Hypoglycemic activity of polysaccharide from Cordyceps.
Article Type: Brief article
Subject: Cordyceps (Health aspects)
Cordyceps (Usage)
Hypoglycemia (Care and treatment)
Hypoglycemia (Research)
Polysaccharides (Health aspects)
Pub Date: 12/22/2006
Publication: Name: Australian Journal of Medical Herbalism Publisher: National Herbalists Association of Australia Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2006 National Herbalists Association of Australia ISSN: 1033-8330
Issue: Date: Winter, 2006 Source Volume: 18 Source Issue: 4
Topic: Event Code: 310 Science & research
Product: Product Code: 2860440 Polysaccharides NAICS Code: 325199 All Other Basic Organic Chemical Manufacturing SIC Code: 2869 Industrial organic chemicals, not elsewhere classified
Geographic: Geographic Scope: Australia Geographic Code: 8AUST Australia
Accession Number: 174817372
Full Text: Li S, Zhang G, Zeng Q, Huang Z, Wang Y, Dong T etal. 2006. Hypoglycemic activity of polysaccharide, with antioxidation, isolate from cultured Cordyceps mycelia. Phytomed 13:6;428-33. (CB)

Cordyceps sinensis is commonly used in China for the treatment of fatigue, night sweating, hyposexualities, hyperglycemia, hyperlipidemia, renal disease, heart disease and liver disease. This study aims to identify the hypoglycemic activity of an isolated polysaccharide from Cordyceps (CSP-1).

Forty healthy mice were divided into 4 groups and administered orally for 7 days either saline solution, tolbutamide (positive control), 200 mg/kg CSP-1 or 400 mg/kg CSP-1. This experiment was repeated in rats which had been made diabetic via the use of streptozotocin and then again in rats which were made diabetic via the use of alloxan.

Each experiment found that tolbuatmide, and both dosages of CSP-1 (with the 400 mg/kg dose having a more significant effect), were effective in lowering blood glucose levels and increasing serum insulin levels. The effect lasted at least 6 hours.

Jerome Sarris

3 Widgee Place, Chapel Hill Qld 4069

Cara Barnes

20 Brendon Street, Tarragindi Qld 4121
Gale Copyright: Copyright 2006 Gale, Cengage Learning. All rights reserved.