Preventing thromboembolism in medical inpatients--time to catch up with the surgeons?
Thromboembolism (Risk factors)
HIV infection (Complications and side effects)
Tuberculosis (Complications and side effects)
|Publication:||Name: South African Medical Journal Publisher: South African Medical Association Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2008 South African Medical Association ISSN: 0256-9574|
|Issue:||Date: Nov, 2008 Source Volume: 98 Source Issue: 11|
|Topic:||Event Code: 200 Management dynamics; 310 Science & research|
|Geographic:||Geographic Scope: South Africa Geographic Code: 6SOUT South Africa|
Heparin prophylaxis for venous thromboembolism has been considered
standard practice for patients undergoing surgical procedures for some
time. (1) Only relatively recently has there been a move to adopt the
practice more widely among medical inpatients, motivated by increasing
good-quality evidence of the burden of the problem and perhaps by
medico-legal concerns. Some researchers suggest that at least 10% of
untreated medical inpatients may develop thrombo-embolic (TE) disease
(either deep-vein thrombosis or pulmonary embolus). (2) A number of
studies have demonstrated the effectiveness of heparin prophylaxis in
this group, with reductions of up to 70% reported in acutely ill medical
inpatients. (3,4) The American of College of Chest Physicians 2004
guidelines recommended the use of heparin or low-molecular-weight
heparin for prophylaxis in acutely ill medical patients who have been
admitted to hospital with congestive heart failure and severe
respiratory disease, or who are confined to bed and have additional risk
One patient group at particular risk of TE disease is those with tuberculosis, with or without HIV infection. It is well recognised that TB is associated with a hypercoaguable state. (6) This is probably a consequence of a combination of factors: elevated plasma fibrinogen, thrombocytosis, direct endothelial damage promoted by the tubercle bacillus, and possibly the use of rifampicin. Additionally, a recent study indicated that an HIV-positive patient is 10 times more likely to develop TE disease than his or her uninfected counterpart, the risk being greatest in the recently hospitalised and those with CD4 counts of less than 500 cells/[micro]l. (7) These data come from studies conducted among patients in well-resourced settings and there is very little information available on the incidence of TE among patients hospitalised with TB or HIV-related illnesses in resource-poor rural settings, in large part owing to problems with diagnosis. D-dimer, commonly used to diagnose TE disease in patients who are otherwise well, is raised in sepsis and therefore unhelpful, (8) and whereas a clinically obvious deep-vein thrombosis may be treated presumptively or confirmed by duplex ultrasound, pulmonary embolism is a difficult diagnosis to make in the rural hospital setting. Additionally, poor access to reliable autopsies and their unacceptability to relatives make it difficult to confirm the cause of death in such hospitals. While this under-reporting contributes to a level of ignorance regarding TE as a cause of death, there is no reason not to suspect that the incidence of TE disease among medical patients unwell enough to require admission to South Africa's hospitals is at least that suggested by studies in Europe and America. Indeed, it is probably considerably higher given the high proportion of medical patients admitted with advanced TB and HIV.
In the absence of good descriptive evidence regarding the incidence of TE disease among medical inpatients in South Africa, it could therefore be argued that all patients admitted with TB or AIDS-related illnesses should be started on heparin prophylaxis routinely. The time has come for the physician, like the surgeon, to ask of each inpatient not 'Why should they be on heparin?' but rather 'Is there any good reason why they shouldn't?'
John Radcliffe Hospital
UK (formerly of Hlabisa Hospital, Hlabisa, KwaZulu-Natal)
Corresponding author: E Moran (firstname.lastname@example.org)
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