Skin problems in individuals with lower-limb loss: literature review and proposed classification system.
|Article Type:||Clinical report|
Skin diseases (Diagnosis)
Skin diseases (Care and treatment)
Bui, Kelly M.
Raugi, Gregory J.
Nguyen, Viet Q.
Reiber, Gayle E.
|Publication:||Name: Journal of Rehabilitation Research & Development Publisher: Department of Veterans Affairs Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2009 Department of Veterans Affairs ISSN: 0748-7711|
|Issue:||Date: Dec 31, 2009 Source Volume: 46 Source Issue: 9|
|Topic:||Event Code: 310 Science & research|
|Geographic:||Geographic Scope: United States Geographic Code: 1USA United States|
Problems with skin integrity can disrupt the daily use of a prosthetic limb and interfere with the independence and lifestyle of individuals with lower-limb loss. Biomechanical factors involved in the interaction between a prosthetic limb and skin interface, including distribution of weight, shear force, moisture, and temperature, can lead to skin problems [1-3].
Skin problems associated with prosthetic limb use are common. While a range of skin diagnoses, such as allergic contact dermatitis, epidermal hyperplasia, malignancies, and ulcerations, have been described , we found no consistency in the literature regarding how these problems are reported. Accordingly, we do not know the epidemiology of the residual-limb dermatologic issues faced by individuals with lower-limb loss. A recent literature review  cited only one study  with sufficient rigor to ascertain a prevalence of 16 percent for skin problems on the residual limb. However, the skin problems reported in that study were limited to abscesses and ulcers, a narrow subset of the whole spectrum of dermatologic issues that could affect prosthetic limb use and user satisfaction.
As a first step toward filling this gap in knowledge, we undertook a systematic review of the literature to better define the prevalence and types of skin problems on the residual limb related to prosthetic use. We use this information to propose a classification system that may be of use in future clinical studies.
We searched the literature published through 2008 using four databases: MEDLINE, EMBASE, CINAHL, and RECAL. MEDLINE is a biomedical database containing publications since the 1950s. EMBASE is a biomedical and pharmacological database containing publications since 1988. CINAHL is a nursing and allied health database containing publications since 1982. RECAL is an orthotics and prosthetics database containing publications from 1900 to 2007. Table 1 shows medical subject headings (MeSH) and free text words that we used to search MEDLINE, CINAHL, and EMBASE. MeSH are standardized terms defined by the National Library of Medicine and arranged in a hierarchical structure that allows searching at various levels of specificity. In RECAL, we used the free text words "skin" and "amputation" (MeSH not available). We restricted our search to the English language and humans in MEDLINE and EMBASE and to the English language in CINAHL (option to limit to human research not available).
We reviewed the title and abstract of all publications identified in our literature search. We selected articles if they discussed skin problems in adults (>18 years old) with lower-limb loss (transtibial, transfemoral, or knee disarticulation, but not foot, ankle, or hip disarticulation) who were fitted with a prosthesis. We excluded articles that discussed wound healing immediately postamputation. We removed duplicate articles obtained from different databases.
Our second selection process involved reviewing study research methodology. We selected articles if they included a description of the inclusion and exclusion criteria and the study population, identified the reason for amputation, identified the level of amputation, and reported both the prevalence and types of skin problems on a residual limb associated with prosthetic limb use. We excluded all case studies, case series, reviews, expert opinions, and letters to editors. We also excluded articles published before 1990 or with a sample size of fewer than 40 subjects.
Lastly, we reviewed the reference lists of these articles for publications related to skin problems in individuals with lower-limb loss (transtibial, transfemoral, or knee disarticulation). Relevant articles published after 1990 underwent the second selection process we mentioned previously.
Our initial search using MeSH and free text words yielded 777 articles: 313 from MEDLINE, 233 from EMBASE, 31 from CINAHL, and 200 from RECAL (Table 2). Our first selection process yielded 71 publications: 50 from MEDLINE, 5 from EMBASE, 3 from CINAHL, and 13 from RECAL (Table 2). We found an additional 19 related articles published after 1990 in the reference lists. We then reviewed the study methodology of the resulting 90 articles and retained 2 publications from MEDLINE and 2 from the reference lists (Table 2).
The 86 articles we excluded included 41 case reports or case series; 16 reviews or expert opinions; 4 letters to editors; 2 duplicated articles; and 7 articles about topics not of interest, including novel treatments for skin problems, quality of life, shear force, or no reported skin problems. We also excluded an additional two articles: one article (with the exception of its abstract) was written in Korean and the other, although referenced in another study, was unpublished. The remaining 14 articles we excluded were clinical studies discussing skin problems in individuals with limb loss. Four studies discussed both upper- and lower-limb amputations [7-10], one of which was published before 1990 . Ten cross-sectional and cohort studies about lower-limb loss did not meet our selection criteria because of insufficient sample size , the presence of nonadult participants [13-17], missing selection criteria , failure to report the prevalence of skin problems [14,18], or lack of skin problem specification [12,17,19-20].
Table 3 identifies the four publications that met our selection criteria, representing research performed in the Netherlands, Canada, the United States, and Singapore from 1990 to 2008 [6,21-23]. All the studies were cross-sectional and obtained data through either a chart review or a questionnaire delivered by mail or telephone. A physician assessed skin problems in three out of the four studies; the last study was by patient self-report . The most common reasons for amputation were vascular disease, diabetes, and trauma. The most common amputation level was transtibial.
The overall prevalence of skin problems ranged from 15 to 41 percent, with increasing prevalence in the more recent studies. The most commonly reported skin problems ([greater than or equal to] 20%) were wounds (including ulcers), abscesses, and blisters. The articles did not specify the method of skin problem assessment (i.e., physical examination, laboratory data, or biopsy).
We found one systematic literature review about skin problems in individuals with lower-limb loss that reviewed the literature published through 2002 . We used similar methodological assessment criteria, including an assessment of the inclusion and exclusion criteria, a description of the study population, and the prevalence rate of skin problems. We added several criteria, including the level of amputation, the reason for amputation, and a description of types of skin problems. These additions allowed us to narrow our focus to lower-limb amputations, better characterize the study populations, and describe the types of skin problems commonly reported in the literature.
The limited number of cohort studies (n = 4), none of which met our inclusion criteria, identifies an area for future research. Because of the inherent limitations of a cross-sectional study, including the inability to obtain an incidence of skin problems and to infer causality of factors that may lead to skin problems, we recommend that future studies answer these questions by using more rigorous study designs.
None of the clinical studies included a definition or standardized method of assessment for skin problems, thus making it difficult for us to describe and categorize the common types of skin problems in individuals with lower-limb loss. In the literature, some studies consider perspiration and hygiene problems as factors leading to skin problems , whereas others categorize these precursor conditions as skin problems themselves [11,14,18]. Some studies reported using patch testing and swab testing to clarify the underlying etiology of skin problems , whereas others did not report how the skin problems were assessed and subsequently diagnosed [15,22]. Description of skin problems varied across studies and depended on the person reporting the skin problems (patient vs physician), with more detailed descriptions provided by physicians. The lack of standardization made it difficult for us to accurately compare the prevalence rates of skin problems across studies and to describe the most commonly occurring skin problems. Differing skin problem prevalence rates may also be attributed to the etiology of the amputation or the country of study.
Our study is limited to reviewing the existing literature (1990-2008) about individuals with lower-limb loss. We did not include unpublished studies, those with a sample size of fewer than 40 subjects, or those written in languages other than English. To the best of our knowledge, this study comprehensively reviews the literature that exists on skin problems in individuals with lower-limb loss. In addition to completing a search inquiry in four databases, we also reviewed reference lists to ensure that we did not miss relevant studies.
We recommend that future classification of lower-limb problems on the residual limb be categorized according to either morphology or etiology rather than with generalizations (e.g., "rash" or "wound"). Hygiene problems, odor, and sweating should be considered precursors to skin problems. We propose a classification schema as shown in Tables 4 and 5, in which the same skin conditions are included regardless of classification strategy. Standardized definitions of skin problems will allow clinicians and researchers to report the prevalence and types of skin problems on residual limbs with improved external validity and reliability.
We conclude that the prevalence of skin problems in individuals with lower-limb loss from 1990 to 2008 was 15 to 41 percent; the most commonly reported skin problems were wounds, abscesses, and blisters. The prevalence and types of skin problems reported varied by study and their respective method of assessment and definition of skin problems. We recommend that future studies use the standard dermatology definitions for skin-problem classification as described in Tables 4 and 5. We also recommend a standardized assessment of an individual's residual limb at regular intervals so that comparisons may be made across studies and the causality of skin problems may be better inferred. Through such studies, we will better understand skin problems in individuals with lower-limb loss and effectively devise prevention and intervention for this significant problem.
Study concept and design: K. M. Bui, G. J. Raugi, G. E. Reiber.
Acquisition, analysis, and interpretation of data: K. M. Bui.
Drafting of manuscript: K. M. Bui, G. J. Raugi.
Critical revision of manuscript for important intellectual content: K. M. Bui, G. J. Raugi, V. Q. Nguyen, G. E. Reiber.
Statistical analysis: K. M. Bui.
Obtained funding: G. E. Reiber.
Administrative, technical, or material support: G. E. Reiber.
Study supervision: G. J. Raugi, G. E. Reiber.
Financial Disclosures: The authors have declared that no competing interests exist.
Funding/Support: This material was based on work supported by the Department of Veterans Affairs Health Services Research and Development Service (grant HR 05-244) and a Career Scientist Award (grant RCS 98-353) to Dr. Reiber.
Additional Contributions: The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs. Dr. Bui is now with the Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, and Dr. Nguyen is now with the Department of Dermatology, Henry Ford Hospital, Detroit, Michigan.
Submitted for publication April 20, 2009. Accepted in revised form August 11, 2009.
[1.] Levy SW. Amputees: Skin problems and prostheses. Cutis. 1995;55(5):297-301. [PMID: 7614842]
[2.] Levy SW. Skin problems of the leg amputee. Prosthet Orthot Int. 1980;4(1):37-44. [PMID: 7367224]
[3.] Spires MC, Leonard JA. Prosthetic pearls: Solutions to thorny problems. Phys Med Rehabil Clin North Am. 1996;7:509-26.
[4.] Meulenbelt HE, Geertzen JH, Dijkstra PU, Jonkman MF. Skin problems in lower limb amputees: An overview by case reports. J Eur Acad Dermatol Venereol. 2007;21(2): 147-55. [PMID: 17243947] DOI:KUm/j.1468-3083.2006.01936.x
[5.] Meulenbelt HE, Dijkstra PU, Jonkman MF, Geertzen JH. Skin problems in lower limb amputees: A systematic review. Disabil Rehabil. 2006;28(10):603-8. [PMID: 16690571] DOI:10.1080/09638280500277032
[6.] Chan KM, Tan ES. Use of lower limb prosthesis among elderly amputees. Ann Acad Med Singapore. 1990;19(6): 811-16. [PMID: 2130743]
[7.] DesGroseilliers JP, DesJardins JP, Germain JP, Krol AL. Dermatologic problems in amputees. Can Med Assoc J. 1978; 118(5):535-37. [PMID: 630514]
[8.] Hirai M, Tokuhiro A, Takechi H. Stump problems in traumatic amputation. Acta Med Okayama. 1993;47(6):407-12. [PMID: 8128915]
[9.] Livingston DH, Keenan D, Kim D, Elcavage J, Malangoni MA. Extent of disability following traumatic extremity amputation. J Trauma. 1994;37(3):495-99. [PMID: 8083915] DOI:10.1097/00005373-199409000-00027
[10.] Lyon CC, Kulkarni J, Zimerson E, Van Ross E, Beck MH. Skin disorders in amputees. J Am Acad Dermatol. 2000; 42(3):501-7. [PMID: 10688725] DOI: 10.1016/S0190-9622(00)90227-5
[11.] Otter N, Postema K, Rijken RA, Van Limbeek J. An open socket technique for through-knee amputations in relation to skin problems of the stump: An explorative study. Clin Rehabil. 1999;13(1):34-43. [PMID: 10327095] DOI:10.1191/026921599701532108
[12.] Rommers GM, Vos LD, Klein L, Groothoff JW, Eisma WH. A study of technical changes to lower limb prostheses after initial fitting. Prosthet Orthot Int. 2000;24(1):28-38. [PMID: 10855436] DOI: 10.1080/03093640008726519
[13.] Koc E, Tunca M, Akar A, Erbil AH, Demiralp B, Arca E. Skin problems in amputees: A descriptive study. Int J Dermatol. 2008;47(5):463-66. [PMID: 18412862] DOI:10.1111/j.1365-4632.2008.03604.x
[14.] Lake C, Supan TJ. The incidence of dermatological problems in the silicone suspension sleeve user. J Prosthet Orthot. 1997;9(3):97-106. DOI:10.1097/00008526-199700930-00003
[15.] Pierce RO Jr, Kernek CB, Ambrose TA 2nd. The plight of the traumatic amputee. Orthopedics 1993;16(7):793-97. [PMID: 8361918]
[16.] Pohjolainen T. A clinical evaluation of stumps in lower limb amputees. Prosthet Orthot Int. 1991;15(3):178-84. [PMID: 1780222]
[17.] Walker CR, Ingram RR, Hullin MG, McCreath SW. Lower limb amputation following injury: A survey of long-term functional outcome. Injury. 1994;25(6):387-92. [PMID: 8045644] DOI:10.1016/0020-1383(94)90132-5
[18.] Hachisuka K, Nakamura T, Ohmine S, Shitama H, Shinkoda K. Hygiene problems of residual limb and silicone liners in transtibial amputees wearing the total surface bearing socket. Arch Phys Med Rehabil. 2001;82(9):1286-90. [PMID: 11552206] DOI: 10.1053/apmr.2001.25154
[19.] Datta D, Vaidya SK, Howitt J, Gopalan L. Outcome of fitting an ICEROSS prosthesis: Views of trans-tibial amputees. Prosthet Orthot Int. 1996;20(2):111-15. [PMID: 8876004]
[20.] Kauzlari N, Kauzlari KS, Kolundzi R. Prosthetic rehabilitation of persons with lower limb amputations due to tumour. Eur J Cancer Care. 2007;16(3):238-43. [PMID: 17508943] DOI:10.1111/j.1365-2354.2006.00727.x
[21.] Baars EC, Dijkstra PU, Geertzen JH. Skin problems of the stump and hand function in lower limb amputees: A historic cohort study. Prosthet Orthot Int. 2008;32(2):179-85. [PMID: 18569886] DOI:10.1080/03093640802016456
[22.] Dudek NL, Marks MB, Marshall SC, Chardon JP. Dermatologic conditions associated with use of a lower-extremity prosthesis. Arch Phys Med Rehabil. 2005;86(4):659-63. [PMID: 15827914] DOI:10.1016/j.apmr.2004.09.003
[23.] Pezzin LE, Dillingham TR, MacKenzie EJ. Rehabilitation and the long-term outcomes of persons with trauma-related amputations. Arch Phys Med Rehabil. 2000;81(3):292-300. [PMID: 10724073] DOI:10.1016/S0003-9993(00)90074-1
Abbreviation: MeSH = medical subject headings.
Kelly M. Bui, MD; (1) Gregory J. Raugi, MD, PhD; (2-3) Viet Q. Nguyen, MD; (1) Gayle E. Reiber, MPH, PhD (2,4) *
(1) School of Medicine, University of Washington, Seattle, WA; (2) Health Services Research and Development Service, Department of Veterans Affairs (VA) Puget Sound Health Care System, Seattle, WA; (3) Primary and Specialty Medical Services, Division of Dermatology, VA Puget Sound Health Care System, Seattle, WA; (4) School of Public Health, University of Washington, Seattle, WA
* Address all correspondence to Gayle E. Reiber, MPH, PhD; VA Puget Sound Health Care System, Health Services Research and Development Service, MS 152, 1660 S. Columbian Way, Seattle, WA 98108; 206-764-2089; fax: 206-764-2935. Email: firstname.lastname@example.org
Table 1. Medical subject headings, free text words, and combinations used in MEDLINE, CINAHL, and EMBASE literature searches. No. MEDLINE 1 amputation/ or disarticulation/ 2 residual limb.mp 3 amputation stumps/ 4 (amputation or stump or disarticulation).mp 5 amputees/ or amputee.mp 6 1 or 2 or 3 or 4 or 5 7 lower extremity/ or leg/ or knee/ or thigh/ 8 (lower extremity or lower limb or tibia or femur or trans-tibial or trans-femoral or leg * or knee * or thigh *).mp 9 (metatarsal or foot or ankle or hip).mp 10 (7 or 8) not 9 11 prosthetic limb.mp 12 artificial limbs/ or artificial limb.mp 13 10 or 11 or 12 14 exp * skin diseases/ or exp * skin/ 15 prosthesis fitting/adverse effect 16 14 or 15 17 6 and 13 and 16 18 Limit to English and humans No. CINAHL 1 amputation/ or amputation, traumatic/ 2 above-knee amputation/ or below-knee amputation 3 residual limb.mp or amputation stumps/ 4 (amputation or stump or disarticulation).mp 5 amputees/ or amputee.mp 6 1 or 2 or 3 or 4 or 5 7 lower extremity/ or knee/ or leg/ or thigh/ 8 (lower extremity or lower limb or tibia or femur or trans-tibial or trans-femoral or leg * or knee * or thigh *).mp 9 (metatarsal or foot or ankle or hip).mp 10 (7 or 8) not 9 11 (prosthetic limb or leg prosthesis).mp 12 artificial limb.mp or limb prosthesis/ 13 10 or 11 or 12 14 exp * skin diseases/ or exp * skin/ 15 prosthesis fitting/adverse effect 16 14 or 15 17 6 and 13 and 16 18 Limit to English No. EMBASE 1 amputation/ or traumatic amputation/ 2 limb amputation/ or leg amputation/ or knee amputation 3 above-knee amputation/ or below-knee amputation 4 residual limb.mp/ or amputation stump/ 5 (disarticulation or amputation or stump or amputee).mp 6 1 or 2 or 3 or 4 or 5 7 limb/ or leg/ or knee/ or lower leg/ or thigh/ 8 femur/ or tibia/ (lower extremity or transtibial or trans-femoral or femur * or tibia * or leg * or knee * or thigh *).mp 9 (metatarsal or foot or ankle or hip).mp 10 (7 or 8) not 9 11 (artificial limb or prosthetic limb or leg prosthesis).mp 12 leg prosthesis/ or limb prosthesis/ or limb prosthesis.mp 13 10 or 11 or 12 14 exp * skin diseases/ or exp * skin/ 15 13 and 14 16 Limit to English and humans 17 -- 18 -- Table 2. Source and number of publications we identified, included, and excluded. Included Publications After First Source Identified Selection * MEDLINE 313 50 EMBASE 233 5 CINAHL 31 3 RECAL 200 13 Reference Lists -- -- Total 777 71 Included Identified in After Second Reference Selection Source Lists ([dagger]) ([double dagger]) MEDLINE -- 2 EMBASE -- 0 CINAHL -- 0 RECAL -- 0 Reference Lists 19 2 Total 19 4 * Title and abstracts were reviewed. Publications were included if discussed skin problems in adults (>18 years old) with lower-limb loss (not foot, ankle, or hip) and in English. ** Titles and abstracts (if available) were reviewed for all articles published after 1990. Articles were included if discussed skin problems in adults (>18 years old) with lower-limb loss (not foot, ankle, or hip). Table 3. Qualified studies of reported skin problems. Country Study Study of Study Type of Study Population Baars et al., The Netherlands Cross-sectional Subjects (60) 2008  chart review Dudek et al., Canada Cross-sectional Subjects (745) 2005  chart review Residual limbs (828) Pezzin et al., United States Cross-sectional Subjects (78) 2000  telephone interview Chan and Tan, Singapore Cross-sectional Subjects (47) 1990  questionnaire (1989-1990) Study Reason for Study Population Amputation (%) Baars et al., Rehabilitation Vascular (63.0) 2008  hospital Trauma (10.0) (1998-2006) Infection (8.0) DM (8.0) Other(11.0) Dudek et al., Amputee clinic PVD/DM (50.0) 2005  (1997-2003) Trauma (33.0) Other (17.0) Pezzin et al., University- Trauma (100.0) 2000  affiliated trauma center (1984-1994) Chan and Tan, Amputee clinic DM (85.1) 1990  Malignancy (8.5) Vascular (6.4) Amputation Level Assessment of Study (%) Skin Problems Baars et al., Transtibial (83.0) Exam by 2008  Knee disarticulation physiatrist (17.0) Dudek et al., Transtibial (66.4) Exam by 2005  Transfemoral physiatrist (19.2) Other (14.4) Pezzin et al., Transtibial (51.0) Patient self- 2000  Transfemoral report (20.0) Knee disarticulation (17.0) Other (12.0) Chan and Tan, Transtibial (93.6) Exam by 1990  Symes (4.3) physiatrist Transfemoral (2.1) Overall Prevalence Types of Skin Study (%) Problems (%) Baars et al., 38 Superficial 2008  wound (69) Blister (22) Folliculitis (6) Rash (3) Dudek et al., 41 Ulcer (27) 2005  Irritation (17) Inclusion cyst (15) Callus (11) Verrucous hyperplasia (9) Blister (7) Fungal infection (5) Cellulitis (2) Other(7) Pezzin et al., 24 Wound or sore 2000  (100) Chan and Tan, 15 Ulcer (57) 1990  Abscess (43) * All clinical studies that described inclusion and exclusion criteria, study population, reason for amputation, level of amputation, skin problems on residual limb related to prosthesis use, and prevalence and types of skin problems. Table 4. Classification of dermatologic problems on residual limbs by morphology. Problem Morphology Hyperplastic or Squamous cell carcinoma Neoplastic Conditions Inclusion cyst/epidermoid cyst Foreign body reaction Callus Verrucous hyperplasia Disruption of Skin Integrity Wound dehiscence Irritation/abrasion Blister/erosion/ulcer Follicular and Pseudofollicular Folliculitis Inflammation Miliaria rubra Interfollicular Inflammation Eczema craquele Dermatophytosis Allergic contact dermatitis Irritant dermatitis Infection Cellulitis Table 5. Classification of dermatologic problems on residual limbs by etiology. Problem Etiology Surgical Complications Wound dehiscence Foreign body reaction Inclusion cyst/epidermoid cyst Reaction to Repetitive Injury Callus Irritation/abrasion Blister/erosion/ulcer Squamous cell carcinoma Reaction to Occlusion: Folliculitis Noninfectious Miliaria rubra Eczema craquele Irritant dermatitis Verrucous hyperplasia Allergic contact dermatitis Reaction to Occlusion: Cellulitis Infectious Dermatophytosis Folliculitis
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