Pudendal nerve entrapment in an Ironman athlete: a case report.
Objective: To present the diagnostic and clinical features of
pudendal nerve entrapment and create awareness amongst clinicians of
this rare and painful condition.
Clinical Features: A 41-year old male ironman athlete complaining of insidious constant penis pain 12-24h after long distance cycling and pain after sexual intercourse. A diagnosis of "cyclist syndrome" also known as pudendal nerve entrapment was made.
Intervention and outcome: Patient was treated twice a week for four weeks using the soft tissue protocol described by Active Release Technique[R] to the obturator internus muscle. After two weeks of treatment his pain decreased to a 5/10 on the pain intensity scale and he began to cycle again. After four weeks of treatment his pain had decreased to 1/10 in intensity and he continued to cycle. At follow-up, approximately 8 weeks and 12 weeks later the patient communicated that his pain is resolved and he has began to train for Ironman Lake Placid 2010.
Conclusion: Pudendal nerve entrapment is a rare, painful condition and is often misdiagnosed due to the fact that the clinical manifestations can mimic other pathologies. It is important to be aware of the clinical features to obtain appropriate diagnosis and treatment of this condition promptly. (JCCA 2010; 54(4):276-281)
KEY WORDS: pudendal nerve, entrapment, neuralgia, obturator internus, pudendal canal, ART[R]
Objectif : Soumettre un diagnostic et des particularites cliniques de compression chronique du nerf honteux, et sensibiliser les medecins a cette affection rare et douloureuse.
Particularites cliniques : Un athlete masculine Ironman de 41 ans se plaint de douleur constante et insidieuse au penis entre 12 et 24 heures apres un long periple a velo, et une douleur apres avoir eu des relations sexuelles. Un diagnostic de << syndrome du cycliste >>, egalement connu sous le nom de compression chronique du nerf honteux, fut emis.
Intervention et resultat : Le patient fut traite deux foispar semaine pendant quatre semaines a l'aide du protocole du tissu mou decrit par Active Release Technique[R] sur le muscle obturateur interne. Apres deux semaines de traitement, sa douleur avait diminue a 5/10 sur l'echelle d'intensite de la douleur, et il a recommence a faire du velo. Apres quatre semaines de traitement, sa douleur avait diminue a 1/10 sur l'echelle d'intensite, et il a continue de faire du velo. Lors du suivi, environ 8 et 12 semaines plus tard, le patient a affirme que sa douleur avait disparu, et qu'il s'entrainait en vue de la competition Ironman a Lake Placid en 2010.
Conclusion : La compression chronique du nerf honteux est une affection rare et douloureuse, souvent mal diagnostiquee en raison du fait que les manifestations cliniques ressemblent a autres pathologies. Il est important de connaitre les particularites cliniques pour emettre un diagnostic exact et traiter l'affection rapidement. (JCCA 2010; 54(4):276-281)
MOTS CLES : nerf honteux, compression chronique, obturateur interne, canal honteux, ART[R]
|Article Type:||Case study|
Entrapment neuropathies (Case studies)
Entrapment neuropathies (Care and treatment)
Athletes (Health aspects)
Durante, Jaclyn A.
MacIntyre, Ian G.
|Publication:||Name: Journal of the Canadian Chiropractic Association Publisher: Canadian Chiropractic Association Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2010 Canadian Chiropractic Association ISSN: 0008-3194|
|Issue:||Date: Oct, 2010 Source Volume: 54 Source Issue: 4|
|Geographic:||Geographic Scope: Canada Geographic Code: 1CANA Canada|
Pudendal neuralgia by pudendal nerve entrapment is described as severe, sharp pain along the course of the pudendal nerve. (1) Genital numbness and erectile dysfunction are two of the major symptoms and the prevalence has been reported to be 50-91% and 13-24% respectively. This can be caused by trauma, infection, tumour, child birth, iatrogenic injury, surgery and/ or microtrauma from cycling. (2) It has been reported that 7-8% of cyclists on long-distance multiday rides experience pudendal neuralgia. (3) Diagnosis of pudendal nerve entrapment is often delayed or misdiagnosed, causing people to suffer with this for 2-10 years. (4) It is important to understand the clinical presentation and diagnostic criteria to allow early diagnosis and appropriate treatment.
A 41-year old male ironman athlete complained of insidious onset of constant penis pain and a dull ache in the perineum 12-24h after long distance cycling. His cycling training consisted of 6-11 hours per week, 3 days a week. The pain began in the beginning of September 2008 and by mid-September he was experiencing pain in the perineum after sexual intercourse and burning during urination. He visited with his medical doctor who diagnosed him with prostatitis and he was prescribed antibiotics for 30 days. He returned to his medical doctor who informed him that STDs were ruled out and he was told that the prostatitis was under control, however the pain was unchanged. At that time, the prostate was palpated for enlargement, an ultrasound was performed to examine the prostate and prostate serum antigen was measured. These tests proved to be normal. In early October he was referred to an urologist who prescribed him with another antibiotic for 30 days. By November 2008, the pain was rated 9/10 in intensity. He saw another urologist who explained that the infection and cycling caused inflammation of the pudendal nerve. At that point he was prescribed naproxen, 750 mg/day. He proceeded to see a sport medical doctor, who told him to experiment with new saddles for his bike. He completed the ironman in late November 2008 and ceased to ride from November 2008 to January 2009. With rest and the use of naproxen the pain intensity decreased to 5/10.
In January 2009, he began to cycle again. However, by February the pain increased to 7/10. For relief he would sit on a frozen water bottle placed in the perineal region and use a foam roller to massage his buttock region. He experimented with a new saddle and it seemed to provide relief. He competed in the ironman in July 2009 and discontinued to ride from July to September 2009 and the pain deceased to 3/10 in intensity. He began to cycle again in September to train for a half-ironman in late fall. The pain intensity increased to 9/10. At this point he was seen by a neurologist who diagnosed him with "cyclist syndrome" and he was prescribed naproxen, rest and to experiment with a new saddle.
Pudendal neuralgia, due to entrapment of the pudendal nerve (PN) has a varied clinical presentation and some suggest that is it due to the anatomical course of the nerve and the fact that the nerve is mixed. The PN arises from the roots of the sacral plexus S2-S4 where 20% consists of motor fibres, 50% are sensory fibres and the last 30% are autonomic. (5,6,7) The PN descends medially and caudal in relation to the trunk of the sciatic nerve. (5,6,7) From there it passes laterally and enters the gluteal region and then traverses the greater sciatic foramen. (5,6,7) Along its course the PN is accompanied by its artery (internal pudendal artery) and vein (internal pudendal vein). The pudendal bundle passes around the termination of the sacrospinous ligament just as it attaches onto the ischial spine. (5,6,7) The PN is now situated between the sacrospinous ligament ventrally and the sacrotuberous ligament dorsally. The PN travels into the perineal region via the lesser sciatic foramen, where it lies underneath the plane of the levator ani muscle. (5) From here it enters a duplication of the fascia of the obturator internus muscles and its medial aspect, which forms the pudendal canal. (5) It is at this location where the PN divides into its three terminal branches: inferior rectal nerve, perineal nerve and the dorsal nerve to the penis/clitoris. (5)
The inferior rectal nerve supplies the integument around the anus, provides sensation to the distal aspect of the anal canal and to the perianal skin. (5,8) It also provides motor innervation to the external anal sphincter. (5,8) The perineal nerve supplies motor innervations to the pelvic floor muscles (transverse perineal muscles, bulbospongiosus, ischiocavernosus, sphincter urethra and the levator ani muscles). (5,8) The sensory braches of the perineal nerve supply the perineum and the ipsilateral posterior surface of the labia majora. Finally, the dorsal nerve of the penis /clitoris is the most superficial branch found at the level of the pubic symphysis. (5,8) This nerve carries afferent sensory information from the clitoris/penis. (5,8)
The anatomical course of the PN has great implications regarding the potential sites for its entrapment. The following are areas in which the PN can become entrapped leading to injury and symptoms of pudendal neuralgia: the zone at the ischial spine, the zone between the sacrospinous and sacrotuberous ligaments, the falciform process (formed by the dense fanning out bands of the medial portion of the sacrotuberous ligament as it attaches to the ischial tuberosity), the zone between the levator ani and obturator internus muscle, within the pudendal canal and lastly compression from the piriformis muscle (Figure 1). (1,5,6,9) A new entrapment site was proposed, which described a distinct narrow osteofibrous canal measuring 3cm long found in all 10 male dissected cadavers. (7) This canal was bordered by the pubic symphysis dorsal-cranially, the inferior pubic ramus and suspensory ligament laterally and the corpus covernosum medially. (7) The dorsal nerve to the penis was found to travel in this canal and thought to be a potential site for entrapment. (7)
[FIGURE 1 OMITTED]
The exact pathophysiology of pudendal nerve entrapment is not completely understood, however there are proposed theories. Neuronal insult can be caused by stretching or compression of the nerve, which may lead to ischemic neuropathy due to transient hypoxemia of the PN. (2) This can result in changes to the intraneural microcirculation and fibre structure, such as fibrosis and or inflammation, leading to impairment of axonal transport of the PN. (2) During cycling, repetitive impacts generate extreme perineal pressure leading to increased friction in the pudendal canal and compression from the surrounding muscular (levator ani, obtruator internus, and piriformis) and ligaments structures (sacrospinous and sacrotuberous). (2,10,11) This constant pressure can lead to loss of gliding of the PN putting it at risk for entrapment. (2,10,11) Also, the biomechanical position adapted while cycling, forward lean posture with arms on the aerobars of the bike, further increases the compression in the perineal region due to pressure from the nose of the saddle. (2,10,11) This chronic perineal microtrauma results in the pathophysiological changes mentioned above. (2)
As mentioned previously, the clinical presentation of pudendal neuralgia is varied due to the fact that the PN is a mixed nerve and has numerous potential entrapment sites creating diverse symptomatology depending on the location of compression. Patients will experience remitting and relapsing neuropathic pain in the distribution of the PN often described as burning, tearing, stabbing, lightning-like, sharp, electrical, and shooting. (6) Genital numbness, the most common symptom with a prevalence of 50-91% in bicyclists, is often the first sign and may be considered a warning sign to clinicians. (10,12) Erectile dysfunction is often associated with pudendal nerve entrapment having a prevalence of 13-24% in bicyclists. (10) Pain and paresthesia, which often begin in one location and spread, may extend as far as the groin, inner leg, buttock, and abdomen. (5) Patients may also experience hyperesthesia and allodynia so intense that they avoid wearing certain clothing that may irritate the area. (5,6) Pudendal neuralgia presents most commonly as unilateral, but in certain instances may be bilateral. (5,6,13) The symptoms are usually aggravated by sitting or cycling and absent or relieved by standing, recumbent position and sitting on a toilet seat. (8)
The physical examination findings of patients suffering from PN entrapment are less concrete. Pain may be elicited during application of pressure on the PN at the ischial spine and palpation inferio-medially to the sciatic notch. (6,14) The most common finding is tenderness with direct palpation of the obturator internus muscle. (4) The symptoms may be worsened by performing passive internal and external rotation of the hip and resisted abduction and adduction of the hip flexed to 90 degrees. (4)
There is no widely confirmatory test available to diagnose pudendal neuralgia explaining why it is often misdiagnosed or delayed. (8) It has been reported that proper diagnosis can take anywhere from 2-10 years. (4) Pudendal neuralgia is a diagnosis of exclusion, therefore all other causes of the symptoms must be ruled out. However, diagnostic criteria for pudendal neuralgia was established and validated by a multidisciplinary working party in Nantes, France and by members of the Francophone Perineal Electrophysiology club in 2008. (15) The criteria are broken down into four diagnostic domains (Table 1).
Following diagnosis of pudendal neuralgia by PN entrapment, treatment usually involves a course of conservative medical care management. Practitioners may begin by prescribing anti-inflammatory and or nerve pain medications. Patients may opt to have a pudendal nerve block with or without the addition of steroids, which have the potential to relieve the symptoms for a longer period of time. (5) Surgical decompression of the PN may be an option for those who encounter only temporary relief with a nerve block. (5,9,14) There are three different approaches and these include: transperineal, transgluteal, and via the ischio-rectal fossa. (5,14) Working in collaboration with medical management, there are several recommendations regarding cycling that one may choose to implement to reduce the symptoms. These include: stretches, short-term cessation of cycling (3-10 days), weight loss, wider saddle, absent or flexible nose on the saddle, tilt the saddle slightly downward, use of a gel saddle, change body posture to a more upright position, rise out of the saddle for 20-30 seconds every 20 minutes, take breaks during long rides and ensure that the bike has been properly fitted. (1,2,3,10,13,16)
In the case presented the chiropractor treated the patient using Active Release Technique (ART)[R], which is described as a hands-on touch and case-management system that allows a practitioner to diagnose and treat soft-tissue injuries. (17) It is performed by contacting the effected muscle, applying a tension and asking the patient to actively contract/shorten the muscle followed by actively stretching/tensioning the muscle. (17) The ART[R] protocol for obturator internus treatment is described as follows. The patient is to begin in the side lying position, involved side up, and the hip in the anatomical position or abducted. The practitioner then places their contact on the distal portion of the muscle and draws tension medially. The practitioner must maintain or increase tension and move the hip into flexion, adduction and external rotation (an assistant may be used to externally rotate the hip). (17) This procedure is conducted several times along the muscle until the practitioner subjectively determines that the tissue is moving properly and the adhesions are no longer palpated. (17)
To date there is no research describing the therapeutic effect ART[R] has on muscle injury. Contemporary soft tissue literature has been focusing on the role of fascia. Fascia is dense irregular connective tissue that allows for continuity throughout the body. (18,19,20,21) Not only does it envelop muscles, fascicles, fibers, tendons, but it penetrates and surrounds organs, bones and nerves. (18,19,20,21,22) Fascia is primarily composed of fibroblasts, mast cells and macrophages while the extracellular matrix is made up of ground substances (dense gel), collagen and elastin fibers. (18,19,20,21,22) Contractile cells have also been identified in fascia and have been termed myofibroblasts. (20,21,22,23,24,25,26) Ruffini organs, a type of mechanoreceptor found in fascia, have been shown to respond to deep pressure. (23,24,27,28) Once ruffini organs are stimulated, altered input is transmitted to the central nervous system, which changes the signal received by the motor unit creating tonus change in the muscle. (23,24,27,28) Perhaps this is an explanation for the therapeutic effect of ART[R], since the protocol involves the practitioner applying pressure to the muscle. Another proposed mechanism rationalizing the role of ART[R] can be extrapolated from the work of Cottingham in 1985 and Schleip in 2003. (20,21,22,29) Golgi receptors, which are a sensory ending, are traditionally found in tendons, but are also found in the muscular portion of the myotendinous junction, ligaments, capsules, fascia and aponeuroses. (29) Golgi receptors are arranged in series in fascia and have been found to respond to muscular contraction/tension. (20,21,22,30) Afferent signals sent from golgi receptors in response to contraction/tension, reach interneurons in the spinal cord, which, in turn, have an inhibitory effect on alpha-motor neurons thereby relaxing muscle. (20,21,27,30) Perhaps ART[R] stimulates the golgi receptors since the protocol involves the patient actively shortening/contracting followed by actively stretching/ tensioning the muscle. It should be noted that the suggested explanations regarding the mechanism of ART[R] are theories and more research is needed in the future to fully understand the mechanism.
Pudendal neuralgia by pudendal nerve entrapment is a rare diagnosis, but it is one that causes extreme pain and limitation in suffering individuals. Patients may be enduring this injury for 2-10 years before the diagnosis is made and finally receive appropriate treatment. Pudendal neuralgia has a varied clinical presentation due to its intricate anatomical structure, which may confuse practitioners. Therefore, it is important to be aware of this condition to avoid delayed and/or misdiagnosis and provide prompt treatment.
(1) Benson JT, Griffis K. Pudendal neuralgia, a sever pain syndrome. Am J Obst Gyn. 2005; 192:1663-1668.
(2) Leibovitch I, Mor Y. The vicious cycling: bicycling related urogentital disorders. Europ Urol. 2005; 47:277-287.
(3) Asplund C, Barkdul T, Weiss BDl. Genitourinary problems in bicyclists. Curr Sports Med Rep. 2007; 6:333-339.
(4) Filler AG. Diagnosis and treatment of pudendal nerve entrapment syndrome subtypes: imaging, injections, and minimal access surgery. Neurosurgery Focus. 2009; 26(2):E9.
(5) Stav K, Dwyer P, Franzeog BS et al. Pudendal neuralgia fact or fiction? Obst Gyn Survey. 2009; 64(3):190-199.
(6) Popeney C, Ansell V, Renney K. Pudendal entrapment as an etiology of chronic perineal pain: diagnosis and treatment. Neurol Urodynamics. 2007; 26:820-827.
(7) Hruby S, Ebmer J, Dellon L et al. Anatomy of pudendal nerve at urogenital diaphragm-new critical site for nerve entrapment. Urology. 2005; 66(5):949-952.
(8) Hough DM, Wittenberg KH, Pawlina W et al. Chronic perineal pain caused by pudendal nerve entrapment: anatomy and ct-guided perineural injection technique. Am J Roentgenology. 2003; 181:561-567.
(9) Robert R, Prat-Pradal D, Labat JJ et al. Anatomic basis of chronic perineal pain: role of the pudendal nerve. Surgical and Radiologic Anatomy. 1998; 20:93-98.
(10) Carpes FP, Dagnese F, Kleinpaul JF et al. Effects of workload on seat pressure while cycling with two different saddles. J Sexual Medicine. 2009; 6:2728-2735.
(11) Ramsden CE, McDaniel MC, Harmon RL et al. Pudendal nerve entrapment as source of intractable perineal pain. Am J Phys Med Rehabilitation. 2003; 82:479-484.
(12) Andersen KV, Bovim G. Impotence and nerve entrapment in long distance amateur cyclists. Act Neurologica Scandinavica. 1997; 95:233-240.
(13) Huang V, Munarriz R, Goldstein. Bicycle riding and erectile dysfunction: an increase in interest (and concern). J Sexual Medicine. 2005; 2:596-604.
(14) Beco J, Climov D, Bex M. Pudendal nerve decompression in perineology: a case series. BioMed Central Surgery. 2004; 4:15.
(15) Labat J, Riant T, Robert R et al. Diagnostic criteria for pudendal neuralgia by pudendal nerve entrapment (Nantes criteria). Neuro Urodynamics. 2008; 27:306-310.
(16) Gemery JM, Nangia AK, Mamourian A et al. Digital three-dimentional modelling of the male pelvis and bicyle seats: impact of rider position and seat design on potential penile hypoxia and erectile dysfunction. Br J Urology International. 2007; 99:135-140.
(17) Leahy M. Active Release Techniques[R] Soft Tissue Management Systems for the Lower Extremity. 2007; p188-189.
(18) Rolf IP. Rolfing: The Integration of Human Structures. Dennis Landman, Santa Monica. 1977.
(19) Oschman JL. Energy Medicine. 2000; Churchill Livingstone, Edinburgh, Scotland.
(20) Schleip R. Fascial plasticity - a new neurobiological explanation: Part 1. J Bodywork Movement Ther. 2003; 7:11-19.
(21) Schleip R. Fascial plasticity - a new neurobiological explanation: Part 2. J Bodywork Movement Ther. 2003; 7:104-116.
(22) Schleip R et al. Passive muscle stiffness may be influenced by active contractility of intramuscular connective tissue. Medical Hypothesis. 2006; 66:66-71.
(23) Yahia L et al. Viscoelastic properties of the human lumbodorsal fascia. J Biomed Eng. 1993; 15:425^29.
(24) Yahia L et al. Sensory innervation of human thoracolumbar fascia. Acta Orthopaedica Scandinavia. 1992; 63:195-197.
(25) Hinz B, Gabbiani G. Mechanism of force generation and transmission by fibroblasts. Current Opinion in Biotechnology. 2003; 14:538-546.
(26) Staubesand J et al. La structure fine de l'aponevrose jambiere. Phlebologie. 1997; 50(1): 105-113.
(27) Stecco C et al. Anatomy of the deep fascia of the upper limb. Second part: study of innervation. Morphologie. 2007; 91:38-43.
(28) Klinger W, Schleip R, Zorn A. European Fascia Research Project Report. Structural Integration-J Rolf Institute. 2004; 1-10.
(29) Cottingham JT. Healing through touch - a history and a review of the phsyiological evidence.1985; Rolf Institute Publications, Boulder, CO.
(30) Keirnan J. Barr's: The Human Nervous System, 8th Ed. 2005; Lippincott Williams and Wilkins, Philadelphia, Pennsylvania.
Jaclyn A. Durante, BSc, DC * Ian G. MacIntyre, DC, FCCSS(C) **
* Graduate Student, Sport Sciences, Canadian Memorial Chiropractic College, Toronto, Canada
** Associate Professor, Canadian Memorial Chiropractic College, Toronto, Canada Address correspondence to: Dr. Jaclyn Durante, 6100 Leslie St., Toronto, Ontario M2H 3J1 Phone: (416) 482-2340 ext. 242 Fax: (416) 482-2560 E-mail: email@example.com
Table 1 Summarized from Labat et al 2008, Diagnostic Criteria for Pudendal neuralgia by Pudendal Nerve entrapment (Nantes Criteria) Essential Diagnostic Complementary Exclusion Criteria Diagnostic Criteria Criteria Pain in the territory Neuropathic pain Exclusively of the PN coccygeal, gluteal, pubic or hypogastric pain Pain predominately Allodynia or Pruritus with sitting hyperpathia Pain with no objective Rectal or vaginal Paroxysmal pain sensory impairment foreign body sensation Pain relieved by Pain worsening during Imaging diagnostic nerve block the day abnormalities able to account for the pain Pain does not wake the Predominately patient at night unilateral Pain triggered by defecation Presence of exquisite tenderness on palpation of the ischial spine Clinical neurophysiology findings of motor latency Essential Diagnostic Associated Signs Not Criteria Excluded the Diagnosis Pain in the territory Buttock pain on sitting of the PN Pain predominately Referred sciatic pain with sitting Pain with no objective Pain referred to the medial sensory impairment aspect of the thigh Pain relieved by Urinary frequency or full diagnostic nerve block bladder Pain does not wake the Pain after ejaculation patient at night Dyspareunia and or pain post-coitus Erectile dysfunction Normal clinical neurophysiology test
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