How broccoli beats cancer.
|Article Type:||Brief article|
Cancer (Care and treatment)
|Publication:||Name: Townsend Letter Publisher: The Townsend Letter Group Audience: General; Professional Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2012 The Townsend Letter Group ISSN: 1940-5464|
|Issue:||Date: August-Sept, 2012 Source Issue: 349-350|
|Product:||Product Code: 8000432 Cancer Therapy; 0160014 Broccoli NAICS Code: 621 Ambulatory Health Care Services; 111219 Other Vegetable (except Potato) and Melon Farming SIC Code: 0161 Vegetables and melons|
|Geographic:||Geographic Scope: United States Geographic Code: 1USA United States|
Sulforaphane, a compound found in broccoli and other cruciferous
vegetables, helps to restore a balance in intracellular processes,
beneficially affecting the genetics behind cancer. Sulforaphane inhibits
histone deacetylases, (HDACs), thereby interfering with the cellular
triggers for cancer. Scientists from Oregon State University (Oregon,
US) studied the effect of sulforaphane on prostate cancer cells, and
revealed that DNA methylation appears to also contribute to the cancer
process. Whereas DNA methylation is a normal process of turning off
genes, helping to control what DNA material is utilized in intracellular
communications, the process is disrupted in cancer cells. Showing that
sulforaphane helps to restore a balance in DNA methylation, the study
authors conclude: "dietary phytochemicals that affect the epigenome
also can trigger DNA damage and repair mechanisms."
Rajendran P, Ho E, Williams DE, Dashwood RH. Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. Clin Epigenetics. 2011;3:4.
by Ronald Klatz, MD, DO, and Robert Goldman, MD, PhD, DO, FAASP
|Gale Copyright:||Copyright 2012 Gale, Cengage Learning. All rights reserved.|