CoQ10 may increase sperm motility and density.
Article Type: Brief article
Subject: Infertility, Male (Care and treatment)
Infertility, Male (Research)
Spermatozoa (Motility)
Spermatozoa (Health aspects)
Spermatozoa (Research)
Author: Hunter, Kim
Pub Date: 09/22/2009
Publication: Name: Australian Journal of Medical Herbalism Publisher: National Herbalists Association of Australia Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2009 National Herbalists Association of Australia ISSN: 1033-8330
Issue: Date: Fall, 2009 Source Volume: 21 Source Issue: 3
Topic: Event Code: 310 Science & research
Geographic: Geographic Scope: Australia Geographic Code: 8AUST Australia
Accession Number: 215249900
Full Text: Safarinejad MR. 2009. Efficacy of Coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. J Urology 182:1;237-48.

CoQ10 is concentrated in cell mitochondria and is a potent antioxidant. As sperm are high energy users with quality linked to oxidative stress, this study examined whether CoQ10 might beneficially affect sperm quality. Two hundred and twelve infertile men were randomly assigned to receive a daily CoQ10 supplement (300 mg) or placebo for 26 weeks. This was followed by 30 weeks with no intervention.

There was an improvement in both sperm density and motility following supplements of the coenzyme. Sperm motility was 28 per mL in the CoQ10 group and 23 per mL in the placebo group and although these are modest improvements they are statistically significant.

Despite this the two values are far below the normal value for sperm motility (50% or greater). A positive association was found with regards to sperm count. Further analysis showed an increase in the percent of normal forms of sperm and an increase in the acrosome reaction of over 100% was observed in the CoQ10 group, compared with a 1% increase in the placebo group. The acrosome reaction aids in egg penetration and subsequently fertilisation.

Interestingly no improvements in pregnancy levels were observed between the groups during the intervention period. The author queried whether a longer treatment period or higher dosage might have resulted in better findings.

Kim Hunter MNHAA
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