Update in surgical pathology.
Article Type: Report
Subject: Cancer (Diagnosis)
Pathology (Practice)
Pathology (Forecasts and trends)
Author: Husain, Aliya N.
Pub Date: 07/01/2009
Publication: Name: Archives of Pathology & Laboratory Medicine Publisher: College of American Pathologists Audience: Academic; Professional Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2009 College of American Pathologists ISSN: 1543-2165
Issue: Date: July, 2009 Source Volume: 133 Source Issue: 7
Topic: Event Code: 200 Management dynamics; 010 Forecasts, trends, outlooks; 350 Product standards, safety, & recalls Computer Subject: Market trend/market analysis
Organization: Organization: World Health Organization
Geographic: Geographic Scope: United States Geographic Code: 1USA United States
Accession Number: 230152032
Full Text: The University of Chicago Pathology Department (Chicago, Illinois) has been giving an annual course, Current Issues in Surgical Pathology, organized by Anthony G. Montag, MD, for the last 8 years. The course duration has varied between 1 to 2 days, with up to 150 attendees. The entire faculty has participated during the years, together with guest speakers from distinguished outside institutions. The goal has been to take various topics, give a brief background introduction, and focus on recently discovered information that would be of practical use to the anatomic pathologist. This special issue is structured similarly. The faculty was invited to select topics in their areas of expertise in which there have been significant advances in etiology, pathogenesis, classification, or management of disease.

Whole textbooks can be written with the above goal in mind. Given the obvious space limitations of this special issue, a key decision was made to avoid in-depth reviews of information that is readily available in books. With the interests of the faculty and the international readers of this journal in mind, updates are provided for a broad range of diseases that practicing pathologists are likely to encounter often. The style of each article varies somewhat based on the authors' preference and the topic being covered. Thus "Frozen Section" expresses a point of view; "Dermatopathology" presents an updated review of selected immunohistochemical stains useful in the diagnosis of skin diseases and a brief overview of commonly used stains; "Lymph Node" summarizes the numerous types of diffuse large B cell lymphoma described in the 2008 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues; "Central Nervous System" reviews diagnostic and prognostic molecular markers of tumors; "Renal Carcinoma" deals with the new advancements made in the fields of genetics and molecular medicine that have helped to better classify renal tumors into distinct clinicopathologic entities with different clinical outcome and have also opened the door for targeted therapies against molecules in their specific pathways; "Renal Diseases" focuses on the accurate evaluation of the nonneoplastic kidney parenchyma, which is as important as the pathologic characterization of the tumor in nephrectomy specimens given that the preservation of renal function is an important consideration for the quality of life and long-term clinical outcome of patients after tumor nephrectomy or nephroureterectomy procedures; "Prostate Cancer" deals with recent updates regarding the roles and functions of the androgen receptor with and without hormone deprivation and also discusses the newly identified gene rearrangements involving the ETS family of transcription factors in prostate cancer and their clinical implications; "Gynecologic Update" reviews the recent advances in the understanding of genetic conditions that have significant practical implications such as assessment of specimens for cancer precursors, possible occult disease, and prospective evaluations for potential genetic conditions; "Liver Pathology" reviews 3 emerging topics, namely, juvenile hemochromatosis, telangiectatic hepatic adenoma, and the distinct pediatric variant of nonalcoholic steatohepatitis; "Gastrointestinal Diseases" is focused on distinction of eosinophilic esophagitis and reflux (a controversial issue) and also points out that drug injury in the esophagus is often overlooked (underdiagnosed); "Breast Update" focuses on lobular neoplasia; "Nonneoplastic Lung Diseases" reviews current concepts and understanding in the pathogenesis of alveolar proteinosis, selected interstitial lung diseases, pulmonary hypertension, and asthma; and "Neoplastic Lung Diseases" focuses on precursor lesions, small adenocarcinomas, bronchioloalveolar carcinoma, and mesothelioma.

The authors thank Dr. Philip T. Cagle, MD, for the opportunity to contribute to this special section.

Accepted for publication January 12, 2009.

From the Department of Pathology, University of Chicago Medical Center, Chicago, Illinois.

The author has no relevant financial interest in the products or companies described in this article.

Reprints: Aliya N. Husain, MD, Department of Pathology, University of Chicago Medical Center, MC6101, 5841 S Maryland Avenue, Chicago, IL 60637 (e-mail: aliya.husain@uchospitals.edu).

Aliya N. Husain obtained her medical degree from the King Edward Medical College in Lahore, Pakistan, in 1980, and after a 1-year house job in internal medicine, she immigrated to the United States where she started her pathology training at the University of South Florida. After the first year, she moved to the Chicago area with her family and completed her training in anatomic and clinical pathology, which was followed by 1 year of surgical pathology fellowship at Loyola University Medical Center in Maywood, Illinois. She continued there as a faculty member during which time she developed her interests in pediatric and pulmonary pathology. In 2002 she was recruited to the University of Chicago where she is an academic surgical pathologist and the pathology director of the sophomore medical student course Clinical Pathophysiology and Therapeutics. Dr Husain is a section editor in pediatric pathology for the Archives of Pathology & Laboratory Medicine.
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