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Guo Ming M Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, - - 2012
Opioid use in HIV infection has been associated with an increased frequency of neurological disease and cognitive impairment and vitamin A deficiency has been linked to progressive HIV disease in drug users. In this report the potential effects of these factors, alone and in combination, on gamma amino butyric acid ...
Subudhi U - - 2012
In the present study, regulatory role of vitamin E and curcumin on antioxidant gene (AOG) expression in hypothyroid rat liver is reported. Adult male rats were rendered hypothyroid by administration of 0.05 % 6-propyl-thiouracil in their drinking water, while vitamin E (200 mg/kg body weight) and curcumin (30 mg/kg body weight) were supplemented ...
Loveland Kate L - - 2011
Commentary on Zhou et al., Estrogen-Regulated Genes in Rat Testes and Their Relationship to Recovery of Spermatogenesis after Irradiation. Biol Reprod 2011; published ahead of print June 8, 2011; DOI: 10.1095/biolreprod.111.091611.
Uchida Tomono - - 2011
We previously found that 2,7,8-trimethyl-2(2'-carboxyethyl)-6-hydroxychroman (γCEHC), a metabolite of the vitamin E isoforms γ-tocopherol or γ-tocotrienol, accumulated in the rat small intestine. The aim of this study was to evaluate tissue distribution of vitamin E metabolites. A single dose of α-tocopherol, γ-tocopherol or a tocotrienol mixture containing α- and γ-tocotrienol ...
Debski B - - 2011
Male young growing rats of Wistar strain (n = 54) were fed a vitamin E deficient diet for 3 days of adaptation period and then 10 days of experimental period. After adaptation half of the rats ran, once per a day, on a treadmill with a rate of 2.0 m/s ...
Tronchini Eleandro A - - 2010
To investigate the effects of 0.1% and 2% vitamin E (α-tocopherol) supplementation on the expression of nitric oxide (NO) in penile tissue of rats with experimentally induced diabetes mellitus (DM). In all, 30 male rats were divided into six groups: normoglycaemic (NG), NG treated with 0.1% vitamin E (NGE1), NG ...
Jang Hye Ryoun - - 2010
Thiazide is known to decrease urinary calcium excretion. We hypothesized that thiazide shows different hypocalciuric effects depending on the stimuli causing hypercalciuria. The hypocalciuric effect of hydrochlorothiazide (HCTZ) and the expression of transient receptor potential vanilloid 5 (TRPV5), calbindin-D(28K), and several sodium transporters were assessed in hypercalciuric rats induced by ...
Yachi Rieko - - 2010
Recently, it has been reported that α-tocopherol (α-Toc) is effective for amelioration of liver damage. However, it is unknown whether other vitamin E analogs are effective. In this study, we investigated the effects of γ-tocopherol (γ-Toc) and tocotrienols (T3) in rats with fatty liver. Rats fed a vitamin E-deficient diet ...
Michaud Josée - - 2010
Calcidiol insufficiency is highly prevalent in chronic kidney disease (CKD), but the reasons for this are incompletely understood. CKD associates with a decrease in liver cytochrome P450 (CYP450) enzymes, and specific CYP450 isoforms mediate vitamin D(3) C-25-hydroxylation, which forms calcidiol. Abnormal levels of parathyroid hormone (PTH), which also modulates liver ...
Uboh F E - - 2010
In this study, gasoline vapors-induced hematotoxicity, growth-depression and weight-loss reversal effect of vitamins A (retinol) and E (α-tocopherol) was assessed in female Wistar albino rats. The rats were exposed to gasoline vapors (17.8 ± 2.6 cm(3)/h/m(3)/day), 6 hours/day, 6 days/week, for 20 weeks. Vitamins A and E at prophylactic dosage ...
Helvig Christian F CF Department of Research and Development, Cytochroma Inc., 330 Cochrane Drive, Markham, Ontario, - - 2010
The progressive decline in kidney function and concomitant loss of renal 1alpha-hydroxylase (CYP27B1) in chronic kidney disease (CKD) are associated with a gradual loss of circulating 25-hydroxyvitamin D(3) (25(OH)D(3)) and 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)). However, only the decrease in 1alpha,25(OH)(2)D(3) can be explained by the decline of CYP27B1, suggesting that insufficiency ...
Kumar R R Breast Cancer Genetics Group, Discipline of Medicine, University of Adelaide and Hanson Institute, SA Pathology, Frome Road, Adelaide, SA 5000, Australia. - - 2010
The biologically active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) ligands VDR (vitamin D receptor) and binds to the vitamin D response element (VDRE) located within target genes to regulate their transcription. Previously we showed that 1,25D-mediated rat CYP24A1 induction via the two critical VDREs is dependent on a short ...
An Jun J Department of Pharmacology, Aichi Medical University School of Medicine, Nagakute, - - 2010
The present study was undertaken to evaluate the effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), a synthesized vitamin E derivative, on carbon tetrachloride (CCl(4))-induced cirrhosis. Rats were treated with hypodermic injections of CCl(4) twice a week to induce the hepatic cirrhosis, and given drinking water containing HTHQ or solvent. Primary cultures of rat ...
Karim Md Razaul - - 2010
Autophagy is an intracellular bulk degradation process induced by nutrient starvation, and contributes to macromolecular turnover and rejuvenation of cellular organelles. We demonstrated that vitamin E was a novel nutritional enhancer of autophagy in freshly isolated rat hepatocytes and rat hepatoma H4-II-E cells. Supplementation of fresh hepatocytes with vitamin E ...
Weiss Batia - - 2010
BACKGROUND: Vitamin A and its derivative retinoic acid regulate various aspects of cell behavior as growth, differentiation, and proliferation. Retinoic acid derivative have been suggested to play a role in processes such as hepatic regeneration and fibrosis. OBJECTIVES: To evaluate the influence of vitamin A on rat liver epithelial cell ...
Azevedo Paula S - - 2010
Experimental studies suggest that vitamin A plays a role in regulating cardiac structure and function. We tested the hypothesis that cardiac vitamin A deficiency is associated with adverse myocardial remodeling in young adult rats. Two groups of young female rats, control (C - n = 29) and tissue vitamin A ...
Ogli S A - - 2009
Infertility is a major reproductive and social problem with a worldwide prevalence of 10-15%. While 11.8-39.0% of infertility cases are attributable to the female, 15.8-42.4% is attributed to the male and 8.0-11.1% to unknown factors. The study investigated the efficacy of the single versus combined regimes of antioxidant vitamins C ...
Subudhi Umakanta - - 2010
Earlier we have demonstrated that oral supplementation of vitamin E and curcumin alleviates hyperthyroidism-induced oxidative stress and distorted histoarchitecture in rat liver [5]. To delineate the underlying mechanism of protection, the present study was undertaken to investigate the regulatory role of vitamin E and curcumin on antioxidant gene (AOG) expression ...
Gençel Osman - - 2010
The levels of liver lipid peroxidation, glutathione peroxidase, reduced glutathione, and vitamins A and E were used to follow the level of oxidative damage caused by ionizing radiation in pregnant rats. The possible protective effects of selenium and vitamin E supplemented to rats housed in concrete-protected cages using hematite and ...
Uzun Fatma Gokce - - 2009
Sexually mature male Wistar rats (weighing 300-320 g and each group 6 animals) were given malathion (27 mg/kg; 1/50 of the LD(50) for an oral dose) and/or vitamin C (200mg/kg)+vitamin E (200mg/kg) daily via gavage for 4 weeks. The sperm counts, sperm motility, sperm morphology, FSH, LH, and testosterone levels, ...
Okura Yuki - - 2009
It has been demonstrated that vitamin E deficiency from birth increases anxiety-related behavior using knockout animals with no vitamin E transfer proteins. The current study was undertaken to elucidate the effect of dietary vitamin E deficiency on anxiety-related behavior of rats in different housing conditions. Male Wistar strain rats were ...
Zaki Mohamed Samir A - - 2009
Amiodarone, a class III antiarrhythmic drug, has been found to be effective in the management of patients with life-threatening ventricular arrhythmias. The aim of this study was to test whether the co administration of vitamin-E with amiodarone can reduce amiodarone-induced liver damage. Twelve male albino rats were divided into three ...
de Oliveira Marcos R - - 2009
Vitamin A is normally stored in the mammalian liver and is physiologically released depending on the need of the organism for the vitamin. However, there is a compelling evidence showing that even the liver is affected by conditions of high vitamin A intake. Based on these previously reported findings showing ...
Pavlovic V - - 2009
BACKGROUND: Monosodium glutamate (MSG) is a commonly used flavor enhancer in modern nutrition. It has been shown that administration of MSG induces toxic effects in various regions of brain, thymus, liver and kidney. Also, it is well-documented that Vitamin C (ascorbic acid) has a protective role in MSG-induced cytotoxicity in ...
Orozco-Barrios Carlos Enrique - - 2009
Vitamin B12 is indispensable for proper brain functioning and cytosolic synthesis of S-adenosylmethionine. Whether its deficiency produces effects on viability and apoptosis of neurons remains unknown. There is a particular interest in investigating these effects in Parkinson disease where Levodopa treatment is known to increase the consumption of S-adenosylmethionine. To ...
Takitani Kimitaka - - 2009
Nonalcoholic fatty liver disease (NAFLD) is a state of excessive accumulation of fat in the liver of persons whose alcohol intake is lower than the classical level for causing liver damage. When inflammation and fibrosis occur in addition to fatty liver, followed by the development of chronic hepatic dysfunction, the ...
Vasatkova Anna - - 2009
OBJECTIVE: The aim of this study is to determine level of metallothioneins (MTs) in brain tissues of rats administered by feed mixtures with different content of mouldy wheat or fungi. DESIGN: Selected male laboratory rats of Wistar albino at age of 28 days were used in our experiments. The rats ...
de Oliveira Marcos Roberto - - 2009
There is a growing body of evidence showing that vitamin A induces toxic effects in several experimental models and in human beings. In the present work, we have investigated the effects of short-term vitamin A supplementation on the adult rat liver redox status. We have found that vitamin A at ...
Kohn Michael H - - 2008
BACKGROUND: The inhibition of the vitamin K cycle by warfarin promotes arterial calcification in the rat. Conceivably, genetically determined vitamin K-deficiency owing to a mutant epoxide reductase subcomponent 1 (Vkorc1) gene, a key component of the vitamin K cycle, might also promote arterial calcification. In the absence of an available ...
Fukuwatari Tsutomu - - 2008
To investigate how aging alters B-group vitamin metabolism, rats were fed with niacin-free 20% casein diet from 3 to 80 wk old, and the urinary excretions of the B group vitamins were periodically measured. The blood and liver B-group vitamin levels in 80-wk-old rats were also compared with those in ...
Gabrashanska Margarita - - 2008
The oxidative-antioxidant status of male Wistar rats infected or uninfected with Fasciola hepatica (Trematoda) and supplemented or unsupplemented with 2Gly.ZnCl(2).2H(2)O was tested through liver biomarkers. The oxidative marker was malondialdehyde concentration. The antioxidant markers were glutathione peroxidase activity and concentrations of zinc, selenium, vitamin A, vitamin C, and vitamin E. ...
Sahoo Dipak Kumar - - 2008
Present study examines effects of curcumin and vitamin E on oxidative stress parameters, antioxidant defence enzymes and oxidized (GSSG) and reduced glutathione (GSH) levels in testis of L-thyroxine (T4)-induced hyperthyroid rats. The oxidative stress in T4-treated rat testis was evident from elevation in oxidative stress parameters such as lipid peroxide ...
Croce Anna Cleta - - 2008
Autofluorescence spectroscopy is a promising and powerful approach for an in vivo, real time characterization of liver functional properties. In this work, preliminary results on the dependence of liver autofluorescence parameters on the nutritional status are reported, with particular attention to vitamin A and lipid accumulation in liver tissue. Normally ...
Forssmann Ulf - - 2008
Chemokines mediate the recruitment of leukocytes to the sites of inflammation. N-terminal truncation of chemokines by the protease dipeptidyl peptidase IV (DPPIV) potentially restricts their activity during inflammatory processes such as allergic reactions, but direct evidence in vivo is very rare. After demonstrating that N-terminal truncation of the chemokine CCL11/eotaxin ...
Ali Badreldin H - - 2009
Gum arabic (GA) is a branched-chain, complex polysaccharide, either neutral or slightly acidic, found as a mixed calcium, magnesium and potassium salt of a polysaccharidic acid. The backbone is composed of 1,3-linked beta-D-galactopyranosyl units. The side chains are composed of two to five 1,3-linked beta-D-galactopyranosyl units, joined to the main ...
Zhang Yan - - 2008
OBJECTIVE: Fructus ligustri lucidi (FLL) is a widely used herb in China that is classically included in antiaging formulas for the treatment of age-related symptoms. Our laboratory previously showed that FLL could regulate calcium balance in young ovariectomized (OVX) rats. In the present study, we aimed to determine whether FLL ...
Ip Julia - - 2008
The use of clozapine is limited by a relatively high incidence of drug-induced agranulocytosis. Clozapine is oxidized by bone marrow cells to a reactive nitrenium ion. Although many idiosyncratic drug reactions are immune-mediated, the fact that patients with a history of clozapine-induced agranulocytosis do not immediately develop agranulocytosis on rechallenge ...
Ekaladze E - - 2008
Distribution of vitamin A after overdose feeding along the digestive tract of rat's intestine was studied by LIFS. Purpose of our pilot study was to investigate possible usage of LIFS for real time monitoring of vitamin A digestion and storage in intestine as in liver and to identify regions of ...
Sato Yasushi - - 2008
There are currently no approved antifibrotic therapies for liver cirrhosis. We used vitamin A-coupled liposomes to deliver small interfering RNA (siRNA) against gp46, the rat homolog of human heat shock protein 47, to hepatic stellate cells. Our approach exploits the key roles of these cells in both fibrogenesis as well ...
Topaloglu Banu - - 2008
The aim of the study reported here was to evaluate the biochemical and histopathologic effects of omeprazole and vitamin E in rats with corrosive esophageal burns. A total of 144 Wistar Albino rats were divided into 12 experimental groups (12 rats per group) and used in an animal study. Group ...
Huang C Q - - 2008
Insulin resistance (IR), IR treated with vitamin D, IR treated with 1alpha-hydroxyvitamin D (1alpha-(OH)D), type 2 diabetes mellitus (T2DM), T2DM treated with vitamin D and T2DM treated with 1alpha-(OH)D were studied in animal models using aged Wistar rats. Glucose infusion rates and levels of urinary albumin (UA), serum 25-hydroxyvitamin D ...
Tateya Ichiro - - 2008
OBJECTIVES: The roles of vitamin A in the vocal fold epithelium are not well documented, although vitamin A has been used as a conservative treatment for laryngeal leukoplakia. The purpose of this study was to analyze the roles of vitamin A in vocal fold epithelial differentiation. METHODS: Vitamin A-deficient (VAD) ...
Tateya Tomoko - - 2008
OBJECTIVES: Vitamin A plays important roles in development, growth, and regeneration. Vitamin A-storing stellate cells have been identified in several organs. The functional roles of vitamin A in the vocal folds are still unknown, although vitamin A-storing vocal fold stellate cells have been observed in the macula flava of human ...
Hfaiedh N - - 2008
ABSTRACT The purpose of this study, carried out in Wistar rats, was to evaluate the protective effect of dietary restriction (performed by intermittent fasting) against oxidative stress induced by a low concentration of nickel chloride in kidney, liver, uterus, and ovary. Lipid peroxidation (TBARS), catalase activity, and the levels of ...
Ruan Qingmin - - 2008
Type 2 transglutaminase (TG2) is an acyltransferase, which also undergoes a GTP-binding/GTPase cycle, with guanine nucleotide and calcium binding reciprocally regulating its transamidation (TG) activity. TG2 is expressed ubiquitously throughout the human body and is the predominant neuronal transglutaminase. Given a postulated role for TG2 in a number of physiological ...
Ramamourthy Gopal
The aim of this study was to investigate the effect of <I>Enicostemma littorale</I> (Gentianaceae) aerial part on antioxidant defense systems of plasma and liver in <I>p</I>-Dimethylaminoazobenzene (<I>p</I>-DAB)-induced hepatocarcinoma in rats. The levels of vitamin-E and vitamin-C were estimated in plasma of control and experimental groups of rats. The levels of ...
Elhag M A - - 2007
This study was designed to investigate the effect of EMR produced by GSM Mobile Phones (MP) on the oxidant and antioxidant status in rats. Rats were divided into three groups: (1) controls, (2) rats exposed to a fractionated dose of EMR (15 min day(-1) for four days) (EMR-F) and (3) ...
Onishi Tomoyuki - - 2008
OBJECTIVE: Calbindin D9k (CB9k) and D28k (CB28k) are intracellular soluble calcium-binding proteins, whose expressions are considered to be regulated by vitamin D. However, the amount of CB28k expression in the kidneys of vitamin D receptor-null mice was reported to be similar to that in wild type mice, suggesting no dependence ...
Ross A Catharine AC Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA. - - 2007
The lungs require an adequate supply of vitamin A for normal embryonic development, postnatal maturation, and maintenance and repair during adult life. We have previously shown that a nutrient-metabolite combination of vitamin A admixed with a small proportion (10%) of retinoic acid (RA), referred to as VARA, acts synergistically to ...
Tateya Ichiro - - 2007
OBJECTIVES: Our previous research demonstrated that vitamin A might be related to vocal fold development. The purpose of this study was to determine whether vitamin A deficiency affects prenatal laryngeal development in rats. METHODS: Two considerations were necessary in designing a study using a rat model: for embryonic survival, vitamin ...
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