Search Results
Results 1 - 50 of 925
1 2 3 4 5 6 7 8 9 10 >
Wang Qiong Q Department of Psychology, Peking University, Beijing, 100871, - - 2014
Early postnatal maternal separation (MS) can play an important role in the development of psychopathologies during ontogeny. In the present study, we investigated the effects of repeated MS (4h per day from postnatal day (PND) 1-21) on locomotor activity and anxiety behavior in open field, spatial learning and reversal learning ...
Rubio-Ruiz María Esther ME Departments of Physiology, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico City, - - 2014
Aim:Metabolic syndrome (MS) and aging are low-grade systemic inflammatory conditions, and inflammation is a key component of endothelial dysfunction. The aim of this study was to investigate the effects of non-steroidal anti-inflammatory drugs (NSAIDs) upon the vascular reactivity in aging MS rats.Methods:MS was induced in young male rats by adding ...
Karim Md Robiul MR College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, - - 2014
Enteric protozoa are frequently found in snakes. Nevertheless, few studies regarding genetic characterization of these parasites have been carried out. We describe here the first molecular survey of protozoan pathogens from snakes in China and the first report on Enterocytozoon bieneusi genotyping in snakes in the world. Here, 240 fecal ...
Chinchilla Misael M Research Department, Universidad de Ciencias Médicas (UCIMED), San José, Costa - - 2014
We collected faecal samples from 24 dusky rice rats, Melanomys caliginosus (Tomes) (Rodentia: Cricetidae: Sigmodontinae), in a Biological Reserve in Costa Rica, and found three (12.5%) to be infected with a species of Eimeria Schneider, 1875, which we describe here as new. Sporulated oöcysts of Eimeria caliginosa n. sp. are ...
Curtis Alan D AD 2nd Department of Microbiology and Immunology, East Carolina University Brody School of Medicine, Greenville, NC, United States of America; The Harriet and John Wooten Laboratory for Alzheimer's and Neurodegenerative Disease Research, East Carolina University Brody School of Medicine, Greenville, NC, United States of - - 2014
Atypical models of experimental autoimmune encephalomyelitis (EAE) are advantageous in that the heterogeneity of clinical signs appears more reflective of those in multiple sclerosis (MS). Conversely, models of classical EAE feature stereotypic progression of an ascending flaccid paralysis that is not a characteristic of MS. The study of atypical EAE ...
Fukasawa Keita - - 2013
Invasive species and anthropogenic habitat alteration are major drivers of biodiversity loss. When multiple invasive species occupy different trophic levels, removing an invasive predator might cause unexpected outcomes owing to complex interactions among native and non-native prey. Moreover, external factors such as habitat alteration and resource availability can affect such ...
Archer Elizabeth K - - 2013
Abstract The members of the African mole-rat family (Bathyergidae) are widely distributed across sub-Saharan Africa. Despite their well-studied biology and reproductive physiology the current knowledge of their ectoparasite fauna is limited and ambiguous due to recent revisions of the bathyergid taxonomy. The common mole-rat (Cryptomys hottentotus hottentotus) is 1 of ...
Mowlavi Gholamreza G Dept. of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran ; Center for Research of Endemic Parasites of Iran (CREPI), Tehran University of Medical Sciences, Tehran, - - 2013
Rats are capable to harbor various pathogens, among which certain species of zoonotic parasites are included. A long-term detection of parasite fauna of rats has sporadically been carried out in Iran. Abundance of these vertebrate pests is of great importance as regards public health issue. The present paper is focused ...
Teem John L - - 2013
Nonindigenous apple snails, Pomacea maculata (formerly Pomacea insularum), are currently spreading rapidly through the southeastern United States. This mollusk serves as an intermediate host of the rat lungworm parasite (Angiostrongylus cantonensis), which can cause eosinophilic meningitis in humans who consume infected mollusks. A PCR-based detection assay was used to test ...
Al Hindi Adnan Ibrahim - - 2013
This study identified the zoonotic endo-parasites and ecto-parasites of Rattus rattus. A total of 41 rats of house (black) rat and Norway (brown) rat were trapped from two regions of Gaza strip. After dissection, isolated protozoa, nematodes and cestodes were identified respectively according standard keys. The results showed that prevalence ...
Czeczot H - - 2013
The aim of the present study was to determine antioxidant defence mechanisms in the rat and Hymenolepis diminuta after long-term infestation. We determined levels of oxidative stress markers, and activity of antioxidant enzymes in the rat small intestine and in particular parts of H. diminuta. Observed changes in antioxidant enzymes ...
Siti Shafiyyah C O - - 2012
A survey was undertaken to investigate the prevalence of intestinal and blood parasites among wild rats in urban area of Kuala Lumpur, Malaysia. A total of 137 stool and blood samples were collected from wild rats from Sentul and Chow Kit areas. Five species of rats were captured and supplied ...
Stockert Jc - - 2012
In standard histological technique, aromatic solvents such as xylene and toluene are used as clearing agents between ethanol dehydration and paraffin embedding. In addition, these solvents are used for de-waxing paraffin sections. Unfortunately, these solvents are harmful and therefore adequate substitutes would be useful. We suggest the use of n-heptane ...
Bell Richard L RL Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA. - - 2012
The purpose of this review paper is to present evidence that rat animal models of alcoholism provide an ideal platform for developing and screening medications that target alcohol abuse and dependence. The focus is on the 5 oldest international rat lines that have been selectively bred for a high alcohol-consumption ...
Zhou Yan Y Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10065, USA. - - 2013
Evidence obtained in humans and rodents indicates that beta-endorphin (encoded by the proopiomelanocortin [POMC] gene) is critical in the regulation of alcohol drinking behavior. However, the alcohol effect on POMC gene expression has not been studied in rodent mesolimbic regions, such as the nucleus accumbens (NAc). In this study, we ...
MaƂkowska Anna - - 2012
Background: This study investigated the relationship between ethanol intake in rats and the resulting level of ethyl glucuronide (EtG) in rat hair. Methods: Rats (n = 50) consumed a 10% ethanol solution for 4 weeks, then EtG was extracted from samples of their hair using a novel extraction procedure involving ...
Maccioni Paola - - 2012
Administration of the GABA(B) receptor agonist, baclofen, and positive allosteric modulator, GS39783, has been repeatedly reported to suppress multiple alcohol-related behaviors, including operant oral alcohol self-administration, in rats. This study was designed to compare the effect of baclofen and GS39783 on alcohol self-administration in 3 lines of selectively bred, alcohol-preferring ...
Derdak Zoltan - - 2012
BACKGROUND: Previous studies demonstrated that the Long-Evans (LE) rats exhibited liver injury and lipid metabolic abnormalities after 8 weeks of ethanol feeding. AIMS: The goal of this study was to investigate if the LE rats develop more advanced hepatic abnormalities (e.g., fibrosis) after long-term feeding with an ethanol-containing Lieber-DeCarli diet. In ...
Jarosz Andrew F - - 2012
That alcohol provides a benefit to creative processes has long been assumed by popular culture, but to date has not been tested. The current experiment tested the effects of moderate alcohol intoxication on a common creative problem solving task, the Remote Associates Test (RAT). Individuals were brought to a blood ...
Murawski N J NJ University of Delaware, Department of Psychology, Newark, DE, USA. - - 2012
Rats exposed to a high binge-like dose of alcohol over postnatal days (PD) 4-9 show reductions in CA1 pyramidal cells and impairments on behavioral tasks that depend on the hippocampus. We first examined hippocampal c-Fos expression as a marker of neuronal activity in normally developing rats following different phases of ...
Hu Cheng-Mu - - 2012
Alcoholic fatty liver (AFL) is a reversible condition, but it can potentiate the development of alcoholic hepatitis and even cirrhosis by increasing oxidant generation, which is one of the key pathogenic factors and could result in alcoholic liver disease (ALD). Total flavonoids from Litsea coreana (TFLC), an active component extracted ...
Loche Antonella - - 2012
N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide (GET73) is a newly synthesized compound structurally related to the clinically used, alcohol-substituting agent, gamma-hydroxybutyric acid (GHB). The present study was designed to assess whether GET73 may share with GHB the capacity to reduce alcohol intake in rats. Additionally, the effect of treatment with GET73 on anxiety-related behaviors and ...
Crespi Francesco - - 2011
Melatonin, an indoleamine hormone synthesized in the pinealocytes, has been implicated as influencing the intake of alcohol in rats. It has been shown that this hormone is voltammetrically electroactive at the surface of pretreated carbon fiber microelectrodes in vitro and in vivo, in rat cerebral melatonergic regions such the pineal ...
Zhang Yue-Hui - - 2011
The expression of CHOP (C/EBP homologous protein), an apoptosis regulated gene, increases during endoplasmic reticulum (ER) stress induced by cyclic stretch and leads to rat AF cells apoptosis. However, whether the suppression of CHOP can inhibit apoptosis and attenuates disc degeneration by cyclic stretch remains unclear. The aim of this ...
Hossain Shahdat - - 2011
The in vitro oxidative stress induced by ethanol/Fenton's reaction in rat liver homogenates decreased significantly in the presence of Syzygium cumini seed extract, suggesting the protective effect of the seed extract against the oxidative stress in liver. To corroborate the in vitro effects by an in vivo experiment, 24 rats ...
Fernando Harshica H Department of Pathology, The University of Texas Medical Branch, Galveston, Texas 77030, - - 2010
 Hepatic steatosis (fatty liver), an early and reversible stage of alcoholic liver disease, is characterized by triglyceride deposition in hepatocytes, which can advance to steatohepatitis, fibrosis, cirrhosis, and ultimately to hepatocellular carcinoma. In the present work, we studied altered plasma and hepatic lipid metabolome (lipidome) to understand the mechanisms and ...
Loi Barbara - - 2010
This study assessed in Sardinian alcohol-preferring (sP) rats a procedure known to promote alcohol drinking and based on the intermittent (once every other day) access to 2 bottles containing alcohol (20%, v/v) and water, respectively (Wise, 1973). To this end, sP rats were exposed - under the 2-bottle choice regimen ...
Derdak Zoltan Z Division of Gastroenterology and Liver Research Center, Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, RI 02903, USA. - - 2011
Chronic ethanol consumption in the Long-Evans (LE) rat has been associated with hepatic p53 activation, and inhibition of the insulin/PI3K/AKT signal transduction cascade due to increased expression of PTEN. We hypothesize that p53 activation and altered insulin signaling may influence the susceptibility of rats to ethanol-induced liver damage. Furthermore, p53 ...
Froehlich J C - - 2010
The use of selective breeding to produce animal models for the study of alcohol abuse and alcoholism represents one of the major advances in the field of alcohol research. Rats selectively bred for alcohol preference and alcohol nonpreference have been useful to both preclinical and clinical investigators in the alcohol ...
Criado José R - - 2010
The selectively bred alcohol-preferring (P) and -nonpreferring (NP) lines were developed from Wistar rats to model high and low voluntary alcohol consumption and have been demonstrated to exhibit many of the characteristics of human alcohol dependence. Electrophysiologic studies have shown P rats exhibit more electroencephalographic fast frequency activity and reduced ...
Rajagopalan Rukkumani - - 2010
Liver fibrosis is one of the major health problems worldwide. Chronic alcohol abuse is one of the main causes of fibrosis. Ingestion of polyunsaturated fatty acids (PUFA) along with alcohol further aggravates the toxicity of alcohol. Fibrosis results due to increased deposition of extra cellular matrix (ECM). The degree of ...
Pohorecky Larissa A - - 2010
Psychosocial stressors are known to alter ingestion of ethanol in humans and experimental animals. We evaluated the effect of novel acute stressors on ethanol ingestion of male triad-housed rats. Based on behavioral and body weight assessments triad members were designated as dominant, subdominant or subordinate rats, housed in triads designated ...
Shinohara Masao M University of Southern California Research Center for Liver Disease, USC/University of California Los Angeles Research Center for Alcoholic Liver and Pancreas Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, - - 2010
Chronic ethanol infusion resulted in greater serum alanine aminotransferase elevation, lipid accumulation, necroinflammation, and focal hepatic cell death in mice than rats. Mice exhibited a remarkable hyperhomocysteinemia but no increase was seen in rats. Similarly, a high-methionine low-folate diet (HMLF) induced less steatosis, serum alanine aminotransferase increase, and hyperhomocysteinemia in ...
Denucci Sarah M SM Departments of Medicine and Pathology, Liver Research Center, Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Pierre Galletti Research Building, 55 Claverick Street, Room 421, Providence, RI 02903, - - 2010
The finding of more severe steatohepatitis in alcohol fed Long Evans (LE) compared with Sprague Dawley (SD) and Fisher 344 (FS) rats prompted us to determine whether host factors related to alcohol metabolism, inflammation, and insulin/IGF signaling predict proneness to alcohol-mediated liver injury. Adult FS, SD, and LE rats were ...
Ostlund Sean B - - 2010
We assessed whether the presence of contextual cues paired with alcohol would disrupt rats' capacity to express appropriate goal-directed action control. Rats were first given differential context conditioning such that one set of contextual cues was paired with the injection of ethanol and a second, distinctive set of cues was ...
Ghimire S R - - 2009
Consumption of alcohol during pregnancy results in fetal alcohol syndrome (FAS) in newborn affecting the central nervous system which is more sensitive to deleterious effect of alcohol. This study was conducted to observe the histological alterations in cerebellum of rat pups born to alcohol consuming mother rats. Virgin female albino ...
Valls-Belles Victoria - - 2010
BACKGROUND: There is increasing evidence indicating that the dietary intake of food with high antioxidant capacity may protect mitochondria from damage and exert positive effects on different pathogenic processes. AIM OF THE STUDY: The present study was designed to evaluate the possible protective effect of alcohol-free beer intake on chain ...
Yokoyama Hirokazu - - 2010
BACKGROUND: We previously reported that an NAD-dependent in situ retinoic acid supply system, which comprises some isoforms of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) and provides retinoic acid from retinol via a 2-step oxidation process, exists in the rat esophagus. Herein, their isoforms responsible for the pathway and its ...
Souza Daniela Martins de - - 2009
This study aimed at morphometrically evaluating the influence of variable caloric values of ethanol consumption on alveolar bone loss in periodontitis in male rats. Thirty-six male rats were randomized into four groups of nine rats each, as follows: Test group A (low) - rats were fed an ethanol-containing liquid diet ...
Engleman Eric A EA Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indiana University-Purdue University at Indianapolis, 791 Union Drive, Indianapolis, IN 46202-4887, USA. - - 2009
A previous study indicated that selectively bred alcohol-preferring (P) rats self-administered ethanol (EtOH) directly into the posterior ventral tegmental area at lower concentrations than Wistar rats. The present study was undertaken to determine involvement of the nucleus accumbens (Acb) with EtOH reinforcement, and a relationship between genetic selection for high ...
Mutlu Ece - - 2009
Clinical and animal data indicate that gut-derived endotoxin and other luminal bacterial products are necessary cofactors for development of alcoholic liver disease (ALD). Although gut leakiness is clearly an important cause of endotoxemia in ALD, it cannot fully explain endotoxemia in all ALD subjects and thus other factors may be ...
Souza Daniela Martins de - - 2009
Alcohol consumption is a risk indicator for periodontal disease. The purpose of this study was to morphometrically evaluate the influence of alcohol consumption on alveolar bone level associated with ligature-induced periodontitis in rats. Thirty-six female rats (Wistar, 120 days-old) were randomly divided into three groups that received a daily administration ...
Nakamoto Kazuo - - 2009
Oxidative stress is frequently considered as a central mechanism of hepatocellular injury in non-alcoholic steatohepatitis (NASH). The aim of this study was to investigate the effects of fermented green tea extracts (FGTE) on NASH. Rats were fed a choline-deficient high-fat diet for 4 weeks to nutritionally generate fatty livers. NASH ...
Yin Hu-Quan - - 2009
The generally accepted hypothesis for the pathogenesis of alcoholic liver disease (ALD) is the two-hit model, which proposes that fat accumulation in the liver increases the sensitivity of the liver to a second hit that leads to inflammatory liver cell damage. In this study we evaluated the effects of Magnolia ...
Forsyth Christopher B - - 2009
Because only 30% of alcoholics develop alcoholic liver disease (ALD), a factor other than heavy alcohol consumption must be involved in the development of alcohol-induced liver injury. Animal and human studies suggest that bacterial products, such as endotoxins, are the second key co-factors, and oxidant-mediated gut leakiness is one of ...
McBride William J WJ Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, United States. - - 2009
The objective of this study was to determine the effects of ethanol injections on protein expression in the nucleus accumbens shell (ACB-sh) of alcohol-preferring (P), alcohol-non-preferring (NP) and Wistar (W) rats. Rats were injected for 5 consecutive days with either saline or 1 g/kg ethanol; 24 h after the last ...
Eyong, EU; ;
The haematological changes following the administration of varying concentrations of alcohol and caffeine for 7days were investigated in six groups of albino Wistar rats. Each group consisted of 8 rats (4 males; 4 females). The parameters assayed include percentage packed cell volume (%PCV), red blood cell (RBC) and white blood ...
Lopez Carlos Henrique - - 2009
Zonation of the actions of ethanol on gluconeogenesis and ketogenesis from lactate were investigated in the bivascularly perfused rat liver. Livers from fasted rats were perfused bivascularly in the antegrade and retrograde modes. Ethanol and lactate were infused into the hepatic artery (antegrade and retrograde) and portal vein. A previously ...
Mitchell Jennifer M - - 2009
The opioid antagonist naltrexone is the standard pharmacotherapy for alcoholism, although compliance is often low. The mechanism by which naltrexone reduces drinking is yet unclear. Here we show that in active alcoholics the magnitude of naltrexone treatment efficacy is correlated with the level of naltrexone-induced aversive side effects. This correlation ...
Das Biplab K - - 2008
Two partially purified organic fractions designated by PR1 and PR2 of the fat free ethanol (95%) extract of aerial parts of Phyllanthus reticulatus were tested for the hepatoprotective activity in rats against CCl(4)-induced liver damage. The rats receiving the fractions showed promising hepatoprotective activity as evident from significant changes of ...
1 2 3 4 5 6 7 8 9 10 >