Conception rates among women with and without HIV, USA.
Article Type: Brief article
Subject: HIV infection (Research)
Pregnancy (Research)
Women (Health aspects)
HIV infection in pregnancy (Research)
HIV infection in women (Health aspects)
Pub Date: 05/01/2011
Publication: Name: Reproductive Health Matters Publisher: Elsevier Science Publishers Audience: General Format: Magazine/Journal Subject: Family and marriage; Health; Women's issues/gender studies Copyright: COPYRIGHT 2011 Reproductive Health Matters ISSN: 0968-8080
Issue: Date: May, 2011 Source Volume: 19 Source Issue: 37
Topic: Event Code: 310 Science & research
Geographic: Geographic Scope: United States Geographic Code: 1USA United States
Accession Number: 259077153
Full Text: Reproductive decision-making for HIV-positive women is complicated, and there are scant data on the relationship between HIV and conception. This study examined the rate of and relative rime to pregnancy by HIV status between 2002 and 2009 in US women enrolled in the Women's Interagency HIV Study, an ongoing, multicentre cohort study of the natural and treated history of HIV infection among 3,766 women with and without HIV. Eligible women were age 45 or less; sexually active with male partner(s) and/or a pregnancy outcome within the past year, anal never reported hysterectomy, tubal ligation, or oopherectomy. of the 1,412 participants, 941 (67%) were HIV-positive. Over the study period, 456 women reported 766 pregnancies. Adjusting for a number of factors, HIV infection was associated with a 40% reduction in the incidence rate of pregnancy (incidence rate ratio 0.60, 95% CI 0.46-0.78). The rime for HIV-positive women to become pregnant was 73% longer compared to HIV-negative women (relative rime 1.73, 95% CI 1.35-2.36). In addition to HIV infection, decreased parity, older age and more male sex partners were independent predictors of lower pregnancy incidence. Despite the beneficial effects of antiretroviral therapy on survival and prevention of mother-to-child transmission, pregnancy incidence remains lower among HIV-positive women, particularly among those with CD4 counts <350. Whether this is due to behavioural differences (e.g. less unprotected sex or higher rates of contraception use) or reduced fertility is not known. (1)

(1.) Linas BS, Minkoff H, Cohen MH, et al. Relative rime to pregnancy among HIV-infected and uninfected women in the Women's Interagency HIV Study, 2002-2009. AIDS 2011;25(5):707-11.
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