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Higher incidence of gynaecological cancers in urban
areas, Egypt.
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| Article Type: | Brief article |
| Subject: |
Genital cancer
(Statistics) Genital cancer (Demographic aspects) Hormone therapy (Complications and side effects) Breast cancer (Statistics) Breast cancer (Demographic aspects) |
| Pub Date: | 05/01/2010 |
| Publication: | Name: Reproductive Health Matters Publisher: Reproductive Health Matters Audience: General Format: Magazine/Journal Subject: Family and marriage; Health; Women's issues/gender studies Copyright: COPYRIGHT 2010 Reproductive Health Matters ISSN: 0968-8080 |
| Issue: | Date: May, 2010 Source Volume: 18 Source Issue: 35 |
| Topic: | Event Code: 680 Labor Distribution by Employer |
| Geographic: | Geographic Scope: Egypt Geographic Code: 7EGYP Egypt |
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| Accession Number: | 236247752 |
| Full Text: |
Cancers specific to female reproductive organs such as the breast,
uterus and ovary, are associated with higher long-term exposure to
oestrogen, and numerous studies have shown that environmental
xenoestrogen presence and exposure is higher in urban areas. Previous
research showed a three to four times higher urban incidence of breast
cancer and oestrogen receptorpositive breast cancers in the Gharbiah
Province of Egypt. This study investigated the urban-rural incidences of
gynaecological cancers to see if they demonstrated the same trend, using
data on all women diagnosed with uterine, ovarian and cervical cancer
taken from the Gharbiah Cancer Registry from 1999-2002. Incidence of all
three cancers was higher in urban areas. Uterine cancer showed the
highest urban-rural incidence rate ratio with a six times higher
incidence among urban women (IRR = 6.07, 95% CI 4.17-8.85). There was an
increasing gradient of urban-rural incidence for all female cancers.
Cancers such as leukaemia (which are mainly genetically determined) had
the lowest urban-rural difference, followed by that seen for all
non-hormonally-related cancers. The inclusion of cancers that are
largely hormonally dependent, e.g. breast and uterus, increased the
urban-rural difference by almost 70% (the urban-rural difference
increased by 146% when only hormone-dependent cancers were considered).
In this population, there is no significant urban-rural difference in
other risk factors for uterine and breast cancer such as fertility rate,
health care access, and behaviour. There is also very low use of
hormonal contraception. The higher exposure of urban women to
environmental oestrogenic compounds may increase the risk of developing
hormone-related cancers. (1) (1.) Dey S, Hablas A, Seifeldin IA, et al. Urban-rural differences of gynaecological malignancies in Egypt (1999-2002). BJOG 2010;117(3):348-55. |
| Gale Copyright: | Copyright 2010 Gale, Cengage Learning. All rights reserved. |
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