An anti-aging medical approach to men's health.
Subject: Longevity (Methods)
Life style (Health aspects)
Coffee (Health aspects)
Prostate cancer (Prevention)
Alfacalcidol (Health aspects)
Calcifediol (Health aspects)
Vitamin D (Health aspects)
Cardiovascular diseases (Prevention)
Multivitamins (Health aspects)
Men (Health aspects)
Men (Care and treatment)
Alertness (Psychology)
Authors: Klatz, Ronald
Goldman, Robert
Pub Date: 07/01/2012
Publication: Name: Townsend Letter Publisher: The Townsend Letter Group Audience: General; Professional Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2012 The Townsend Letter Group ISSN: 1940-5464
Issue: Date: July, 2012 Source Volume: 348
Product: Product Code: 2095000 Processed Coffee NAICS Code: 31192 Coffee and Tea Manufacturing SIC Code: 2095 Roasted coffee; 2834 Pharmaceutical preparations
Geographic: Geographic Scope: United States Geographic Code: 1USA United States
Accession Number: 297056588
Full Text: The US Centers for Disease Control and Prevention (CDC) reports that 11.9% of men ages 18 years and older rate their health as fair or poor. Many of the leading causes of poor or failing health among men may be readily preventable, as well as successfully treatable. In this article, we present the latest studies suggesting practicable take-action preventative nutritional approaches that may help to improve the quality, and quite possibly extend the quantity, of life among our male readers.

Summary health statistics for U.S. adults: National Health Interview Survey. Appendix III, table XIII. 2010. Reported at http://www.cdc.govinchs/fastats/mens_health.htm; accessed 4 April 2012.


Anti-Aging Lifestyle May Profoundly Extend Lifespan

Following the tenets of the anti-aging lifestyle may be a predominant factor in prolonging how long--and well--you live. Lars Wilhelmsen and colleagues from the University of Gothenburg (Sweden) analyzed data from The 1913 Men epidemiological study, which began in 1963, when one-third of all the 50-year-old men residing in Gothenburg had a cardiovascular check-up. Every 10 years since, a new group of 50-year-olds has been called in, and those who were already taking part in the study have been given another check-up. The men born in 1913 were examined when they were 50, 54, 60, 67, 75, and 80 years of age. Of the 855 men who took part in the study from the start, 111 (13%) were still alive at age 90. The researchers found the following factors enabled the greatest chances of living to age 90:

* do not smoke

* consume moderate amounts of coffee.

* at a good socioeconomic status at the age of 50 (measured in terms of housing costs)

* engaged in good physical working capacity at the age of 54

* low cholesterol at age 50

As well, the team reports, "Variables of greatest importance at higher ages were low blood pressure and measures related to good cardiorespiratory function," leading them to conclude: "Low levels of cardiovascular risk factors, high socio-economic status and good functional capacity, irrespective of parents' survival, characterize men destined to reach the age of 90."

Svardsudd WK, Eriksson H, Rosengren A, et al. Factors associated with reaching 90 years of age: a study of men born in 1913 in Gothenburg, Sweden. J Int Med. 22 Dec, 2010.

Coffee May Lower Risk of Lethal Prostate Cancer

Coffee contains a number of beneficial compounds that act as antioxidants, reduce inflammation, and regulate insulin, and previous studies have associated coffee with a lower risk of Parkinson's disease, type 2 diabetes, gallstone disease, and liver cancer or cirrhosis. Lorelei Mucci and colleagues from Harvard School of Public Health (US) examined the association between coffee consumption and the risk of prostate cancer, particularly the risk for aggressive prostate cancer among 47,911 US men in the Health Professionals Follow-Up Study who reported their coffee consumption every four years from 1986 to 2008. During the study period, 5035 cases of prostate cancer were reported, including 642 fatal or metastatic cases. The researchers found that men who consumed the most coffee (six or more cups daily) had nearly a 20% lower risk of developing any form of prostate cancer. Importantly, the inverse association with coffee was even stronger for aggressive prostate cancer. Men who drank the most coffee had a 60% lower risk of developing lethal prostate cancer. Noting that the reduction in risk was seen whether the men drank decaffeinated or regular coffee, and does not appear to be due to caffeine, the team observed that drinking one to three cups of coffee per day was associated with a 30% lower risk of lethal prostate cancer. They conclude: "We observed a strong inverse association between coffee consumption and risk of lethal prostate cancer. The association appears to be related to non-caffeine components of coffee."


Wilson KM, Kasperzyk JL, Rider JR, et al. Coffee consumption and prostate cancer risk and progression in the Health Professionals Follow-up Study. J Nati Cancer Inst. May 17, 2011.

Vitamin D Vital for Heart Health

Previously, some studies have linked vitamin D deficiency to an increased risk of cardiovascular disease. Qi Sun and colleagues from Harvard School of Public Health (US) evaluated the associations between both dietary and supplemental vitamin D and cardiovascular disease risk. The team assessed data collected on 74,272 women enrolled in the Nurses' Health Study and 44,592 men enrolled in the Health Professionals Follow-Up Study, none of whom had cardiovascular disease at the start of the study. At the end of the study, 9886 cases of coronary heart disease and stroke were documented. The researchers found a 16% reduction in heart disease among men who met the Dietary Reference Intake (DRI) of vitamin D of at least 600 IU per day, as compared with men with daily intakes of less than 100 IU. Commenting on the potential mechanism, the team posits that vitamin D may influence the reninangiotensin system (linked to blood pressure regulation), function of the endothelium (the cells lining blood vessels), insulin resistance, and systemic inflammation. The authors conclude: "These observations suggest that a higher intake of vitamin D is associated with a lower risk of [cardiovascular disease] in men."

Sun Q, Shi L, Itimm EB, et al. Vitamin D intake and risk of cardiovascular disease in US men and women. Am J Clin Nurr. July 2011.

Daily Multivitamin Improves Alertness and Well-Being

Among healthy men, a daily multivitamin and mineral supplement with added plant extracts helps to boost alertness and feelings of well-being. Andrew Pipingas and colleagues from Swinburne University (Australia) enrolled 50 men, ages 50 to 69 years, in an 8-week-long study. Each subject received either a multivitamin containing vitamins, minerals, antioxidants, and plant extracts, or placebo. The team measured mood and stress using a standardized assessment scale. After 8 weeks, among the participants receiving the vitamin supplement, a notable decrease in measures of depression, anxiety, and stress was observed. As well, among the vitamin supplemented group, significant improvement in alertness was reported by the subjects. Observing an "improvement in ... general daily functioning in the multivitamin group," the study authors conclude: "Supplementation with a multivitamin, mineral and herbal formulation may be useful in improving alertness and reducing negative mood symptoms and may also improve feelings of general day-to-day well-being."

Harris E, Kirk J, Rowsell R, et at The effect of multivitamin supplementation on mood and stress in healthy older men. Hum Psychopharmacol, 16 November 2011.

Sustained Fitness Promotes Long Life

Men who are physically fit in their 40s, and maintain that fitness level for a decade, reduce their risk of all-cause death by 30%. Duck-chul Lee and colleagues from the University of South Carolina at Columbia (US) explored the independent and combined associations of changes in fitness as estimated from a maximal treadmill test and BMI with all-cause and cardiovascular disease mortality. The team revealed that men who were physically fit in their 40s, and maintained that fitness level for a decade, reduced their risk of all-cause death by 30%--as compared with men who were flabby at age 40. Specifically, during more than 11 years of follow-up, the researchers found that those men who maintained their baseline fitness levels had a 28% lower risk of cardiovascular disease death, while those who improved their fitness had a 40% and 44% lower risk of all-cause and cardiovascular disease death, respectively, as compared with those who remained unfit. Whereas body mass index (BMI) status had little impact on risk of death in those who remained fit, BMI had variable yet nonsignificant impact on those who lost fitness or were unfit at the study's start. For every 1-metabolic equivalent (MET) improvement in fitness, there was a 15% lowering of the risk of all-cause death, and a 19% reduction in cardiovascular disease death. Observing, "Maintaining or improving fitness is associated with a lower risk of all-cause and [cardiovascular disease] mortality in men," the study authors urge: "Preventing age-associated fitness loss is important for longevity regardless of [body mass index] change."

Lee D-c, Sui X, Artero EG, et al. Long-term effects of changes in cardiorespiratory fitness and body mass index on all-cause and cardiovascular disease modality in men: the Aerobics Center Longitudinal Study. Circulation. 2011;124:2483-2490.

We encourage our male readers to adopt the hallmarks of the anti-aging lifestyle. Namely, eat a healthful diet, stay physically active, don't smoke, and get regular checkups and screenings. Coupled with the nutritional approaches reviewed above, adopting the anti-aging lifestyle will certainly help increase your ability to achieve a long and robust life.

To stay updated on the latest breakthroughs in natural, nontoxic approaches to curb inflammation, visit the World Health Network (, the official educational website of the A4M and your one-stop resource for authoritative anti-aging information. Be sure to sign up for the free Longevity Magazine e-journal, your weekly health newsletter featuring wellness, prevention, and biotech advancements in longevity.

by Ronald Klatz, MD, DO, and Robert Goldman, MD, PhD, DO, FAASP
Gale Copyright: Copyright 2012 Gale, Cengage Learning. All rights reserved.