Water extracts of cinnamon in diabetes and in cervical cancer.
Article Type: Report
Subject: Blood sugar (Measurement)
Insulin resistance (Care and treatment)
Cervical cancer (Risk factors)
Cervical cancer (Prevention)
Diabetes (Care and treatment)
Materia medica, Vegetable (Health aspects)
Plant extracts (Health aspects)
Cinnamon (Usage)
Cinnamon (Health aspects)
Medicine, Botanic (Research)
Medicine, Herbal (Research)
Author: Hunter, Kim
Pub Date: 06/22/2010
Publication: Name: Australian Journal of Medical Herbalism Publisher: National Herbalists Association of Australia Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2010 National Herbalists Association of Australia ISSN: 1033-8330
Issue: Date: Summer, 2010 Source Volume: 22 Source Issue: 2
Topic: Event Code: 310 Science & research
Geographic: Geographic Scope: Australia Geographic Code: 8AUST Australia
Accession Number: 232178435
Full Text: Stoecker BJ, Zhan Z et al. 2010. Cinnamon extract lowers blood glucose in hyperglycemic subjects. Presented at the Federation of American Societies for Experimental Biology (FASEB) Annual Meeting, Anaheim, CA, April 26. Abstract only published FASEB Journal 24:722.1.

This double blind placebo controlled study used an extract called CinSulin (water extract of cinnamon) from the Chinese company Tang An Medical to reduce glucose levels in people with insulin resistance. Insulin resistance occurs when cells become less sensitive to the glucose lowering effects of insulin resulting in increases in blood levels of glucose and eventually type 2 diabetes.

The authors recruited 137 hyperglycemic patients (72 female, average age 61, average BMI 25.3) who were randomly assigned to receive placebo or a 500 mg daily dose (250 mg capsule twice daily) of the cinnamon extract for two months. At the beginning of the study insulin resistance was significantly correlated with diastolic blood pressure, postprandial glucose and insulin, triglycerides, fructosamine, BMI and negatively correlated with HDLC.

After 2 months, fasting glucose decreased in the cinnamon supplemented group by 7.5% from an average of 8.85 to 8.19 mmol/L, while the placebo group experienced a decrease of only 1.6% from 8.57 to 8.44 mmol/L. Furthermore blood sugar levels two hours after a carbohydrate rich meal decreased by 12% following cinnamon supplementation, compared with only 3.1% in the placebo group. Insulin concentrations and insulin resistance tended to be improved by cinnamon supplements but differences were not significant.

This clinical trial adds to the growing evidence that aqueous cinnamon extract may be beneficial for insulin resistant populations.

Koppikar SJ et al, 2010. Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential. BMC Cancer 10;210. The entire paper is open access via www.biomedcentral.com.

This cell line study considered the potential of a water extract of cinnamon as a chemoproventive agent by studying its anti neoplastic activity against the cervical cancer cell line, SiHa. Chemoprevention includes the use of synthetic or natural agents (alone or in combination) to block the development of cancer in human beings.

The aqueous cinnamon extract (ACE-c) was analysed for its cinnamaldehyde content by HPTLC analysis. The polyphenol content of ACE-c was measured and a cytotoxicity analysis was performed by MTT assay. The authors studied the effect of the ACE-c on growth kinetics by performing growth curve, colony formation and soft agar assays. The cells treated with ACE-c were analyzed for wound healing assay as well as for matrix metalloproteinase-2 (MMP-2) expression at mRNA and protein level by RT-PCR and zymography respectively. Her-2 protein expression was analyzed in the control and ACE-c treated samples by immunoblotting as well as confocal microscopy. Apoptosis studies and calcium signaling assays were analyzed by FACS. Loss of mitochondrial membrane potential in cinnamon treated cells was studied by JC-1 staining and analyzed by confocal microscopy as well as FACS.

Results showed that cinnamon altered the growth kinetics of SiHa cells in a dose dependent manner. Cells treated with ACE-c exhibited reduced number of colonies compared to the control cells. The treated cells exhibited reduced migration potential that could be explained due to downregulation of MMP-2 expression. Interestingly the expression of Her-2 oncoprotein was significantly reduced in the presence of ACE-c.

Cinnamon extract induced apoptosis in the cervical cancer cells through increase in intracellular calcium signaling as well as loss of mitochondrial membrane potential. These results show that cinnamon could be used as a potent chemopreventive drug in cervical cancer.

Kim Hunter mnhaa

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