Flavonoid from oranges lowers blood pressure.
Article Type: Brief article
Subject: Orange (Nutritional aspects)
Blood pressure (Control)
Bioflavonoids (Health aspects)
Flavones (Health aspects)
Flavonoids (Health aspects)
Author: Gaby, Alan R.
Pub Date: 04/01/2012
Publication: Name: Townsend Letter Publisher: The Townsend Letter Group Audience: General; Professional Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2012 The Townsend Letter Group ISSN: 1940-5464
Issue: Date: April, 2012 Source Issue: 345
Product: Product Code: 0174015 Oranges NAICS Code: 11131 Orange Groves SIC Code: 0174 Citrus fruits
Geographic: Geographic Scope: United States Geographic Code: 1USA United States
Accession Number: 286257208
Full Text: Twenty-four overweight men (aged 50-65 years) were randomly assigned to consume 250 ml of orange juice twice a day (providing 292 mg per day of hesperidin); a control drink with sugar composition similar to that of orange juice, plus 146 mg twice a day of hesperidin in capsule form; or the control drink plus 1 capsule twice a day of placebo (control group). Each participant received each of the 3 treatments during 3 separate 4-week periods. Compared with the control period, mean diastolic blood pressure was significantly lower by 3.2 mm Hg with the control drink plus hesperidin, and by 5.5 mm Hg with orange juice. Systolic blood pressure did not differ between treatment periods.

Comment: The results of this study indicate that supplementation with approximately 300 mg per day of hesperidin (an amount present in 500 ml of orange juice) significantly decreased diastolic blood pressure in overweight males. The greater effect of orange juice, as compared with quercetin, suggests that other substances present in orange juice (such as potassium) also have an antihypertensive effect. The concentration of hesperidin in oranges is greatest in the pith (the white portion of the peel).

Morand C et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in heallhy volunteers. Am I Clin Nutr. 2011;93:73-80.
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