PET-CT in head and neck cancer.
Article Type: Report
Subject: CT imaging (Usage)
CT imaging (Health aspects)
Head and neck cancer (Diagnosis)
Head and neck cancer (Care and treatment)
PET imaging (Usage)
PET imaging (Health aspects)
Authors: Koppula, Bhasker
Rajendran, Joseph G.
Pub Date: 04/01/2010
Publication: Name: Applied Radiology Publisher: Anderson Publishing Ltd. Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2010 Anderson Publishing Ltd. ISSN: 0160-9963
Issue: Date: April, 2010 Source Volume: 39 Source Issue: 4
Geographic: Geographic Scope: United States Geographic Code: 1USA United States
Accession Number: 231310680
Full Text: In the United States, extracranial head-and-neck carcinomas constitute 2% to 3% of all cancers, whereas globally they represent [greater than or equal to] 6% of all cancers. Cancer of the head and neck affects approximately 30,000 to 50,000 Americans annually and is a major public health problem. The majority of head and neck cancers are squamous-cell carcinomas and in spite of several diagnostic advances, a vast majority of these are still diagnosed in advanced stages. Early detection and accurate staging are essential for treatment and prognosis. After therapy, timely detection of recurrence is critical to achieve an optimal outcome as well as to plan salvage therapy, because recurrent disease and metastatic spread to distant sites is usually unresponsive to therapy. (1)

Ironically, the incidence of head-and-neck cancer remains unchanged, even though it is largely preventable because of its close association with common carcinogens, such as tobacco and alcohol. Its incidence is higher in low socioeconomic groups, and it is prevalent among military veterans, accounting for [greater than or equal to] 8% of all new cancers. The clinical course of these neoplasms is difficult to predict based on current clinicopathological prognostic criteria. (2) Prevalent use of combined positron emission tomography and computed tomography (PET-CT) in the evaluation of locoregional and distant metastatic disease has significantly enhanced capabilities for early detection and staging, providing significant prognostic implications in the management of these patients.

Anatomic imaging modalities like CT and magnetic resonance imaging (MRI) are the standard imaging techniques used for the evaluation of a patient with head-and-neck cancer. They provide structural information and rely on certain morphologic criteria like nodal size and contrast-enhancement patterns. However these criteria are not very specific for active disease. For example, the quoted specificities are as low as 39% and 48% for CT and MRI, respectively, for the detection of nodal metastases in patients with head-andneck cancer with the use of 10 mm as the size criterion for diseased, neck lymph nodes. (3) After radical surgery or radiation therapy for head-and-neck malignancies, normal tissue planes are altered substantially and limit the use of these anatomic imaging modalities with further reduction in specificities in assessing residual or recurrent disease. (4-7) However, after chemotherapy and/or radiation therapy, changes in tumor metabolism precede morphologic changes, providing an advantage for PET applications.

Radiopharmaceutical tracers like [sup.18]F-fluorodeoxyglucose (FDG) helps evaluate tumor metabolism, and the information obtained is essentially independent of tumor location and lesion size. For these reasons, PET using glucose-analogue FDG has been successfully used in the evaluation of tumor aggressiveness, (8,9) for staging of nodal disease in the neck, (10-12) for treatment evaluation, (9-13) and in surveillance of recurrent disease (14-17) in patients with head-and-neck cancer. Lack of anatomic detail, once a major limitation of PET as localization to a particular structure in the complicated head-and-neck anatomy (especially in post-therapy patients), is obviated by the use of a combined PET-CT technique that permits almost simultaneous image acquisition and exact coregistration of anatomic and metabolic data sets. The coregistration significantly improves diagnostic accuracy. In this way, the PET-CT technique improves anatomic localization of PET abnormalities and reduces the number of equivocal PET interpretations (Figure 1). (18,19)

The treatment paradigm for patients with head-and-neck cancers has shifted in the past 2 decades from a primarily surgical approach to a combination of therapies that includes surgery, preoperative or postoperative radiation therapy, and neoadjuvant or induction chemotherapy. Radiotherapy is an important treatment modality, which may be used as an adjunct to surgery for control of nodal disease or it may be used effectively as a primary treatment with or without chemotherapy in a majority of patients with head-and-neck cancer. Concurrent chemotherapy has further improved treatment results but is associated with higher normal-tissue toxicity. While neck irradiation effectively controls microscopic disease, it results in a higher morbidity when the radiation dose is intensified to a larger treatment volume using conventional techniques. Currently, treatment decisions are based on data extrapolated from retrospective institutional series and cannot be applied reliably to treatment planning for individual patients, limiting the ability to tailor the intensity and apply targeted therapy for an individual patient without increasing toxicity. Close proximity of important normal tissues and organs, such as the salivary glands, requires more stringent radiation dosimetry. Biological insights on these cancers obtained by PET-CT will permit selection and targeting to achieve more efficacious and less morbid treatments.

PET and PET-CT principles

The technique of FDG PET is based on the detection of coincident annihilation photons released during decay of FDG, which is a glucose analogue that competes with glucose for the same transport system to enter into metabolically active cells. Malignant cells show increased glycolysis leading to increased glucose utilization resulting from up-regulation of hexokinase activity. However, there is no single explanation for this increased glycolysis in malignant cells.


The effect of increased glycolysis in malignant cells was first described by Otto Warburg in 1924 and is known as Warburg effect: it is proportional to their metabolic activity. Tumor cells take up glucose by facilitated transport using glucose transporters (GLUT). It then undergoes glycolysis with formation of pyruvate under aerobic conditions. FDG is initially phosphorylated like glucose, but unlike glucose-6-phosphate, FDG-6-phosphate cannot undergo further metabolism and thus gets trapped and accumulates within metabolically active tumor cells. This accumulation of FDG-6-phosphate within the cell, combined with a higher concentration of neoplastic cells in a tumor, form the basis for the successful use of FDG in PET tumor imaging.

Because glucose competes with FDG for uptake into metabolically active cells, it is important to have adequate control of the blood-glucose level to improve the sensitivity of the examination. (19) Control of blood-glucose is very important in diabetic patients and care needs to be taken to make sure that the blood-glucose levels are not high (<150 mg). Use of insulin to lower blood-glucose levels prior to FDG scanning is generally not advisable, as it would pump into the muscles, resulting in interpretative difficulties.

The most common way of expressing the FDG uptake is the Standardized Uptake Value (SUV), which is the ratio of FDG concentration in a region of interest to its concentration in the whole body. Several factors including body weight, surface area, partial volume effect, injected dose and time after tracer injection affect the calculated SUV values.

PET evaluation is limited by poor anatomic detail, and correlation with some other form of imaging, such as CT, is desirable for differentiating normal from abnormal radiotracer uptake. Although the combination of separately acquired CT and PET scans using retrospective or prospective registration methods is more accurate than CT alone, this approach is limited by patient movement and by difficulty in exactly correlating points on CT and PET scans. Bayer et al. (20) described the prototype PET-CT scanner used in clinical imaging, in which precisely coregistered functional and anatomic images can be obtained by performing a PET study and a CT study on the same scanner without moving the patient. PET-CT is a unique fusion of the cross-sectional anatomic information provided by CT and the metabolic information provided by PET. This technique of fusion imaging offers the potential for improved detection and localization of head-and-neck cancer with one imaging tool. PET-CT has become an accepted and widely used imaging modality for the staging and follow-up/surveillance of head-and-neck cancer.

The PET portion of the PET-CT scan is performed approximately 1 hour after intravenous injection of 6 to 15 mCi of FDG. Helical CT data (pitch 1.1 to 1.6) is immediately acquired preceding acquisition of 3-dimensional emission data (5 to 10 min per bed position, 2 to 5 bed positions per patient). Patient preparation typically includes fasting, control of the blood-sugar level, etc. Necessary measures are taken to reduce FDG uptake in brown fat. If needed, patients are also administered lorazepam. When PET-CT images are used for radiation therapy planning, patients are imaged with the same immobilization devices that would be used during their radiation therapy. The PET scans are corrected for attenuation with coefficients obtained by scaling the CT numbers to the PET energy level (511 kV). The helical CT scans are reconstructed into 512 pixel x 512 pixel images with a section thickness that matches the PET scans (2.4 mm to 3.4 mm).

Evaluation of primary tumor

The extent of local disease in patients amenable for curative treatment affects the decision to treat with definitive surgery with or without postoperative radiotherapy or radical radiotherapy with or without chemotherapy. The conventional work-up often provides sufficient information to determine the extent of primary disease. PET has been shown to be highly sensitive and specific in detecting clinically evident primary disease in >90% of patients; however, it has a limited role in providing additional information with regard to the extent of primary disease following conventional work up. (21-23) PET scanning has minimal impact on T-staging following conventional assessment. Typical T-stage classifications are

* Tis: Carcinoma in situ,

* T1: [less than or equal to] 2 cm in greatest dimension,

* T2: [greater than or equal to] 2 cm but [less than or equal to] 4 cm in greatest dimension,

* T3: [greater than or equal to] 4 cm in greatest dimension, and

* T4: Invading through cortical bone, inferior alveolar nerve, floor of the mouth, or skin of the face.

However, PET provides valuable additional information in relation to nodal and distant disease staging. One exception is the use of PET in identifying the primary tumor site in patients who present with cervical lymph node metastatic head-and-neck squamouscell carcinoma (HNSCC) from a clinically undetectable or unknown primary tumor. MRI is typically the initial imaging study of choice because, compared with PET-CT without contrast material, it is capable of more accurately delineating the extent of tumor and evaluating perineural involvement and intracranial extent of disease. In this manner, MRI is nearly comparable with non-contrast PET-CT in accuracy in detecting regional nodal metastasis. However, PET-CT with contrast material may be a reasonably accurate alternative for delineating the extent of disease at initial presentation.

Evaluation of nodal metastatic disease

For evaluating metastatic disease in cervical lymph nodes, FDG PET-CT has been previously shown to be comparable to, or superior than, conventional imaging in detecting regional lymph nodal metastases during initial staging. (24-26) An average sensitivity of 87% to 90% and a specificity of 80% to 93% were reported for FDG PET-CT; (27) compared with a sensitivity of 61% to 97% and a specificity of 21% to 100% for MRI or CT. FDG PET-CT plays an important role in identifying disease in lymph nodes in unexpected locations (upper mediastinum and axillae) and detecting unsuspected distant metastatic disease. PET-CT has an advantage over conventional imaging, in this setting, because of its whole-body coverage and its sensitivity to lesions that may be missed by conventional imaging such as subtle bone metastases that may not be detectable on a routine chest or abdominal CT scan.

PET can detect occult distant metastatic disease in as many as 10% of patients with advanced local-regional disease. PET-CT also has another advantage in detecting a synchronous malignancy specifically involving the upper aero-digestive tract, as the risk factors for these malignancies is the same and include tobacco chewing, smoking and alcohol ingestion.


Evaluation of unknown primary tumor

Up to 10% of all head-and-neck malignant lesions present with lymph nodal metastases without clear evidence of a primary tumor site (Figure 2). Treatment of this group of patients is a challenge as a large or full extent of the pharyngeal mucosa needs to be irradiated which may harbor the putative primary tumor site. Irradiation of such an extensive area is associated with significant morbidity and possibly for a little gain. Identification of the occult primary site is critical in management as this can be amenable for surgical resection and thus in defining and limiting the extent of radiotherapy.

The evaluation for unknown primary tumor involves thorough clinical examination, endoscopic evaluation and morphologic imaging like MRI or CT. Anatomic evaluation may be limited if the tumor is very small, superficial, and is subtle and difficult to separate from adjacent normal structures, or if it is limited by technical factors like motion or streak artifacts. A large review by Schoder and Yeung of11 studies, which included more than 300 patients, has shown a sensitivity ranging from 10% to 60% for PET evaluation for unknown primary tumor site. (27) Another meta analysis involving patients who had an initial negative physical examination and MRI results, showed that FDG PET and PET-CT were able to detect the primary tumor in 27% of patients (40 of 150 patients). (28)

A useful approach to identify the unknown primary site is to obtain a PET-CT, especially in the absence of positive findings on clinical examination, in-office endoscopy and MRI. If a suspect focus is identified on PET-CT, the patient should undergo panendoscopy, during which a frozen-section biopsy of the suspect focus can be obtained. If this is negative, then further biopsy specimens from the most common locations for primary tumors can be obtained. However, if PET-CT does not show a suspect focus for a primary tumor, then the patient can undergo panendoscopy right away to obtain biopsy specimens from the usual and most common sites of primary tumors. (29) Thus PET-CT would provide a road map for a targeted biopsy.

Role of PET-CT in radiotherapy planning

Accurate spatial delineation of targets is very important with treatment modalities delivering highly conformal 3-dimensional radiation dose distributions, such as intensity-modulated radiation therapy (IMRT) and stereotactic radiosurgery (SRS). Both IMRT and SRS are commonly used treatment modalities for head-and-neck carcinomas.

In this era of highly conformal radiotherapy, integrated FDG PET-CT scanning provides a bridge between anatomic imaging and functional imaging for optimal radiotherapy planning. (30-31) Modification of target volumes in <20% of cases with use of PET-CT has been shown in many publications, compared with CT alone. Accordingly, PET-CT can be used as an adjunct imaging study for radiation treatment planning after definition of the target by CT or MRI, which have higher spatial resolution and are better at depicting marrow space infiltration and perineural spread of tumor (both are better shown by MRI). PET-CT is used to identify the normal size and normal-appearing lymph nodes with high metabolic activity as part of high-dose target volume for radiation. PET-CT also has a role in defining or contouring the primary tumors whose borders are difficult to distinguish by anatomic imaging alone. However, the abnormal appearing nodes or tumors on CT and MRI with equivocal metabolic activity on PET are also included in the treatment volume. (29)

Treatment response assessment and surveillance

Assessment of treatment response and surveillance for recurrence in head-and-neck cancers poses diagnostic challenges. Most head-and-neck cancers are treated with different approaches including surgery, chemotherapy and radiotherapy in different combinations. Post-treatment effects make it difficult to distinguish normal post-therapy tissue changes from tumor recurrence clinically, radiologically and histologically. Neck dissection and surgical flap reconstructions distort the normal neck anatomy and make detection of recurrent neoplasm challenging on the basis of structural changes alone. Radiation therapy can further complicate imaging by making tissue planes indistinct and by causing edema that may produce an increase in tissue volume. These changes can obscure persistent or residual disease as well as recurrent disease and limit evaluation by physical examination and anatomic imaging modalities like CT and MRI. (22,32)

Similarly, PET-CT is also limited by nonspecific uptake of FDG in lymphoid tissues, salivary glands, muscles and soft tissues, resulting from post inflammatory changes. PET-CT has been shown in multiple studies, to be more accurate in identifying and delineating the residual and recurrent tumors. (33-37) PET-CT is useful in monitoring the treatment response and for accurately assessing residual disease after surgery, chemoradiation alone or in combination with surgery.

Limitations of PET-CT

Variable FDG uptake in normal structures such as nasal turbinates, pterygoid muscles, salivary glands, extra-ocular muscles, and lymphoid tissues of the adenoids and Waldeyer ring may result in difficulty interpreting the PET-CT scan. This may result in false-positive findings. Similarly, normal uptake of FDG in contracting muscles, as for example in tense/ anxious patients or in talkative patients, may also lead to false-positive findings. However, even though overlap between tumor and physiologic uptake may confound interpretation, PET-CT allows direct correlation of FDG uptake with anatomic structures to reduce false-positive results.

Another limitation of PET is that smaller lesions (<1 cm) may not be reliably detected unless FDG uptake is intense, because these lesions are typically below the spatial resolution of the current scanners. The perceived SUV in small lesions may be significantly decreased in small lesions, resulting from partial volume-averaging effects, and thus the metabolic activity may be underestimated resulting in false-negative results with the FDG uptake typically falling in the benign range (<2.5 to 3.0). (15,38-39)

Inflammatory changes in tissues resulting from prior surgery may result in increased glycolysis and therefore in increased FDG uptake. Also, increased uptake of radiotracer at sites of inflammation resulting from those caused by infection, including granulomatous conditions and foreign bodies, can also result in difficulty in interpretation of PET findings. Macrophages in inflammatory lesions can demonstrate increased FDG uptake and can result in false-positive results. (15,40)

Performance of PET-CT after radiation and chemotherapy for evaluating response to treatment and its value in accurate assessment depends on the time period that has elapsed after the definitive treatment. PET-CT performed 4 months after completion of treatment more accurately reflects disease status than does the scan performed immediately after therapy. (41) PET performed within 1 month of treatment may yield studies with poor utility. A prospective study of a small group of patients (n = 12) evaluated the usefulness of PET-CT scan after 1 month of treatment and found that a positive study accurately indicated disease, but concluded that a negative study was unreliable in demonstrating absence of disease (negative predictive value 14%). Anatomic imaging modalities, such as CT and MRI, were more reliable in that series in demonstrating absence of disease with a negative predictive value of 50%. (41)

Tumors with inherently low FDG uptake such as the majority of salivary gland tumors and those tumors with significant necrosis (with lower amounts of metabolically active malignant tissue) can potentially yield false-negative or equivocal results. (42-44) The role of FDG PET-CT in these situations will have to be carefully weighed against the benefits to the patient.

Future directions

Developments in system technology and radiopharmaceuticals promise to make PET-CT much more useful and versatile in the future. More efficient PET instrumentation with regards to both electronic design as well as development of newer detector materials promise faster image acquisition and higher spatial resolution.

Newer detector materials like Lutetium-yttrium oxyorthosilicate and other recent Lutetium oxyorthosilicate crystals have renewed interest in the time of flight (TOF) reconstruction algorithm, which was described in the 1980s. TOF techniques can more accurately localize the origin of the annihilation reaction, leading to higher image quality, reduced image noise, lesser radiotracer dose (and thus a reduced patient dose), and shorter imaging time. This technique is most useful in heavy patients and is generally better at imaging deeper tissues. This technique will play a key role in radiation therapy planning by precisely mapping the tumor tissue and avoiding radiation to the adjacent normal tissue.

A number of other radiopharmaceuticals are being investigated and appear very promising for answering specific questions about tumor biology and in selecting and directing appropriate therapy. These include cell proliferation tracers [C-11]-thymidine and [[sup.18]F]-fluorothymidine; amino acids, such as [C-11]-methionine; membrane synthesis tracers [C-11]-acetate; and hypoxia tracers, such as [[sup.18]F]-fluoromisonidazone (FMISO). However, all these tracers are still in the research stage and are not yet approved for clinical use. They hold the promise for successful applications in specific clinical situations. Use of multiple tracers and diagnostic modalities will help personalize cancer therapy for the individual patient, with PET-CT playing a major role in this regard.


Combined PET-CT imaging optimizes the interpretation of FDG PET findings in head-and-neck cancer. Superior localization of radiotracer uptake with this technique can improve diagnostic accuracy and help avoid interpretative pitfalls. Improved resolution of the scanners in the future will help address the limitation related to lesion size and may make PET-CT more valuable in initial tumor staging and surveillance of recurrence and evaluation of residual tumor.

The development of tumor-specific ligands will enhance the usefulness of PET-CT in the detection of early-stage tumors and in the evaluation of tumors with low FDG avidity. Successful treatment outcome for patients with head-and-neck cancer will be more likely thanks to better predictive abilities, as well as better differentiation of tumor from radiation reaction and/or scar, and by improved abilities to precisely localize the tumor.

In the future, treatment targeting may be more effective with the addition of information from biomarkers rather than based solely on morphologic data that will play a major role in personalizing cancer therapy.


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Bhasker Koppula, MD, and Joseph G. Rajendran, MD, DMRT, FASNC

Dr. Koppula is a Resident, Division of Nuclear Medicine, and Dr. Rajendran is an Associate Professor of Radiology and Radiation Oncology (Adjunct), Division of Nuclear Medicine, Department of Radiology, University of Washington, Seattle, WA.
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