Fluoride toothpastes of different concentrations for preventing dental caries in children and adolescents.
Article Type: Brief article
Subject: Dental caries (Prevention)
Fluorides (Health aspects)
Dentifrices (Health aspects)
Author: Wright, Graeme
Pub Date: 04/01/2010
Publication: Name: European Archives of Paediatric Dentistry Publisher: European Academy of Paediatric Dentistry Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2010 European Academy of Paediatric Dentistry ISSN: 1818-6300
Issue: Date: April, 2010 Source Volume: 11 Source Issue: 2
Product: Product Code: 2844420 Toothpaste NAICS Code: 325611 Soap and Other Detergent Manufacturing SIC Code: 2844 Toilet preparations
Geographic: Geographic Scope: United States Geographic Code: 1USA United States
Accession Number: 277106737
Full Text: Fluoride toothpastes of different concentrations for preventing dental caries in children and adolescents. Walsh T, Worthington HV, Glenny AM, et al. Cochrane Database of Systematic Reviews 2010, Issue 1. Art. No.: CD007868. DOI:10.1002/ 14651858. CD007868.pub2.

Summary. To determine the relative effectiveness of fluoride toothpastes of different concentrations in preventing dental caries in children and adolescents, and to examine the potentially modifying effects of baseline caries level and supervised tooth brushing. A search was undertaken on Cochrane Oral Health Group's Trials Register, CENTRAL, MEDLINE and several other databases up to 8 June 2009. Randomised controlled trials and cluster-randomised controlled trials comparing fluoride toothpaste with placebo or fluoride toothpaste of a different concentration in children up to 16 years of age with a follow-up period of at least 1 year were inclused. The primary outcome was caries increment in the permanent or deciduous dentition as measured by the change in decayed, (missing), filled tooth surfaces (D(M) FS/d(m)fs) from baseline. 75 studies were included, of which 71 studies comprising 79 trials contributed data to the network meta-analysis, network meta-regression or meta-analysis. Comment. This review confirms the benefits of using fluoride toothpaste in preventing caries in children and adolescents when compared to placebo, but only significantly for fluoride concentrations of 1000 ppm and above. The relative caries preventive effects of fluoride toothpastes of different concentrations increase with higher fluoride concentration. The decision of what fluoride levels to use for children under 6 years should be balanced with the risk of fluorosis.
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