The effect of hypericum perforatum on the wound healing and scar of cesarean.
|Article Type:||Clinical report|
St. John's wort
|Publication:||Name: Alternative Medicine Review Publisher: Thorne Research Inc. Audience: Academic; Professional Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2010 Thorne Research Inc. ISSN: 1089-5159|
|Issue:||Date: April, 2010 Source Volume: 15 Source Issue: 1|
|Geographic:||Geographic Scope: United States Geographic Code: 1USA United States|
OBJECTIVE: The aim of this study was to determine the effects of
Hypericum perforatum on cesarean wound healing and hypertrophic scar.
DESIGN: This was a randomized, double-blind clinical trial study.
SETTING: The study was conducted in Samen-Ol-Aemmeh (Pbuh) Hospital in
Mashhad, Iran. SUBJECTS: The subjects included 144 women with surgical
childbirth who had eligible criteria. INTERVENTION: The participants
were randomly assigned to three groups. The treatment and placebo groups
applied H. perforatum or placebo ointment 3 times a day for 16 days
based on consecutive coded ointments. The control group remained without
any intervention postoperatively. ASSESSMENT: Wound healing was assessed
on the 10th day postcesarean using the REEDA scale (REEDA stands for
redness, edema, ecchymosis, discharge, and approximation), which had
criteria including redness, edema, ecchymosis, discharge, and
approximation. On the 40th day, the degree of scarring was assessed
using the Vancouver scar scale including pigmentation, height,
pliability, and vascularity. The subjects were also asked some questions
about pain by using the Visual Analogue Scale and pruritus of scar.
RESULTS: The mean age of all the study subjects was 23.50 +/- 4.03 and
mean parity was 1.23 +/- 0.48. There were significant differences in
wound healing on the 10th day (p < 0.005) and scar formation on the
40th day postpartum (p < 0.0001) between treatment group with placebo
and control groups. However, the placebo group had no differences in
wound healing (p = 0.93) and scar formation (p = 0.11) with the control
group. In addition, significantly lower pain and pruritus were reported
by the treatment group compared with the placebo and control groups on
the 40th day postpartum. CONCLUSIONS: Topical application of H.
perforatum is safe and can facilitate cesarean wound healing and
minimize formation of scar and its pain and pruritus.
J Altern Complement Med 2010;16:113-117.
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