|Article Type:||Brief article|
Multiple sclerosis (Diagnosis)
Multiple sclerosis (Prognosis)
Multiple sclerosis (Genetic aspects)
Apoptosis (Physiological aspects)
Biological markers (Usage)
|Author:||Santelli, Jeanine Seguin|
|Publication:||Name: Journal of the New York State Nurses Association Publisher: New York State Nurses Association Audience: Academic Format: Magazine/Journal Subject: Health; Health care industry Copyright: COPYRIGHT 2011 New York State Nurses Association ISSN: 0028-7644|
|Issue:||Date: Spring-Winter, 2011 Source Volume: 42 Source Issue: 1-2|
|Topic:||Event Code: 310 Science & research|
|Geographic:||Geographic Scope: United States Geographic Code: 1USA United States|
Ferrandi, C., Richard, F., Tavano, P., Hauben, E., Barbie, V.,
Gotteland, J., ... Zaratin, P. F. (2011). Characterization of immune
cell subsets during the active phase of multiple sclerosis reveals
disease and c-Jun N-terminal kinase pathway biomarkers. Multiple
Sclerosis journal, 17(1), 43-56.
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. Programmed death (apoptosis) of lymphocytes is essential for the immune system to function. A defect in the cycle of activated T lymphocyte death is involved in the pathology of MS. The purpose of this study was to identify the potential role of the c-Jun N-terminal kinase (JNK) pathway in regulating these T cell responses in people diagnosed with MS. Blood samples were obtained from healthy volunteers. Blood and urine samples plus other data including demographics, medical history, current medications, and 12-lead electrocardiogram were obtained from MS patients with the relapsing-remitting form of the disease.
The researchers were able to identify a gene expression signature that can correlate with disease status and differentiate the active from stable phases of MS. The researchers highlighted that the JNK/inflammation/ apoptosis pathway plays a significant role in MS, and the information can be used to design a prognostic/diagnostic gene card for MS patient stratification and ultimately improved patient outcomes.
Jeanine Seguin Santelli, Nazareth College, Rochester, NY
|Gale Copyright:||Copyright 2011 Gale, Cengage Learning. All rights reserved.|