Delayed pubertal development by hypothalamic suppression causes an increase in periosteal modeling but a reduction in bone strength in growing female rats/Hipotalamik baskilamaya bagli gecikmis pubertal gelismenin disi ratlarda etkisi.
Abstract: 23-day-old female rats were injected with a GnRH-antagonist at 2 dosage levels (n=15/group). The low dose group (1.25 mg/kg/dose) received daily injections for 27 days (sacrifice 49 days). The high dose group received (5.0 mg/kg/dose) only 5 days per week over a 26 day period (sacrifice 48 days). Significant delays in pubertal development. Femoral lengths were shorter in the and serum IGF-1 were higher. Bone strength and stiffness were lower in the GnRH-a groups. Cortical bone area was decreased and total area was not different. There was a decrease in % Ct.Ar/T.Ar. Stress and Young's modulus were also decreased. Endocortical bone formation rates decreased and there was an increase in periosteal labeled surface. A dose response between bone strength and GnRH-antagonist dosage was found.
Authors: Yingling, V.R.
Taylor, G.
Pub Date: 08/01/2008
Publication: Name: From the Osteoporosis World Publisher: Galenos Yayincilik Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2008 Galenos Yayincilik ISSN: 1300-9141
Issue: Date: August, 2008
Accession Number: 195755864
Full Text: Yingling V.R., Taylor G.

Bone 2008,42:1137-43
Gale Copyright: Copyright 2008 Gale, Cengage Learning. All rights reserved.