|
J Zoo Wildl Med.: Application of galactomannan
analysis and protein electrophoresis in the diagnosis of aspergillosis
in avian species.
|
|
|
|
|
| Article Type: | Brief article |
| Subject: |
Antigens
(Testing) Antigens (Health aspects) Aspergillosis (Diagnosis) Blood protein electrophoresis (Usage) Birds (Health aspects) Animals (Diseases) Animals (Diagnosis) |
| Authors: |
Cray, C. Watson, T. Rodriguez, M. Arheart, K.L. |
| Pub Date: | 06/01/2009 |
| Publication: | Name: Journal of Avian Medicine and Surgery Publisher: Association of Avian Veterinarians Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2009 Association of Avian Veterinarians ISSN: 1082-6742 |
| Issue: | Date: June, 2009 Source Volume: 23 Source Issue: 2 |
| Topic: | Event Code: 330 Product information |
| Product: | SIC Code: 2836 Biological products exc. diagnostic |
| Geographic: | Geographic Scope: United States Geographic Code: 1USA United States |
|
|
|
| Accession Number: | 252006961 |
| Full Text: |
Previous studies support the possible application of galactomannan,
a major antigen of Aspergillus species, to aspergillosis diagnosis in
avian and other animal species. An assay is commercially available for
use with human serum and bronchoalveolar lavage fluid samples. In the
current study, galactomannan results from plasma samples were compared
between birds with histologically confirmed aspergillosis and those that
were clinically normal presumptively non-Aspergillus infected birds per
submitting practitioners' responses to a questionnaire. It was
observed that infected birds demonstrated a 2.6-fold increase in
galactomannan over birds without evidence of aspergillosis. With the use
of a galactomannan index of 0.5 as a cutoff, the sensitivity and
specificity of the test were found to be 67% and 73%, respectively. In
addition, plasma samples were analyzed for abnormalities in protein
electrophoretic patterns. Infected birds had a higher incidence of
increased beta and/or gamma globulin concentrations. Test sensitivity
and specificity were 73% and 70%, respectively. If the 2 tests were used
as a panel, then the sensitivity was 89% and specificity was 48%. These
data indicate that both galactomannan and protein electrophoresis may be
valuable tools in the diagnosis of avian aspergillosis. 2009;40:64-70. |
| Gale Copyright: | Copyright 2009 Gale, Cengage Learning. All rights reserved. |