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Can J Physiol Pharmacol: Dietary fenugreek seed
regresses preestablished cholesterol gallstones in
mice.
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| Article Type: | Report |
| Subject: |
Gallstones
(Diet therapy) Fenugreek (Health aspects) |
| Authors: |
Reddy R.L. Srinivasan, K. |
| Pub Date: | 12/01/2009 |
| Publication: | Name: Alternative Medicine Review Publisher: Thorne Research Inc. Audience: Academic; Professional Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2009 Thorne Research Inc. ISSN: 1089-5159 |
| Issue: | Date: Dec, 2009 Source Volume: 14 Source Issue: 4 |
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| Accession Number: | 215514466 |
| Full Text: |
An animal study was carried out to evaluate the influence of
dietary fenugreek seeds on regression of preestablished cholesterol
gallstones (CGS). CGS was induced by feeding a high-cholesterol diet for
10 weeks. After CGS induction, the animals were maintained for a further
10 weeks on experimental diets of high cholesterol, 6% fenugreek powder,
12% fenugreek powder, or basal control. Incidence of CGS and its
severity were evaluated at the end of this feeding regimen. The
incidence of CGS was significantly lowered as a result of dietary
fenugreek seeds, the extent of regression being 61% and 64% in the low
and high dose groups compared with 10% regression in the basal control
group. The antilithogenic influence of dietary fenugreek was accompanied
by significant reductions of more than 35% in serum cholesterol
concentration. Hepatic cholesterol concentration was also profoundly
lowered by dietary fenugreek, being 53%-63% lower than that of the basal
control diet. Biliary cholesterol concentration was significantly lower
as a result of dietary fenugreek during the post-CGS induction period,
resulting in a decreased cholesterol:phospholipid ratio (0.44 and 0.40
compared with 0.79 in the basal control group). Biliary cholesterol:
bile acid ratio was lowered by 67% and 73% upon feeding fenugreek,
significantly lower than that in the basal control group. The
cholesterol saturation index in the bile was also beneficially lowered
by fenugreek treatment during the post-CGS induction period (the index
was 0.90 and 0.42 compared with 1.86 in the basal control group). The
present study provides evidence of the potency of hypolipidemic
fenugreek seeds in regressing preestablished CGS, and this beneficial
antilithogenic effect is attributable to its primary influence on
cholesterol levels. This finding is significant in the context of
evolving a dietary strategy to address CGS, which could help in
preventing the incidence and regression of existing CGS and controlling
possible recurrence. 2009;87:684-693. |
| Gale Copyright: | Copyright 2009 Gale, Cengage Learning. All rights reserved. |