A rare manifestation of brucellosis: cervical lymphadenitis/ Brusellozisin nadir klinik prezentasyonu: servikal lenfadenit.
Human brucellosis is a multisystem and potentially lethal disease
of zoonotic origin with highly variable and nonspecific clinical
presentation. Although lymphadenopathy in the course of brucellosis is
10-20%,there is only one case of isolated cervical LAP as unique
manifestation. We hereby present a case of isolated cervical LAP due to
brucella mellitensis in a 12 year old boy.
(J Pediatr Inf 2009, 3: 190-1)
Key words: Brucellosis, lymphadenopathy
Brusellozis, oldukca degisken ve ozgul olmayan bul gularla klinige yansiyan, butun sistemleri tutabilen, hayvan kaynakli, oldurucu potansiyele sahip bir has taliktir. Lenfadenopati, brucellosis 'in seyri esnasinda %10-20 vakada gorulmekte birlikte, izole Servikal len fadenit ile basvuran sadece bir vaka vardir. Burada, izole Servikal lenfadenit ile basvuran oniki yasindaki bir erkek cocuk sunulacaktir.
(Cocuk Enf Derg 2009; 3: 190-1)
Anahtar kelimeler: Brusellozis, lenfadenopati
|Article Type:||Case study|
Lymphatic diseases (Case studies)
Children (Case studies)
|Publication:||Name: Journal of Pediatric Infection Publisher: Aves Yayincilik Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2009 Aves Yayincilik ISSN: 1307-1068|
|Issue:||Date: Dec, 2009|
Human brucellosis is a multisystemic and potentially lethal disease of zoonotic origin with highly variable and nonspecific clinical presentations (1). Although the occurrence of lymphadenopathy (LAP) in the course of brucellosis is 10-20% (2), there is only one case of isolated cervical LAP as a unique manifestation. Hereby in this study, a case of isolated cervical LAP due to brucella mellitensis in a 12 year-old boy is presented.
A 12 year-old boy was admitted to the hospital with history of fever, malaise and enlarged left cervical lymph nodes for the previous two weeks. The patient's medical history was nonspecific. He had no history of surgery and no known drug allergies. His birth was uneventful and his immunizations, including the BCG vaccine, were up to date. He was born in a city and reported no animal contact. A detailed dietary history revealed consumption of unpasteurized dairy pooducts. On admission, he was febrile (38.5[degrees]C) and tachycardic (124 beats /min) and a cervical lymph node enlargement, 8x8 cm in size in the left anterior region, was detected.
There was no rash, organomegaly or tenderness over the bones and no evidence of joint swelling or effusion. Neurological examination and other physical examinations did not reveal any significant pathology.
Viral serology for Ebstein Barr Virus, Cytomegalovirus, Toxoplasmosis, Human Immune Deficiency Virus and Hepatitis virus were all negative. Tubercullin skin test and nitroblue tetra zolium dye reduction tests were also negative. Thus the patient had received a course of amikacin for 11 days and Cefazolin for 21 days. At the end of the third week, the report of Brucella agglutination test was received showing 1: 1280 titers, Elisa Igm positive and IgG negative. Doxycycline, streptomycin and rifampicin treatment was started. Streptomycin therapy was stopped on the 15th day.
The patient improved very slowly with the drug treatment. Even though the patient had gained 3 kg, he still had a draining sinus from incised Lymphadenopathy at the end of sixth week. Therefore duration of therapy was extended to 12 weeks. After completion of the treatment the patient recovered with no LAP and brucella agglutination titer decreased to 1: 640. After 6 months of follow up, no relapse was reported and the patient had gained 5 kg weight during this period.
Brucellosis is a systemic disease that can involve any organ or system of the body. Human brucellosis is known for protean manifestations (3, 4) such as, joint pain, low backache, night sweats, cough, testicular pain, anorexia, jaundice, headache, fatigue, convulsions, hepatosplenomegaly, weight loss, swollen hands, and burning feet. Although the most frequent form of brucella is a systemic one, local forms of brucella can occur in bones, joints, heart, lung, central nervous system, liver, spleen, testes and the ovaries (5, 6). Lymphadenopathy can be seen in 3.1-20%of patients (7, 2). Nevertheless brucellosis with localized lymphadenitis has been rarely reported (8, 6). Nadler et al. reported a 54 year old woman with suppurative lymphadenitis accompanied by erythema, pain, fever, and pus drainage. Brucella suis was detected as a causative agent. Varane et al. reported 42 year old male with an isolated cervical Lymphadenopathy due to Brucella melitensis without systemic signs and symptoms.
[FIGURE 1 OMITTED]
In the above presented case, even though no brucella species from obtained sample (blood cultures, pus) was detected, the positive results of brucella stantard tube agglutination test (STA) and Elisa for brucella were considered and the treatment with streptomycin, doxcycline and riphampicine was started. Blood culture provides definite proof of brucellosis but may not provide a positive result for all patients even under ideal conditions (2). Antigen detection by enzyme-linked immunosorbent assay as an alternative to blood culture is reported (g). Even though no brucella species on blood culture was detected, in this presented case both Elisa and STA being positive denoted diagnosis for brucella. With proper treatment the patient improved and at the follow up during sixth months no relapse was detected.
To the best of our knowledge, this is the first report of lymphadenitis associated with brucella in childhood. It is proposed that, in the differential diagnosis of localized lymphadenitis, brucellosis should be kept in mind.
Gelis Tarihi: 07.06.2008
Kabul Tarihi: 01.12.2008
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(6.) Varona JF, Guerra JM, Guillen V, Guillen S, Menassa A, Palenque E . Isolated cervical Lymphadenopathy as unique manifestation of Brucellosis.Scand J Infect Dis 2002; 34: 538-40.
(7.) Mantur BG, Amarnath SK, Shinde RS. Review of clinical and laboratory features of human Brucellosis. Indian J Med Microbiol 2007; 25: 188-202.
(8.) Nadler H, Dolan C, Forgacs P, George H. Brucella suis: an unusual cause of suppurative lymphadenitis in an outpatient. J Clin Microbiol 1982; 16: 575-6.
(9.) AI-Shamahy HA, Wright SG. Enzyme-linked immunosorbent assay for Brucella antigen detection in human sera. J Med Microbiol 1998; 47: 169-72.
Bayram Ozhan, Fulya Kamit, Ikbal Akduman, Yilmaz Ay, Mehmet Helvaci
Tepecik Education and Research Hospital, Children's Health and Medicine Clinic, izmii; Turkey
Dr. Bayram Ozhan
Tepecik Education and Research Hospital, Children's Health and Medicine Clinic, izmir, Turkey
Mobile: +90 532 283 07 21
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