Conception rates among women with and without HIV, USA.
|Article Type:||Brief article|
Women (Health aspects)
HIV infection in pregnancy (Research)
HIV infection in women (Health aspects)
|Publication:||Name: Reproductive Health Matters Publisher: Elsevier Science Publishers Audience: General Format: Magazine/Journal Subject: Family and marriage; Health; Women's issues/gender studies Copyright: COPYRIGHT 2011 Reproductive Health Matters ISSN: 0968-8080|
|Issue:||Date: May, 2011 Source Volume: 19 Source Issue: 37|
|Topic:||Event Code: 310 Science & research|
|Geographic:||Geographic Scope: United States Geographic Code: 1USA United States|
Reproductive decision-making for HIV-positive women is complicated,
and there are scant data on the relationship between HIV and conception.
This study examined the rate of and relative rime to pregnancy by HIV
status between 2002 and 2009 in US women enrolled in the Women's
Interagency HIV Study, an ongoing, multicentre cohort study of the
natural and treated history of HIV infection among 3,766 women with and
without HIV. Eligible women were age 45 or less; sexually active with
male partner(s) and/or a pregnancy outcome within the past year, anal
never reported hysterectomy, tubal ligation, or oopherectomy. of the
1,412 participants, 941 (67%) were HIV-positive. Over the study period,
456 women reported 766 pregnancies. Adjusting for a number of factors,
HIV infection was associated with a 40% reduction in the incidence rate
of pregnancy (incidence rate ratio 0.60, 95% CI 0.46-0.78). The rime for
HIV-positive women to become pregnant was 73% longer compared to
HIV-negative women (relative rime 1.73, 95% CI 1.35-2.36). In addition
to HIV infection, decreased parity, older age and more male sex partners
were independent predictors of lower pregnancy incidence. Despite the
beneficial effects of antiretroviral therapy on survival and prevention
of mother-to-child transmission, pregnancy incidence remains lower among
HIV-positive women, particularly among those with CD4 counts <350.
Whether this is due to behavioural differences (e.g. less unprotected
sex or higher rates of contraception use) or reduced fertility is not
(1.) Linas BS, Minkoff H, Cohen MH, et al. Relative rime to pregnancy among HIV-infected and uninfected women in the Women's Interagency HIV Study, 2002-2009. AIDS 2011;25(5):707-11.
|Gale Copyright:||Copyright 2011 Gale, Cengage Learning. All rights reserved.|