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Hydatid cyst.
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| Article Type: | Case study |
| Subject: |
Diagnostic imaging
(Usage) Echinococcosis (Causes of) Echinococcosis (Diagnosis) Echinococcosis (Care and treatment) Echinococcosis (Case studies) |
| Authors: |
Tsai, Jason Weiss, Clifford R. Fishman, Elliot K. Horton, Karen M. |
| Pub Date: | 01/01/2009 |
| Publication: | Name: Applied Radiology Publisher: Anderson Publishing Ltd. Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2009 Anderson Publishing Ltd. ISSN: 0160-9963 |
| Issue: | Date: Jan-Feb, 2009 Source Volume: 38 Source Issue: 1-2 |
| Geographic: | Geographic Scope: United States Geographic Code: 1USA United States |
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| Accession Number: | 208536109 |
| Full Text: |
CASE SUMMARY A 24-year-old woman presented with a 1-year history of weight loss and diarrhea. She described her diarrhea as watery and foul-smelling and noted that it was worse at night. She also reported a 20-lb weight loss in the previous month without decreased appetite or energy level. She denied nausea, vomiting, fever, chills, or abdominal pain associated with the diarrhea. Her family history was significant for gastric carcinoma in her maternal grandfather and colon cancer in a maternal aunt. The physical examination was significant for a cachectic appearance. Laboratory findings revealed a decreased white blood cell count (2.1 x [10.sup.3]/mL), decreased hemoglobin (10.9 g/dL), and slightly elevated aspartate aminotransferase (41 U/L). The remaining liver function test results were normal. A 74-hour fecal fat study exhibited steatorrhea. Stool trypsin was normal. IMAGING FINDINGS Computed tomography (CT) of the liver was obtained before and after the administration of 120 mL of nonionic contrast (Omnipaque 350, GE Healthcare, Princeton, NJ) on a Sensation 16 scanner (Siemens Medical Solutions, Malvern, PA) using 0.75-mm collimation, 120 KVp, 300 mAs, 0.75 slice thickness with reconstruction of data every 0.5 mm. The axial images showed a well-defined, avascular 3-cm ovoid lesion in the left lobe (Figure 1). The lesion measured 51 HU before the administration of contrast, with no evidence of enhancement on either the arterial- or venous-phase images. The lesion was poorly visualized on both noncontrast and arterial-phase contrast-enhanced CT but was clearly seen as a well-defined, low-density mass on venous-phase imaging. Based on the CT findings, the possibility of an atypical hepatic adenoma or focal nodular hyperplasia was initially considered but was considered unlikely. In light of the recent history of weight loss, there was a concern for neoplasm or abscess, and so a biopsy was performed. Under ultrasound guidance, 2 passes with a 22-gauge Chiba needle were performed in the lesion. Evaluation of the aspirated material revealed the presence of echinococcal hooklets, yielding a final diagnosis of hydatid cyst (Figure 2). The patient was placed on albendazole therapy and referred to a gastrointestinal parasitologist for further treatment. After the biopsy, it was discovered that the patient had taken 2 trips to Mexico within the past 2 years and that her symptoms had begun just after her first trip. DIAGNOSIS Hydatid cyst, with an atypical appearance on CT DISCUSSION [FIGURE 1 OMITTED] [FIGURE 2 OMITTED] The differential diagnosis of a solitary hepatic cystic mass is broad and includes simple (bile duct) cyst, benign adenoma, focal nodular hyperplasia, metastatic lesion, biliary cystadenoma or cystadenocarcinoma, primary hepatoma, pyogenic or amebic abscess, and echinococcal cyst. Imaging findings on CT can help to narrow the diagnosis. Simple cysts result from congenital defects in bile-duct formation. (3) Radiographically, they are well-defined, measure water density, and do not exhibit enhancement after the administration of intravenous contrast. This lesion did not measure water density and did not exhibit enhancement (either early or delayed). Hepatic adenomas and focal nodular hyperplasia are usually hypervascular and, unlike the lesion in this case, usually enhance, especially during the arterial phase. The possibility of atypical avascular adenoma remained on the differential until the time of biopsy, as did focal nodular hyperplasia. Primary hepatoma and metastasis were also included in the differential diagnosis, although in sequential imaging these generally enhance to a greater degree than as seen in this case. Cystadenomas appear as low-attenuation intrahepatic masses on CT as well. They are typically more cystic in nature than hydatid cysts, with thick nodular walls and septations. Pyogenic abscesses are variable in appearance radiographically and can often be confused with amebic abscesses. However, both can generally be distinguished from hydatid cyst (and from each other) by correlation with the clinical picture and laboratory data. (4) An echinococcal cyst is most often seen radiographically as a well-defined area of low attenuation on CT, often with several classic diagnostic findings. These include focal or segmental cyst wall thickening, crescentic calcification of cyst borders, and the presence of daughter cysts. (5) None of these CT findings were apparent in this case. Classically, the diagnostic imaging method of choice for assessing cystic lesions of the liver has been ultrasound, as it is noninvasive, accessible, and sensitive. (6) However, as the use of CT as a primary imaging modality continues to rise, and as CT has become a preferred modality in the investigation of liver lesions, it is important to consider hydatid cyst in the differential diagnosis when presented with unusual cystic lesions in the liver, regardless of whether classic CT features are present. This case illustrates that a detailed clinical history is essential in narrowing down a differential diagnosis--especially when imaging findings are nonspecific. CONCLUSION Hydatid disease remains an endemic problem in many parts of the world. Despite attempts to identify imaging findings that distinguish hepatic echinococcal cysts from other hepatic cystic lesions, echinococcosis is still a challenging disease to diagnose radio graphically. This case of hydatid cyst in the liver with atypical CT findings demonstrates the importance of a broad differential diagnosis that includes hydatid cyst when investigating any unusual hepatic cystic lesions. REFERENCES (1.) Polat P, Kantarci M, Alper F, et al. Hydatid disease from head to toe. RadioGraphics. 2003;23:475-494; quiz 536-537. (2.) Parwani AV, Burroughs FH, Ali SZ. Echinococcal cyst of the liver. Diagn Cytopathol. 2004;31:111-112. (3.) Cowles RA, Mulholland MW. Solitary hepatic cysts. J Am Coll Surg. 2000;191:311-321. Comment in: J Am Coll Surg. 2001;192:804. (4.) Murphy BJ, Casillas J, Ros PR, et al. The CT appearance of cystic masses of the liver. Radio Graphics. 1989;9:307-322. (5.) Haddad MC, Birjawi GA, Khouzami RA, et al. Unilocular hepatic echinococcal cysts: Sonography and computed tomography findings. Clin Radiol. 2001;56:746-750. (6.) Sayek I, Onat D. Diagnosis and treatment of uncomplicated hydatid cyst of the liver. World J Surg. 2001;25:21-27. Prepared by Jason Tsai, MD, Tufts University Medical Center, Boston, MA, and Clifford R. Weiss, MD, Elliot K. Fishman, MD, and Karen M. Horton, MD, Johns Hopkins Hospital, Baltimore, MD. |
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