Coriander has benefits for diabetes and metabolic syndrome.
Article Type: Report
Subject: Coriander (Usage)
Coriander (Health aspects)
Coriander (Reports)
Diabetes (Care and treatment)
Diabetes (Models)
Diabetes (Reports)
Hypoglycemic agents (Research)
Antilipemic agents (Research)
Metabolic syndrome X (Research)
Materia medica, Vegetable (Research)
Plant extracts (Research)
Author: Finney-Brown, Tessa
Pub Date: 12/22/2011
Publication: Name: Australian Journal of Medical Herbalism Publisher: National Herbalists Association of Australia Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2011 National Herbalists Association of Australia ISSN: 1033-8330
Issue: Date: Winter, 2011 Source Volume: 23 Source Issue: 4
Topic: Event Code: 310 Science & research
Product: Product Code: 2834121 Antidiabetic Preparations NAICS Code: 325412 Pharmaceutical Preparation Manufacturing SIC Code: 2834 Pharmaceutical preparations
Accession Number: 275312596
Full Text: Aissaoui A, Zizi S, Israili Z, Lyoussi B, 2011. Hypoglycemic and hypolipidemic effects of Coriandrum sativum L. in Meriones shawi rats. J Ethnopharmacol 137;652-61.

Coriandrum sativum (coriander) is a common herb that grows throughout much of the world. Although not utilised often in Western herbal medicine, in Morocco coriander is a traditional medicine for a number of diseases including diabetes and dyslipidemia. Other scientifically validated actions include antihypertensive, anti-inflammatory, anxiolytic, antimicrobial, diuretic and cognition improvement. Given the increasing global health problem of diabetes and obesity, with its concomitant insulin resistance and dyslipidemia/hyperlipidemia, it is becoming imperative that we find effective safe ways to treat these conditions.

The current study was designed to find evidence for the traditional use of coriander in diabetes and to assess its hypoglycemic and hypolipidemic actions. Both normal and obese hyperglycemic hyperlipidemic (OHH) Meriones shawi rats were used. Two treatment regimens were employed: a single oral dose of aqueous coriander seed extract (20 mg/kg) and 30 days of sub chronic dosing in the same amount. The effects were compared with glibenclamide (GLB) (2.5 mg/kg), a standard antidiabetic drug of the sulfonylurea class. Indices measured included blood levels of glucose, insulin, total cholesterol (TC), HDL cholesterol, LDL cholesterol, triglycerides (TG), urea and creatinine.

One group of rats was fed a hypercaloric diet and had forced limitation on physical activity for up to 90 days in order to cause significant metabolic changes mimicking those in diabetes/metabolic syndrome. This resulted in the development of obesity, hypercholestrolemia, hypertriglyceridemia, dyslipidemia (decrease in HDL cholesterol and increase in LDL cholesterol), hyperglycemia, hyperinsulinemia and insulin resistance.

After a single dose of coriander extract to the obese OHH rats there was a significant reduction in blood glucose at 2, 4 and 6 h post treatment similar to that elicited by GLB. In normal rats there was also a significant reduction. There was no significant change in plasma levels of insulin, TC, LDL cholesterol, HDL cholesterol and TG of either OHH or normal rats by administration of single doses of test substances.

After sub chronic dosing there was a significant decrease in plasma glucose levels in the OHH rats starting on day 7 and reaching normoglycemia on day 21 (similar to the effects of GLB). Normal rats also experienced a drop in blood glucose levels. There was a significant decrease in plasma insulin and insulin resistance in the OHH rats which was greater than that experienced with GLB. Total cholesterol, LDL and TG were significantly reduced in OHH rats (more so than with GLB) and HDL levels dropped. There was a significant reduction in the atherosclerotic index and no change in urea and creatinine levels (indicating no adverse effects on kidney function).

These results suggest that aqueous extract of coriander seed may be a safe effective treatment for the elevated lipids and blood sugars in diabetics and those with metabolic syndrome. In traditional medicine the usual dose of Coriandrum sativum seed powder is from 1-5 g three times a day which translates to 43-71 mg/kg oral dose for a 70 kg person.

Tessa Finney-Brown MNHAA

tessafinneybrown@gmail.com
Gale Copyright: Copyright 2011 Gale, Cengage Learning. All rights reserved.


 
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