Probiotics enhance bowel prep for colonoscopy.
|Article Type:||Brief article|
Colonoscopy (Patient outcomes)
Probiotics (Health aspects)
|Author:||Gaby, Alan R.|
|Publication:||Name: Townsend Letter Publisher: The Townsend Letter Group Audience: General; Professional Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2012 The Townsend Letter Group ISSN: 1940-5464|
|Issue:||Date: April, 2012 Source Issue: 345|
|Geographic:||Geographic Scope: United States Geographic Code: 1USA United States|
One hundred-four patients with constipation and 107 patients
without constipation who were scheduled for colonoscopy were randomly
assigned to receive, in double-blind fashion, a probiotic preparation
(Bacillus subtilis [10.sup.9] colony-forming units], and Streptococcus
faecium [9 x [10.sup.9] colony-forming units]) or placebo 3 times per
day for 2 weeks prior to the colonoscopy. All patients received oral
sodium phosphate for bowel cleansing prior to the procedure. In the
group with constipation, the proportion of patients who had a
satisfactory bowel preparation was significantly higher in the placebo
group than in the placebo group (54.9% vs. 20.8%; p < 0.001).
Preparation quality was sighiticantly better in patients without
constipation than in those with constipation, and was not affected by
probiotics treatment. Among constipation patients, preparation-related
adverse events and post-colonoscopy symptoms were less frequent and less
severe in the probiotics group than in the placebo group.
Comment: This study demonstrates that, in patients with constipation, pretreatment with a specific probiotic preparation for 2 weeks as part of bowel preparation significantly improved colonic mucosa visualization during colonoscopy and reduced preparation-related and post-colonoscopy gastrointestinal symptoms. Previous research has demonstrated that a wide range of other probiotic strains are beneficial for chronic constipation. It is therefore likely that other strains would also be useful for bowel preparation in constipated patients scheduled for colonoscopy.
Lee H et al. A feasibility study of probiotics pretreatment as a bowel preparation for colonoscopy in constipated patients. Dig Dis Sci. 2010; 55:2344-2351.
|Gale Copyright:||Copyright 2012 Gale, Cengage Learning. All rights reserved.|