Topical anti-inflammatory and analgesic activity of Verbena officinalis.
|Article Type:||Brief article|
(Care and treatment)
Verbena (Health aspects)
|Publication:||Name: Australian Journal of Medical Herbalism Publisher: National Herbalists Association of Australia Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2007 National Herbalists Association of Australia ISSN: 1033-8330|
|Issue:||Date: Spring, 2007 Source Volume: 19 Source Issue: 1|
|Geographic:||Geographic Scope: Australia Geographic Code: 8AUST Australia|
Calve M. 2006. Anti-inflammatory and analgesic activity of the
topical preparation of Verbena officinalis L. J Ethnopharmacol
Verbena officinalis (vervain) has traditional use in European folk medicine as a topical treatment for inflammation. The effects of a vervain cream consisting of a 50% methanolic extract (VO-1%, 1.5%, 2%, 2.5%, 3%) were tested on a carrageenan induced oedema and formalin testing animal model. Piroxicam gel and methyl salicylate ointment were used as positive controls for anti-inflammatory and analgesic activity respectively.
Vervain cream was discovered to reduce inflammatory edema dose dependently, with the 3% extract possessing activity similar to Piroxicam gel. In the analgesia test vervain cream dose dependently exerted topically induced analgesia, although not to the same extent as methyl salicylate. The active constituents identified as for the antinociceptive and anti-inflammatory activity are believed to be the iridoids, caffeoyl derivatives and flavonoids.
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