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J Zoo Wildl Med.: Serologic response and safety to
vaccination against avian influenza using inactivated H5N2 vaccine in
zoo birds.
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| Article Type: | Reprint |
| Subject: |
Vaccination
(Methods) Vaccination (Management) Avian influenza (Risk factors) Avian influenza (Prevention) Zoo animals (Health aspects) Bird populations (Health aspects) |
| Authors: |
Lecu, A. De Langhe, C. Petit, T. |
| Pub Date: | 03/01/2010 |
| Publication: | Name: Journal of Avian Medicine and Surgery Publisher: Association of Avian Veterinarians Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2010 Association of Avian Veterinarians ISSN: 1082-6742 |
| Issue: | Date: March, 2010 Source Volume: 24 Source Issue: 1 |
| Topic: | Event Code: 200 Management dynamics Computer Subject: Company business management |
| Product: | Product Code: 8000146 Vaccination & Immunization NAICS Code: 621999 All Other Miscellaneous Ambulatory Health Care Services |
| Geographic: | Geographic Scope: France Geographic Code: 4EUFR France |
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| Accession Number: | 252005039 |
| Full Text: |
Due to the spread of the H5N1 highly pathogenic strain of avian
influenza virus across Europe, a preventive vaccination occurred in
early 2006 among 135 French zoologic institutions. Approximately 25,000
birds were vaccinated with a H5N2 inactivated vaccine. Among them, 4,369
birds were monitored by members of Association Francophone des
Veterinaires de Parc Zoologique regarding safety issues of the
vaccination protocol. A total of 1,686 blood samples were collected
before the first injection (n = 255), at the time of booster (n = 463),
60 day after the booster (n = 514), and 180 day (n = 229) and 330 day (n
= 217) after the initial injection. Thus, sera of 126 species
representing 15 different avian orders were tested using the
hemagglutinin inhibition assay to evaluate seroconversion and the
long-term serologic profile of selected anti-H5 antibody. Safety was
considered satisfactory in all orders, and there were no deleterious
effects on largevolume injection/body weight ratio. After the second
injection, 71% of the birds developed a titer [greater than or equal to]
32, with a mean titer of 558. Titers then decreased in all birds, with
42% of the remaining birds having a titer [greater than or equal to] 32
at day 180 and only 26% at day 330. Results demonstrated that a booster
42 days after initial vaccination was mandatory to raise the titer above
32, considered to be the protective level in poultry, and to increase
the number of seroconverted birds. Differences in the serologic
responses among the orders and species of birds were detected and could
be linked with the variation of vaccine dose injected per body weight or
with species-specific immune response. The protocol for additional
campaigns will be adjusted for some bird orders through the increase of
injected dose or a half yearly booster to sustain better titers over the
year. Vaccination is a useful tool, together with biosecurity, that
should always be used as a primary method of preventing and controlling
avian influenza outbreaks. 2009;40:731-743. |
| Gale Copyright: | Copyright 2010 Gale, Cengage Learning. All rights reserved. |