Clinical effects of Hibiscus sabdariffa on hypertension.
|Article Type:||Brief article|
(Dosage and administration)
Hibiscus (Health aspects)
Hypertension (Drug therapy)
|Publication:||Name: Australian Journal of Medical Herbalism Publisher: National Herbalists Association of Australia Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2007 National Herbalists Association of Australia ISSN: 1033-8330|
|Issue:||Date: Spring, 2007 Source Volume: 19 Source Issue: 1|
|Topic:||Event Code: 310 Science & research|
|Geographic:||Geographic Scope: Australia Geographic Code: 8AUST Australia|
Herrera-Arellano A, Miranda-Sanchez J, Avila-Castro P,
Herrera-Alvarez S, Jimenez-Ferrer Jet al. 2007. Clinical Effects
Produced by a Standardized Herbal Medicinal Product of Hibiscus
sabdariffa on Patients with Hypertension. A Randomized, Double-blind,
Lisinopril-Controlled Clinical Trial. Planta Med 73:6-12.
A clinical trial was carried out on 168 subjects aged 25-61 with stages 1 or 2 HT received either Hibiscus sabdariffa standardised to 250 mg of total anthocyanins or lisinopril 10 mg daily for 4 weeks. Effectiveness, safety, tolerability and success were determined. Serum Na, K, and Cl were measured as well as plasmatic ACE (angiotensin converting enzyme) activity.
Both groups displayed a reduction in blood pressure however the lisinopril control group had a more significant decrease (15.79/15.68% compared to 11.58/12.21% decrease displayed by the H. sabdariffa group). The hibiscus group showed and increase in serum Cl by 3.42 meq/L and a decreased plasma Na by 2.04 meq/L, while K levels were not affected. The control group increased serum C1 by 2.87 meq/L. ACE activity was also reduced in both groups however this reduction was significantly higher in the lisinopril group.
This study indicated that H. sabdariffa exerts its antihypertensive effects through at least 2 modes of action, as a diuretic and as an ACE inhibitor. Alternative dosages need to be tested to determine if there is a dose dependant response.
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|Gale Copyright:||Copyright 2007 Gale, Cengage Learning. All rights reserved.|