HPV testing as an adjunct to conventional cytology, Japan.
Article Type: Brief article
Subject: Medical tests (Usage)
Papillomavirus infections (Diagnosis)
Papillomavirus infections (Research)
Cervical cancer (Risk factors)
Cervical cancer (Diagnosis)
Cervical cancer (Research)
Pub Date: 05/01/2011
Publication: Name: Reproductive Health Matters Publisher: Elsevier Science Publishers Audience: General Format: Magazine/Journal Subject: Family and marriage; Health; Women's issues/gender studies Copyright: COPYRIGHT 2011 Reproductive Health Matters ISSN: 0968-8080
Issue: Date: May, 2011 Source Volume: 19 Source Issue: 37
Topic: Event Code: 310 Science & research
Geographic: Geographic Scope: Japan Geographic Code: 9JAPA Japan
Accession Number: 259077139
Full Text: In the US, HPV testing as an adjunct to cervical smears for cervical screening has been approved by the FDA. In Japan, HPV testing is not widely used. This study assessed the effectiveness of including HPV testing as an adjunct, which was implemented by the Government of Kanazawa City from 2004 to 2009. Patients with atypical epithelial cells on cytological smear underwent parallel testing for high-risk HPV types with the Hybrid Capture II system. Colposcopy and biopsy (if necessary) were carried out on all those who were HPV-positive with atypical cells, as well as those with low- or high-grade intraepithelial lesions, and those with invasive cervical cancer. Results in 62,645 women who underwent screening were compared with those obtained before HPV screening was initiated. Adjunct HPV testing resulted in the number of colposcopies increasing from 2.98% to 4.29% of those screened. However, the positive predictive value increased and the detection of 64 women with CIN2 and CIN 3 prevented development of serious invasive cancers. The authors conclude that HPV testing as an adjunct to conventional cytology in cervical cancer screening seems to increase detection sensitivity. (1)

(1.) Inoue M, Okamura M, Shigeru Hashimoto S, et al. Adoption of HPV testing as an adjunct to conventionaI eytology in cervical cancer screening in Japan. International Journal of Gynecology and Obstetrics 2010;111:110-14.
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