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Male circumcision and risk of HIV in Australian
homosexual men.
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| Article Type: | Brief article |
| Subject: |
HIV infection
(Risk factors) HIV infection (Demographic aspects) Circumcision (Health aspects) Circumcision (Research) |
| Pub Date: | 05/01/2010 |
| Publication: | Name: Reproductive Health Matters Publisher: Reproductive Health Matters Audience: General Format: Magazine/Journal Subject: Family and marriage; Health; Women's issues/gender studies Copyright: COPYRIGHT 2010 Reproductive Health Matters ISSN: 0968-8080 |
| Issue: | Date: May, 2010 Source Volume: 18 Source Issue: 35 |
| Topic: | Event Code: 310 Science & research |
| Geographic: | Geographic Scope: Australia Geographic Code: 8AUST Australia |
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| Accession Number: | 236247776 |
| Full Text: |
In contrast to findings among African heterosexuals, data on the
association of circumcision and HIV infection in men who have sex with
men are few and conflicting. The Health in Men (HIM) prospective cohort
study recruited 1,426 HIV-negative homosexual men from community-based
sources in Sydney, Australia, between 2001 and 2004 and followed them
until mid-2007. 66% were circumcised. Participants underwent annual HIV
testing, and detailed information on sexual risk behaviour was collected
biannually. Median follow-up time was 3.9 years. There were 53 HW
seroconversions during the 5,161 person years of follow-up: an incidence
of 0.78 per 100 person-years. Overall, circumcision did not
significantly reduce the risk of HIV infection (hazard ratio 0.78,
p=0.42). However, circumcision was associated with a significant
reduction in HIV incidence among the one-third of participants who
reported a preference for the insertive role in anal intercourse (hazard
ratio 0.11, p=0.041) and whose sexual behaviour closely and consistently
reflected this preference. This finding is based on only seven
infections amongst men with such a preference, five of which were in
uncircumcised men, and these small numbers are a key limitation of the
analysis. Amongst the 10% of person-years in men who reported only
insertive sex and no receptive sex, circumcision did not significantly
reduce HIV risk. The investigators call for randomised controlled trials
to further explore the relationship. (1) (1.) Templeton D J, Fengyi J, Mao L, et al. Circumcision and risk of HIV infection in Australian homosexual men. AIDS 2009;23(17):2347-51. |
| Gale Copyright: | Copyright 2010 Gale, Cengage Learning. All rights reserved. |
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