Disease-modifying agents in progressive multiple sclerosis: management of 100 patients at Louis Stokes Cleveland VAMC, spinal cord injury division.
Article Type: Report
Subject: Interferon beta-1a (Health aspects)
Interferon beta-1a (Research)
Methotrexate (Health aspects)
Methotrexate (Research)
Multiple sclerosis (Drug therapy)
Multiple sclerosis (Development and progression)
Multiple sclerosis (Research)
Multiple sclerosis (Prognosis)
Authors: Mangla, Saisho
Jain, Seema
Selkirk, Stephen
Pub Date: 10/01/2011
Publication: Name: Journal of Rehabilitation Research & Development Publisher: Department of Veterans Affairs Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2011 Department of Veterans Affairs ISSN: 0748-7711
Issue: Date: Oct, 2011 Source Volume: 48 Source Issue: 10
Topic: Event Code: 310 Science & research
Geographic: Geographic Scope: United States Geographic Code: 1USA United States
Accession Number: 301479275
Full Text: INTRODUCTION

Multiple sclerosis (MS) is a chronic and progressive disease of the central nervous system (CNS), in which physical disability progresses over time. It remains the most common cause of nontraumatic neurological disability in young adults and is a significant cause of disability in the U.S. veteran population. The indirect and direct medical costs are an estimated $12 billion annually and include provider healthcare, physical therapy, rehabilitation needs, and medications but also lost productivity, missed workdays, and loss of individual earnings. Healthcare costs, as expected, increase with increasing disability, reflecting frequent complications that occur in disabled patients regardless of the underlying disease [1].

Four distinct clinical courses of MS have been defined [2], but the majority of the disease commences with relapsing-remitting MS (RRMS). The relapsing-remitting course is presumably driven by recurrent waves of focal inflammation into the brain, manifesting as acute disability, which improves, to a varying degree, after the exacerbation. These episodes of acute focal CNS inflammation are mirrored in the magnetic resonance imaging (MRI) of patients with RRMS as T2 hyperintensities, although some of these episodes and MRI sequelae may be clinically silent. Diagnostic criteria are based on the separation of lesions in time and space (different anatomical locations within the CNS). This criterion has not changed, although multiple revisions to the original criteria [3] have included the use of MRI to support this basic clinical tenet [4]. In over half of these patients, the relapsing-remitting disease course will convert to secondary progressive MS (SPMS). Twenty-five years after the diagnosis of RRMS, 75 percent of patients will have converted to SPMS [5]. This change is identified clinically by the absence or near-absence of relapses, with disability continuing to progress.

In contrast, approximately 7 to 20 percent of patients [6-7] have primary progressive MS (PPMS) characterized by neurological disability that progressively worsens over time in the absence of acute relapses. Over 80 percent of patients with PPMS will present with a slowly progressive spastic paraparesis. This subtype presumably lacks the intense punctate inflammatory events that result in exacerbations. Rather, PPMS is thought to be either neurodegenerative in nature or related to low-level persistent inflammation. The MRI findings in patients with PPMS are distinct because volume loss is more prominent with a lesser amount of T2 abnormalities compared with patients with RRMS. Diagnostic criteria have been described and include the exclusion of other causes, progression in the absence of relapses, a clinical syndrome consistent with the diagnosis, and supporting MRI and cerebral spinal fluid studies [8]. Interestingly, the clinical course of PPMS is nearly indistinguishable from SPMS. Over time, patients with these two subtypes are equally disabled. This result is true regardless of the severity of the initial relapsing-remitting course for patients with SPMS, suggesting that focal inflammatory events are perhaps less important in determining long-term disability levels [5,9-10]. Figure 1 gives the main characteristics of RRMS, SPMS, and PPMS.

Originally, the utility of defining these MS subtypes helped in recruiting appropriate patients for clinical trials. Currently, these distinctions are important because of differences in prognosis between subtypes, as well as differences in responsiveness to Food and Drug Administration (FDA)-approved MS medications. Medications target the inflammatory nature of the disease, and although they have demonstrated the capability to decrease the number of relapses a patient experiences, the evidence that these treatments significantly alter the disease course in terms of disability progression over time is weak [11]. Furthermore, little evidence exists to suggest that these medications are effective for patients with a progressive disease course.

Here, we present data regarding the management of 100 patients with MS cared for by a multidisciplinary team in the Spinal Cord Injury (SCI) Division of the Louis Stokes Cleveland Department of Veterans Affairs (VA) Medical Center (LSCVAMC), with a focus on the use of disease-modifying agents (DMAs).

METHODS

Institutional review board approval allowed us to identify patients with the diagnosis of MS from the SCI Division patient registry at the LSCVAMC. We extracted the diagnosis subtype from neurology clinic notes or through direct evaluation. By reviewing the medications that the LSCVAMC prescribed to the patient, we identified the current treatment. We determined the level of disability in patients using the Expanded Disability Status Scale (EDSS). The EDSS is the most widely used scale for determining disability and disease progression in patients with MS [12]. Patient progression in the EDSS score indicates disease progression and is an important measure in MS clinical trials. In this study, we inferred the EDSS score either from physical therapy evaluations that are completed annually by the SCI Division or through direct evaluation. We determined spasticity management by the presence of spasticity medications (Valium, baclofen, intrathecal baclofen, tizanidine, dantrolene) in the patients' medication list. Finally, we extracted demographic data from the electronic chart. We de-identified all data according to LSCVAMC policies.

RESULTS

Characteristics of Spinal Cord Injury MS Cohort

The SCI Division MS cohort is composed of patients with spinal cord involvement defined by having either neurogenic bowel or bladder and/or gait dysfunction attributed to a lesion in the spinal cord. Patients are usually referred to the SCI Division for rehabilitation needs (wheelchair, durable medical equipment, etc.) or continued management of neurogenic bowel or bladder. The majority of patients in our cohort were male (overall male-female ratio was 7:1). This ratio is significantly different from cohorts previously reported on and likely represents the male predominance of the veteran population. This male predominance decreases in the RRMS subgroup (male-female, 3:1) and increases in the PPMS (male-female, 33:1). The average age of the cohort was 58 years old, while the average age of patients with PPMS was 60 years old, SPMS 57 years old, and RRMS 53 years old (Table 1).

Disability Profile

Patients managed by the SCI Division had an average EDSS score of 6.6. The average EDSS score of patients with PPMS was higher (7.4), while the score of patients with RRMS was lower (4.5). The average EDSS score of patients with SPMS was 6.6. This generally reflects that spinal cord involvement, a prerequisite for the SCI Division, results in impaired gait and higher EDSS score (Table 1). Bladder dysfunction was found in >90 percent of patients and 100 percent of patients with PPMS, while bowel dysfunction was less common overall but was documented in nearly all patients with PPMS. Because of the level of disability, most patients (70%) required spasticity management (data not shown). Many of these patients were prescribed more than one medication for spasms, and 6 percent had an intrathecal baclofen pump for spasticity management.

To identify the complications associated with disease and disability, we determined the reason for the last hospital admission. The most common presentation leading to acute hospital admission was grouped into general medicine issues, including chest pain, wound management, shortness of breath, and lower-limb edema. The second most common reason for acute hospital admission was complications of neurogenic bladder, including urinary tract infection, urinary retention, traumatic hypospadias, stent placement for renal calculi, and cystolitholapaxy. We documented acute admissions directly associated with MS disease activity in 13 admissions, 8 of these were in patients with RRMS (Table 2).

MS Subtypes

The majority of patients managed by the SCI Division had a diagnosis of SPMS or PPMS (85%). Only 15 percent of patients had RRMS and qualified for care from the SCI Division. This finding is consistent with the concept that patients with progressive disease have higher disability levels and more spinal cord involvement than patients with RRMS. However, the percentage of patients with PPMS was notable compared with that of patients with SPMS (Figure 2). Clearly, if RRMS represents the majority of patients diagnosed, then the progressive disease subtypes should be overrepresented by SPMS. In our cohort, the ratio of SPMS to PPMS was 1.3:1.0. Whether this finding resulted from the skewing of sex in the VA population to male predominance or from a higher percentage of PPMS among veterans is unclear.

Management of MS with FDA-Approved Disease-Modifying Agents

All patients taken together, the most common treatment administered was Copaxone (21%), followed by interferon [beta]-1a (10%), methotrexate (8%), Copaxone with methotrexate (8%), and interferon [beta]-1b (5%). Notably, 37 percent of patients received no treatment at all. Nearly all patients with RRMS were treated with one of the FDA-approved DMAs (Copaxone, Rebif, interferon [beta]-1a, or interferon [beta]-1b) (Figure 2). One patient with RRMS had received Tysabri.

In contrast, no patients with SPMS were currently being treated with Novantrone, which is FDA-approved for this subclass. Only two patients followed by the SCI Division had ever received this drug. The majority of patients with SPMS were treated with Copaxone (18%), interferon [beta]-1a (12%), methotrexate (8%), Copaxone plus methotrexate (10%), or interferon [beta]-1a plus methotrexate (6%). The majority of patients with PPMS were not treated (51%). However, 21 percent of patients were prescribed Copaxone and another 8 percent received Copaxone plus methotrexate (Figure 2).

[FIGURE 2 OMITTED]

DISCUSSION

Progressive forms of MS are difficult to manage. Multiple reports describing the natural history of PPMS suggest a worse prognosis and more significant disability levels compared with patients with RRMS. SPMS is known to follow a similar course, with advancing levels of disability [7,13]. The progressive disease course is defined by the absence or near absence of clinically identifiable relapses, making this diagnosis intuitively less responsive to FDA-approved medications that decrease relapse rates in patients with MS. With these considerations in mind, we reviewed a cohort of patients whom the LSCVAMC SCI Division manages and most have progressive disease. Although cohorts of veterans and non-veterans with MS have been well described, progressive disease has not been extensively defined in veterans, particularly in terms of the rehabilitation needs, medical comorbidities, and use of DMAs.

Our cohort consisted primarily of male subjects because of the male predominance in military service. Therefore, comparing the demographics of our cohort with those that have been described was difficult. Having said this, some details can be extrapolated and compared with other cohorts. Specifically, the subgroup of patients with PPMS was clearly more disabled than the subgroup with RRMS or SPMS. This finding agrees with the concept that the diagnosis of PPMS confers a worse prognosis than RRMS. Also, as we expected, the RRMS subgroup had relatively more female patients than the PPMS subgroup, which is thought to affect male and females equally. Finally, the vast majority of patients were Caucasian, which is also consistent with cohorts described previously [14-15].

The patients in the cohort were generally referred to the SCI Division because of extensive rehabilitation needs and medical complications. Studies have demonstrated that comprehensive multidisciplinary centers offer care that improves patients' satisfaction and quality of life [16]. However, these centers are often urban-based and not realistically routinely accessible to most patients. More commonly, patients receive care from a variety of different disciplines, including internists, physiatrists, and neurologists. Our study confirms the concept that patients with progressive disease have a significant degree of disability and related medical comorbidities [13]. Medical admissions and admissions for complications from neurogenic bladder were three times more common than admissions for disease-specific events, such as exacerbation or worsening neurological function, further emphasizing the need for multidisciplinary management of patients with progressive MS.

The level of disability in our cohort resulted in extensive rehabilitation and medical services. However, the management of the disease process itself in patients not only with progressive disease but also with advanced disease was notable. Specifically, more than one in four patients with progressive disease was prescribed Copaxone. Two large-scale trials have been completed to study its effectiveness in progressive disease. The first was a trial that included 109 patients with either SPMS or PPMS. It failed to demonstrate efficacy for the drug in slowing the rate of disease progression [17]. Secondary analysis suggested the possibility that patients with PPMS may have responded to treatment, and subsequently, a large-scale, multicenter trial, PROMiSe [18], enrolling only patients with PPMS, was undertaken. This trial enrolled 943 patients with PPMS at multiple centers worldwide but failed to demonstrate efficacy in preventing disability progression over time. The study was halted prematurely because of perceived futility [18]. This failure was surprising to many, given the alleged claim that Copaxone modifies chronic inflammation and decreases MRI indicators of neurodegenration [19].

We propose several reasons why so many patients are still being treated with Copaxone, even though well-designed trials have demonstrated a lack of efficacy. First, physicians may not be familiar with the complex data and the FDA indications of this drug; second, progressive disease may instill a sense of hopelessness for both patient and provider. The FDA approval and favorable side-effect profile make Copaxone an easy choice. Third, often, as patients convert to SPMS from RRMS, providers view this decline as a therapeutic failure of interferon [beta] and therefore convert patients to Copaxone. As patients continue to decline and progress with SPMS, they are continued on their last prescribed DMA, even though it is not relevant.

Similar to Copaxone use, almost one in four patients with progressive disease was prescribed one of the three available interferon [beta]s. No evidence supports the use of this drug in PPMS, and data regarding its use in SPMS is suspect. Four large-scale studies have been conducted to determine the efficacy of interferon [beta] in patients with progressive disease. The first, the European SPMS trial, was the only of these to demonstrate efficacy, showing a significant delay in disability progression by 9 months in treated patients [20]. However, three subsequent trials have failed to recapitulate this success, making the clinical decision regarding the use of this drug in progressive disease complex [21-23]. Extensive post hoc analysis suggests that unless a patient is having active relapses in the SPMS state, no evidence exists to support efficacy.

The inappropriate use of Copaxone and interferon [beta] in progressive MS not only exposes patients to ineffective therapies with potentially harmful side effects but also represents an unnecessary economic cost to patients and the healthcare system. In the VA system, the average cost for a 1-year treatment of Copaxone is $18,052.84 for each patient. In our cohort alone, this amount represents >$523,508 a year spent on therapy that is ineffective. The average cost of Avonex, Betaseron, and Rebif is $13,731, $10,038, and $14,073 a year, respectively, for each patient. In our cohort, this cost represents an additional $325,137 a year. In total, >$800,000 a year was spent on therapy that lacks proof of efficacy in well-designed, multicenter, placebo-controlled, blinded studies. In contrast, medications like methotrexate that have been used with similar efficacy cost $8.36 a year. These costs vary from year to year based on negotiated contracts but have remained relatively stable over time. Studies of costs for these medications in the private sector have shown an increase of 13.6 percent annually from 2004 to 2007, with stable use [24]. This finding suggests that the costs of DMAs are not likely to decrease in the near future.

This study has multiple limitations, including that it is a retrospective chart review study and is limited to a cohort of 100 patients in the Cleveland VA system. The cost of DMAs is based on nationwide contracted information and can be generalized to the entire VA system, but the use of DMAs at other facilities was not reviewed here. Furthermore, private sector use was not reviewed and our conclusions cannot necessarily be generalized to these patients either. Finally, our conclusions pertain only to patients with progressive MS and should not limit the use of DMAs in patients with RRMS. The exact time of conversion of RRMS to SPMS can be difficult to identify, and therefore, if the exact subtype of MS remains in question, patients should continue taking DMAs until their progressive course becomes clinically apparent.

CONCLUSIONS

In summary, the LSCVAMC SCI Division cohort consisting mostly of patients with progressive disease, which was disproportionately male, had complex medical issues requiring interdisciplinary care and multiple hospital admission for non-MS-related medical reasons. Many patients, although significantly disabled, were continued on MS medications, which have been shown to be ineffective in altering the disease course of PPMS and SPMS. This finding underscores the importance of multidisciplinary management of patients with progressive MS, as well as a need to resist treating progressive subtypes of MS with medications that lack efficacy. Rather, the focus should be on symptomatic treatment and preventing complications in patients who are chronically disabled until medications with proven efficacy become available.

at a Glance

Multiple sclerosis (MS) is an inflammatory disease of the brain and spinal cord. It is a chronic disease affecting young adults. A significant number of patients with MS have a progressive form of the disease that results in increasing disabilities over time without improvement. Unfortunately, no medication exists to slow the disease in these patients. We reviewed the medical charts of progressive patients and found that many of them were prescribed MS drugs that were inappropriate. The use of these drugs in progressive patients exposes them to potential side effects and diverts medical resources that could be used for supportive and symptomatic care.

Abbreviations: CNS = central nervous system, DMA = disease-modifying agent, EDSS = Expanded Disability Status Scale, FDA = Food and Drug Administration, LSCVAMC = Louis Stokes Cleveland Department of Veterans Affairs Medical Center, MRI = magnetic resonance imaging, MS = multiple sclerosis, PPMS = primary progressive MS, RRMS = relapsing-remitting MS, SCI = spinal cord injury, SPMS = secondary progressive MS, VA = Department of Veterans Affairs.

ACKNOWLEDGMENTS

Author contributions:

Acquisition of data: S. Jain.

Analysis and interpretation of data: S. Mangla, S. Jain.

Drafting of Manuscript: S. Selkirk.

Critical revision of manuscript for important intellectual content: S. Selkirk.

Statistical Analysis: S. Mangla, S. Jain.

Financial Disclosure: The authors have declared that no competing interests exist.

Funding/Support: This material was unfunded at the time of manuscript preparation.

Institutional Review: The authors received institutional review board approval from the LSCVAMC.

Participant Follow-Up: The authors do not plan to inform the participants of the publication of this study.

Disclaimer: The views expressed in this article are those of the authors and do not necessarily represent the position or policy of the VA or the Department of Defense.

Submitted for publication October 14, 2010. Accepted in revised form May 11, 2011.

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ResearcherID: Stephen Selkirk, MD, PhD: F-3655-2011

Saisho Mangla, BS; (1) Seema Jain; (1) Stephen Selkirk, MD, PhD (2-3)*

Departments of Neuroscience and Neurology, Case Western Reserve School of Medicine, Cleveland, OH; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Spinal Cord Injury Division, Cleveland, OH

* Address all correspondence to Stephen Selkirk, MD, PhD; Louis Stokes Cleveland VA Medical Center, Spinal Cord Injury Division, 10701 East Blvd, Mayfield Heights, OH 44124; 216-791-3800; fax: 216-707-5902. Email: stephenselkirkmdphd@gmail.com

DOI: 10.1682/JRRD.2010.10.0200
Figure 1.

RRMS, SPMS, and PPMS disease courses of multiple sclerosis (MS)
and their main characteristics.

Relapsing Remitting MS (RRMS)

* Majority of patients have RRMS.

* Characterized by acute attacks
(exacerbations), resulting in
disability that partially or completely
resolves.

Secondary Progressive MS (SPMS)

* Majority of RRMS patients will
convert to SPMS.

* Characterized by increasing
disability in the absence of
exacerbations.

* Poor prognosis.

Primary Progressive MS (PPMS)

* Progression of disability from
disease onset without
exacerbations.

* Poor prognosis.


Table 1.
Cohort characteristics are classified according to
multiple sclerosis (MS) subtype.

Characteristic   PPMS   SPMS   RRMS   All

Sex (F:M)        1:33   1:6    1:3    1:7
EDSS (score)     7.4    6.6    4.5    6.6
Age (yr)          60     57     53    58
Race (%)
Caucasian         60     64     53    63
Black             16      6     20    12
Unknown           21     25     26    22

EDSS = Expanded Disability Status Scale, F = female,
M = male, PPMS = primary progressive MS,
RRMS = relapsing-remitting MS, SPMS = secondary
progressive MS.

Table 2.
Diagnosis associated with patient's last hospital admission was
recorded. Majority of admissions were associated with medical issues
or complications of neurogenic bladder. Minority of admissions were
related directly to multiple sclerosis (MS) disease activity and
concentrated in relapsing-remitting MS subgroup.

Type of Admission                                               Number

Medical
Coagulopathy (1), necrotic wound (1), chest pain (4),               24
shortness of breath (3), lower-limb edema (1), CHF (2),
fall (1), pneumonia (2), atrial arrhythmia (1), frostbite (1),
DVT (1), wound management (2), colonoscopy (3),
abdominal pain (1)

Neurogenic Bladder-Related
Cystoscopy with RPG/stent placement (1), cystolitholap-              19
axy (1), stent change (1), cystoscopy with stent removal
(1), cystoscopy (3), worsening incontinence (1), UTI (5),
urosepsis (2), ileovesicostomy (1), proximal right ureteral/
hydronephrosis (1), urodynamics (1), urinary retention (1)

MS-Related
MS exacerbation (11), worsening gait (1), worsening                  13
vision (1)

Psychiatric
Adjustment disorder with anxiety (1), suicide attempt (2)            3

Neurology-Related
Seizure-like episodes, mental status change (not toxic               2
metabolic)

Social
Placement needed, alcohol dependence                                 2

Rehabilitation-Related
Short-term rehabilitation and durable medical equipment              3
needs

CHF = congestive heart failure, DVT = deep venous thrombosis,
RPG = retro-grade pyelogram, UTI = urinary tract infection.
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