Is there a benefit from lycopene supplementation in men with prostate cancer? A systematic review.
|Article Type:||Brief article|
Lycopene (Health aspects)
Prostate cancer (Development and progression)
|Publication:||Name: Alternative Medicine Review Publisher: Thorne Research Inc. Audience: Academic; Professional Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2010 Thorne Research Inc. ISSN: 1089-5159|
|Issue:||Date: April, 2010 Source Volume: 15 Source Issue: 1|
|Topic:||Event Code: 310 Science & research|
Lycopene has a chemopreventive effect against prostate cancer but
its role in prostate cancer progression is unknown; many patients
increase their intake of lycopene, although there are no evidence-based
guidelines to suggest an effect. Our objective was to conduct a
systematic review of literature to evaluate the association between
lycopene intake and prostate cancer progression. MEDLINE, EMBASE CINAHL
Plus, Web of Science, AMED and CENTRAL databases were systematically
searched using terms for lycopene and prostate cancer progression to
identify studies published before January 2009. Eight intervention
studies were identified (five with no control group; one with an
unmatched control group; and two randomized controlled trials (RCTs)).
An inverse association was observed between lycopene intake and PSA
levels in six studies. The rates of progression measured by bone scan in
one RCT were lower in the intervention group. Lycopene resulted in
lowering cancer-related symptoms (pain, urinary tract symptoms), and
severe toxicity or intolerance was not evident. However, the evidence
available to date is insufficient to draw a firm conclusion with respect
to lycopene supplementation in prostate cancer patients and larger RCTs
are required in broader patient groups.
Prostate Cancer Prostatic Dis 2009;12:325-332.
|Gale Copyright:||Copyright 2010 Gale, Cengage Learning. All rights reserved.|