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HPV testing as an adjunct to conventional cytology,
Japan.
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| Article Type: | Brief article |
| Subject: |
Medical tests
(Usage) Papillomavirus infections (Diagnosis) Papillomavirus infections (Research) Cervical cancer (Risk factors) Cervical cancer (Diagnosis) Cervical cancer (Research) |
| Pub Date: | 05/01/2011 |
| Publication: | Name: Reproductive Health Matters Publisher: Elsevier Science Publishers Audience: General Format: Magazine/Journal Subject: Family and marriage; Health; Women's issues/gender studies Copyright: COPYRIGHT 2011 Reproductive Health Matters ISSN: 0968-8080 |
| Issue: | Date: May, 2011 Source Volume: 19 Source Issue: 37 |
| Topic: | Event Code: 310 Science & research |
| Geographic: | Geographic Scope: Japan Geographic Code: 9JAPA Japan |
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| Accession Number: | 259077139 |
| Full Text: |
In the US, HPV testing as an adjunct to cervical smears for
cervical screening has been approved by the FDA. In Japan, HPV testing
is not widely used. This study assessed the effectiveness of including
HPV testing as an adjunct, which was implemented by the Government of
Kanazawa City from 2004 to 2009. Patients with atypical epithelial cells
on cytological smear underwent parallel testing for high-risk HPV types
with the Hybrid Capture II system. Colposcopy and biopsy (if necessary)
were carried out on all those who were HPV-positive with atypical cells,
as well as those with low- or high-grade intraepithelial lesions, and
those with invasive cervical cancer. Results in 62,645 women who
underwent screening were compared with those obtained before HPV
screening was initiated. Adjunct HPV testing resulted in the number of
colposcopies increasing from 2.98% to 4.29% of those screened. However,
the positive predictive value increased and the detection of 64 women
with CIN2 and CIN 3 prevented development of serious invasive cancers.
The authors conclude that HPV testing as an adjunct to conventional
cytology in cervical cancer screening seems to increase detection
sensitivity. (1) (1.) Inoue M, Okamura M, Shigeru Hashimoto S, et al. Adoption of HPV testing as an adjunct to conventionaI eytology in cervical cancer screening in Japan. International Journal of Gynecology and Obstetrics 2010;111:110-14. |
| Gale Copyright: | Copyright 2011 Gale, Cengage Learning. All rights reserved. |
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