How broccoli beats cancer.
Article Type: Brief article
Subject: Broccoli (Health aspects)
Cancer (Care and treatment)
Cancer (Methods)
Authors: Klatz, Ronald
Goldman, Robert
Pub Date: 08/01/2012
Publication: Name: Townsend Letter Publisher: The Townsend Letter Group Audience: General; Professional Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2012 The Townsend Letter Group ISSN: 1940-5464
Issue: Date: August-Sept, 2012 Source Issue: 349-350
Product: Product Code: 8000432 Cancer Therapy; 0160014 Broccoli NAICS Code: 621 Ambulatory Health Care Services; 111219 Other Vegetable (except Potato) and Melon Farming SIC Code: 0161 Vegetables and melons
Geographic: Geographic Scope: United States Geographic Code: 1USA United States
Accession Number: 303012879
Full Text: Sulforaphane, a compound found in broccoli and other cruciferous vegetables, helps to restore a balance in intracellular processes, beneficially affecting the genetics behind cancer. Sulforaphane inhibits histone deacetylases, (HDACs), thereby interfering with the cellular triggers for cancer. Scientists from Oregon State University (Oregon, US) studied the effect of sulforaphane on prostate cancer cells, and revealed that DNA methylation appears to also contribute to the cancer process. Whereas DNA methylation is a normal process of turning off genes, helping to control what DNA material is utilized in intracellular communications, the process is disrupted in cancer cells. Showing that sulforaphane helps to restore a balance in DNA methylation, the study authors conclude: "dietary phytochemicals that affect the epigenome also can trigger DNA damage and repair mechanisms."

Rajendran P, Ho E, Williams DE, Dashwood RH. Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. Clin Epigenetics. 2011;3:4.

by Ronald Klatz, MD, DO, and Robert Goldman, MD, PhD, DO, FAASP
Gale Copyright: Copyright 2012 Gale, Cengage Learning. All rights reserved.