Effect of isoflavones on age related hepatocytes.
Article Type: Brief article
Subject: Liver cells (Health aspects)
Isoflavones (Health aspects)
Oxidative stress (Prevention)
Pub Date: 12/22/2006
Publication: Name: Australian Journal of Medical Herbalism Publisher: National Herbalists Association of Australia Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2006 National Herbalists Association of Australia ISSN: 1033-8330
Issue: Date: Winter, 2006 Source Volume: 18 Source Issue: 4
Geographic: Geographic Scope: Australia Geographic Code: 8AUST Australia
Accession Number: 174817375
Full Text: Castillo C, Salazar V, Ariznavarreta C, Vara E, Tresguerres JAF. 2006. Effect f isoflavone administration on age-related hepatocyte changes in old ovariectomized female Wistar rats. Phytomed 13:7;468-76. (AC)

Aging seems to be due to the accumulation of oxidative damage in cells and molecules compounded by deleterious effects of menopause and ovariectomy. The process of aging induces several changes in structure and function on different systems and organs including the liver.

This study investigated whether the administration of a commercial soy extract containing 10% isoflavones was able to modify some oxidative stress and inflammation in hepatocytes of female rats. Treatment with either estradiol or isoflavones was able to improve all the parameters altered in hepatocytes to a similar level. Ovariectomy induced a significant reduction in uterine weight which was considerably counteracted by the estradiol treatment. Administration of the soy extract containing isoflavones did seem to prevent oxidatives change in the hepatocytes but did not modify the uterine weight.

Jerome Sarris

3 Widgee Place, Chapel Hill Qld 4069

Cara Barnes

20 Brendon Street, Tarragindi Qld 4121
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