Hospitalization and medical evacuation of army personnel due to toxic inhalational exposure--operations Iraqi Freedom and Enduring Freedom, 2001 through mid 2011.
Article Type: Report
Subject: American soldiers (Health aspects)
Author: Sharkey, Jessica M.
Pub Date: 07/01/2012
Publication: Name: U.S. Army Medical Department Journal Publisher: U.S. Army Medical Department Center & School Audience: Professional Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2012 U.S. Army Medical Department Center & School ISSN: 1524-0436
Issue: Date: July-Sept, 2012
Topic: Event Name: War on Terrorism, 2001-
Organization: Government Agency: United States. Army
Geographic: Geographic Scope: Iraq; Afghanistan Geographic Name: Iraq; Iraq; Afghanistan; Afghanistan Geographic Code: 7IRAQ Iraq; 9AFGH Afghanistan
Accession Number: 301479566
Full Text: BACKGROUND

Problem Statement

Following the first Gulf War (1991), concerns related to potential toxic inhalational exposures among military personnel were raised that remain unresolved. Similar exposure concerns during deployment have arisen as a result of current efforts, including military support of Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF). During these conflicts, extensive intermittent ambient sampling has been conducted at select locations within the US Central Command area of operations (CENTCOM AO) (1) and questionnaires aimed at documenting service members' environmental exposures while deployed have been completed. Some work has been done to characterize exposure to specific exposure events on a population level. However, research regarding the possible relationship(s) between deployment-associated toxic inhalational exposures and subsequent health outcomes is limited, due to the fact that quantitative, verifiable exposure information at the individual level is difficult to ascertain.

Potential Exposures

The current conflicts in Southwest Asia comprise the longest period of continuous armed conflict in US history. As a result, almost all US military personnel serving since 2001 have deployed in support of these operations, (2,3) typically 12 months at a time, with many service members deploying multiple times. As a result, concerns regarding environmental exposures during deployment have been documented frequently by deployed service members. (4) Helmer et al found that concern for poor air quality from burning trash, smoke from oil well fires, and sand/dust was documented in 34%, 20%, and 16%, respectively, of reviewed medical records. (5) Air sampling conducted by the Department of Defense (DoD) in Southwest Asia areas of operation identified particulate matter (PM) as a major environmental exposure of concern. (6) Deployment-associated sources of PM include fine sand and dust that was resuspended by strong winds or troop activities, exhaust from the engines of heavy machinery (gas, diesel, turbine), the industrial landscape that is characteristic of some locales, and potentially toxic smoke from burn pits and fires.6 Concern regarding these population level deployment-related exposures, as well as uncertainty regarding the health effect of combined exposures has highlighted the need for deeper understanding of individual environmental exposure during deployment. Gaining this understanding is complicated by the fact that personal exposure experiences vary with the unit, their mission, and location. Further, there may be unplanned or accidental exposures not reflected in available aggregate sampling data.

Exposure Events

Large populations have potentially had inhalational exposures due to ambient conditions, localized sources (industry), unplanned events (releases/venting of toxic substances, fires), and activities such as waste management. Available sampling data indicate that measured levels are rarely of acute concern, but if sustained, may be associated with or contribute to chronic health effects. The availability of sampling data varies, with most available data reflecting ambient conditions, and minimal data available for unplanned incidents.

Burn Pits

In addition to naturally occurring, ambient PM, burn pits are being recognized as a contributing source of PM at many OIF and OEF deployment locations in Southwest Asia. (4,7) Prior to 2010, burn pits were widely used as waste management tools at locations where more sophisticated methods of solid waste disposal (incinerators, reuse/recycling, containerized removal by contractors) were not feasible methods for trash disposal in the wartime environment. A burn pit is formally defined as:

Open-air burn pit use is now minimized due to the potential for both short-term and long-term health effects.

In response to concerns regarding the possible health effects brought about or exacerbated by exposure to smoke plumes originating from burn pits during deployment, several research initiatives to examine potential associations have been conducted. The Armed Forces Health Surveillance Center, Naval Health Research Center, and US Army Public Health Command conducted a series of evaluations that found exposure to burn pits was not associated with incidents of or worsening prevalent respiratory health diseases. However, it was acknowledged that, in light of study limitations, further investigation is needed to establish a better understanding of the relationship between exposure and outcome. (9) The Institute of Medicine* recently released the results of their study, Long-Term Health Consequences of Exposure to Burn Pits in Iraq and Afghanistan ([dagger], 7) which, among other things, concluded that it is uncertain whether exposures to emissions from burn pits have caused long-term health effects. But the report also included:

Despite the current absence of definitive evidence citing a direct link between burn pit smoke exposure and longterm chronic respiratory conditions among OIF and OEF veterans, deployed military forces, following DoD policies, have been decreasing their reliance on burn pits.

Fires

Not surprisingly, significant fire events have been documented in the combat theaters of Southwest Asia. The impact on the environment included air pollutants that may have had potentially detrimental consequences on the respiratory health of exposed military personnel. One study conducted after the Kuwait oil well fires at the end of the 1991 Gulf War found a statistically significant positive association between the prevalence of selfreported exposure to the smoke and self-reported symptoms of asthma and bronchitis. That association did not hold when modeled exposure was assessed in conjunction with the same respiratory outcomes. (10) Petruccelli et al found increased reports of respiratory symptoms (such as cough, shortness of breath, upper respiratory tract irritation) among Soldiers with potential exposure to the Kuwait oil fires, a phenomenon that mostly dissipated at redeployment. (11) More pertinent to the current conflict is the Al Mishraq sulfur fire that burned in Iraq for 3 weeks in June 2003. A retrospective cohort study indicated more self-reported respiratory symptoms on the Postdeployment Health Assessment, DD Form 2796 (administered within 3 months of the end of deployment), among exposed personnel but did not show an increase of chronic respiratory conditions in association with exposure to the smoke plume. (12)

Geological Dust

An analysis conducted by Englebrecht et al13 on air samples collected from the CENTCOM AO implicated geological dust as one of the 3 main pollutants in the environment. The samples of interest showed generally expected composition, both chemical and mineralogical, when compared to samples from the Sahara and desert regions of the United States and China. However, average mass and chemical concentrations of the CENT-COM AO samples used in the analysis are as much as 10 times greater than those seen in samples from 10 rural and urban sites in the US near to military bases with similarly dry climates. Notably, the levels detected during this sampling program's efforts regularly exceeded the 24-hour standards set by the US Environmental Protection Agency. (14)

Exhaust and Industrial Byproducts

The operational setting in Iraq is largely desert, and industrial in nature. Existing infrastructure sources that contribute to air pollution include oil, cement, and fertilizer industries. The terrain of Afghanistan is mostly rugged mountains and desert, and environmental conditions have been described as degraded. Coupled with inherent environmental stressors of war, including factors like exhaust from military vehicles/heavy machinery and chemicals released during explosions, the extent of PM generated from these sources is of major concern regarding the respiratory health of our service members while deployed. (15-17)

Identification of Exposures Using Disease and Nonbattle Injury Data

Acute, high level exposures would likely affect few individuals, but are typically not reflected by sampling due to their unplanned nature. While individuals may seek care, these occurrences have not been systematically evaluated. Disease and nonbattle injury (DNBI) is the term for an illness and/ or injury that is not directly related to enemy action or participation in direct combat. Reporting of DNBIs from deployed settings can be used to evaluate the frequency and nature of individual toxic inhalational exposures. They can include injuries and illnesses resulting from training or recreational activities or occupational and environmental exposures indirectly caused by military service. Throughout the history of US conflict, DNBIs have contributed significantly to decreased force strength and operational readiness of our fighting troops. (18-20) In order to highlight the impact of environmental exposures on the individual Soldier across the US Army, the focus of this article is DNBI related to toxic substance exposures, particularly those that are inhalational in nature, which resulted in hospitalizations or medical evacuations from the combat theater from 2001 through mid 2011. Since medical visits which did not result in hospitalization are not included, the data does not reflect exposures which may have been less severe.

DATA SOURCES

The DoD Standard Inpatient Data Records database stores information regarding inpatient medical encounters within the military health system. The electronic records for all hospitalizations occurring during deployment were accessed through the Patient Administration Systems and Biostatistics Activity. The US Transportation Command Regulating and Command and Control Evacuation System (TRAC2ES) is a web-based data repository that stores information pertaining to all patient regulation and movement throughout DoD activities and locations. (21) Specifically, TRAC2ES contains individual health-related data necessary to coordinate the transition of personnel requiring medical evacuation from the operational environment to a location where specialized medical care can be provided. (22) In-theater hospitalization data was reviewed to identify hospitalizations among active duty Soldiers due to toxic inhalation exposures between 2001 and mid 2011. External cause codes were reviewed and available records were further refined to identify additional information and need for medical evacuation.

RESULTS

Toxic Substance Exposure

Disease and nonbattle injuries related to toxic substance exposures are specified as one of the following 3 categories: poisoning by ingestion of toxic substances, poisoning by inhalation of toxic substances, or adverse systemic or skin reaction by contact with a toxic substance. The most commonly occurring subcategory is ingestion of toxic substances, followed by inhalation of toxic substances, then adverse systemic or skin reaction with a toxic substance. Table 1 shows the distribution for each toxic substance exposure category.

Hospitalizations

Demographics

The data for all US Army personnel with a history of OIF and OEF deployments between 2001 and mid 2011 were eligible for capture in the query for toxic inhalation-related hospitalizations and evacuations. A total of 100 such hospitalizations was identified. The distribution of population demographics for those hospitalizations is shown in Table 2.

Causes, Trends, and Theater Distribution

Specific causes (identified by ICD-9 ** codes in the primary diagnosis field) that attributed to toxic inhalational international Classification of Diseases, Ninth Revision exposures consisted mostly of toxic effects of gases, fumes, and vapors (not otherwise specified, n=22; not elsewhere classified, n=7), and toxic effects of chlorine gas (n=14). These diagnoses represent 43% of all toxic inhalational exposure hospitalizations (N=100). As shown in Figure 1, the frequency of toxic inhalational hospitalizations increased from 2001 through 2003, before decreasing and remaining fairly stable between 2004 and 2007, increased in 2008 before declining from 2009 through mid 2011. Operation-specific counts indicate the majority (n=91) of toxic inhalational exposure hospitalizations occurred in OIF, with 9 hospitalizations recorded from OEF.

[FIGURE 1 OMITTED]

Evacuations

Data gathered from TRAC2ES indicated 26 air evacuations from the combat theaters of OIF and OEF between 2001 and mid 2011 with toxic inhalational exposure listed as the cause of injury. The population demographics for those evacuations is presented in Table 3.

As shown in Figure 2, the frequency of evacuations for toxic inhalation increased from 2001 through 2004, decreased in 2005 before increasing and levelling between 2006 and 2008, then declined in 2009 and remained fairly stable through mid 2011. Theater-specific counts indicate the majority of toxic inhalational exposure evacuations were made from OIF (n=20), with 6 evacuations recorded from OEF.

CONCLUSION

Disease and nonbattle injuries have contributed significantly to overall morbidity and mortality associated with battle throughout the history of US conflict, and the current conflicts are no exception. (18,20) Based on the available data, poisoning by exposure to toxic substances, including toxic inhalations, is relatively infrequent. Some cases are serious enough to warrant in-theater hospitalization, a subset of which results in out-of-theater medical evacuation.

While deployed in support of OIF and OEF, our military personnel may experience toxic substance exposures that can have respiratory health consequences. Unfortunately, most of these exposures in the deployment environment cannot be avoided, and the demands of combat operations and wartime stressors may hinder adequate preventive measures. While both the acute and chronic health effects of such exposures are not yet fully understood, studying such a relationship is difficult due to a lack of individual exposure data. Hospitalization and medical evacuation data related to toxic inhalational exposures were examined in an effort to better understand the extent of true exposure during deployment at the individual level in an objective fashion. Available data indicate that the number of toxic inhalational exposures significant enough to require hospitalization from 2001 through mid 2011 is small relative to the number of troops who were deployed and potentially exposed during that time period. A smaller subset of the hospitalized service members required medical evacuation due to severe inhalational exposures. As the data used in this study were limited to those toxic exposures significant enough to require hospitalization or medical evacuation, it represents some fraction of a still unquantified denominator that includes exposures that may have resulted in symptoms or medical evaluation, but not hospitalization. Additionally, toxic inhalation exposures may affect individuals with conditions which make them more susceptible to exacerbations, such as asthma. (23) These hospitalizations would most likely be coded with the primary condition (asthma) and not the precipitating exposure. Therefore, while available data indicate that acute inhalational injury of significance is a rare event, this likely represents the "tip of the iceberg" of inhalational exposures while deployed.

[FIGURE 2 OMITTED]

The concern that the DoD has not truly identified the full impact of toxic inhalational exposures during military operations is not new, however. In fact, some personnel have received treatment due to environmental exposures during deployment, yet systems previously available have not captured this information adequately. As a result, some very specific solutions have been recently developed to improve the quality of the data collected when exposures result in medically notable encounters. These efforts include the establishment of the Defense Occupational and Environmental Health Readiness System-Incident Reporting module, *** an official DoD archive system that includes fields for collection of incident data, personnel rosters, and medical/duty status; the institution of specific ICD-9 causal codes for consistent reporting and surveillance; development of base camp periodic occupational and environmental monitoring summaries and incident/hazard specific factsheets. Additionally, the US Army Public Health Command's Environmental Medicine Program now offers an Environmental Medicine Clinical Consult Service, the only official environmental medicine level V support ([dagger][dagger]) offered through the Army Medical Command which provides documents and presents recommendations regarding diagnostics and/or medical documentation to address individual concerns associated with environmental exposures (see inset below). These tools facilitate more comprehensive evaluation, documentation, and reporting of toxic inhalational events and other environmental exposure incidents, and improve the DoD's ability to address post deployment health concerns related to such exposures.

US Army Public Health Command Environmental Medicine Consult Service

Building E1570

Aberdeen Proving Ground-Edgewood Area, Maryland

21010-5400

Telephone: 410-436-2714

Email: USAPHC-EMP@AMEDD.army.mil

REFERENCES

(1.) National Research Council. Review of the Department of Defense Enhanced Particulate Matter Surveillance Program Report. Washington, DC: The National Academies Press; 2010. Available at: http://www.nap.edu/catalog.php?record_id=12911. Accessed March 23, 2012.

(2.) Cavallaro G. If you haven't deployed yet, stand by: search for Soldiers without a combat tour could result in break for multiple deployers. Army Times [serial online]. February 24, 2008. Available at: http://www.armytimes.com/news/2008/02/army_deploy_080225w/. Accessed October 27, 2011.

(3.) Mitchell B. Army Seeks Deployment Equality. Military.com News [serial online]. May 19, 2009. Available at: http://www.military.com/news/article/army-seeks-deployment-equality.html. Accessed October 27, 2011.

(4.) Smith B, Wong CA, Smith TC, Boyko EJ, Gackstetter GD, Ryan MAK. Newly reported respiratory symptoms and conditions among military personnel deployed to Iraq and Afghanistan: a prospective population-based study. Am J Epidemiol. 2009; 170(11):1433-1442.

(5.) Helmer DA, Rossignol M, Blatt M, Agarwal R, Teichman R, Lange G. Health and exposure concerns of veterans deployed to Iraq and Afghanistan. J Occup Environ Med. 2007;49(5):475-480.

(6.) Weese CB, Abraham JH. Potential Health implications associated with particulate matter exposure in deployed settings in southwest Asia. Inhal Toxicol. 2009;21(4):291-296.

(7.) Institute of Medicine. Long-Term Health Consequences of Exposure to Burn Pits in Iraq and Afghanistan. Washington, DC: The National Academies Press; 2011. Available at: http://www.iom.edu/Reports/2011/Long-Term-HealthConsequences-of- Exposure-to-Burn-Pits-in-Iraq-and-Afghanistan.aspx#. Accessed March 21, 2012.

(8.) Department of Defense Instruction 4715.19: Use of Open-Air Burn Pits in Contingency Operations. Washington, DC: US Dept of Defense; February 15, 2011:9.

(9.) Armed Forces Health Surveillance Center. Epi demiological Studies of Health Outcomes Among Troops Deployed to Burn Pit Sites. Washington, DC: US Dept of Defense; May 27, 2010. Available at: http://www.afhsc.mil/viewDocument?file=100604_FINAL_Burn_Pit_Epi_Studies.pdf. Accessed March 23, 2012.

(10.) Lange JL, Schwartz DA, Doebbeling BN, Heller JM, Thorne PS. Exposures to the Kuwait oil fires and their association with asthma and bronchitis among gulf war veterans. Environ Health Perspect. 2002;110(11):1141-1146.

(11.) Petruccelli BP, Goldenbaum M, Scott B, et al. Health Effects of the 1991 Kuwait Oil Fires: A Survey of US Army Troops. J Occup Environ Med. 1999;41(6):433-439.

(12.) Misraq Sulfur Fire Environmental Exposure Assessment, June 2003 through March 2007. Epidemiological Consultation Number 64-FF-064C-07. Aberdeen Proving Ground, MD: US Army Center for Health Promotion and Preventive Medicine. April, 2009.

(13.) Engelbrecht JP, McDonald EV, Gillies JA, Jayanty RK, Casuccio G, Gertler AW. Characterizing mineral dusts and other aerosols from the Middle East. Inhal Toxicol. 2009;21(4):297-336.

(14.) Abraham JH, DeBakey SF, Reid L, Zhou J, Weese CB. Does deployment to Iraq and Afghanistan affect respiratory health of US military personnel?. J Occup Environ Med. In press.

(15.) Dixon M, Fitz-Gibbon S. The environmental consequences of the war on Iraq [press release]. London, UK: The Green Party. April 2003. Available at: http://www.docstoc.com/docs/26639534/The-Environmental-Consequences-of- the-War-onIraq. Accessed March 23, 2012.

(16.) El Raey M. Air quality and atmospheric pollution in the Arab region. Kingdom of Bahrain: United Nations Environment Programme-Regional Office for West Asia; 2011. Available at: http://www.un.org/esa/sustdev/csd/csd14/escwaRIM_bp1.pdf. Accessed September 12, 2011.

(17.) Mosher DE, Lachman BE, Greenberg MD, Nichols T, Rosen B, Willis HH. Green warriors: Army environmental considerations for contingency operations from planning through post-conflict. Santa Monica, CA: RAND Corporation, 2008. Available at: http://www.rand.org/pubs/monographs/MG632. Accessed March 23, 2012.

(18.) Hauret KG, Taylor BJ, Clemmons NS, Block SR, Jones BH. Frequency and causes of nonbattle injuries air evacuated from Operations Iraqi Freedom and Enduring Freedom, US Army, 2001-2006. Am JPrevMed. 2010;38(suppl 1):S94-S107.

(19.) Sanders JW, Putnam SH, Frankart C, et al. Impact of illness and non-combat injury during Operations Iraqi Freedom and Enduring Freedom (Afghanistan). Am J Trop Med Hyg. 2005;73(4):713-719.

(20.) Wojcik BE, Humphrey RJ, Czejdo B, Hassell LH. U.S. Army disease and nonbattle injury model, refined in Afghanistan and Iraq. Mil Med. 2008;173(9):825-835.

(21.) Zouris JM, Wade AL, Magno CP. Injury and illness casualty distributions among U.S. Army and Marine Corps personnel during Operation Iraqi Freedom. Mil Med. 2008;173(3):247-252.

(22.) Harman DR, Hooper TI, Gackstetter GD. Aeromedical evacuations from Operation Iraqi Freedom: a descriptive study. Mil Med. 2005;170(6):521-527.

(23.) Roop SA, Niven AS, Calvin BE, Bader J, Zacher LL. The prevalence and impact of respiratory symptoms in asthmatics and nonasthmatics during deployment. Mil Med. 2007;172(12):1264-1269.

(24.) Field Manual 4-02: Force Health Protection in a Global Environment. Washington, DC: US Dept of the Army; February 2003: sect 2-4. [This manual, although currently characterized by the Army as obsolete, is still the governing document pending publication of Army Techniques Publication 4-02.8 during 2013.]

* The Institute of Medicine is the health component of the National Academy of Sciences. It is an independent, nonprofit organization that works outside of government to provide unbiased and authoritative advice to decision makers and the public. Information available at: http://www.iom.edu/About-IOM.aspx.

** International Classification of Diseases, Ninth Revision

*** https://doehrs-ih.csd.disa.mil/Doehrs/

([dagger]) The Institute of Medicine final report is discussed in detail in the article on page 43.

([dagger][dagger]) Level V is support provided by the US Army Public Health Command and the Navy and Marine Corps Public Health Center. Responsibilities include, but are not limited to, supporting deployed level I - IV preventive medicine personnel; performing definitive testing of air, water, and soil samples; and performing vector pathogen testing. (24)

Jessica M. Sharkey, MPH

AUTHOR

Ms Sharkey is an Epidemiologist for the Environmental Medicine Program of the Occupational and Environmental Portfolio, US Army Public Health Command, Aberdeen Proving Ground, Maryland.
an area, not containing ... an incinerator or other equipment
   specifically designed ... for burning of solid waste, designated
   for the purpose of disposing of solid waste by burning in the
   outdoor air at a location with more than 100 attached or assigned
   personnel and that is in place longer than 90 days. (8)


... the committee's review of the literature and the data from JBB
   [Joint Base Balad] suggests that service in Iraq or
   Afghanistan--that is, a broader consideration of air pollution than
   exposure only to burn pit emissions--might be associated with
   long-term health effects, particularly in susceptible (for example,
   those who have asthma) or highly exposed subpopulations (such as
   those who worked at the burn pit). (7)(pll4)


Table 1. Distribution of in-theater (OIF and OEF) toxic substance
exposures (DNBI) requiring hospitalization from 2001 through mid 2011.

Toxic Substance Exposure         Environment When Exposed   Total

                             Training   On-Duty   Unknown

Poisoning by ingestion of       1         414       14       429
toxic substances

Poisoning by inhalation of      0         95         5       100
toxic substances

Adverse systemic or skin        11        45         0       56
reaction by contact with a
toxic substance

Total                           12        554       19       585

Source: DoD Standard Inpatient Data Records database
OIF indicates Operation Iraqi Freedom
OEF indicates Operation Enduring Freedom
DNBI indicates disease and nonbattle injury

Table 2. Population
demographics of Soldiers
hospitalized in theater due to
toxic inhalation exposures
from 2001 to mid 2011
(N=100).

Category              No.

Age (years)

17-19                 6
20-29                 62
30-39                 24
40-49                 6
50-59                 2

Gender

Male                  93
Female                7

Rank

E1-E3                 25
E4-E6                 64
E7-E9                 1
WO1-WO5               3
O1-O3                 6
O4-O10                1

Component

Active Army           67
Army Reserve          20
Army National Guard   13

Source: DoD Standard Inpatient
Data Records database

Table 3. Population demographics
of Soldiers evacuated from
theater due to toxic inhalation
exposures from 2001 to mid
2011 (N = 26).

Category         No.    %
Age (years)
17-19             1    3.8
20-29            14   53.8
30-39             9   34.6
40-49             2    7.7
Gender
Male             22   84.6
Female            4   15.4
Rank
E1-E3            15   57.7
E4-E6             9   34.6
O1-O3             2    7.7
Component
Active Army      16   61.5
Not annotated    10   38.5

Source: US Transportation Command
Regulating and Command and
Control Evacuation System
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