Menopause transition data.
Article Type: Brief article
Subject: Menopause (Health aspects)
Cardiovascular diseases (Risk factors)
Women (Health aspects)
Author: Kent, Athol
Pub Date: 04/01/2010
Publication: Name: South African Journal of Obstetrics and Gynaecology Publisher: South African Medical Association Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2010 South African Medical Association ISSN: 0038-2329
Issue: Date: April, 2010 Source Volume: 16 Source Issue: 2
Accession Number: 225792464
Full Text: The Study of Women's Health Across the Nation (SWAN) is an American initiative that documents women through their menopause transition. Over 1 000 women are being monitored from about the age of 47 years for the next 10 years of their lives.

Sutton-Tyrell et al. (J Am Coll Cardiol 2009; 54: 2366-2375) report that deleterious lipid changes coincide with the cessation of menstruation. More precisely, in the year before and after her final menstrual period a woman is likely to experience substantial increases in total cholesterol levels. Also raised are low-density lipoproteins and apolipoprotein B, which are associated with raised cardiovascular risk. The changes are independent of age and ethnicity. Quite how these changes can be influenced by exogenous hormones or lifestyle remains to be seen.

Athol Kent

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