim of the study was to analyze the effect of a single irradiation on chemokine gene expression in the rat liver and in isolated rat hepatocytes. RNA extracted from livers and from hepatocytes within the first 48 h after irradiation was analyzed by real-time PCR and the Northern blot ...
Iwata Yasuhide - - 2008
BACKGROUND: Epidemiological studies suggest that radiation exposure may be a potential risk factor for schizophrenia in adult humans. Here, we investigated whether adult irradiation in rats caused behavioral abnormalities relevant to schizophrenia. METHODOLOGY/PRINCIPAL FINDINGS: A total dose of 15-Gy irradiation in six fractionations during 3 weeks was exposed to the ...
Peters Gjalt-Jorn Ygram - - 2008
Ecstasy (MDMA, 3, 4-methylenodioxymethamphetamine) use is widespread in the Netherlands, with a lifetime prevalence of 4.3%, and two-thirds of dance party visitors being ecstasy users. However, research into Dutch ecstasy use patterns is lacking. In addition, recent studies suggest that ecstasy users cease their use automatically, which implies that interventions ...
Atwood Todd - - 2007
PURPOSE: To investigate if in vivo localized proton magnetic resonance spectroscopy (MRS) can detect putative metabolic changes in the irradiated rat brain and quantitatively measure brain metabolite changes in this model. MATERIALS AND METHODS: A total of 20 adult male Fischer 344 rats were exposed to a fractionated regimen of ...
Rousseau Julia - - 2007
The goal of the present study was to evaluate the efficacy of intracerebral (i.c.) administration of carboplatin by means of convection-enhanced delivery (CED) in combination with fractionated, external beam photon irradiation for the treatment of F98 glioma-bearing rats. Carboplatin (20 microg/20 microL) was administrated i.c. by CED to F98 glioma-bearing ...
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