Topical anti-inflammatory and analgesic activity of Verbena officinalis.
Article Type: Brief article
Subject: Inflammation (Care and treatment)
Verbena (Health aspects)
Verbena (Usage)
Author: Sarris, Jerome
Pub Date: 03/22/2007
Publication: Name: Australian Journal of Medical Herbalism Publisher: National Herbalists Association of Australia Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2007 National Herbalists Association of Australia ISSN: 1033-8330
Issue: Date: Spring, 2007 Source Volume: 19 Source Issue: 1
Geographic: Geographic Scope: Australia Geographic Code: 8AUST Australia
Accession Number: 174818464
Full Text: Calve M. 2006. Anti-inflammatory and analgesic activity of the topical preparation of Verbena officinalis L. J Ethnopharmacol 107;380-2.

Verbena officinalis (vervain) has traditional use in European folk medicine as a topical treatment for inflammation. The effects of a vervain cream consisting of a 50% methanolic extract (VO-1%, 1.5%, 2%, 2.5%, 3%) were tested on a carrageenan induced oedema and formalin testing animal model. Piroxicam gel and methyl salicylate ointment were used as positive controls for anti-inflammatory and analgesic activity respectively.

Vervain cream was discovered to reduce inflammatory edema dose dependently, with the 3% extract possessing activity similar to Piroxicam gel. In the analgesia test vervain cream dose dependently exerted topically induced analgesia, although not to the same extent as methyl salicylate. The active constituents identified as for the antinociceptive and anti-inflammatory activity are believed to be the iridoids, caffeoyl derivatives and flavonoids.

Jerome Sarris

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