Multiple sclerosis.
Article Type: Brief article
Subject: Multiple sclerosis (Research)
Multiple sclerosis (Diagnosis)
Multiple sclerosis (Prognosis)
Multiple sclerosis (Genetic aspects)
Apoptosis (Research)
Apoptosis (Physiological aspects)
Biological markers (Usage)
Author: Santelli, Jeanine Seguin
Pub Date: 03/22/2011
Publication: Name: Journal of the New York State Nurses Association Publisher: New York State Nurses Association Audience: Academic Format: Magazine/Journal Subject: Health; Health care industry Copyright: COPYRIGHT 2011 New York State Nurses Association ISSN: 0028-7644
Issue: Date: Spring-Winter, 2011 Source Volume: 42 Source Issue: 1-2
Topic: Event Code: 310 Science & research
Geographic: Geographic Scope: United States Geographic Code: 1USA United States
Accession Number: 278760667
Full Text: Ferrandi, C., Richard, F., Tavano, P., Hauben, E., Barbie, V., Gotteland, J., ... Zaratin, P. F. (2011). Characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-Jun N-terminal kinase pathway biomarkers. Multiple Sclerosis journal, 17(1), 43-56.

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. Programmed death (apoptosis) of lymphocytes is essential for the immune system to function. A defect in the cycle of activated T lymphocyte death is involved in the pathology of MS. The purpose of this study was to identify the potential role of the c-Jun N-terminal kinase (JNK) pathway in regulating these T cell responses in people diagnosed with MS. Blood samples were obtained from healthy volunteers. Blood and urine samples plus other data including demographics, medical history, current medications, and 12-lead electrocardiogram were obtained from MS patients with the relapsing-remitting form of the disease.

The researchers were able to identify a gene expression signature that can correlate with disease status and differentiate the active from stable phases of MS. The researchers highlighted that the JNK/inflammation/ apoptosis pathway plays a significant role in MS, and the information can be used to design a prognostic/diagnostic gene card for MS patient stratification and ultimately improved patient outcomes.

Jeanine Seguin Santelli, Nazareth College, Rochester, NY
Gale Copyright: Copyright 2011 Gale, Cengage Learning. All rights reserved.

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