A randomized controlled (intervention) trial of ischemic compression therapy for chronic carpal tunnel syndrome.
Abstract: Study Design: Randomized clinical trial.

Objective: The aim of this study was to evaluate the effect of ischemic compression therapy in the treatment of chronic carpal tunnel syndrome.

Method: Fifty-five patients suffering from carpal tunnel syndrome were randomized to two groups. Thirty-seven patients received 15 experimental treatments which consisted of ischemic compressions at trigger points located in the axilla of the shoulder, the length of the biceps muscle, at the bicipital aponeurosis and at the pronator teres muscle in the hollow of the elbow. Eighteen patients received the control treatment involving ischemic compression on trigger points located in the deltoid muscle, supraspinatus muscle and infraspinatus muscle. Of the 18 patients forming the control group, 13 agreed to receive the experimental treatments after the 15 control treatments. Outcome measures included a validated 18-question questionnaire to assess the severity of symptoms and functional status in carpal tunnel syndrome, and a quantification of the patients' perceived improvement, using a scale from 0% to 100%. Outcome measures evaluations were completed at baseline, after 15 treatments, 30 days following the last treatment, and 6 months later.

Results: For the disability questionnaire, a significant reduction of symptoms was noted only in the experimental group. In the experimental group the outcome at baseline was 33.5 (SD, 10.3); after 15 treatments it was 18.6 (SD, 7.0). The control group outcome at baseline was 36.3 (SD, 15.2); after 15 treatments it was 26.4 (SD, 9.9) and after the crossover (15 control treatments plus 15 experimental treatments) 20.2 (SD, 12.2). A significant between group difference (P < 0.021) was noted in the patients' perceived improvement after 15 treatments: 67 (SD, 26) percent and 50 (SD, 25) percent respectively for the experimental and control groups.

Conclusion: This practice-based clinical trial suggests that myofascial therapy using ischemic compression the length of the biceps, at the bicipital aponeurosis, at the pronator teres and at the subscapularis muscles could be a useful approach to reduce symptoms associated with the carpal tunnel syndrome. Patients' perceived improvement in functional capacities persisted over a 6-month period. (JCCA 2010; 54(3):155-163)

KEY WORDS: chiropractic, myofascial trigger points, ischemic compression, carpal tunnel syndrome, randomized clinical trial

Methodologie: essai clinique randomise. Objectif: le but de la presente etude est d'evaluer l'effet de la compressotherapie ischemique dans le traitement du syndrome du canal carpien chronique.

Methode: Cinquante-cinq patients souffrant du syndrome du canal carpien ont ete separes aleatoirement en deux groupes. Trente-sept patients ont recu 15 traitements experimentaux, qui consistaient en des compressions ischemiques a des points gachettes situes dans le creux axillaire de l'epaule, le long du biceps, a l'aponevrose bicipitale et au muscle rond pronateur situe dans le creux du coude. Dix-huit patients ont recu le traitement controle, qui comprenait des compressions ischemiques sur des points gachettes situes dans le muscle deltoide, le muscle sus-epineux et le muscle sous-epineux. Des 18 patients du groupe controle, 13 ont accepte de recevoir les traitements experimentaux a la suite des 15 traitements controles. Les mesures des resultats incluent un questionnaire valide de 18 questions servant a evaluer la gravite des symptomes et les capacites fonctionnelles relativement au syndrome du canal carpien, ainsi qu'une quantification des ameliorations percues par les patients, au moyen d'une echelle allant de 0% a 100 %. Les evaluations mesurant les resultats ont ete effectuees au niveau de base, apres 15 traitements, 30 jours apres le dernier traitement et six mois plus tard.

Resultats: du cote du questionnaire sur l'invalidite, une diminution significative des resultats n'a ete remarquee que chez le groupe experimental. Pour le groupe experimental, le resultat au niveau de base etait de 33,5 (ecart-type: 10,3); apres 15 traitements, il etait de 18,6 (ecart-type: 7,0). Le resultat du groupe controle au niveau de base etait de 36,3 (ecart-type : 15,2); apres 15 traitements, il etait de 26,4 (ecarttype: 9,9) et apres le traitement croise (15 traitements controles et 15 traitements experimentaux) de 20,2 (ecart-type: 12,2). Une difference significative entre les groupes (p < 0,021) a ete notee dans la perception qu'ont les patients de leur amelioration apres 15 traitements: 67% (ecart-type: 26) et 50% (ecarttype: 25) respectivement pour le groupe experimental et le groupe controle.

Conclusion: Cet essai clinique fonde sur la pratique suggere que la therapie myofasciale au moyen de compressions ischemiques le long du biceps, a l'aponevrose bicipitale, au muscle rond pronateur et aux muscles subscapulaires pourrait s'averer un moyen utile de reduire les symptomes associes au syndrome du canal carpien. L'amelioration des capacites fonctionnelles, telle que percue par les patients, a persiste pendant 6 mois. (JCCA 2010; 54(3):155-163)

MOTS CLES: chiropratique, point gachette myofascial, compressions ischemiques, syndrome du canal carpien, essai clinique randomise.
Article Type: Report
Subject: Carpal tunnel syndrome (Care and treatment)
Carpal tunnel syndrome (Research)
Carpal tunnel syndrome (Diagnosis)
Physical therapy (Health aspects)
Therapeutics, Physiological (Health aspects)
Authors: Hains, Guy
Descarreaux, Martin
Lamy, Anne-Marie
Hains, Francois
Pub Date: 07/01/2010
Publication: Name: Journal of the Canadian Chiropractic Association Publisher: Canadian Chiropractic Association Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2010 Canadian Chiropractic Association ISSN: 0008-3194
Issue: Date: July, 2010 Source Volume: 54 Source Issue: 3
Topic: Event Code: 310 Science & research
Geographic: Geographic Scope: Canada Geographic Code: 1CANA Canada
Accession Number: 259589954
Full Text: Introduction

Carpal tunnel syndrome (CTS) is one of the most common and most clinically significant of all nerve entrapment syndromes. (1) Numbness and paresthesia along the distribution of the median nerve in the hand, i.e. the thumb, index, major and half the ring finger are common symptoms related to CTS. Symptoms and concurrent discomfort often peak at night and may wake the patient several times. To ease pain and discomfort, the patient will shake the affected hand(s) and flex the fingers vigorously. (2)

Point prevalence of CTS is estimated at 2.7% and it is typically diagnosed in adults over the age of 30.3 The symptoms generally originate from a nerve compression occurring when the median nerve runs through a fibrous or fibro-osseous tunnel or switches direction around a fibrous or muscular band. (2,4)

Forty-seven percent of CTS cases can be related to the patient's occupation. Over the last decades, there has been a major increase in work-related CTS cases. (5,6) Compression or entrapment may be present at a number of sites along the median nerve. (7,8) To describe such phenomenon, Leahy uses the expression "the whole nerve syndrome". (7)

Conservative allopathic treatment usually includes wrist support, change in activities and anti-inflammatory medication. If symptoms are not relieved by a conservative approach within a six-month period, cortisone injections may be used. Wrist surgery (carpal tunnel release) is considered where symptoms remain pronounced and motor and sensitive functions decline. (4,9) There are three main reasons why patients agree to undergo surgery for CTS: (1) relief of night pain (36% of surgical patients), (2) relief of hand numbness (21%), (3) relief of daytime pain (13%).10

Furthermore, almost a third of the patients who have undergone CTS surgery experience persistent or recurrent symptoms after surgery and report that the initial improvement associated with carpal tunnel surgery is lost within less than two years. (10) The most significant discomfort described by patients after carpal tunnel surgery is pain in the area of the scar, and a weakened hand. (10) On average, two years following surgery, 30% of patients characterize their results as being poor to medium. (11)

Natural history of CTS

When CTS is not treated surgically, the symptoms usually disappear after nine months in the case of one half of those patients who do not move on to a surgical procedure. However, 22% of such patients continue to have symptoms eight years later. (12)

Self-rating scales represent the most valid assessment method for CTS. (13) When clinical symptoms are not conclusive and common CTS diagnostic procedures are unable to confirm the presence of median nerve compression, it may be necessary to use electrodiagnostic procedures. (13-15) These procedures are rarely appropriate for initial CTS assessment, but are essential when it comes to pre-surgery examinations. (13-15)S

Carpal tunnel syndrome is commonly treated in chiropractic. In 1988, the number of cases of CTS declared by various specialists broke down as follows: chiropractors (23%), specialists in internal medicine (19%), neurologists (14%), and family physicians (9%). (5)

A CTS survey study involving 254 physicians was carried out in 74 outpatient sentinel practices in 30 US states and three Canadian provinces. The authors of the study collected data from 552 CTS patients. (16) Of this number, 23.5% were women, 70.4% were aged between 30 and 49, and 61.4% said that their work involved physical strain or repetitive movements. Clinicians determined that 43.1% of these cases were caused by the work itself. These practitioners rarely used electrodiagnostic procedures, preferring conservative initial treatment such as wrist support and anti-inflammatory medication, while cortisone injections were rarely used. (16) Another study showed that 40% of 125 CTS sufferers who received conservative treatments over a period of 30 months said that they were willing to put up with their low-level residual symptoms for the rest of their life. (17)

Rationale for using ischemic compression therapy in the treatment of carpal tunnel syndrome

Since, in patients suffering from carpal tunnel syndrome, the median nerve is more than twice (2.1 times) its normal size when it enters the carpal tunne (l,18) the authors of the present trial hypothesized that part of the cause of the related oedema could be noxious myofascial sites along the median nerve course. Along its course, part of this nerve enters the axilla of the shoulder, runs immediately adjacent to the biceps, and descends within the hollow of the elbow under the pronator teres muscle and the bicipital aponeurosis. Other authors suggest that compression or entrapment may be present at a number of sites along the median nerve. (7-8) In the present trial, the clinicians found hypertonicity and trigger points (TrPs) along the biceps of every participant. Trigger points in the hollow of the elbow were also present in all cases. It was suspected that eliminating the trigger points located along the median nerve course would diminish the CTS symptoms with or without normalizing the size of the median nerve.

Figure 1 illustrates the trigger point locations along the biceps, at the bicipital aponeurosis and in the pronator teres muscle. In skeletal muscles the blood flow is extremely variable and it is tied to the activity level. At rest, only 25% of their capillaries are open. (19) With exercise the blood flow can increase up to 10 times, at which point almost all the capillaries open up to admit more blood. (19) In the present trial, the affected biceps (principally) was in partial and continual contraction because of TrPs. It is known that TrPs in a muscle cause a partial contraction. (20,21) This contraction state results in higher consumption of oxygen and glucose. However during the night, with blood flow being much less, the supply of oxygen and glucose diminishes and lactic acid then accumulates and accentuates the contraction state. The authors of the present trial speculate that, during the night, the median nerve being more irritated, the patient is awakened by increased numbness and pain in the hand. Shaking the arm vigorously increases the blood flow, eliminates the lactic acid, and consequently the biceps relaxes partially, the median nerve is less irritated and the numbness and pain diminish.

Our primary hypothesis of interest was that private clinic patients with CTS who are treated with ischemic compression on TrPs localized along the biceps, in the axilla and in the hollow of the elbow would exhibit more significant reduction in the severity of symptoms and improvement in functional status in comparison with patients treated with ischemic compression on TrPs localized in the deltoid, supraspinatus and infraspinatus muscles.

Methods

Participants

This prospective randomized clinical trial was conducted in a private clinic located in Trois-Rivieres, Quebec. The study was approved by the ethics committee of the Universite du Quebec a Trois-Rivieres.

An advertisement was placed in a local newspaper on three different occasions offering CTS sufferers the opportunity to take part in this research project. The first 55 eligible patients were included in the study and underwent a course of 15 chiropractic treatments at a rate of three treatments per week (see Table 1). Thirty-seven patients received the experimental treatment; eighteen were given the control treatment (see Patient Flowchart). Patients accepted into the study were required to read and sign an informed consent form.

Randomization procedure

Each subject was randomly assigned to either the experimental group or the control group at a 2:1 ratio using a table of random numbers. Sixty numbers (2/3 even, 1/3 odd) were mixed in an envelope, and an independent research assistant drew a number for each participant, who was then allocated accordingly.

Treatment protocols

All the patients included in this study presented multiple trigger points (TrPs) and taut bands along the biceps and at the bicipital aponeurosis. TrPs at the pronator teres muscle were also common clinical findings, but were not present in two patients. Twenty patients had TrPs in the axilla of the shoulder. All patients were examined for TrPs in these four areas while in a supine position, the arm supine and spread along the body or, in the case of the axilla of the shoulder, the hand of the patient under his head.

[FIGURE 1 OMITTED]

Patients were advised to stop any treatments other than that provided by the chiropractor treating their CTS. During the treatment, at each visit, pressure was applied for 5-15 seconds to each of the identified trigger points. Thumb tip pressure (one thumb over the other) was then applied for 5 seconds every 2 cms, along the biceps. For the TrPs located in the hollow of the elbow (pronator teres, biceps aponeurosis) and in the axilla (subscapularis), the pressure was maintained for 15 seconds. Trigger points were treated using a light pressure, which was gradually increased until it reached the participant's maximum pain tolerance level. The patients were blinded to treatment allocation and therefore did not know whether they were in the control or the experimental group.

Seventeen patients received 15 control treatments consisting of ischemic compressions of latent or active trigger points located in the posterior region of the clavicle (supraspinatus area), on the deltoid (anterior and lateral region), and on the center of the shoulder blade (infraspinatus area). Since TrPs are often found in these locations, this control treatment would appear plausible to the patient and the authors believed that it would not induce significant clinical changes as concerned CTS symptoms. Following the control treatment phase of the study, the 18 patients who received fifteen control treatments were offered the opportunity to receive fifteen further treatments. They were still blinded to the kind of treatment they would receive. Thirteen agreed to continue with the treatment and, this time, only the experimental treatment was given.

Outcome measures

In order to quantify the severity of symptoms and the functional status of patients, a standard validated questionnaire (20) specific to patients suffering from CTS was used. The scales used in this questionnaire are highly reproducible (Pearson correlation coefficient, R = 0.91 and 0.93 for severity of symptoms and functional status, respectively) and internally consistent (Cronbach alpha, 0.89 and 0.91 for severity of symptoms and functional status, respectively). (20) This type of questionnaire was chosen because carpal tunnel patients generally consult their clinicians due to the severity of the symptoms experienced and the difficulty they have in carrying out normal daily tasks. The first part of the questionnaire defines the functional status of the patient while carrying out eight daily activities. The second part, using 10 simple questions, defines the severity of the symptoms experienced by the patient. All participants completed the questionnaire before and after the treatment protocol. A numerical scale where patients could rate their perceived improvement from 0% to 100% was also used. For the experimental group the questionnaire and numerical scale were also completed 30 days after the last treatment and 6 months later. For the control group, the questionnaire and the numerical scale were also completed after the crossover. The questionnaires were filled in without the assessor being present.

Statistical analysis

To test the effects of experimental treatment over the Time, a repeated-measures one-way ANOVA was performed. The same analysis was completed to test the cross-over effect in the control group. When a main effect of Time was observed for the experimental group, post hoc comparisons were performed using Tukey tests. A t-test for independent samples was used to compare the perceived improvement percentage between the control and experimental groups after 15 treatments. For all analyses statistical significance was set at p < 0.05.

Results

All 55 participants received the initial fifteen treatments and completed the questionnaires as intended. Fifty-five patients were randomly assigned to one of the two treatment groups. The t-test showed no statistically significant difference between the two groups' baseline characteristics (see Table 2).

The experimental group symptoms and functional status scale questionnaire mean scores (and standard deviations) were 33.5 (SD, 10.3) at baseline; 18.6 (SD, 7.0) after 15 treatments; 17.5 (SD, 6.1) thirty days following the last treatment, and 20.7 (SD, 7.4) at 6 months. The experimental group maintained a significant reduction in the symptoms and functional status scale questionnaire scores at both follow-up evaluations (One-way ANOVA: F (3, 108) = 39.2, p < 0.0001). Conversely, the repeated-measure ANOVA yielded a significant decrease for the control group only after the cross-over: 36.3 (SD, 15.2) at baseline; 26.4 (SD, 9.9) after 15 placebo treatments; and 20.2 (SD, 12.2) after the cross-over (One-way ANOVA: F (SD, 2, 24) = 10.1, p < 0.001). Figure 2 illustrates the symptoms and functional status scale questionnaire changes in both groups throughout the trial. Mean (SD) improvement in the symptoms and functional status scale questionnaire are presented in Table 3.

[ILLUSTRATION OMITTED]

[FIGURE 2 OMITTED]

A significant difference (p < 0.021) was noted between the two groups regarding the perceived improvement scores after 15 treatments. The mean perceived percentage of improvement was 67 (26) and 50 (25) for the experimental and control groups respectively. Table 4 presents the mean scores from the perceived improvement numerical scale for both groups throughout the experiment.

Discussion

In this study, patients' symptoms associated with CTS improved in the majority of patients who received ischemic compression therapy in the axilla of the shoulder, the length of the biceps, at the bicipital aponeurosis and at the pronator teres muscle. The data from the two questionnaires showed an improvement in both groups, but the improvement was significantly greater in the experimental group than in the control group. Moreover, a significant reduction in pain and improved functional status were noted after the crossover (75% improvement) when the participants in the control group received the experimental treatment. Even though the study protocol included 15 treatments, many patients (89%) in the experimental group reported improvement within six treatments. They either said so spontaneously or when asked by the clinician during the 6th visit. In this study, only ischemic compression therapy was used, but one may suppose that the results could be improved if such therapy was combined with ergonomic recommendations per se. (23) No side effects were reported during the treatments, except for a slight sensitivity reported by a small number of patients after the first few treatments.

The most pathognomonic symptom of myofascial pain syndrome is the presence of pressure-sensitive palpable nodules that reproduce the chief complaint: they are called trigger points. (24) These TrPs may be located in muscles, ligaments, tendons, fascias and articular capsules. (25) Ischemic compressions are amongst the most popular methods of treatment used by chiropractors for patient care of the myofascial pain syndrome. The National Board of Chiropractic Examiners 2005 Job Analysis reported that over 91% of chiropractors use trigger point therapy for passive adjustive care. (26)

Overuse of the biceps can cause myofascial irritations and subsequent hypertonicity. Gerwin (22) claims that a myofascial trigger point refers to a zone of intense pain in a hardened muscle band that triggers pain when mechanically stimulated by plucking it manually. He added that there is a segmental hyper-contraction within the muscle fiber. The present authors speculate that the hypertonicity of the biceps, pronator teres and subscapularis muscles can irritate the median nerve and may cause local oedema. Consequently, the nerve may be pinched when it runs through the narrow space of the carpal tunnel, and this would result in numbness and impairment of distal motor and sensory functions. The longer this process lasts (months-years), the more severe the neuropathy becomes, causing muscular weakness in the hand. We would argue that eliminating the TrPs along the median nerve relaxes the muscles and removes a source of irritation to the median nerve.

The treatment of the whole median nerve was used effectively in a case study by Leahy. (7) The median nerve may be damaged along its whole length, from its root, between the cervical vertebrae, down to and including the wrist. (8) According to Bonebrake et al., (27) conservative treatment of CTS is intended to lessen muscular and fibrous restriction. In their study, treatment was applied along the whole median nerve and, amongst other techniques, they used ischemic compression. In a recent trial by George,28 five patients suffering from CTS were treated three times weekly for two weeks using the Active Release Technique (ART) with a protocol designed to affect the median nerve. Using the Boston Questionnaire, they concluded that ART offered a significant reduction of the symptom severity and improvement of the functional status of the patients.

Davis (29) published a randomized clinical trial that showed a significant improvement in CTS syndrome amongst the patients. Myofascial massage along the median nerve was used with the chiropractic group but, since there were other modalities involved, the authors could not assess which was the active component of their intervention.

Limitations of the study

The total number of participants was small and there were only two treating chiropractors. The number of patients in the control group was small, compared with the number of those in the treatment group. The reason for this was that the treating clinicians found it difficult to construct a practice-based study that provided a group with what they considered would be a near placebo treatment. There was only a short-term follow-up comparison of the two group results and therefore it is unclear whether the results reported in this study would persist beyond the point of treatment cessation. The compression sites treated by the clinicians were considered very important on the basis of clinical experience, though very few others have treated these sites in the context of carpal tunnel syndrome. Finally, the control group was crossed over immediately after the 15 initial control treatments. In the absence of a wash-out period, a potential nonspecific effect of the placebo intervention could have carried over into the active treatment period among those patients who did participate in the crossover portion of the study.

Conclusion

This practice-based (pragmatic) clinical trial suggests that myofascial therapy using ischemic compression along the biceps, at the bicipital aponeurosis, at the pronator teres and at the subscapularis muscles could be a useful approach to reducing symptoms associated with the carpal tunnel syndrome. Patients' perceived improvement in functional capacities persisted over a six-month period. This last observation is based only on the before-and-after analysis of within group data. Future research on CTS should include a larger number of participants, a parallel placebo treatment group and long-term assessments.

References

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(2) Phalen GS. The carpal-tunnel syndrome. Clinical evaluation of 598 hands. Clin Orthop Relat Res. 1972; 83:29-40.

(3) Atroshi I, Gummesson C, Johnson R, et al. Prevalence of carpal tunnel syndrome in the general population. JAMA. 1999; 282:153-158.

(4) Practice parameter for carpal tunnel syndrome (summary statement). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 1993; 43:2406-9.

(5) Occupational disease surveillance: carpal tunnel syndrome. MMWR Morb Mortal Wkly Rep. 1989; 38:485-9.

(6) Einhorn N, Leddy JP. Pitfalls of endoscopic carpal tunnel release. Orthop Clin North Am. 1996; 27:373-80.

(7) Leahy M, Mock L. Myofascial release technique and mechanical compromise of peripheral nerves of the upper extremity. Chiropr Sports Med. 1992; 6:139-50.

(8) Normand MC, Descarreaux M. Est-ce vraiment un syndrome du canal carpien? J Can Chiropr Assoc. 2000; 44:149-56.

(9) Keller RB, Largay AM, Soule DN, Katz JN. Maine Carpal Tunnel Study: small area variations. J Hand Surg [Am]. 1998; 23:692-6.

(10) Bessette L, Keller RB, Liang MH, Simmons BP, Fossel AH, Katz JN. Patients' preferences and their relationship with satisfaction following carpal tunnel release. J Hand Surg [Am]. 1997; 22:613-20.

(11) Cotton P. Symptoms may return after carpal tunnel surgery. JAMA. 1991; 265:1922, 1925.

(12) DeStefano F, Nordstrom DL,Vierkant RA. Long-term symptom outcomes of carpal tunnel syndrome and its treatment. J Hand Surg [Am]. 1997; 22:200-10.

(13) Katz JN, Gelberman RH, Wright EA, Lew RA, Liang MH. Responsiveness of self-reported and objective measures of disease severity in carpal tunnel syndrome. Med Care. 1994; 32:1127-33.

(14) Phalen GS. The birth of a syndrome, or carpal tunnel revisited. J Hand Surg [Am]. 1981; 6:109-10.

(15) Atcheson SG. Carpal tunnel syndrome: is it work-related? Hospital Pract (Off Ed). 1999; 34:49-56; quiz 147.

(16) Miller RS, Iverson DC, Fried RA, Green LA, Nutting PA. Carpal tunnel syndrome in primary care: a report from ASPN. Ambulatory Sentinel Practice Network. J Fam Pract. 1994; 38:337-44.

(17) Katz JN, Larson MG, Sabra A, Krarup C, Stirrat CR, Sethi R, Eaton HM, Fossel AH, Liang MH. The carpal tunnel syndrome: diagnostic utility of the history and physical examination findings. Ann Intern Med. 1990; 112:321-7.

(18) Mesgarzadeh M, Schneck CD, Bonakdarpour A. Carpal tunnel: MR imaging. Part I. Normal anatomy. Radiology. 1989; 171:743-8.

(19) Marieb EN. Essentials of human anatomy and physiology. 2nd ed. 1988, Menlo Park, Calif.; Don Mills, Ont.: Benjamin/Cummings Pub. Co. xii, 417.

(20) Levine DW, Simmons BP, Koris MJ, Daltroy LH, Hohl GG, Fossel AH, Katz JN. A self-administered questionnaire for the assessment of severity of symptoms and functional status in carpal tunnel syndrome. J Bone Joint Surg Am. 1993; 75:1585-92.

(21) Simons DG. Review of enigmatic MTrPs as a common cause of enigmatic musculoskeletal pain and dysfunction. J Electromyography Kinesiol. 2004; 14:95-107.

(22) Gerwin RD, Dommerholt J, Shah J P. An expansion of Simons' integrated hypothesis of trigger point formation. Current Pain and Headache Reports. 2004; 8:468-75.

(23) Verhagen AP, Bierma-Zeinstra SM, Feleus A, Karels C, Dahaghin S, Burdorf L, de Vet HC, Koes BW. Ergonomic and physiotherapeutic interventions for treating upper extremity work-related disorders in adults. Cochrane Database Syst Rev. 2004; CD003471.

(24) Borg-Stein J, Stein J. Trigger points and tender points. Rheum Dis North Am. 1996; 22(2):305-322.

(25) Travel JG, Simons DG. Myofascial pain and dysfunction; the trigger point manual. Vol.1. Philadelphia: Williams and Wilkins 1983: p. 19.

(26) Christensen M. Job analysis of chiropractic. National Board of chiropractic examiners. Greeley, CO. 2005; 136.

(27) Bonebrake AR, Fernandez JE, Dahalan JB, Marly RJ. A treatment for carpal tunnel syndrome: results of a followup study. J Manipulative Physiol Ther. 1993; 16:125-39.

(28) Georges JW, Tepe R, Busold D et al. The effects of Active Release Technique on carpal tunnel patients: a pilot study. J Chiropr Med. 2006; 5:119-121.

(29) Davis PT, Hulbert JR, Kassak KM et al. Comparative efficacy of medical and chiropractic treatments for carpal tunnel syndrome: a randomized clinical trial. J Manipulative Physiol Ther. 1998; 21:317-326.

Guy Hains DC * Martin Descarreaux DC, PhD [[dagger]] Anne-Marie Lamy DC * Francois Hains DC, FCCS(C), MSc *

* Private practice,

[[dagger]] Professor, Universite du Quebec a Trois Rivieres, Quebec

Corresponding author:

Guy Hains, DC

2930 Cote Richelieu, Trois-Rivieres, Quebec, Canada, G8Z 3Y8

Phone: 819-375-5600,

E-Mail: guy.hains@tr.cgocable.ca

Fax: 819-379-4397
Table 1 Inclusion and exclusion criteria

Inclusion                           Exclusion

* Be between 20 and 60 years old.   * History of upper limb or neck
                                    surgery, pregnancy and systemic
* Suffer from numbness in the       pathologies possibly related to
hand affecting the thumb, the       CTS, such as hypothyroidism,
index finger, the middle finger     diabetes and rheumatoid arthritis.
and one half of the ring finger.

* Have suffered on a daily basis
for at least 3 months.

* Agree to a course of 15
chiropractic treatments at
no cost.

* All patients had to show at
least 2 of the following physical
signs: a Tinnel positive sign, a
Phallen positive sign, sleep
problems caused by hand
discomfort.

Table 2 Baseline characteristics of the experimental and control
groups. () = SD

                                          Symptoms
                                          duration    Disability
Group          N     Gender      Age       (years)       score

Experimental   37   11M; 26F   46 (6.7)   4.3 (2.9)   33.5 (15.2)
Control        18   10M; 8F    47 (7.2)   2.4 (3.1)   36.3 (10.2)

Table 3 Mean (SD) improvement in severity of symptoms and
functional status (%).

                                        30 days after
                        15 treatments    treatments

Experimental (N = 37)      42 (21)         45 (21)
Control (N = 18)           26 (18)           --

                                         15 control plus
                        6 months after   15 experimental
                          treatments        treatments

Experimental (N = 37)       36 (23)
Control (N = 18)              --              48 (15)

Table 4 Mean (SD) score from the perceived improvement
numerical scale (%).

                                         30 days after
                        15 treatments     treatments

Experimental (N = 37)      67 (26)          67 (30)
Control (N = 18)           50 (25)            --

                                         15 control plus
                        6 months after   15 experimental
                          treatments        treatments

Experimental (N = 37)      56 (35)
Control (N = 18)             --             75 (21)
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