Induction to abortion interval in second trimester medical abortion.
Article Type: Brief article
Subject: Abortion, Therapeutic (Demographic aspects)
Abortion, Therapeutic (Patient outcomes)
Abortion, Therapeutic (Research)
Gestational age (Influence)
Gestational age (Research)
Mifepristone (Dosage and administration)
Mifepristone (Research)
Misoprostol (Dosage and administration)
Misoprostol (Research)
Pub Date: 05/01/2010
Publication: Name: Reproductive Health Matters Publisher: Reproductive Health Matters Audience: General Format: Magazine/Journal Subject: Family and marriage; Health; Women's issues/gender studies Copyright: COPYRIGHT 2010 Reproductive Health Matters ISSN: 0968-8080
Issue: Date: May, 2010 Source Volume: 18 Source Issue: 35
Topic: Event Code: 310 Science & research
Accession Number: 236247755
Full Text: This study explored the effect of length of pregnancy on the induction-to-abortion interval of medical second trimester abortion. Information was collected retrospectively on a consecutive series of 270 women with pregnancies of 12 to 22.6 weeks, who underwent abortion in Barcelona, Spain, from April 2006 to June 2009. All the women received a single oral dose of 200 mg mifepristone and 36-48 hours later, a course of misoprostol (an initial vaginal dose of 800 mcg plus four oral doses of 400 mcg at three-hourly intervals). The mean length of pregnancy was 18 weeks. The mean induction-to-abortion interval was 9.8 hours, and 91% of the women aborted successfully within 24 hours. Length of pregnancy (p<0.001) and parity (p<0.003) were the only two variables independently associated with the induction-to-abortion interval. The mean induction-to-abortion interval was 12.9 hours in those beyond 20 weeks of pregnancy, about four hours longer than for those who were 12-20 weeks pregnant. The proportion of women over 20 weeks of pregnancy who aborted within 12 hours was 59%, compared to 81% who were at 12-20 weeks. The nulliparous women needed longer, a mean of l0.1 hours, compared to women with a previous live birth (8.1 hours). This information is relevant for counselling and planning of second trimester medical abortions. (1)

(1.) Gomez O, Borras A, Rabanal A, et al. Mifepristone-misoprostol midtrimester abortion: impact of gestational age on the induction-to-abortion interval. Contraception 2010;81:97-101.
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